(lee'' voe se tir' i zeen)
L : Contraindication for lactation (breast feeding)
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication & Dosage||Oral
Adult: As hydrochloride: 5 mg daily in the evening; 2.5 mg may be adequate in some patients. Max dose: 5 mg daily.
Child: As hydrochloride: 6-11 yr: 2.5 mg once daily. Max dose: 2.5 mg daily. â‰¥12 yr: 5 mg once daily; 2.5 mg may be adequate is some patients. Max dose: 5 mg daily. All doses to be taken in the evening.
Special Populations: If CrCl 30-50 mL/minute, 5 mg on alternate days. If CrCl < 30 mL/minute, avoid.
|Administration||Immediate-release: May be taken with or without food. Avoid grapefruit juice.
Retard, GITS & OROS: May be taken with or without food. Avoid grapefruit juice. Swallow whole, do not chew/crush.
|Overdosage||Symptoms: Drowsiness, agitation, restlessness. Management: Supportive and symptomatic.|
|Contraindications||Lactation. End-stage renal disease (CrCl <10 ml/min) or haemodialysis patients. Child 6-11 yr with renal impairment.|
|Special Precautions||Renal impairment. May impair ability to drive or operate machinery.|
|Adverse Drug Reactions||Fatigue, somnolence, dry mouth, nasopharyngitis, pyrexia, cough, epistaxis.|
|Drug Interactions||Additive sedation with alcohol and other CNS depressants. Please consult detailed drug interactions before prescribing.|
|Pregnancy Category (US FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Storage||Oral: Store at 20-25°C (68-77°F).|
|Pharmacology||Levocetirizine, an active isomer of cetirizine, selectively inhibits histamine H1-receptors.
Absorption: Rapidly and extensively absorbed from the GI tract (oral); peak plasma concentration in 0.9 hr.
Distribution: Protein-binding: 91-92%.
Metabolism: Via aromatic oxidation, N- and O-dealkylation and taurine conjugation.
Excretion: Via urine (85.4%), via faeces (12.9%), as metabolites and unchanged drug; 8 hr (plasma half-life).
|ATC Classification||R06AE09 - levocetirizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.|
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ACITRIN-L||ACI Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 201.00 MRP|
|ACITRIN-L Solution||ACI Ltd.||Levocetirizine dihydrochloride INN 2.5mg/5ml||Oral Solution||60ml: 40.00 MRP|
|ALCET||Healthcare Pharmacuticals Ltd.||Levocetirizine Dihydrochloride INN 5mg||Tablet||100's MRP 350 Tk|
|ALCET SYRUP||Healthcare Pharmacuticals Ltd.||Levocetirizine Dihydrochloride INN 2.5mg/5ml||Syrup||60ml, MRP 50 Tk|
|CEVOZIN||Ad-din pharmaceuticals Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 200.00 MRP|
|CLARIGEN||Drug International Ltd||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 200.00 MRP|
|CURIN||Beximco Pharmaceuticals Ltd||Levocetirizine Dihydrochloride INN 5mg||Tablet||100's: 350.00 MRP|
|ENACET||Somatec Pharmaceuticals Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 201.00 MRP|
|LACER||Everest Pharmaceuticals Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||50's: 100.00 MRP|
|LECET||Pacific Pharmaceuticals Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||50's: 100.00 MRP|
|LECETRIN||Delta Pharma Limited||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 200.00 MRP|
|LECITIN||Zenith Pharmaceuticals Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 200.00 MRP|
|LEREX||Asiatic Laboratories Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||50's: 100.00 MRP|
|LEVANT||Bristol Pharma Limited||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 200.00 MRP|
|LEVOCET||Alco Pharma Ltd||Levocetirizine dihydrochloride INN 5mg||Tablet||50's: 100.00 MRP|
|LEVOCETRIL||Chemist Laboratories Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 200.00 MRP|
|LEVOREX||Popular Pharmaceuticals Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 201.00 MRP|
|LINGIN||Sandoz/Novartis||Levocetirizine dihydrochloride INN 5mg||Tablet||5x10's, MRP 160.00|
|LISET||Syntho Laboratories Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||50's: 100.00 MRP|
|LOZIN||Kemiko Pharmaceuticals Ltd||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 200.00 MRP|
|LUPRON||Kumudini Pharma Ltd||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 200.00 MRP|
|MEGATROL||Peoples Pharma Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 160.00 MRP|
|POLAN||Globe Pharmaceuticals Ltd||Levocetirizine dihydrochloride INN 5mg||Tablet||50's: 100.00 MRP|
|PUROTROL||Square Pharmaceuticals Ltd.||Levocetirizine 5mg||Tablet||5x10's: 175.50 MRP|
|RINOCET||R A K Pharmaceuticals Pvt. Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 200.00 MRP|
|RINOTIN||Biopharma Laboratories Ltd||Levocetirizine dihydrochloride INN 5mg||Tablet||100's: 201.00 MRP|
|Seasonix||Incepta Pharmaceuticals Limited||Levocetirizine Dihydrochloride INN 5mg||Tablet||10x10's:MRP 350 Tk|
|SEASONIX Solution||Incepta Pharmaceuticals Limited||Levocetirizine Dihydrochloride INN 2.5mg/5ml||Solution||60ml: 40.00 MRP|
|VERIZIN||Sharif Pharmaceuticals Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||50's: 100.00 MRP|
|VOCET||Apex Pharmaceuticals Ltd.||Levocetirizine dihydrochloride INN 5mg||Tablet||50's: 100.00 MRP|
Why is this medication prescribed?
Levocetirizine is used to relieve runny nose; sneezing; and redness, itching, and tearing of the eyes caused by hay fever, seasonal allergies, and allergies to other substances such as dust mites, animal dander, and mold. It is also used to treat symptoms of hives, including itching and rash. Levocetirizine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
How should this medicine be used?
Levocetirizine comes as a tablet to take by mouth. It is usually taken once a day in the evening with or without food. Take levocetirizine at the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take levocetirizine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
What special precautions should I follow?
Before taking levocetirizine,
- tell your doctor if you are allergic to levocetirizine, cetirizine, or any other medications.
- tell your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; medications for anxiety, mental illness, or seizures; ritonavir (Norvir, in Kaletra); sedatives; sleeping pills; theophylline; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or ever have had kidney disease.
- tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking levocetirizine, call your doctor. Do not breast-feed while you are taking levocetirizine.
- you should know that levocetirizine may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
- ask your doctor about the safe use of alcoholic beverages while you are taking levocetirizine. Alcohol can add to the drowsiness caused by this medication.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Levocetirizine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
swelling of the arms, hands, feet, ankles, or lower legs
Levocetirizine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.
Symptoms of overdose may include:
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: U.S. National Library of Medicine.
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.