mph Bangladesh


Molecule Info

 
Indication & Dosage

 Indications:

  • Supplementation of calcium and vitamin D3
  • Prevention and treatment of osteoporosis
  • For healthy bone formation and maintenance
  • To reduce phosphate absorption from the gut in patients with hyperphosphatemia
  • Treatment of chronic renal failure

Each tablet contains 500 mg elemental Calcium as Calcium Carbonate USP (or BP) and 200 IU Vitamin D USP (or BP). 1 tablet 1-2 times daily with food or as directed by  the physician.

Administration Should be taken with food.
Contraindications Patients with hypercalcaemia and/or hypercalciuria. Nephrolithiasis, hypervitaminosis D, hypophosphataemia.
Special Precautions Impaired calcium absorption in achlorhydria which is common in elderly. Increased risk of hypercalcaemia and hypercalciuria in hypoparathyroid patients receiving high doses of vitamin D. Caution when using in patients with history of kidney stones. Renal impairment; frequent monitoring of serum calcium and phosphorus is recommended.
Adverse Drug Reactions Constipation, flatulence, nausea, abdominal pain and diarrhoea. Pruritus, rash and urticaria.
Drug Interactions May affect the absorption of tetracycline when used together. Concurrent use with systemic corticosteroids may reduce calcium absorption. Thiazide diuretics may decrease urinary excretion of calcium. Concurrent use with ion-exchange resins may reduce GI absorption of vitamin D. Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D, monitor ECG and serum calcium levels. Bisphosphonate or sodium fluoride should be given at least 3 hr before calcium-containing preparations. Please consult detailed drug interactions before prescribing.
Food Interaction Foods that are rich in oxalic acid (e.g. spinach and rhubarb) and phytic acid (e.g. whole cereals) may reduce calcium absorption by formation of insoluble calcium salts, thus calcium products should not be taken within 2 hr of eating such foods.
Storage Oral: Store below 25°C.
Mechanism of Action Calcium carbonate is a calcium supplement that is used in deficiency states and as an adjunct in the prevention and treatment of osteoporosis. Vitamin D3 is a fat-soluble sterol, it aids in the regulation of calcium and phosphate homeostasis and bone mineralisation.
Absorption: Calcium carbonate: About 15-25% gets absorbed in the GI tract. Converted to calcium chloride by gastric acid. Vitamin D: Well-absorbed in the GI tract in the presence of bile.
Metabolism: Vitamin D: Undergoes hydroxylation in the liver and kidney to form the active metabolite, 1,25-dihydrocolecalciferol.
Excretion: Vitamin D and metabolites are mainly excreted in the bile and faeces.
ATC Classification A12AA04 - calcium carbonate; Belongs to the class of calcium-containing preparations used as dietary supplements. 
A11CC05 - colecalciferol; Belongs to the class of vitamin D and analogues. Used as dietary supplements. 
A02AC01 - calcium carbonate; Belongs to the class of calcium-containing antacids. Used for the treatment of acid-related disorders.

Brand/Product Info


Total Products : 72                                                                        
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
A-CAL D The Acme Laboratories Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
ACICAL-D ACI Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 120.60 MRP
AMBEECAL-D Ambee Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's: 49.65 MRP
APOCAL-D Apex Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 52.50 & 105.00 MRP
ARISTOCAL D Beximco Pharmaceuticals Ltd Calcium 500mg (as Calcium Carbonate USP)+ Vitamin D USP 200 IU Tablet 50's: 250.00 MRP
BEUCAL D R A K Pharmaceuticals Pvt. Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 150.00 MRP
BONI D Delta Pharma Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
BPCAL-D Bristol Pharma Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's, 50's: 99.00 & 165.00 MRP
CADMIN General Pharmaceuticals Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 99.30 MRP
CADOLIN Jayson Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 99.30 MRP
CAL D Pacific Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's, 100's: 150.00 & 500.00 MRP
CALBO-D 15'S Square Pharmaceuticals Ltd. Calcium + Vitamin D (500mg + 200 IU) Tablet 15's: 75.30 MRP
CALBO-D 30'S Square Pharmaceuticals Ltd. Calcium + Vitamin D (500mg + 200 IU) Tablet 30's: 150.60 MRP
CALBO-D VITA Square Pharmaceuticals Ltd. Calcium + Vitamin D (600mg + 400 IU) Effervescent Tablet 10's: 150.50 MRP
CALBON D Aristopharma Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
CALBORAL-D Square Pharmaceuticals Ltd. Coral Calcium + Vitamin D (500mg + 200 IU) Tablet 5x6's: 300.90 MRP
CALCI-D Plus Rephco Laboratories Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's: 49.50 MRP
CALCIBOST-D Sharif Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
CALCICAL-D Techno Drugs Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 90.00 MRP
CALCIN-D Renata Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's, 60's: 60.15 & 120.30 & 240.60 MRP
CALCIUM-A & D Ad-din pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 90.00 MRP
CALCIUM-D Navana Pharmaceuticals Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
CALDICAL-D Ziska Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
CALDIL-PLUS Drug International Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 100's: 400.00 MRP
CALDIVIT GlaxoSmithKline Bangladesh Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 120.00 MRP
CALFOR-D Asiatic Laboratories Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 49.50 & 99.00 MRP
CALIUM Plus Pharmadesh Laboratories Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 105.00 MRP
CALMAX-D Hudson Pharmaceuticals Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 120.00 MRP
CALMET-D Somatec Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 49.20 & 98.40 MRP
CALOS-D Modern Pharmaceuticals Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
CALPO-D Medicon Laboratories Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
CALSIL Plus Silva Pharmaceuticals Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
CALSTO D Monico Pharma Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 150.00 MRP
Calvimax Incepta Pharmaceuticals Limited Calcium carbonate 1250mg+ Colecalciferol 200IU Tablet 1x30's :MRP 120 Tk
CARBEN-D Benham Pharmaceuticals Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 97.50 MRP
CARBOCAL D Globe Pharmaceuticals Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 99.00 MRP
CARMO-D S.N. Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 99.00 MRP
CASALT-D Kemiko Pharmaceuticals Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's, 50's: 120.00 & 250.00 MRP
CORALCAL-D Radiant Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 50's: 400.00 MRP
DOS Central Pharmaceuticals Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 120.00 MRP
EDICAL-D Edruc Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 48.00 & : 96.00 IP
EUROCAL-D Euro Pharma Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
EVECAL D Everest Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 99.00 MRP
IPICAL-D IBN SINA Pharmaceutical Industry Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 75.00 & 120.00 MRP
ISOCAL-D Doctors Chemical Works Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 90.00 MRP
M. CAL-D Millat Pharmaceuticals Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 120.00 MRP
MAXCAL-D Novus Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 150.00 MRP
MAXICAL Orion Pharma Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.30 & 120.60 MRP
MONOCAL D Concord Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 50's: 200.00 MRP
NEOCAL D The White Horse Pharma Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 120.00 MRP
ORACAL D Amico Laboratories Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 150.00 MRP
ORTHOCAL-D Biopharma Laboratories Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.30 & 120.60 MRP
OSCAL-D Unimed & Unihealth Manufacturers Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 120.00 MRP
OSCAL-D Forte Unimed & Unihealth Manufacturers Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 150.00 MRP
OSMIN-D Shamsul Alamin Pharmaceuticals Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 49.95 & 99.90 MRP
OSSI D Kumudini Pharma Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's: 49.50 MRP
OSTACID-D Rangs Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 49.50 & 99.00 MRP
OSTIUM-D APC Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 99.00 MRP
OSTOCAL D Eskayef Bangladesh Ltd Calcium 500mg (as Calcium Carbonate USP)+ Vitamin D USP 200 IU Tablet 15's, 20's & 30's MRP: 60.00, 80.00 & 120.00
OSTOGEN D Opsonin Pharma Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 120.00 MRP
OSTOPLUS-D Desh Pharmaceuticals (Pvt) Ltd Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's, 50's: 90.00 & 150.00 MRP
PEOCAL D Peoples Pharma Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 7's, 15's, 30's: 19.00 & 38.00 & 75.00 MRP
PROTEBON D Beacon Pharmaceuticals Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 150.00 MRP
REJUVEN-D Novo Healthcare and Pharma Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's, 50's: 49.50 & 99.00 & 165.00 MRP
ROCAL - D Healthcare Pharmacuticals Ltd. Calcium 500mg (as Calcium Carbonate USP)+ Vitamin D USP 200 IU Tablet 60's MRP 360 Tk
ROCAL-D Vita Healthcare Pharmacuticals Ltd. Calcium 600mg (as Calcium Carbonate USP)+ Vitamin D USP 400 IU Tablet 10's MRP 130 Tk
SANDOCAL-D Sandoz/Novartis Calcium 500mg (as Calcium Carbonate USP)+ Vitamin D USP 200 IU Tablet 50's: MRP 400.00
SEECAL Plus Seema Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 120.00 MRP
STARCAL-D NIPRO JMI Pharma Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 30's: 120.60 MRP
SUPLICAL-D Cosmic Chemical Industries Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 60.00 & 120.00 MRP
ULTRACAL-D Popular Pharmaceuticals Ltd. Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's, 60's: 60.32 & 120.62 & 241.24 MRP
XTRACAL-D Pharmasia Limited Calcium carbonate USP 1250mg+ Vit. D3 (chole-calciferol) USP 200 IU Tablet 15's, 30's: 49.65 & 99.30 MRP

Gen. MedInfo

Why is this medication prescribed?

This combination is prescribed for dietary supplementation and to prevent & treat osteoporosis. There are some other conditions where Calcium & Vitamin D supplementation required.

Osteoporosis is a common bone disorder that causes a progressive loss in bone density and mass. As a result, bones become thin, weakened, and easily fractured. It is estimated that more than 1.3 million osteoporosis-associated (or "osteoporotic") fractures occur every year in the United States, primarily of bone within the spine (the vertebrae), the hip, and the forearm near the wrist.

A number of treatments can help to prevent loss of bone and treat low bone mass. However, the first step in preventing or treating osteoporosis is to consume foods and drinks that provide calcium, a mineral essential for bone strength, and vitamin D, which aids in calcium breakdown and absorption.

CALCIUM AND VITAMIN D BENEFITS

Good nutrition is important at all ages to keep the bones healthy.

  • Taking calcium reduces bone loss and decreases the risk of fracturing the vertebrae (the bones that surround the spinal cord).
  • Consuming calcium during childhood (eg, in milk) can lead to higher bone mass in adulthood. This increase in bone density can reduce the risk of fractures later in life.
  • Calcium also has benefits in other body systems by reducing blood pressure and cholesterol levels.
  • Calcium and vitamin D supplements have been shown to help prevent tooth loss in older adults.

RECOMMENDATIONS FOR CALCIUM

General recommendations — Premenopausal women and men should consume at least 1000 mg while postmenopausal women should consume as high as 1200 mg (total diet plus supplement). 

Calcium in the diet — The primary sources of calcium in the diet include milk and other dairy products, such as hard cheese, cottage cheese, or yogurt, as well as green vegetables, such as kale and broccoli. Cottage cheese and ice cream contain approximately 150 mg of calcium per 4 oz (120 mL). Other foods, such as dark green vegetables, some nuts, breads, and cereals, supply an average of 200 mg of calcium daily. Some cereals, soy products, and fruit juices are fortified with up to 1000 mg of calcium per serving.

Calcium supplements — The body is able to absorb calcium contained in supplements as well as from dietary sources. If it is not possible to get enough calcium from dietary sources, consult a healthcare provider to determine the best type, dose, and timing of calcium supplements. The table shows the calcium and vitamin D content in commonly available supplements.

  • Calcium carbonate is effective and is the least expensive form of calcium. It is best absorbed with a low-iron meal (such as breakfast). Calcium carbonate is not absorbed well in people who also take a specific medication for gastroesophageal reflux (called a proton pump inhibitor or H2 blocker).
  • Calcium citrate is absorbed best when it is taken on an empty stomach.
  • Many natural calcium carbonate preparations such as oyster shells or bone meal contain some lead. The low lead levels in calcium supplements are unlikely to be a health risk because calcium blocks lead absorption.
  • Calcium supplements should be taken in divided doses (eg, in the morning and evening). Doses above 500 mg are not absorbed as well as smaller doses.
  • Calcium supplements do not replace other osteoporosis treatments. Calcium is less effective than other treatments, including hormone replacement, bisphosphonates (eg, risedronate and alendronate), and raloxifene. Calcium has additive benefits when used along with other treatments.

Underlying gastrointestinal diseases — Patients who do not adequately absorb nutrients from the gastrointestinal tract (due to malabsorption) may require more than 1000 mg of calcium per day. In such cases, a healthcare provider can help to determine the optimal dose of calcium.

Medications — All medications should be discussed with a healthcare provider to ensure that possible interactions with calcium are identified. Certain medications change the amount of calcium that is absorbedand/or excreted. As an example, loop diuretics (eg, furosemide, Lasix®) increase the amount of calcium excreted in the urine.

On the other hand, thiazide diuretics (eg, hydrochlorothiazide, HCTZ) can reduce levels of calcium in the urine, potentially reducing the risk of bone loss and kidney stones.

Side effects of calcium — Calcium is usually easily tolerated when it is taken in divided doses several times per day. Some people experience side effects related to calcium, including constipation and indigestion. Calcium supplements interfere with the absorption of iron and thyroid hormone and, therefore, these medications should be taken at different times.

Kidney stones — There is little evidence that consuming large amounts of calcium (from foods and drinks) increases the risk of kidney stones, or that consuming small amounts of calcium decreases the risk. In fact, avoiding dairy products is likely to increase the risk of kidney stones.

However, use of calcium supplements may increase the risk of kidney stones in susceptible individuals by raising the level of calcium in the urine. This is particularly true if the supplement is taken between meals or at bedtime.

IMPORTANCE OF VITAMIN D

Vitamin D decreases bone loss and lowers the risk of fracture, especially in older men and women. Along with calcium, vitamin D also helps to prevent and treat osteoporosis. To absorb calcium efficiently, an adequate amount of vitamin D must be present.

Vitamin D is normally made in the skin after exposure to sunlight.

Recommendations for vitamin D — The current recommendation is that men over 70 years and postmenopausal women consume at least 800 international units of vitamin D per day. Lower levels of vitamin D are not as effective while high doses can be toxic, especially if taken for long periods of time. Although the optimal intake has not been clearly established in premenopausal women or in younger men with osteoporosis, 600 international units of vitamin D daily is generally suggested.

Vitamin D is available as an individual supplement and is included in most multivitamins and some calcium supplements. Milk is the best dietary source of vitamin D, with approximately 100 international units per cup.

Ref: www.uptodate.com

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

 


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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