Meloxicam

(mel ox' i cam)

PCaution when used during lactation : Caution when used during pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage Oral route
Rheumatoid arthritis
Adult: 15 mg daily as a single dose. Patients with increased risk of adverse effects: Initially 7.5 mg.
Elderly: 7.5 mg daily for long-term treatment.
Oral
Ankylosing spondylitis
Adult: 15 mg daily as a single dose. Patients with increased risk of adverse effects: Initially 7.5 mg.
Elderly: 7.5 mg daily for long-term treatment.
Oral
Acute exacerbations of osteoarthritis
Adult: 7.5 mg daily up to a max of 15 mg as a single dose.
Elderly: 7.5 mg daily.
Oral
Juvenile rheumatoid arthritis
Child: â‰¥2 yr: 125 mcg/kg ocne daily. Max dose: 7.5 mg daily.
Rectal
Ankylosing spondylitis
Adult: 15 mg daily as a single dose. Patient with increased risk of adverse effects: Initially 7.5 mg. Limit use to the shortest time possible.
Elderly: 7.5 mg daily. Limit use to the shortest time possible.
Rectal
Rheumatoid arthritis
Adult: 15 mg daily as a single dose. Patient with increased risk of adverse effects: Initially 7.5 mg. Limit use to the shortest time possible.
Elderly: 7.5 mg daily. Limit use to the shortest time possible.
Rectal
Acute exacerbations of osteoarthritis
Adult: 7.5 mg daily up to a max of 15 mg daily as a single dose. Limit use to the shortest time possible.
Elderly: 7.5 mg daily. Limit use to the shortest time possible.

Special Populations: In patients with an increased risk of adverse reactions: Initially, 7.5 mg daily. Dialysis patients: Max daily dose of 7.5 mg.
Administration May be taken with or without food.
Overdosage Symptoms: Lethargy, drowsiness, nausea, vomiting, epigastric pain. Severe symptoms e.g. apnoea, metabolic acidosis, coma, nystagmus, seizures, leukocytosis, renal failure may occur. Management: Supportive and symptomatic. Multiple doses of charcoal may be needed; cholestyramine increases meloxicam clearance. Not dialysable.
Contraindications Hypersensitivity to meloxicam, aspirin or other NSAIDs; severe hepatic impairment; bleeding disorders; renal failure without dialysis. Rectal admin in patients with proctitis, haemorrhoids or rectal bleeding.
Special Precautions History of GI disease, asthma, hypertension, CVD or risk factors, fluid retention or heart failure. Monitor patients with advanced renal disease. May impair ability to drive or operate machinery. Elderly. Pregnancy (avoid in the 3rd trimester) and lactation.
Adverse Drug Reaction(s) Dyspepsia, headache, nausea, diarrhoea, upper respiratory tract infection, abdominal pain, dizziness, oedema, flatulence, influenza-like symptoms, back pain, muscle spasms, musculoskeletal pain, rash, anaemia. GI perforation, ulceration and/or bleeding. In children: Abdominal pain, vomiting, diarrhoea, headache, pyrexia.
Potentially Fatal: Stevens Johnson syndrome, thrombocytopenia, interstitial nephritis and idiosyncratic liver abnormality.
Drug Interactions May reduce effects of antihypertensives. Increased clearance with bile acid sequestrants e.g. colestyramine. Increased risk of renal failure with diuretics; may reduce natriuretic effects of furosemide and thiazides. May increase toxicity of methotrexate.
Potentially Fatal: May increase plasma concentrations and toxicity of lithium. Increased risk of severe GI effects with aspirin, warfarin. Please consult detailed drug interactions before prescribing.
Food Interaction Avoid herbal preparations or food with antiplatelet activity e.g. alfalfa, anise, bilberry, bladderwrack, bromelain, cat's claw, celery, coleus, cordyceps, dong quai, evening primrose, feverfew, fenugreek, garlic, ginger, ginkgo biloba, red clover, horse chestnut, grapeseed, green tea, ginseng, guggul, horse chestnut seed, horseradish, licorice, prickly ash, red clover, reishi, sweet clover, turmeric, white willow.
Pregnancy Category (FDA)

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Category D: In 3rd trimester or near term. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Storage Oral: Store at 25°C (77°F).
Pharmacology Meloxicam inhibits prostaglandin synthesis by reducing cyclooxygenase enzyme activity. This results in decreased production of prostaglandin precursors.
Absorption: Well absorbed from the GI tract (oral).
Distribution: Protein-binding: 99%.
Metabolism: Extensively hepatic via oxidation pathway.
Excretion: Via urine and faeces (as inactive metabolites); 20 hr (elimination half-life).
ATC Classification M01AC06 - meloxicam; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, oxicams. Used in the treatment of inflammation and rheumatism.

Brand/Product Info


Total Products : 1 
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
MELCAM 15 Square Pharmaceuticals Ltd. Meloxicam 15mg Tablet 5x10's: 201.50 MRP

Gen. MedInfo

IMPORTANT WARNING: 

People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as meloxicam may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take meloxicam right before or right after the surgery.

NSAIDs such as meloxicam may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while taking meloxicam. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin; aspirin; other NSAIDs such as ibuprofen or naproxen or oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone. Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking meloxicam and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to meloxicam. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with meloxicam and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

 

Why is this medication prescribed?

Meloxicam is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Meloxicam is also used to relieve the pain, tenderness,swelling, and stiffness caused by juvenile rheumatoid arthritis (a type of arthritis that affects children) in children 2 years of age and older. Meloxicam is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

How should this medicine be used? 

Meloxicam comes as a tablet and suspension (liquid) to take by mouth. It is usually taken once a day with or without food. Take meloxicam at the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take meloxicam exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well before each use to mix the medication evenly.

Other uses for this medicine 

Meloxicam is also used sometimes to treat ankylosing spondylitis (arthritis that mainly affects the spine). Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow? 

Before taking meloxicam, 

  • tell your doctor if you are allergic to meloxicam, aspirin or other NSAIDs such as ibuprofen and naproxen or any other medications.
  • tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril, captopril, enalapril, fosinopril (Monopril), lisinopril, and quinapril; cholestyramine; diuretics ('water pills'); lithium; and methotrexate. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had asthma, especially if you have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); swelling of the hands, feet, ankles, or lower legs; or kidney or liver disease.
  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breast-feeding. If you become pregnant while taking meloxicam, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking meloxicam.

What should I do if I forget a dose? 

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause? 

Meloxicam may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: 

  • diarrhea

  • constipation

  • gas

  • sore throat

  • cough

  • runny nose

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately. Do not take any more meloxicam until you speak to your doctor: 

  • fever

  • blisters

  • rash

  • hives

  • itching

  • swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs

  • difficulty breathing or swallowing

  • hoarseness

  • pale skin

  • fast heartbeat

  • unexplained weight gain

  • nausea

  • excessive tiredness

  • lack of energy

  • yellowing of the skin or eyes

  • pain in the right upper part of the stomach

  • flu-like symptoms

  • cloudy, discolored, or bloody urine

  • back pain

  • difficult or painful urination

Meloxicam may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication? 

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose 

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

Symptoms of overdose may include:

  • lack of energy

  • drowsiness

  • nausea

  • vomiting

  • stomach pain

  • bloody, black, or tarry stools

  • vomit that is bloody or looks like coffee grounds

  • difficulty breathing

  • seizures

  • coma

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.