mph Bangladesh


Levosalbutamol (US, Levalbuterol)

(lee-voe-sal-byoo-tah-mole) (lev al byoo' ter ol) 

Molecule Info

Content & description

Levosalbutamol Sulphate equivalent to Levosalbutamol INN 1mg & 2mg Tablet.

Levosalbutamol Sulphate equivalent to Levosalbutamol INN 1mg/5ml Syrup.

Levosalbutamol is a single isomer b2 -agonist that differs from racemic salbutamol by elimination of -salbutamol. Levosalbutamol is an effective bronchodilator whose primary Pharmacology is unimpeded by -salbutamol. Thus, when compared with racemic salbutamol, clinically comparable bronchodilation can be achieved with doses that substantially lessen beta-mediated side effects.

Indication & dosage

Levosalbutamol tablet & syrup are indicated for the treatment or prevention of bronchospasm in adults, adolescents, and children 6 years of age and older with reversible obstructive airway disease.

Tablet:

Adults and adolescents above 12 years: 1-2mg three times daily,

Children : 1mg three times daily.

Syrup:

Adults: 5-10 ml three times daily,

Children : 5 ml three times daily.

Precautions

Potentially serious hypokalemia may result from b2 agonist therapy. Particular caution is advised in acute severe asthma as this effect may be potentiated by hypoxia and by concomitant treatment with Xanthine derivatives, steroids and diuretics. Serum potassium levels should be monitored in such situations. Levosalbutamol, like all other beta-adrenergic agonists, can produce a clinically significant cardiovascular effect in some patients, as measured by pulse rate, blood pressure. Although such effects are uncommon after administration of Levosalbutamol at recommended doses, if they occur, the drug may need to be discontinued. Oral Levosalbutamol should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias or hypertension.

Pregnancy / lactation

Use of oral Levosalbutamol in pregnant or nursing mothers should be considered only if the expected benefit to the mother is greater than any possible risk to the foetus or the infant. It is not known whether Levosalbutamol is excreted in human milk. Caution should be exercised when oral Levosalbutamol is administered to a nursing woman.

Side effects

Potentially serious hypokalaemia may result from b2 agonist therapy. This effect may be potentiated by hypoxia. Particular caution is advised in severe asthma, with monitoring of serum potassium levels. Other side effects such as palpitation, fine tremors of the skeletal muscle  and muscle cramps may occur. The other likely side effects are gastrointestinal disturbances such as nausea, vomiting, burning substernal or epigastric pain and diarrhoea. In some cases nervousness, headache, dizziness, fatigue and sleeplessness may occur.

Contraindications

Hypersensitivity to any of the components of the formulation.

Drug interactions

Other short-acting sympathomimetic bronchodilators or epinephrine should be used with caution with Levosalbutamol. If additional adrenergic drugs are to be administered by any route, they should be used with caution to avoid deleterious cardiovascular effects.

Overdosage

The expected symptoms with overdosage are those of excessive beta-adrenergic stimulation and/or occurrence or exaggeration of any of the symptoms listed under side effects e. g. tachycardia, nervousness, headache, tremor, nausea, dizziness, fatigue and sleeplessness. Hypokalaemia also may occur. Treatment consists of discontinuation of oral Levosalbutamol together with appropriate symptomatic therapy. In the event of serious poisoning, the stomach should be emptied and, if necessary, a beta-blocker administered with caution in patients with a history of bronchospasm.

mph Class

Antiasthmatic & COPD Preparations

 

Brand/Product Info


Total Products : 51                                                   
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ACTISAL Silva Pharmaceuticals Limited Levosalbutamol sulphate INN 1mg & 2mg Tablet 100's each: 90.33 & 170.64 MRP
ACTISAL Syrup Silva Pharmaceuticals Limited Levosalbutamol sulphate INN 1mg/5ml Syrup 50ml, 100ml: 25.10 & 35.14 MRP
AIRE Delta Pharma Limited Levosalbutamol sulphate INN 1mg & 2mg Tablet 50's each: 45.00 & 85.00 MRP
AIRE Syrup Delta Pharma Limited Levosalbutamol sulphate INN 1mg/5ml Syrup 50ml: 25.00 MRP
AROLAX Navana Pharmaceuticals Limited Levosalbutamol sulphate INN 1mg & 2mg Tablet 100's each: 90.00 & 171.00 MRP
AROLAX Syrup Navana Pharmaceuticals Limited Levosalbutamol sulphate INN 1mg/5ml Syrup 60ml, 100ml: 25.09 & 35.13 MRP
ASMOLEX-L Aristopharma Ltd. Levosalbutamol sulphate INN 1mg & 2mg Tablet 1mg x100's, 2mg x50's: 80.00 & 75.00 MRP
ASMOLEX-L Syrup Aristopharma Ltd. Levosalbutamol sulphate INN 1mg/5ml Syrup 100ml: 35.00 MRP
BRIZY Eskayef Bangladesh Ltd Levosalbutamol Sulphate INN equivalent to Levosalbutamol 1mg & 2mg Tablet 50's each, MRP: 43.00 & 85.00
BRIZY Syrup Eskayef Bangladesh Ltd Levosalbutamol Sulphate INN equivalent to Levosalbutamol 1mg/5ml Syrup 60ml MRP: 28.00
BRODIL LEVO ACI Ltd. Levosalbutamol sulphate INN 1mg & 2mg Tablet 100's each: 90.00 & 171.00 MRP
BRODIL LEVO Syrup ACI Ltd. Levosalbutamol sulphate INN 1mg/5ml Syrup 50ml, 100ml: 25.09 & 35.13 MRP
BROMOL Somatec Pharmaceuticals Ltd. Levosalbutamol sulphate INN 1mg & 2mg Tablet 100's each: 91.00, 171.00 IP
BROMOL Syrup Somatec Pharmaceuticals Ltd. Levosalbutamol sulphate INN 1mg/5ml Syrup 100ml: 35.13 IP
COMFIL Pharmasia Limited Levosalbutamol sulphate INN 1mg/5ml Syrup 100ml: 35.00 MRP
COMFIL-2 Pharmasia Limited Levosalbutamol sulphate INN 2mg Tablet 50's: 85.50 MRP
LEBROD Alco Pharma Ltd Levosalbutamol sulphate INN 1mg & 2mg Tablet 100's each: 75.00 & 140.00 MRP
LEBROD Syrup Alco Pharma Ltd Levosalbutamol sulphate INN 1mg/5ml Syrup 100ml: 35.00 MRP
LEBUTAL Pacific Pharmaceuticals Ltd. Levosalbutamol sulphate INN 1mg & 2mg Tablet 100's each: 100.00 & 190.00 MRP
LEBUTAL Syrup Pacific Pharmaceuticals Ltd. Levosalbutamol sulphate INN 1mg/5ml Syrup 100ml: 40.00 MRP
LESAL Apex Pharmaceuticals Ltd. Levosalbutamol sulphate INN 1mg & 2mg Tablet 50's each: 45.00 & 75.00 MRP
LESAL Syrup Apex Pharmaceuticals Ltd. Levosalbutamol sulphate INN 1mg/5ml Syrup 60ml, 100ml: 25.00 &35.00 MRP
LEVAIR General Pharmaceuticals Ltd Levosalbutamol sulphate INN 1mg & 2mg Tablet 1mg x100's, 2mg x50's: 90.00 & 85.50 MRP
LEVAIR Syrup General Pharmaceuticals Ltd Levosalbutamol sulphate INN 1mg/5ml Syrup 100ml: 35.13 MRP
LEVENTA Novo Healthcare and Pharma Ltd. Levosalbutamol sulphate INN 1mg/5ml Syrup 100ml: 35.00 MRP
LEVOSTAR 1 Square Pharmaceuticals Ltd. Levosalbutamol 1mg Tablet 10x10's: 100.00 MRP
LEVOSTAR 2 Square Pharmaceuticals Ltd. Levosalbutamol 2mg Tablet 5x10's: 100.00 MRP
LEVOSTAR SYP 100 Square Pharmaceuticals Ltd. Levosalbutamol 1mg/5 ml Syrup 100 ml: 45.13 MRP
LEVOSTAR SYP 50 Square Pharmaceuticals Ltd. Levosalbutamol 1mg/5 ml Syrup 50 ml: 30.10 MRP
LIVODEL Popular Pharmaceuticals Ltd. Levosalbutamol sulphate INN 1mg & 2mg Tablet 100's each: 90.04 & 171.04 MRP
LIVODEL Syrup Popular Pharmaceuticals Ltd. Levosalbutamol sulphate INN 1mg/5ml Syrup 100ml: 35.13 MRP
PURILIN Opsonin Pharma Limited Levosalbutamol sulphate INN 1mg & 2mg Tablet 100's each: 90.00 & 170.00 MRP
PURILIN Syrup Opsonin Pharma Limited Levosalbutamol sulphate INN 1mg/5ml Syrup 50ml, 100ml: 25.00 & 35.00 MRP
Purisal 0.31 Incepta Pharmaceuticals Limited Levosalbutamol Hydrochloride INN equivalent to Levosalbutamol 0.31mg/3ml Nebuliser Solution 10x1's:MRP 100 Tk
Purisal 0.63 Incepta Pharmaceuticals Limited Levosalbutamol Hydrochloride INN equivalent to Levosalbutamol 0.63mg/3ml Nebuliser Solution 10x1's:MRP 150 Tk
Purisal 1 Incepta Pharmaceuticals Limited Levosalbutamol Sulphate INN equivalent to Levosalbutamol 1 mg Tablet 10x10's:MRP 90 Tk
Purisal 1.25 Incepta Pharmaceuticals Limited Levosalbutamol Hydrochloride INN equivalent to Levosalbutamol 1.25mg/3ml Nebuliser Solution 10x1's:MRP 200 Tk
Purisal 100ml Incepta Pharmaceuticals Limited Levosalbutamol Sulphate INN equivalent to Levosalbutamol 1mg/5ml Syrup 100ml:MRP 38 Tk
Purisal 2 Incepta Pharmaceuticals Limited Levosalbutamol Sulphate INN equivalent to Levosalbutamol 2mg Tablet 10x10's:MRP 170 Tk
Purisal Syrup Incepta Pharmaceuticals Limited Levosalbutamol Sulphate INN equivalent to Levosalbutamol 1mg/5ml Syrup 50ml:MRP 25 Tk
RESPIRA 1 Beximco Pharmaceuticals Ltd Levosalbutamol Sulphate INN eq. to Levosalbutamol 1mg Tablet 100's: 90.00 MRP
RESPIRA 2 Beximco Pharmaceuticals Ltd Levosalbutamol Sulphate INN eq. to Levosalbutamol 2mg Tablet 100's: 170.00 MRP
RESPIRA Inhaler Beximco Pharmaceuticals Ltd Levosalbutamol 50 mcg/ Actuation Syrup 200MD: 200.00 MRP
RESPIRA SYRUP Beximco Pharmaceuticals Ltd Levosalbutamol Sulphate INN eq. to Levosalbutamol 1mg/5ml Syrup 100ml: 38.00 MRP
SALMOLIN-L The Acme Laboratories Ltd. Levosalbutamol sulphate INN 1mg & 2mg Tablet 100's each: 91.00 & 170.00 MRP
SALMOLIN-L Syrup The Acme Laboratories Ltd. Levosalbutamol sulphate INN 1mg/5ml Syrup 60ml: 25.10 MRP
SANLEV 1 MG TABLET Sandoz/Novartis Levosalbutamol Sulphate INN equivalent to Levosalbutamol 1mg Tablet 10x10's, MRP 150
SANLEV 2 MG TABLET Sandoz/Novartis Levosalbutamol Sulphate INN equivalent to Levosalbutamol 2mg Tablet 10x10's, MRP 250
TRULAX Renata Limited Levosalbutamol sulphate INN 1mg/5ml Syrup 100ml: 35.00 MRP
VENTISAL-L IBN SINA Pharmaceutical Industry Ltd. Levosalbutamol sulphate INN 2mg Tablet 100's: 200.00 IP
VENTISAL-L Syrup IBN SINA Pharmaceutical Industry Ltd. Levosalbutamol sulphate INN 1mg/5ml Syrup 50ml, 100ml: 30.00, 40.00 IP

Gen. MedInfo

Why is this medication prescribed?

Levosalbutamol /Levalbuterol is used to prevent or relieve the wheezing, shortness of breath, coughing, and chest tightness caused by lung disease such as asthma and chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways). Levosalbutamol /Levalbuterol is in a class of medications called beta agonists. It works by relaxing and opening air passages to the lungs to make breathing easier.

How should this medicine be used?

Levosalbutamol /Levalbuterol may come as a solution (liquid) to inhale by mouth using a nebulizer (machine that turns medication into a mist that can be inhaled), a concentrated solution to be mixed with normal saline and inhaled by mouth using a nebulizer, and as an aerosol to inhale by mouth using an inhaler. The solution for oral inhalation is usually used three times a day, once every 6 to 8 hours. The inhaler is usually used every 4 to 6 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use levalbuterol exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

If your asthma symptoms become worse, if levalbuterol inhalation becomes less effective, or if you need more doses than usual of the asthma medications you use as needed, your condition may be getting worse. Do not use extra doses of levalbuterol. Call your doctor right away.

Levosalbutamol /Levalbuterol controls symptoms of asthma and other lung diseases but does not cure these conditions. Continue to use levalbuterol even if you feel well. Do not stop using levalbuterol without talking to your doctor.

If you are using the inhaler, your medication will come in canisters. Each canister of levalbuterol aerosol is designed to provide 200 inhalations. After the labeled number of inhalations has been used, later inhalations may not contain the correct amount of medication. Throw away the canister after you have used the labeled number of inhalations even if it still contains some liquid and continues to release a spray when it is pressed.

You will need to keep track of the number of inhalations you have used. You can divide the number of inhalations in your inhaler by the number of inhalations you use each day to find out how many days your inhaler will last. Do not float the canister in water to see if it still contains medication.

The inhaler that comes with levalbuterol aerosol is designed for use only with a canister of albuterol. Never use it to inhale any other medication, and do not use any other inhaler to inhale levalbuterol.

Be careful not to get levalbuterol inhalation into your eyes.

Do not use your levalbuterol inhaler when you are near a flame or source of heat. The inhaler may explode if it is exposed to very high temperatures.

Before you use Levosalbutamol /levalbuterol for the first time, read the written instructions that come with the inhaler or nebulizer. Ask your doctor, pharmacist, or respiratory therapist to show you how to use it. Practice using the inhaler or nebulizer while he or she watches.

If your child will be using the inhaler, be sure that he or she knows how to use it. Watch your child each time he or she uses the inhaler to be sure that he or she is using it correctly.

To use the aerosol inhaler, follow these steps:

  1. Remove the protective dust cap from the end of the mouthpiece. Check the mouthpiece for dirt or other objects. Be sure that the canister is fully and firmly inserted in the mouthpiece.

  2. Shake the inhaler well.

  3. If you are using the inhaler for the first time or if you have not used the inhaler in more than 3 days, you will need to prime it. To prime the inhaler, press down on the canister four times to release four sprays into the air, away from your face. Be careful not to get albuterol in your eyes.

  4. Breathe out as completely as possible through your mouth.

  5. Hold the canister with the mouthpiece on the bottom, facing you, and the canister pointing upward. Place the open end of the mouthpiece into your mouth. Close your lips tightly around the mouthpiece.

  6. Breathe in slowly and deeply through the mouthpiece.At the same time, press down once on the container with your middle finger to spray the medication into your mouth.

  7. As soon as the medication is released, remove your finger from the canister and remove the mouthpiece from your mouth.

  8. Try to hold your breath for 10 seconds.

  9. If you were told to use two puffs, wait 1 minute and then repeat steps 4 to 8.

  10. Replace the protective cap on the inhaler.

To use the solution or the concentrated solution for oral inhalation, follow these steps:

  1. Open the foil pouch by tearing through the rough edge along the side of the pouch and remove one vial. Leave the rest of the vials inside the foil pouch to protect them from light. Look at the solution in the vial to be sure it is colorless. If it is not colorless, call your doctor or pharmacist and do not use the solution.

  2. Twist off the top of the vial and squeeze all of the liquid into the reservoir of your nebulizer. Do not add any other medications to the nebulizer because it may not be safe to mix them with levalbuterol. Use all nebulized medications separately unless your doctor specifically tells you to mix them.

  3. If you are using the concentrated solution, add the amount of normal saline that your doctor told you to use to the reservoir. Gently swirl the nebulizer to mix the normal saline and the concentrated solution.

  4. Connect the nebulizer reservoir to your mouthpiece or facemask.

  5. Connect the nebulizer to the compressor.

  6. Sit upright and place the mouthpiece in your mouth or put on the facemask.

  7. Turn on the compressor.

  8. Breathe calmly, deeply, and evenly until mist stops forming in the nebulizer. This should take between 5 and 15 minutes.

  9. Clean the nebulizer according to the manufacturer's instructions.

Clean your inhaler or nebulizer regularly. Follow the manufacturer's directions carefully and ask your doctor or pharmacist if you have any questions about cleaning your inhaler or nebulizer. If you do not clean your inhaler properly, the inhaler may become blocked and may not spray medication. If this happens, follow the manufacturer's directions for cleaning the inhaler and removing the blockage.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using levalbuterol,

  • tell your doctor if you are allergic to levosalbutamol /levalbuterol, salbutamol /albuterol (Ventolin, others) or any other medications.

  • tell your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: beta blockers such as atenolol, labetalol, metoprolol, nadolol, and propranolol; digoxin; diuretics ('water pills'); epinephrine; medications for colds; and other inhaled medications to relax the air passages such as metaproterenol and pirbuterol. Also tell your doctor  if you are taking the following medications or if you have stopped taking them within the past 2 weeks: antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine, doxepin, imipramine (Tofranil), nortriptyline, protriptyline, and trimipramine; and monoamine oxidase inhibitors such as isocarboxazid, phenelzine, tranylcypromine, and selegiline. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had high blood pressure, irregular heartbeat, any other type of heart disease, seizures, diabetes, hyperthyroidism (condition in which there is too much thyroid hormone in the body), or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using levalbuterol, call your doctor.

  • you should know that levalbuterol inhalation sometimes causes wheezing and difficulty breathing immediately after it is inhaled, especially the first time you use a new canister of albuterol aerosol. If this happens, call your doctor right away. Do not use levalbuterol inhalation again unless your doctor tells you that you should.

 What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.

What side effects can this medication cause?

Levosalbutamol /Levalbuterol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache

  • dizziness

  • nervousness

  • uncont rollable shaking of a part of the body

  • heartburn

  • vomiting

  • cough

  • weakness

  • fever

  • diarrhea

  • muscle pain

  • leg cramps

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • chest pain

  • fast or pounding heartbeat

  • hives

  • skin rash

  • itching

  • increased difficulty breathing or difficulty swallowing

  • hoarseness

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

Levosalbutamol /Levalbuterol may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Do not puncture the aerosol container and do not discard it in an incinerator or fire.

Levalbuterol solution must be protected from light. Store unused vials in the foil pouch, and discard all unused vials 2 weeks after you open the pouch. If you remove a vial from the pouch, you should protect it from light and use it within 1 week.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, call local medical emergency services.

Symptoms of overdose may include:

  • seizures

  • chest pain

  • fast, pounding, or irregular heartbeat

  • nervousness

  • headache

  • dry mouth

  • uncontrollable shaking of a part of the body

  • nausea

  • dizziness

  • extreme tiredness

  • weakness

  • difficulty falling or staying asleep

This medication may cause other side effects.  Consult your doctor if you have any unusual problems while taking this.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

 

 


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

Simple Breath Test Might Diagnose Heart Failure An experimental breath test, designed to quickly identify patients suffering from heart failure simply by analyzing the contents of a...
Osteoporosis drug stops Breast cancer growth   News & Events News & Events     HIGHLIGHTS Osteoporosis drug stops growth of breast cancer...
Generic drug safety info loophole FDA plans to close generic drug safety info loophole The US Food and Drug Administration has announced plans to speed up the dissemination of...
Large trials unpublished   News & Events News & Events   HIGHLIGHTS Almost 1 in 3 of large clinical trials unpublished after...
TB activists boo Indian minister News & Events News & Events   HIGHLIGHTS TB activists at world conference boo Indian minister off...
Key bone marrow protein identified News & Events News & Events   HIGHLIGHTS Key bone marrow protein identified as potential new leukemia...