mph Bangladesh


Chlorpheniramine

(klor fen ir' a meen)

P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

 
Indication & Dosage Oral
Allergic conditions
Adult: 4 mg every 4-6 hr. Max: 24 mg daily. 
Child: 1-2 yr: 1 mg bid, 2-5 yr: 1 mg every 4-6 hr, 6-12 yr: 2 mg every 4-6 hr. Max: 6 mg daily (1-5 yr); 12 mg daily (6-12 yr). 
Parenteral
Adjunct in the emergency treatment of anaphylactic shock
Adult: 10-20 mg IM, SC, or slow IV inj over 1 min. Max dose: 40 mg daily.
Child: 87.5 mcg/kg SC 4 times daily

Incompatibility: Incompatible with calcium chloride, kanamycin sulfate,noradrenaline acid tartrate, pentobarbital sodium and meglumine adipiodone.
Incompatibility: Incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium and meglumine adipiodone.
Administration May be taken with or without food.
Contraindications Hypersensitivity, neonates.
Special Precautions Elderly, pylori duodenal obstruction, angle-closure glaucoma, urinary retention, prostatic hyperplasia, epilepsy, renal and hepatic impairment. May affect performance of skilled tasks. BPH, bladder neck obstruction, hypertension. Pregnancy, lactation.
Adverse Drug Reactions CNS depression, sedation, drowsiness, lassitude, dizziness. GI upsets, anorexia, or increased appetite, epigastric pain, blurring of vision, dysuria, dryness of mouth, tightness in chest, hypotension, muscular weakness, tinnitus, euphoria, headache, paradoxical CNS stimulation.
Potentially Fatal: CV collapse and respiratory failure.
Drug Interactions Potentiates sedative effect of psychotropic drugs e.g. barbiturates, hypnotics, opioid analgesics, anxiolytics and antipsychotics. Interaction with alcohol could be dangerous (sedation/excitation). Please consult detailed drug interactions before prescribing. 
Food Interaction Reduced bioavailability
Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Storage Oral: Store below 25°C. Parenteral: Store below 25°C.
Pharmacology Chlorphenamine is an H1-receptor antagonist which competetively blocks H1-receptor sites on tissues.
Duration: 4-6 hr.
Absorption: Absorbed relatively slowly from the GI tract (oral); peak plasma concentrations after 2.5-6 hr.
Distribution: Widely distributed; CNS. Protein-binding: 70%.
Metabolism: Extensive; converted to desmethyl- and didesmethylchlorphenamine.
Excretion: Via urine (as unchanged drug and metabolites).
ATC Classification R06AB04 - chlorphenamine ; Belongs to the class of substituted alkylamines used as systemic antihistamines.

Brand/Product Info


Total Products : 59                                                           
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ALERJESS Ad-din pharmaceuticals Ltd. Chlorpheniramine maleate 4mg Tablet 200's: 20.00 MRP
ALERJESS Syrup Ad-din pharmaceuticals Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 14.00 MRP
ALLERMINE Renata Limited Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 14.14 MRP
ANTISTA Square Pharmaceuticals Ltd. Chlorpheniramine Maleate 2mg/5 ml Syrup 100 ml: 21.85 MRP
BIOCIN Biopharma Laboratories Ltd Chlorpheniramine maleate 4mg Tablet 100's: 20.00 MRP
BIOCIN Syrup Biopharma Laboratories Ltd Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 14.05 MRP
CENTAGAN Central Pharmaceuticals Ltd Chlorpheniramine maleate 2mg/5ml Syrup 60ml, 100ml: 9.50 & 12.00 MRP
CHLORPHENIRAMINE Medimet Pharmaceuticals Ltd Chlorpheniramine maleate 4mg Tablet 100's: 18.00 MRP
CLORAMIN Orion Pharma Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 13.05 MRP
DENAMINE Desh Pharmaceuticals (Pvt) Ltd Chlorpheniramine maleate 4mg Tablet 500's: 80.00 MRP
DENAMINE Syrup Desh Pharmaceuticals (Pvt) Ltd Chlorpheniramine maleate 2mg/5ml Syrup 60ml: 8.75 MRP
DISTAMIN Doctors Chemical Works Ltd Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 14.00 MRP
ELICIN Reliance Pharmaceuticals Ltd. Chlorpheniramine maleate 4mg Tablet 100's: 20.00 MRP
ELICIN Syrup Reliance Pharmaceuticals Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 60ml: 10.00 MRP
ERAMIN Pharmadesh Laboratories Limited Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
ERAMIN Syrup Pharmadesh Laboratories Limited Chlorpheniramine maleate 2mg/5ml Syrup 60ml, 100ml: 9.31 & 20.00 MRP
EXPILIN Gaco Pharmaceutical Ltd. Chlorpheniramine maleate 4mg Tablet 100's, 500's: 20.00 & 100.00 MRP
EXPILIN Syrup Gaco Pharmaceutical Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 60ml: 9.00 MRP
G-ANTIHISTAMINE Gonoshasthaya Pharmaceuticals Ltd Chlorpheniramine maleate 4mg Tablet 100's & 1000's pot: 21.00 & 80.00 MRP
HISNUL Somatec Pharmaceuticals Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 60ml, 100ml: 8.03 & 14.10 MRP
HISTACIN Jayson Pharmaceuticals Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
HISTACIN Injection Jayson Pharmaceuticals Ltd. Chlorpheniramine maleate 10mg/ml Injection 10 amps: 33.40 MRP
HISTACIN Syrup Jayson Pharmaceuticals Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 60ml, 100ml: 8.09 & 12.63 MRP
HISTACO Supreme Pharmaceuticals Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
HISTACO Syrup Supreme Pharmaceuticals Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 60ml: 9.00 MRP
HISTADYL Rephco Laboratories Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
HISTADYL Syrup Rephco Laboratories Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 60ml: 11.70 MRP
HISTAL Opsonin Pharma Limited Chlorpheniramine maleate 2mg/5ml Syrup 60ml: 9.60 MRP
HISTALEX The Acme Laboratories Ltd. Chlorpheniramine maleate 4mg Tablet 100's: 20.00 MRP
HISTALEX Syrup The Acme Laboratories Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 21.78 MRP
HISTAMINE Ziska Pharmaceuticals Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 120.00 MRP
HISTANOL Chemist Laboratories Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 105.00 MRP
HISTANOL Syrup Chemist Laboratories Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 13.30 MRP
HISTASON Hudson Pharmaceuticals Ltd Chlorpheniramine maleate 4mg Tablet 500's: 80.00 MRP
HISTASON Syrup Hudson Pharmaceuticals Ltd Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 12.00 MRP
HISTATAB Bristol Pharma Limited Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
HISTIN Apollo Pharmaceutical Laboratories Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 105.00 MRP
HISTOSIN Aexim Pharmaceutical Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 80.00 MRP
HISTOSIN Syrup Aexim Pharmaceutical Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 12.00 MRP
HITAGEN General Pharmaceuticals Ltd Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
HITAGEN Syrup General Pharmaceuticals Ltd Chlorpheniramine maleate 2mg/5ml Syrup 60ml, 100ml: 8.03 & 14.03 MRP
MYCETRA Mystic Pharmaceuticals Limited Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 14.14 MRP
PENAMIN APC Pharmaceuticals Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
PHENOMARK Hallmark Pharmaceuticals Ltd Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 21.60 MRP
PHERAMIN Amico Laboratories Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
PHERAMIN Syrup Amico Laboratories Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 11.70 MRP
PIRITON GlaxoSmithKline Bangladesh Limited Chlorpheniramine maleate 4mg Tablet 500's: 101.74 MRP
PIRITON Syrup GlaxoSmithKline Bangladesh Limited Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 21.75 MRP
REMACIN Reman Drug Laboratories Ltd. Chlorpheniramine maleate 4mg Tablet 200's: 40.00 MRP
SAFAMIN Benham Pharmaceuticals Ltd Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 13.65 MRP
SALTAMIN Salton Pharmaceuticals Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
SALTAMIN Syrup Salton Pharmaceuticals Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 13.00 MRP
SEDILUX-M Modern Pharmaceuticals Ltd Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
SEDILUX-M Syrup Modern Pharmaceuticals Ltd Chlorpheniramine maleate 2mg/5ml Syrup 60ml, 100ml: 9.60 & 14.19 MRP
SINAMIN IBN SINA Pharmaceutical Industry Ltd. Chlorpheniramine maleate 4mg Tablet 500's: 100.00 MRP
SINAMIN Syrup IBN SINA Pharmaceutical Industry Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 100ml: 14.19 MRP
SYMIN Syntho Laboratories Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 60ml: 9.50 MRP
WINKOL Globe Pharmaceuticals Ltd Chlorpheniramine maleate 2mg/5ml Syrup 60ml, 100ml: 8.00 & 12.00 MRP
ZISTACIN Zenith Pharmaceuticals Ltd. Chlorpheniramine maleate 2mg/5ml Syrup 60ml, 100ml: 9.00 & 13.90 MRP

Gen. MedInfo

IMPORTANT WARNING:

U.S FDA Intends to Remove Some Unapproved Cough, Cold, and Allergy Drugs from the Market

This safety alert does not apply to this medication, but only to some products which contain this medication. In addition, it is important that you know that there is not a problem with most of the products described in this medication monograph. And some drug companies may decide to seek full approval from the FDA so that they can continue marketing their products.

On March 2, 2011, the Food and Drug Administration (FDA) issued a safety alert about certain unapproved prescription cough, cold, and allergy products containing this drug in combination with other drugs. These products are not currently approved by the FDA for safety, effectiveness, and quality. FDA asked drug companies to stop shipping most of these products for sale in the US within the next 6 months. Although some of these products have been marketed for many years, laws about what a company must prove to FDA for drug product approval have gotten tougher and increased enforcement of these laws is now taking place. The FDA took this action due to concerns about certain potential risks associated with use of these medications. These risks may include:

  • the possibility of improper use in infants and young children

  • potentially risky combinations of ingredients

  • patients receiving too much or too little of the medication because of problems with the way some ''timed-release'' products are made

If you are concerned that the prescription cough, cold, and allergy medication you are taking is not approved by the FDA, you should talk to your doctor or pharmacist. If the medication you are taking is not approved, your doctor can prescribe another prescription medication or your doctor or pharmacist can suggest an over-the-counter (OTC) cough, cold, and allergy product for your condition. There are many safe and effective alternative approved products that can be taken instead. Your doctor probably prescribed the medicine without knowing that FDA had not approved it. This is because it has been so difficult for doctors and pharmacists to find out that these products are unapproved. For additional information:

 

Why is this medication prescribed? 

Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.

How should this medicine be used? 

Chlorpheniramine comes as a tablet, a capsule, an extended-release (long-acting) tablet and capsule, a chewable tablet, and a liquid to take by mouth. The regular capsules and tablets, chewable tablets, and liquid are usually taken every 4 to 6 hours as needed. The extended-release (long-acting) tablets and capsules are usually taken twice a day in the morning and evening as needed. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Take chlorpheniramine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Chlorpheniramine comes alone and in combination with fever and pain reducers, expectorants, cough suppressants, and decongestants. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using 2 or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose.This is especially important if you will be giving cough and cold medications to a child.

Nonprescription cough and cold combination products, including products that contain chlorpheniramine, can cause serious side effects or death in young children. Do not give these products to children younger than 4 years of age. If you give these products to children 4-11 years of age, use caution and follow the package directions carefully.

If you are giving chlorpheniramine or a combination product that contains chlorpheniramine to a child, read the package label carefully to be sure that it is the right product for a child of that age. Do not give chlorpheniramine products that are made for adults to children.

Before you give a chlorpheniramine product to a child, check the package label to find out how much medication the child should receive. Give the dose that matches the child's age on the chart. Ask the child's doctor if you don't know how much medication to give the child.

If you are taking the liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.

If you are using the extended-release tablets or capsules, swallow them whole. Do not break, crush, chew, or open them.

Other uses for this medicine 

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow? 

Before taking chlorpheniramine, 

  • tell your doctor if you are allergic to chlorpheniramine, any other medications, or any of the ingredients in the chlorpheniramine product you plan to use. Check the package label for a list of the ingredients.
  • tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: other medications for colds, hay fever, or allergies; medications for anxiety, depression, or seizures; muscle relaxants; narcotic medications for pain; sedatives; sleeping pills; and tranquilizers.
  • tell your doctor if you have or have ever had asthma, emphysema, chronic bronchitis, or other types of lung disease; glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision); ulcers; diabetes; difficulty urinating (due to an enlarged prostate gland); heart disease; high blood pressure; seizures; or an overactive thyroid gland.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking chlorpheniramine, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking chlorpheniramine.
  • you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
  • ask your doctor about the safe use of alcohol while you are taking chlorpheniramine. Alcohol can make the side effects of chlorpheniramine worse.

What special dietary instructions should I follow? 

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose? 

Chlorpheniramine is usually taken as needed. If your doctor has told you to take chlorpheniramine regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause? 

Chlorpheniramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: 

  • drowsiness

  • dry mouth, nose, and throat

  • nausea

  • vomiting

  • loss of appetite

  • constipation

  • headache

  • increased chest congestion

 Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • vision problems

  • difficulty urinating

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. 

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

 

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