Amoxicillin + Clavulanic Acid
(a mox i sil' in) (klav' yoo lan ic)
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||
|Special Precautions||History of allergy especially to cephalosporins, infectious mononucleosis, severe renal impairment.|
|Adverse Drug Reaction(s)||Nausea, vomiting, diarrhoea, indigestion, rash and urticaria, candida superinfection.
Potentially Fatal: Anaphylactic reaction with CV collapse esp with parenteral use.
|Drug Interactions||Allopurinol may reduce renal tubular secretion of amoxicillin thus increasing the serum levels of amoxicillin. Concurrent use may reduce the efficacy of oral contraceptives.
|Food Interaction||None on absorption. But incidence and severity of GI effects may be reduced.|
|Storage||Oral: Store below 25°C. Parenteral: Store below 25°C.|
|Pharmacology||Clavulanic acid has a high affinity for and binds to certain Î²-lactamases that generally inactivate amoxicillin by hydrolyzing its Î²-lactam ring. Combining clavulanate potassium with amoxicillin extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other penicillins and cephalosporins.
Distribution: Protein binding: About 25% (Clavulanic acid); about 18% (Amoxicillin). Amoxicillin distributes readily into most body tissues and fluids except the brain and spinal fluid.
Excretion: Half-life after oral admin: 1.3 hr (Amoxicillin); 1 hr (Clavulanic acid). About 50-70% of amoxicillin and 25-40% of clavulanic acid are excreted unchanged in urine during the 1st 6 hr after admin.
|ATC Classification||J01CA04 - amoxicillin; Belongs to the class of penicillins with extended spectrum. Used in the treatment of systemic infections.|
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|AMOCLAV||Techno Drugs||Co-amoxiclav 125/31 (Amoxycillin trihydrate 125mg+ Clavulanic acid 31.25mg)/5ml/5ml||Suspension||60ml, 100ml: 130.00 & 190.00 MRP|
|AMOCLAV 1200 I/V||Techno Drugs||Co-amoxiclav 1000/200 Powder for reconstitution (Amoxycillin 1000mg (as sodium salt)+ Clavulanic acid 200mg as Potassium salt)/vial||IV Injection||1200mg vial: 200.00 MRP|
|AMOCLAV 1gm||Techno Drugs||Co-amoxiclav 875/125 (Amoxycillin trihydrate 875mg+ Clavulanic acid 125mg)||Tablet||6's: 138.00 MRP|
|AMOCLAV 375||Techno Drugs||Co-amoxiclav 250/125 (Amoxycillin trihydrate 250mg+ Clavulanic acid 125mg)||Tablet||20's: 300.00 MRP|
|AMOCLAV 600 I/V||Techno Drugs||Co-amoxiclav 1000/200 Powder for reconstitution (Amoxycillin 500mg (as sodium salt)+ Clavulanic acid 100mg as Potassium salt)/vial||IV Injection||600mg vial: 110.00 MRP|
|AMOCLAV 625||Techno Drugs||Co-amoxiclav 500/125 (Amoxycillin trihydrate 500mg+ Clavulanic acid 125mg)||Tablet||18's: 360.00 MRP|
|AMOCLAV FORTE||Techno Drugs||Co-amoxiclav 400/57 (Amoxycillin trihydrate 400mg+ Clavulanic acid 57.50mg)/5ml||Suspension||35ml: 83.00 MRP|
|CLAMOX||Opsonin Pharma Limited||Co-amoxiclav 125/31 (Amoxycillin trihydrate 125mg+ Clavulanic acid 31.25mg)/5ml||Suspension||100ml: 150.00 MRP|
|CLAMOX 375||Opsonin Pharma Limited||Co-amoxiclav 250/125 (Amoxycillin trihydrate 250mg+ Clavulanic acid 125mg)||Tablet||18's: 297.00 MRP|
|CLAMOX 625||Opsonin Pharma Limited||Co-amoxiclav 500/125 (Amoxycillin trihydrate 500mg+ Clavulanic acid 125mg)||Tablet||12's: 240.00 MRP|
|CLAMOX DS||Opsonin Pharma Limited||Co-amoxiclav 400/57 (Amoxycillin trihydrate 400mg+ Clavulanic acid 57.50mg)/5ml||Suspension||35ml: 90.00 MRP|
|DEMOXICLAVE||Drug International Ltd||Co-amoxiclav 125/31 (Amoxycillin trihydrate 125mg+ Clavulanic acid 31.25mg)/5ml||Suspension||100ml: 150.00 MRP|
|DEMOXICLAVE FORTE||Drug International Ltd||Co-amoxiclav 400/57 (Amoxycillin trihydrate 400mg+ Clavulanic acid 57.50mg)/5ml||Suspension||35ml: 90.00 MRP|
|DEMOXICLAVE-375||Drug International Ltd||Co-amoxiclav 250/125 (Amoxycillin trihydrate 250mg+ Clavulanic acid 125mg)||Tablet||21's: 336.00 MRP|
|DEMOXICLAVE-625||Drug International Ltd||Co-amoxiclav 500/125 (Amoxycillin trihydrate 500mg+ Clavulanic acid 125mg)||Tablet||21's: 504.00 MRP|
|FIMOXYCLAV||Sanofi||Co-amoxiclav 125/31 (Amoxycillin trihydrate 125mg+ Clavulanic acid 31.25mg as Potassium salt)/5ml||Suspension||100ml: 220.83 MRP|
|FIMOXYCLAV 1200||Sanofi||Co-amoxiclav 1000/200 Powder for reconstitution (Amoxycillin 1000mg (as sodium salt)+ Clavulanic acid 200mg as Potassium salt)/vial||IV Injection||1200mg (combipack): 276.04 MRP|
|FIMOXYCLAV 1gm||Sanofi||Co-amoxiclav 875/125 (Amoxycillin trihydrate 875mg+ Clavulanic acid 125mg as Potassium salt)||Tablet||20's: 803.00 MRP|
|FIMOXYCLAV 375||Sanofi||Co-amoxiclav 250/125 (Amoxycillin trihydrate 250mg+ Clavulanic acid 125mg as Potassium salt)||Tablet||30's: 722.70 MRP|
|FIMOXYCLAV 400/57||Sanofi||Co-amoxiclav 400/57 (Amoxycillin trihydrate 400mg+ Clavulanic acid 57.50mg as Potassium salt)/5ml||Suspension||50ml: 220.83 MRP|
|FIMOXYCLAV 600||Sanofi||Co-amoxiclav 1000/200 Powder for reconstitution (Amoxycillin 500mg (as sodium salt)+ Clavulanic acid 100mg as Potassium salt)/vial||IV Injection||600mg (combipack): 140.53 MRP|
|FIMOXYCLAV 625||Sanofi||Co-amoxiclav 500/125 (Amoxycillin trihydrate 500mg+ Clavulanic acid 125mg as Potassium salt)||Tablet||30's: 903.30 MRP|
|MOXACLAV 0.6||Square Pharmaceuticals Ltd.||Amoxicillin 500mg + Clavulanic Acid 100mg||IV Injection||1x1's: 140.42 MRP|
|MOXACLAV 1.2||Square Pharmaceuticals Ltd.||Amoxicillin 1000mg + Clavulanic Acid 200mg||IV Injection||1x1's: 275.83 MRP|
|MOXACLAV 1.2G||Square Pharmaceuticals Ltd.||Amoxicillin 1000mg+ Clavulanic Acid 200mg||IV Injection||1's: 275.00 MRP|
|MOXACLAV 1G||Square Pharmaceuticals Ltd.||Amoxicillin 875mg + Clavulanic Acid 125mg||Tablet||2x6's: 361.2 MRP|
|MOXACLAV 375||Square Pharmaceuticals Ltd.||Amoxicillin 250mg + Clavulanic Acid 125mg||Tablet||4 x6's: 481.44 MRP|
|MOXACLAV 600||Square Pharmaceuticals Ltd.||Amoxicillin 500mg+ Clavulanic Acid 100mg||IV Injection||1's: 140.00 MRP|
|MOXACLAV 625||Square Pharmaceuticals Ltd.||Amoxicillin 500mg + Clavulanic Acid 125mg||Tablet||3x6's: 451.44 MRP|
|MOXACLAV FORTE||Square Pharmaceuticals Ltd.||Amoxicillin 400mg+ Clavulanic Acid 57.5mg /5ml||Powder for Suspension||35ml: 90.34 MRP|
|MOXACLAV FORTE||Square Pharmaceuticals Ltd.||Amoxicillin + Clavulanic Acid (400mg + 57.5mg)/5 ml||Powder for Suspension||35 ml: 90.61 MRP|
|MOXACLAV SUSP||Square Pharmaceuticals Ltd.||Amoxicillin + Clavulanic Acid (125mg + 31.25mg)/5 ml||Powder for Suspension||100 ml: 175.53 MRP|
|MOXACLAV SUSP 60||Square Pharmaceuticals Ltd.||Amoxicillin + Clavulanic Acid (125mg + 31.25mg)/5 ml||Powder for Suspension||60 ml: 135.92 MRP|
|MOXACLAV Suspension||Square Pharmaceuticals Ltd.||Amoxicillin 125mg+ Clavulanic Acid 31.25mg /5ml||Suspension||60 & 100ml: 135.51 & 175.00 MRP|
|TYCLAV 1000||Beximco Pharmaceuticals Ltd||Amoxicillin 875 mg + clavulanic acid 125 mg||Tablet||12's: 420.00 MRP|
|TYCLAV 375||Beximco Pharmaceuticals Ltd||Amoxicillin 250 mg + clavulanic acid 125 mg||Tablet||18's: 360.00 MRP|
|TYCLAV 625||Beximco Pharmaceuticals Ltd||Amoxicillin 500 mg + clavulanic acid 125 mg||Tablet||18's: 450.00 MRP|
Why is Amoxicillin-Clavulanic acid prescribed?
The combination of amoxicillin and clavulanic acid is used to treat certain infections caused by bacteria, including infections of the ears, lungs, sinus, skin, and urinary tract. Amoxicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria. Clavulanic acid is in a class of medications called beta-lactamase inhibitors. It works by preventing bacteria from destroying amoxicillin. Antibiotics will not work for colds, flu, or other viral infections.
How should Amoxicillin-Clavulanic acid be used?
The combination of amoxicillin and clavulanic acid may come as a tablet, a chewable tablet, and a suspension (liquid) to take by mouth or as I/V Injection. It is usually taken with a meal or a snack every 8 hours (three times a day) or every 12 hours (twice a day). To help you remember to take amoxicillin and clavulanate, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take amoxicillin and clavulanic acid exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Shake the liquid well before each use to mix the medication evenly.
The chewable tablets should be chewed thoroughly before they are swallowed. The other tablets should be taken with a full glass of water.
The 250 mg and 500 mg tablets of amoxicillin and clavulanic acid contain the same amount of clavulanic acid. Do not substitute two 250 mg tablets for one 500 mg tablet. The 250 mg regular tablet and the 250 mg chewable tablet contain different amounts of clavulanic acid. They also should not be substituted.
Take amoxicillin and clavulanic acid until you finish the prescription, even if you feel better. Stopping amoxicillin and clavulanic acid too soon may cause bacteria to become resistant to antibiotics.
Other uses for Amoxicillin-Clavulanic acid
Amoxicillin-Clavulanic acid may be prescribed for other uses; ask your doctor for more information.
What special precautions to follow?Before taking amoxicillin and clavulanic acid,
- inform your doctor if you are allergic to amoxicillin, clavulanic acid, penicillin, cephalosporins, or any other medications.
- inform your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention either of the following: allopurinol and probenecid. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- inform your doctor if you have or have ever had kidney or liver disease, allergies, asthma, hay fever, hives, or mononucleosis.
- you should know that amoxicillin and clavulanic acid may decrease the effectiveness of oral contraceptives (birth control pills). Plan to use another form of birth control while taking amoxicillin and clavulanic acid.
- inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking amoxicillin and clavulanic acid, call your doctor.
What special dietary instructions to follow?
Unless your doctor informs you otherwise, continue your normal diet.
What to do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can Amoxicillin-Clavulanic acid cause?Amoxicillin and clavulanic acid may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
mild skin rash
severe skin rash
difficulty breathing or swallowing
vaginal itching and discharge
yellowing of the skin or eyes
Amoxicillin and clavulanic acid may cause other side effects. Call your doctor if you have any unusual problems while taking Amoxicillin-Clavulanic acid.
In case of emergency/overdose
In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, call local medical emergency services.Symptoms of overdose may include:
What other information to know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to amoxicillin and clavulanic acid.
If you are diabetic, check your sugar while taking Amoxicillin-Clavulanic acid.
Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the amoxicillin and clavulanic acid, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: MedlinePlus, U.S. Natl. Library of Medicine
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.