(az' tree oh nam)
P:Caution when used during pregnancy
L :Contraindicated in lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||
Bone and joint infections
Lower respiratory tract infections
Skin and soft tissue infections
Urinary tract infections
impairment: Moderate-severe impairment: Same initial doses, adjust maintenance doses according to the patient's CrCl. Haemodialysis: A
supplementary dose of 1/8 of the initial dose may be given after each session.
Incompatibility: Incompatible with cefradine, metronidazole, nafcillin and vancomycin.
|Administration||Should be taken with food.
|Overdosage||If needed, haemodialysis and/or peritoneal dialysis may be used to remove drug from serum.|
|Special Precautions||Hypersensitivity to other Î²-lactams; renal and hepatic impairment; pregnancy.|
|Adverse Drug Reaction(s)||IV: Phloebitis and thrombophloebitis. IM: Pain and swelling at inj site; diarrhoea, nausea, vomiting, altered taste; jaundice,
hepatitis, high liver enzymes; long prothrombin time, partial thromboplastin time; rash, urticaria, eosinophilia.
Potentially Fatal: Thrombocytopenia, neutropenia; overgrowth of susceptible organisms; pseudomembranous colitis.
|Drug Interactions||Concurrent use with oral anticoagulants may increase prothrombin time.
|Lab Interference||Intereferes with urine glucose test using cupric sulfate. False-positive with Coomb's test.|
|Pregnancy Category (FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Storage||Intramuscular: Once reconstituted, it should be used within 48 hr if stored at 15-30Â°C or 7 days if stored at 2-8Â°C. Parenteral: Once reconstituted, it should be used within 48 hr if stored at 15-30Â°C or 7 days if stored at 2-8Â°C.|
|Pharmacology||Aztreonam exhibits bactericidal action by inhibiting bacterial cell wall synthesis due to its high affinity for
penicillin-binding protein 3 (PBP-3) of gram-negative bacteria. It is highly resistant to hydrolysis by Î²-lactamases. It is active
against Enterobacteriaceae spp, E. coli, Klebsiella, Proteus, Providencia, Salmonella, Serratia,
Shigella and Yersinia spp..
Absorption: Absorbed poorly from the GI tract (oral).
Distribution: Body tissues and fluids (wide), bile, CSF (especially in the presence of meningitis), crosses the placenta and enters breast milk. Protein-binding: 56%.
Metabolism: Minimal metabolism; SQ-26992 (primary metabolite, inactive).
Excretion: Via urine by renal tubular secretion and glomerular filtration (60-70% as unchanged), via faeces (small amounts of unchanged drug and metabolites); 1.7 hr (elimination half-life). Removed by dialysis and peritoneal dialysis (lesser extent).
|ATC Classification||J01DF01 - aztreonam; Belongs to the class of monobactams. Used in the treatment of systemic infections.|
About your treatment
Your doctor has ordered aztreonam, an antibiotic, to help treat your infection. The drug will be either injected into a large muscle (such as your buttock or hip) or added to an intravenous fluid that will drip through a needle or catheter placed in your vein for 30 to 60 minutes, two to four times a day.
Aztreonam eliminates bacteria that cause many kinds of infection, including pneumonia and gynecological, urinary tract, skin, bone, joint, stomach, and blood infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Your health care provider (e.g. doctor) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how your infection and symptoms respond to the medication.
PrecautionsBefore administering aztreonam,
- tell your doctor if you are allergic to aztreonam, penicillin, cephalosporins [e.g., cefaclor, cefadroxil, or cephalexin], or any other drugs.
- tell your doctor what prescription and nonprescription medications you are taking, especially antibiotics and vitamins.
- tell your doctor if you have or have ever had kidney, heart, or gastrointestinal disease (especially colitis).
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking aztreonam, call your doctor.
- if you have diabetes and regularly check your for sugar level.
Administering your medication
Before you administer aztreonam, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.
It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason because your infection could worsen and result in hospitalization. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.
Side effectsAztreonam may cause side effects. Tell your health care provider if any of these symptoms are severe or do not go away:
changes in taste sensation
unusual bleeding or bruising
- sore mouth or throat
Storing your medication
Your health care provider probably will give you a several-day supply of aztreonam at a time. If you are receiving aztreonam intravenously (in your vein), you probably will be told to store it in the refrigerator or freezer.
Take your next dose from the refrigerator 1 hour before using it; place it in a clean, dry area to allow it to warm to room temperature.
If you are told to store additional aztreonam in the freezer, always move a 24-hour supply to the refrigerator for the next day's use.
Do not refreeze medications.
If you are receiving aztreonam intramuscularly (in your muscle), your health care provider will tell you how to store it properly.
Store your medication only as directed. Make sure you understand what you need to store your medication properly.
Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.
In case of emergency/overdose
In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.
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This medication may cause other side effects. Consult your doctor if you have any unusual problems while taking this.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: MedlinePlus, U.S. Natl. Library of Medicine
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