(lor at' a deen)
P Â - Contraindicated in pregnancy
L Â - Contraindicated in lactation
|Indication & Dosage||Oral
Adult:Â 10 mg once daily.
Child:Â 2-5 yr: 5 mg once daily. 6-12 yr: 10 mg once daily.
Renal impairment:Â Dosage may need to be reduced to alternate day admin.
Hepatic impairment:Â Dosage may need to be reduced to alternate day admin.
Special Populations:Â In patients with liver failure: Start with 10 mg on alternate days.
|Administration||May be taken with or
|Contraindications||Pregnancy, lactation, children <2 yr.|
|Special Precautions||Severe hepatic damage, epilepsy, renal insufficiency.|
|Adverse Drug Reactions||Fatigue, giddiness, dizziness, dry mouth, headache, nausea, somnolence.|
|Drug Interactions||Plasma concentrations increased by ketoconazole, cimetidine, nefazodone, erythromycin and possibly other inhibitors of CYP3A4.Â Please consult detailed drug interactions before prescribing.|
|Lab Interference||Reactions to skin testing procedures may be reduced.|
|Pregnancy Category (US FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Pharmacology||Loratadine is a non-sedating antihistamine. It
works by selectively binding to peripheral histamine H1Â -receptors on effector cells.
Absorption:Â Absorbed rapidly from the GI tract (oral); peak plasma concentrations after 1 hr. Absorption delayed by the presence of food.
Distribution:Â Enters breast milk, does not cross the blood-brain barrier. Protein-binding: 98%.
Metabolism:Â Extensively hepatic; converted to descarboethoxyloratadine (desloratadine).
Excretion:Â Via urine and faeces (as metabolites);elimination half-life 8.4 hr (loratadine) and 28 hr (desloratadine).
|ATC Classification||R06AX13 - loratadine ; Belongs to the class of other agents used as systemic antihistamines.|
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ALARON||ACI Ltd.||Loratadine INN 10mg||Tablet||100's: 301.00 MRP|
|ALARON Suspension||ACI Ltd.||Loratadine INN 5mg/5ml||Suspension||60ml: 30.11 MRP|
|ALERT||Apollo Pharmaceutical Laboratories Ltd.||Loratadine INN 10mg||Tablet||100's: 273.00 MRP|
|ALEZE||UniDerma Pharmaceuticals Ltd.||Loratadine INN 10mg||Tablet||50's: 125.00 MRP|
|ALEZE Syrup||UniDerma Pharmaceuticals Ltd.||Loratadine INN 5mg/5ml||Syrup||60ml: 26.00 MRP|
|ANALOR||Techno Drugs||Loratadine INN 10mg||Tablet||50's: 150.00 MRP|
|CLADIN||Ad-din pharmaceuticals Ltd.||Loratadine INN 10mg||Tablet||100's: 225.00 MRP|
|DIN-10||Millat Pharmaceuticals Ltd||Loratadine INN 10mg||Tablet||100's: 300.00 MRP|
|ELADIN||Jayson Pharmaceuticals Ltd.||Loratadine INN 10mg||Tablet||50's: 152.50 IP|
|ELADIN Suspension||Jayson Pharmaceuticals Ltd.||Loratadine INN 5mg/5ml||Suspension||60ml: 26.40 IP|
|ELO||Edruc Limited||Loratadine INN 10mg||Tablet||100's: 250.00 MRP|
|Encilor||Incepta Pharmaceuticals Limited||Loratadine INN 10 mg||Tablet||10x10's:MRP 300 Tk|
|ERADEX||Doctors Chemical Works Ltd||Loratadine INN 10mg||Tablet||50's: 136.50 MRP|
|ITCHLOR||NIPRO JMI Pharma Ltd.||Loratadine USP 10mg||Tablet||30's: 90.60 MRP|
|ITCHLOR Suspension||NIPRO JMI Pharma Ltd.||Loratadine USP 5mg/5ml||Suspension||60ml: 30.12 MRP|
|KEVIL||Kemiko Pharmaceuticals Ltd||Loratadine INN 10mg||Tablet||100's: 300.00 MRP|
|KEVIL Suspension||Kemiko Pharmaceuticals Ltd||Loratadine INN 5mg/5ml||Suspension||60ml: 26.00 MRP|
|LODIN||Amico Laboratories Ltd.||Loratadine INN 10mg||Tablet||100's: 300.00 MRP|
|LORA||Opsonin Pharma Limited||Loratadine INN 10mg||Tablet||100's: 250.00 MRP|
|LORA Suspension||Opsonin Pharma Limited||Loratadine INN 5mg/5ml||Suspension||60ml: 25.00 MRP|
|LORACIL||Ziska Pharmaceuticals Ltd.||Loratadine INN 10mg||Tablet||100's: 250.00 MRP|
|LORADIN||Aristopharma Ltd.||Loratadine INN 10mg||Tablet||100's: 300.00 MRP|
|LORAT||Drug International Ltd||Loratadine INN 10mg||Tablet||100's: 300.00 MRP|
|LORATEC||Desh Pharmaceuticals (Pvt) Ltd||Loratadine INN 10mg||Tablet||100's: 200.00 MRP|
|LORATIN||Square Pharmaceuticals Ltd.||Loratadine 10mg||Tablet||10x10's: 301.00 MRP|
|LORATIN FAST||Square Pharmaceuticals Ltd.||Loratadine 10mg||Orally Dispersible Tablet||10x10's: 301.00 MRP|
|LORATIN SUSP||Square Pharmaceuticals Ltd.||Loratadine 5mg/5 ml||Suspension||60 ml: 30.20 MRP|
|LOREN||Pharmadesh Laboratories Limited||Loratadine INN 10mg||Tablet||100's: 200.00 MRP|
|LORFAST||Biopharma Laboratories Ltd||Loratadine INN 10mg||Tablet||50's: 150.50 MRP|
|LORFAST Suspension||Biopharma Laboratories Ltd||Loratadine INN 5mg/5ml||Suspension||60ml: 26.10 MRP|
|LORIN||General Pharmaceuticals Ltd||Loratadine INN 10mg||Tablet||100's: 301.00 MRP|
|LORIN Suspension||General Pharmaceuticals Ltd||Loratadine INN 5mg/5ml||Suspension||60ml: 30.11 MRP|
|LTDIN||Modern Pharmaceuticals Ltd||Loratadine INN 10mg||Tablet||100's: 250.00 MRP|
|NOSERAL||Peoples Pharma Ltd.||Loratadine INN 10mg||Tablet||50's: 120.50 MRP|
|ORADIN||Eskayef Bangladesh Ltd||Loratadine USP 10mg||Tablet||100's MRP: 300.00|
|ORADIN FT||Eskayef Bangladesh Ltd||Loratadine USP 10mg FT||Tablet (flash/orally dispersible)||40's MRP: 160.00|
|ORADIN Suspension||Eskayef Bangladesh Ltd||Loratadine USP 5mg/5ml||Suspension||60ml MRP: 30.00|
|OWN||The Acme Laboratories Ltd.||Loratadine INN 10mg||Tablet||100's: 300.00 MRP|
|OWN Suspension||The Acme Laboratories Ltd.||Loratadine INN 5mg/5ml||Suspension||60ml: 26.10 MRP|
|PRETIN||Beximco Pharmaceuticals Ltd||Loratadine INN 10mg||Tablet||100's: 300.00 MRP|
|SALORA||Shamsul Alamin Pharmaceuticals Ltd||Loratadine INN 10mg||Tablet||50's: 150.00 MRP|
|SILORA||IBN SINA Pharmaceutical Industry Ltd.||Loratadine INN 10mg||Tablet||50's: 125.00 MRP|
Why is this medication prescribed?
Loratadine is used to temporarily relieve the symptoms of hay fever (allergy to pollen, dust, or other substances in the air) and other allergies. These symptoms include sneezing, runny nose, and itchy eyes, nose, or throat. Loratadine is also used to treat itching and redness caused by hives. However, loratadine does not prevent hives or other allergic skin reactions. Loratadine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Loratadine is also available in combination with pseudoephedrine (Sudafed, others). This monograph only includes information about the use of loratadine alone. If you are taking the loratadine and pseudoephedrine combination product, read the information on the package label or ask your doctor or pharmacist for more information.
How should this medicine be used?Â
Loratadine may come as a syrup (liquid), an immediate acting and extended release tablet, and a rapidly disintegrating (dissolving) tablet to take by mouth. It is usually taken once a day with or without food. Follow the directions on the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take loratadine exactly as directed. Do not take more or less of it or take it more often than directed on the package label or recommended by your doctor. If you take more loratadine than directed, you may experience drowsiness.
If you are taking the rapidly disintegrating tablet, follow the package directions to remove the tablet from the blister package without breaking the tablet. Do not try to push the tablet through the foil. After you remove the tablet from the blister package, immediately place it on your tongue and close your mouth. The tablet will quickly dissolve and can be swallowed with or without water.
Do not use loratadine to treat hives that are bruised or blistered, that are an unusual color, or that do not itch. Call your doctor if you have this type of hives.
Stop taking loratadine and call your doctor if your hives do not improve during the first 3 days of your treatment or if your hives last longer than 6 weeks. If you do not know the cause of your hives, call your doctor.
If you are taking loratadine to treat hives, and you develop any of the following symptoms, get emergency medical help right away: difficulty swallowing, speaking, or breathing; swelling in and around the mouth or swelling of the tongue; wheezing; drooling; dizziness; or loss of consciousness. These may be symptoms of a life-threatening allergic reaction called anaphylaxis. If your doctor suspects that you may experience anaphylaxis with your hives, he may prescribe an epinephrine injector (EpiPen). Do not use loratadine in place of the epinephrine injector.Â
Do not use this medication if the safety seal is open or torn.
Other uses for this medicineÂ
This medication may be recommended for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking loratadine,Â
- tell your doctor if you are allergic to loratadine, any other medications, or any of the ingredients in the type of loratadine you will be taking. Check the package label for a list of the ingredients.
- tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention medications for colds and allergies.
- tell your doctor if you have or have ever had asthma or kidney or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking loratadine, call your doctor.
- if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent mental retardation), you should know that some brands of the orally disintegrating tablets may contain aspartame that forms phenylalanine.
What special dietary instructions should I follow?Â
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?Â
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Loratadine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:Â
difficulty falling asleep or staying asleep
red or itchy eyes
Some side effects may be serious. If you experience any of the following symptoms, stop taking loratadine and call your doctor immediately:Â
swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles, or lower legs
difficulty breathing or swallowing
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom)and away from light. Use the orally disintegrating tablets immediately after you remove them from the blister package, and within 6 months after you open the outer foil pouch. Write the date that you open the foil pouch on the product label so that you will know when 6 months have passed. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdoseÂ
In case of overdose,Â consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.
Symptoms of overdose may include:
fast or pounding heartbeat
unusual body movements
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref:Â Â U.S. National Library of Medicine.
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.