P - Caution when used during pregnancy
L - Caution when used during lactation
|Indication & Dosage
Adult: As ointment (per g containing calcipotriol 50 mcg and betamethasone dipropionate 0.643 mg): ≥18 yr: Apply to the affected area(s) once daily up to 4 wk. Max dose: 100 g/wk.
||May be taken with or without food.
||May elevate serum calcium levels. Excessive use of topical corticosteroids may suppress the pituitary-adrenal functions resulting in secondary adrenal insufficiency. Treatment includes discontinuing the drug and instituting symptomatic treatment.
||Known or suspected disorders of calcium metabolism. Patients with erythrodermic, exfoliative and pustular psoriasis.
||Not to be used on face, axillae or groin. Not to be applied to more than 30% of the body surface area. Monitor serum calcium levels; treatment should be temporarily discontinued if levels exceeded normal range. Prolonged usage or concurrent use with occlusive dressings may increase absorption of the drugs into the systemic circulation. Regular monitoring for evidence of hypothalamic-pituitary-adrenal axis suppression is recommended. Efficacy and safety have not been evaluated in patients with severe renal or hepatic impairment. Pregnancy and lactation.
|Adverse Drug Reactions
||Pruritus, rash, burning sensation of the skin, dry skin, erythema, rash, dermatitis, eczema, photosensitivity and hypersensitivity reactions. May aggravate psoriasis.
||Topical/Cutaneous: Store between 20-25°C.
||Betamethasone dipropionate is a synthetic corticosteroid that has anti-inflammatory, antipruritic and vasoconstrictive properties. Calcipotriol is a vitamin D analogue. It may induce differentiation and suppress proliferation of keratinocytes.
Absorption: Betamethasone dipropionate: Percutaneous absorption depends on several factors e.g. use of occlusive dressings and integrity of the epidermal barrier.
Distribution: Betamethasone dipropionate: Once absorbed systemically, it is bound to plasma proteins in varying extents.
Metabolism: Betamethasone dipropionate: Once absorbed through the skin, it is metabolised mainly by the liver.
Excretion: Betamethasone dipropionate: Once absorbed through the skin, it is excreted largely renally; may also be excreted via the bile.
||S01CB04 - betamethasone; Belongs to the class of corticosteroids/antiinfectives/mydriatics combinations. Used in the treatment of eye diseases.
D07AC01 - betamethasone; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
H02AB01 - betamethasone; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
D05AX02 - calcipotriol; Belongs to the class of other topical agents used in the treatment of psoriasis.
S02BA07 - betamethasone; Belongs to the class of corticosteroids used in the treatment of inflammation of the ear.
A07EA04 - betamethasone; Belongs to the class of corticosteroids acting locally. Used in the treatment of intestinal inflammation.
R03BA04 - betamethasone; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, glucocorticooids.
S03BA03 - betamethasone; Belongs to the class of corticosteroids used in ophthalmologic and otologic preparations.
C05AA05 - betamethasone; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids.
D07XC01 - betamethasone; Belongs to the class of potent (group III) corticosteroids in other combinations. Used in the treatment of dermatological diseases.
R01AD06 - betamethasone; Belongs to the class of topical corticosteroids used as nasal decongestants.
S01BA06 - betamethasone; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.