(mer oh pen' em)
P:Caution when used during pregnancy
L:Caution when used during lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||Intravenous route
Adult: 0.5-1 g every 8 hr.
Child: Neonate: <7 days: 20 mg/kg 12 hrly (severe infection 40 mg/kg 12 hrly); 7-28 days: 20 mg/kg 8 hrly (severe infection 40 mg/kg 8 hrly). 1-3 mth: 10 mg/kg 8 hrly; >3 mth and <50 kg: 10-20 mg/kg 8 hrly.
Skin and skin structure infections
Renal impairment: Haemodialysis: Usual dose after dialysis session.
Reconstitution: Direct inj or infusion: add 10 ml of sterile water to 500 mg or 20 ml of sterile water to 1 g. Can be further diluted with compatible IV solution (50-200 ml).
Incompatibility: Admixture: Amphotericin B, metronidazole and multivitamins. Y-site: Amphotericin B, diazepam and metronidazole. Syringe: Pantoprazole.
|Overdosage||Treatment: symptomatic. In normal patients, rapid renal elimination will occur. In patients with renal impairment, haemodialysis will remove meropenem and metabolite.|
|Special Precautions||History of hypersensitivity to carbapenem, pencillins or other Î²-lactam antibiotics; infants <3 mth; renal insufficiency; neurological disorders; pregnancy, lactation. Not recommended for use in MRSA.|
|Adverse Drug Reaction(s)||Diarrhoea, nausea, vomiting, abdominal pain; headache; constipation; rash, pruritus, uticaria; apnoea; phlebitis, thrombophlebitis,
swelling and pain at inj site; disturbances in LFTs (may cause increases in serum transaminases, alkaline phosphatase, lactic dehydrogenase). Rarely:
erythema multiforme; eosinophilia, thrombocytopenia, leucopenia, neutropenia; seizures and CNS effects reported in patients with underlying CNS disorders or
Potentially Fatal: Anaphylaxis; pseudomembranous colitis; Stevens-Johnsons sydrome.
|Drug Interactions||Serum levels may be increased by probenecid. May reduce serum valproic acid levels; sub-therapeutic levels may be reached in some patients. Please consult detailed drug interactions before prescribing.|
|Pregnancy Category (FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Storage||Once reconstituted, up to 2 hr at 15-25Â°C or up to 12 hr at 4Â°C.|
|Pharmacology||Meropenem is a carbapenem that works by inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls by
binding to one or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting to bacterial lysis.
Distribution: Widely distributed into body tissues and fluids; CSF; bile.
Metabolism: More stable to renal dehydropeptidases; converted to one inactive metabolite.
Excretion: Via urine within 12 hr by glomerular filtration and tubular secretion (70% unchanged). Elimination half-life: 1 hr. Removed by dialysis.
|ATC Classification||J01DH02 - meropenem; Belongs to the class of carbapenems. Used in the treatment of systemic infections.|
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ARONEMI/V||ACI Ltd.||Meropenem trihydrate 500mg & 1gm (I/V)||Injection||500mg,1gm vial: 652.45 & 1204.52 MRP|
|AROPEN I/V||Aristopharma Ltd.||Meropenem trihydrate 500mg (I/V)||Injection||500mg,1gm vial: 650.00 & 1200.00 MRP|
|CARBANEM I/V||Sanofi||Meropenem trihydrate 500mg (I/V)||Injection||500mg,1gm vial: 652.45 & 1204.52 MRP|
|FULSPEC I/V||The Acme Laboratories Ltd.||Meropenem trihydrate 500mg (I/V)||Injection||500mg,1gm vial: 652.46 & 1204.53 MRP|
|I-Penam 1 gm||Incepta Pharmaceuticals Limited||Meropenem 1 gm/vial Injection||IV Injection||1x1's:MRP 1300 Tk|
|I-Penam 500 mg||Incepta Pharmaceuticals Limited||Meropenem 500 mg/vial Injection||IV Injection||1x1's:MRP 700 Tk|
|MARKS I/V||Opso Saline Ltd.||Meropenem trihydrate 500mg (I/V)||Injection||500mg,1gm vial: 652.44 & 1254.72 MRP|
|MEROBAC I/V||Popular Pharmaceuticals Ltd.||Meropenem trihydrate 500mg (I/V)||Injection||500mg,1gm vial: 652.45 & 1003.77 MRP|
|MEROCAR I/V||Globe Pharmaceuticals Ltd||Meropenem trihydrate 500mg (I/V)||Injection||30's: 300.00 MRP|
|MEROJECT IV||Eskayef Bangladesh Ltd||Meropenem 500mg & 1gm vial||IV Injection||500mg & 1gm, MRP: 650.00 & 1200.00|
|MEROM I/V||Techno Drugs||Meropenem trihydrate 500mg (I/V)||Injection||500mg,1gm vial: 650.00 & 1200.00 MRP|
|MEROMAX I/V||Orion Pharma Ltd.||Meropenem trihydrate 500mg (I/V)||Injection||500mg,1gm vial: 652.45 & 1204.45 MRP|
|MERONIX I/V||Novo Healthcare and Pharma Ltd.||Meropenem trihydrate 500mg & 1gm (I/V)||Injection||500mg,1gm vial: 650.00 & 1200.00 MRP|
|MEROPEN I/V||Renata Limited||Meropenem trihydrate 500mg & 1gm (I/V)||Injection||500mg,1gm vial: 700.00 & 1300.00 MRP|
|Neopenem 1gm||Healthcare Pharmacuticals Ltd.||Meropenem 1 gm/vial Injection||IV Injection||1gm, MRP 1250 Tk|
|NEOPENEM 500mg||Healthcare Pharmacuticals Ltd.||Meropenem 500 mg/vial Injection||IV Injection||500mg, MRP 700 Tk|
|RONEM I/V||Opsonin Pharma Limited||Meropenem trihydrate 500mg & 1gm (I/V)||Injection||500mg,1gm vial: 650.00 & 1200.00 MRP|
|ROPENEM I/V||Drug International Ltd||Meropenem trihydrate 500mg & 1gm (I/V)||Injection||500mg,1gm vial: 501.64 & 960.00 MRP|
|SPECBAC 1G||Square Pharmaceuticals Ltd.||Meropenem 1 gm||IV Injection||1x1's: 1208.15 MRP|
|SPECBAC 500||Square Pharmaceuticals Ltd.||Meropenem 500mg||IV Injection||1x1's: 654.42 MRP|
Why is this medication prescribed?
Meropenem is an antibiotic that helps treat infection. The drug will be either injected into a large muscle (such as your buttock or hip) or added to an intravenous fluid that will drip through a needle or catheter placed in your vein for at least 15 minutes or more, one to three times a day.
Meropenem eliminates bacteria that cause many kinds of infections, including pneumonia and urinary tract, skin, bone, and stomach infections. This medication is sometimes prescribed for other uses; ask your doctor for more information.
Your health care provider (e.g. doctor) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how your infection and symptoms respond to the medication.
Before administering meropenem,
- tell your doctor if you are allergic to meropenem, penicillin, cephalosporins [cefaclor, cefadroxil or cephalexin] or any other drugs.
- tell your doctor what prescription and nonprescription medications you are taking, especially probenecid, valproic acid and vitamins.
- tell your doctor if you have or have ever had kidney or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking meropenem, call your doctor.
Administering your medicatio
Before you administer meropenem, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.
It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason because your infection could worsen and result in hospitalization. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.
Meropenem may cause side effects. Tell your health care provider if any of these symptoms are severe or do not go away:
If you experience any of the following symptoms, call your health care provider immediately:
fatigue and sleepiness
Storing your medication
Your health care provider may give you a several-day supply of meropenem at a time. You may receive vials and intravenous fluids to prepare your doses at home. You may receive a special bag with the vial of meropenem attached and directions on how to prepare the solution to infuse.
Store your medication only as directed. Make sure you understand what you need to store your medication properly.
Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.
In case of emergency/overdose
In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.
Signs of infection
If you are receiving meropenem in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). If you experience any of these effects near your intravenous catheter, tell your health care provider as soon as possible:
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: U.S. National Library of Medicine.
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.