mph Bangladesh


Clotrimazole

(kloe trim' a zole)

PCaution when used during lactation / LCaution when used during lactation Caution during pregnancy and lactation

Molecule Info

 |See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage Oropharyngeal candidiasis
Adult: Per lozenge contains 10 mg orally clotrimazole: Suck 1 lozenge 5 times daily for 14 days. For prevention in patients receiving immunosuppressant therapy: 1 lozenge tid for the immunosuppressant treatment duration. 
Otic/Aural
Fungal otitis externa
Adult: Apply 1% solution to affected area.
Topical/Cutaneous
Skin fungal infections
Adult: Apply a 1% cream/lotion/solution bid-tid for 2-4 wk, may be used with a 1% powder to prevent reinfection. 
Vaginal
Vulvovaginal candidiasis
Adult: As pessary: 100 mg daily for 6 days, 200 mg daily for 3 days or 500 mg as a single dose; alternatively, apply 1, 2 or 10% cream.
Contraindications Hypersensitivity.
Special Precautions Avoid contact with eyes upon topical application. Childn <3 yrs. Pregnancy, lactation.
Adverse Drug Reaction(s) Topical: Erythema, stinging, irritation; hypersensitivity reactions; contact dermatitis. Oral: GI disturbances, dysuria, mental depression, elevated liver enzymes.
Drug Interactions Antagonism with polyene antibiotics. Please consult detailed drug interactions before prescribing.
Pregnancy Category (FDA)

ROUTE(S) : Topical / Vaginal
Category B
: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).

ROUTE(S) : Mouth/Throat
Category C
: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Storage Store below 30°C.
Pharmacology Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.
Absorption: Negligible through intact skin (topical); 3-10% (vaginal).
Metabolism: Hepatic; converted to inactive metabolites.
Excretion: Urine, faeces (as metabolites).
ATC Classification D01AC01 - clotrimazole; Belongs to the class of imidazole and triazole derivatives for topical use. Used in the treatment of fungal infection. 
A01AB18 - clotrimazole; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. 
G01AF02 - clotrimazole; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.

Brand/Product Info


Total Products : 35                                   
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
AFUN CRM Square Pharmaceuticals Ltd. Clotrimazole 10mg/gm Cream 10 gm: 35.11 MRP
AFUN VT Square Pharmaceuticals Ltd. Clotrimazole 200mg Vaginal Tablet 1x3's: 60.18 MRP
ARISTEN Aristopharma Ltd. Clotrimazole 10mg/gm Eye Ointment 4gm: 55.00 MRP
CANTEN Pharmadesh Laboratories Limited Clotrimazole 1% cream Cream 10gm: 29.00 MRP
CANTRIM Rephco Laboratories Ltd. Clotrimazole 1% cream Cream 10gm: 28.00 MRP
Clarizol Incepta Pharmaceuticals Limited Each ml solution contains Clotrimazole BP 10 mg Solution 20ml:MRP 50 Tk
Clarizol Drop Incepta Pharmaceuticals Limited Clotrimazole 1% Ear Drop 10ml:MRP 80 Tk
CLODAL Globe Pharmaceuticals Ltd Clotrimazole 1% cream Cream 10gm: 25.00 MRP
CLODERM General Pharmaceuticals Ltd Clotrimazole 1% cream Cream 10gm: 35.10 MRP
CLOSTEN Alco Pharma Ltd Clotrimazole 1% cream Cream 10gm: 25.00 MRP
CLOTRIM The Acme Laboratories Ltd. Clotrimazole 1% cream Cream 5gm & 10gm: 18.31 & 28.60 MRP
CLOTRIM V The Acme Laboratories Ltd. Clotrimazole BP 200mg Suppository 200mg x3's: 60.21 MRP
CLOTRIM VT The Acme Laboratories Ltd. Clotrimazole BP 200mg Tablet 200mg x3's: 60.21 MRP
CLOTRIZOLE Reman Drug Laboratories Ltd. Clotrimazole 1% cream Cream 10gm: 30.11 MRP
CLOTZOL Sharif Pharmaceuticals Ltd. Clotrimazole 1% cream Cream 10gm: 29.00 MRP
CLOZOL VT Chemist Laboratories Ltd. Clotrimazole BP 200mg Tablet 200mg x3's: 60.00 MRP
CLOZOX UniDerma Pharmaceuticals Ltd. Clotrimazole 1% cream Cream 10gm: 25.00 MRP
DERMASIM ACI Ltd. Clotrimazole 1% cream Solution 20ml: 50.19 MRP
DERMASIM Cream ACI Ltd. Clotrimazole 1% cream Cream 15gm: 30.11 IP
DERMASIM VT ACI Ltd. Clotrimazole BP 500mg Tablet 500mg x1's: 60.00 MRP
FUNGIN IBN SINA Pharmaceutical Industry Ltd. Clotrimazole 1% cream Cream 10gm: 35.00 IP
FUNGIZOL Reman Drug Laboratories Ltd. Clotrimazole 10mg/gm (1%) Eye Ointment 4gm: 55.00 MRP
FUNGIZOL Drop Reman Drug Laboratories Ltd. Clotrimazole 10mg/ml (1%) Eye Drop 10ml: 75.50 MRP
FUSTEN Kumudini Pharma Ltd Clotrimazole 1% cream Cream 10gm: 25.00 MRP
KANIS Gaco Pharmaceutical Ltd. Clotrimazole 10mg/1ml Ear Drop 10ml: 60.00 MRP
KANIS Cream Gaco Pharmaceutical Ltd. Clotrimazole 1% cream Cream 10gm: 30.00 MRP
LODERM Ad-din pharmaceuticals Ltd. Clotrimazole 1% cream Cream 10gm: 23.00 MRP
MARET Mystic Pharmaceuticals Limited Clotrimazole 1% cream Cream 10gm: 30.00 MRP
NEOSTEN CREAM Beximco Pharmaceuticals Ltd Clotrimazole BP 10mg/gm Cream 20gm: 40.00 MRP
NEOSTEN VT Beximco Pharmaceuticals Ltd Clotrimazole BP 0.2gm Tablet 3's: 60.00 MRP
TINATRIM GlaxoSmithKline Bangladesh Limited Clotrimazole 1% cream Cream 10gm: 35.10 MRP
TRIDERM 10gm Healthcare Pharmacuticals Ltd. Clotrimazole BP 10mg/gm (1%) Cream 10gm, MRP 30 Tk
TRIDERM 20gm Healthcare Pharmacuticals Ltd. Clotrimazole BP 10mg/gm (1%) Cream 20gm, MRP 40 Tk
TRIMAZOLE Opsonin Pharma Limited Clotrimazole 1% cream Cream 10gm: 25.00 MRP
ZENESTEN Doctors Chemical Works Ltd Clotrimazole 1% cream Cream 10gm & 20gm: 25.00 & 31.27 MRP

Gen. MedInfo

Why is Clotrimazole prescribed?

Clotrimazole is used to treat yeast infections of the vagina, mouth, and skin such as athlete's foot, jock itch, and body ringworm. It can also be used to prevent oral thrush in certain patients.

Clotrimazole is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should Clotrimazole be used?

Clotrimazole may come as a cream, lotion, powder and solution to apply to the skin; lozenges (called troches) to dissolve in the mouth; and vaginal tablets and vaginal cream to be inserted into the vagina. Clotrimazole is usually used five times a day for 14 days for oral thrush, twice a day (in the morning and evening) for 2 to 8 weeks for skin infections, and once a day at bedtime for 3 or 7 days for vaginal infections. Follow the directions on the package or your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use clotrimazole exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

To use the topical cream, lotion, or solution, thoroughly clean the infected area, allow it to dry, and then gently rub the medication in until most of it disappears. Use just enough medication to cover the affected area. You should wash your hands after applying the medication.

The lozenges should be placed in the mouth and dissolved slowly over about 15 to 30 minutes. Do not chew or swallow the lozenges whole.

 To use clotrimazole vaginal cream or vaginal tablets, read the instructions provided with the medication and follow these steps:

  1. Fill the special applicator that comes with the cream to the level indicated or unwrap a tablet, wet it with lukewarm water, and place it on the applicator as shown in the instructions that come with the product.

  2. Lie on your back with your knees drawn upward and spread apart.

  3. Insert the applicator high into your vagina (unless you are pregnant), and then push the plunger to release the medication. If you are pregnant, insert the applicator gently. If you feel resistance (hard to insert), do not try to insert it further; call your doctor.

  4. Withdraw the applicator.

  5. Discard the applicator if it is disposable. If the applicator is reusable, pull it apart and clean it with soap and warm water after each use.

  6. Wash your hands promptly to avoid spreading the infection.

The vaginal cream or tablets should be applied when you lie down to go to bed. The drug works best if you do not get up again after applying it except to wash your hands. You may wish to wear a sanitary napkin while using the vaginal cream or tablets to protect your clothing against stains. Do not use a tampon because it will absorb the drug. Do not douche unless your doctor informs you to do so.

Continue to use clotrimazole even if you feel well. Do not stop using clotrimazole without talking to your doctor. Continue using Clotrimazole during your menstrual period.

If you obtained the clotrimazole skin cream, lotion, or solution without a prescription, use it for 4 weeks for athlete's foot and 2 weeks for jock itch or body ringworm. If your symptoms do not improve by that time, stop using the medication and consult either a pharmacist or doctor.

If you obtained clotrimazole vaginal cream or tablets without a prescription and this is the first time you have had vaginal itching and discomfort, talk with a physician before using clotrimazole. However, if a doctor previously told you that you had a yeast infection and if you have the same symptoms again, use the vaginal cream or tablets as directed on the package for 3 or 7 consecutive days, preferably at night. If your symptoms do not improve within 3 or 7 days, call your doctor. If your symptoms return in less than 2 months, also call your doctor.

What special precautions to follow?

Before using clotrimazole,

  • inform your doctor if you are allergic to clotrimazole or any other drugs.
  • inform your doctor what prescription and nonprescription drugs you are taking, especially antibiotic medications and vitamins.
  • inform your doctor if you have or have ever had liver disease, problems with your immune system, human immunodeficiency virus infection (HIV), acquired immunodeficiency syndrome (AIDS), diabetes, or a history of alcohol abuse.
  • inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using clotrimazole, call your doctor.
  • inform your doctor if you drink alcohol.

What to do if I forget a dose?

Take or insert the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.

What side effects can Clotrimazole cause?

Clotrimazole may cause side effects. If you experience any of the following symptoms, call your doctor immediately:

  • itching

  • burning

  • irritation

  • redness

  • swelling

  • stomach pain

  • fever

  • foul-smelling discharge if using the vaginal product

  • upset stomach or vomiting with the lozenges (troches)

What to know about storage and disposal of Clotrimazole?

Keep Clotrimazole in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not freeze. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What other information to know?

Keep all appointments with your doctor. Clotrimazole cream, lotion, and solution are for external use only. Do not let clotrimazole get into your eyes. Do not swallow the topical cream, lotion, or solution. Do not swallow the vaginal tablets or vaginal cream.

If you have a vaginal infection, refrain from sexual intercourse. An ingredient in the cream may weaken certain latex products like condoms or diaphragms; do not use such products within 72 hours of using Clotrimazole. Wear clean cotton panties (or panties with cotton crotches), not panties made of nylon, rayon, or other synthetic fabrics.

Do not let anyone else use your medication. If you still have symptoms of infection after you finish the clotrimazole, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

| See FDA approved Brand Manufacturer's Prescribing Information (VT) |

 

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