P : Contraindicated in pregnancy
L : Contraindicated in lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||Community-acquired pneumonia, Acute bacterial exacerbation of chronic bronchitis
Adult: 100-300 mg orally daily, as a single dose or 2 divided doses.
Renal impairment: Dosage adjustment may be necessary in severe impairment.
Special Populations: Renal impairment: Maintenance: 200 mg every other day.
|Administration||May be taken with
or without food.
|Contraindications||Hypersensitivity; pregnancy and lactation; children <18 yr.|
|Special Precautions||History of CNS disorders, pseudomembranous colitis, superinfection, severe renal dysfunction, epilepsy, G6PD deficiency, myasthenia gravis, patients with QT prolongation, uncorrected electrolyte disturbances, bradycardia, or pre-existing cardiac disease. Avoid exposure to strong sunlight or sunlamps during treatment. Discontinue treatment if patients experience tendon pain, inflammation or rupture; subsequent use of fluoroquinolones in these patients is not recommended. Avoid in MRSA infections due to high risk of resistance. Ensure adequate fluid intake to reduce risk of crystalluria.|
|Adverse Drug Reaction(s)||Diarrhoea,
abdominal pain, nausea, vomiting; jaundice, renal failure, elevation of liver enzymes, BUN and creatinine; anaphylactoid reaction, headache, dizziness,
convulsions; tremors, myalgia; rhabdomyolysis, thrombocytopenia and eosinophilia.
Potentially Fatal: AV block; anaphylaxis.
|Drug Interactions||Cations such as aluminum, magnesium, zinc and iron may reduce the bioavailability of sparfloxacin. May increase the plasma
concentrations of theophylline and tizanidine. May enhance the effect of warfarin and glibenclamide. May decrease the renal clearance of methotrexate.
Excretion may be reduced by probenecid. May alter serum levels of phenytoin.
Potentially Fatal: Corticosteroids may increase risk of tendon rupture. Increased risk of seizures with NSAIDs. Risk of additive QT prolongation effect when used with class Ia or III antiarrhythmic drugs, astemizole, terfenadine, cisapride, erythromycin, pentamidine, phenothiazines or TCAs. Please consult manufacturer's PIL for detailed drug interactions before prescribing.
|Pregnancy Category (FDA)||Category C: Contraindicated in 1st trimester. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.|
|Pharmacology||Sparfloxacin inhibits the supercoiling activity of DNA gyrase which is an enzyme essential for DNA
replication thus promoting the breakage of DNA structures. It has activity against S. pneumoniae, S. aureus, H. influenzae, K. pneumoniae, M.
catarrhalis and Mycobacterium spp.
Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 3-6 hr.
Distribution: Widely distributed into tissues including respiratory tissues. Protein-binding: 45%.
Metabolism: Hepatic (by glucuronidation).
Excretion: Excreted in equal amounts in the urine and faeces as unchanged drug and glucuronide metabolites; elimination half-life: 20 hr.
|ATC Classification||J01MA09 - sparfloxacin; Belongs to the class of quinolones, fluoroquinolone. Used in the treatment of systemic infections.|
Total Products : 22
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ACIFLOX||ACI Ltd.||Sparfloxacin INN 200mg||Tablet||10's: 150.60 MRP|
|FLOXIPAR||The Acme Laboratories Ltd.||Sparfloxacin INN 200mg||Tablet||30's: 120.30 MRP|
|MEGA-FLOX||Hudson Pharmaceuticals Ltd||Sparfloxacin INN 200mg||Tablet||20's: 300.00 MRP|
|OMNIFLOX||Aristopharma Ltd.||Sparfloxacin INN 200mg||Tablet||10's: 180.00 MRP|
|PARFLOX||Somatec Pharmaceuticals Ltd.||Sparfloxacin INN 200mg||Tablet||10's: 150.60 MRP|
|PARLOX||Eskayef Bangladesh Ltd||Sparfloxacin INN 200mg||Tablet||10's MRP: 150.00|
|PIOCIN-200||Millat Pharmaceuticals Ltd||Sparfloxacin INN 200mg||Tablet||6's: 84.00 MRP|
|QUINOFLOX||Healthcare Pharmacuticals Ltd.||Sparfloxacin INN 200 mg||Tablet||10's MRP 150 Tk|
|ROXIPAR||Cosmic Chemical Industries Limited||Sparfloxacin INN 200mg||Tablet||10's: 150.00 MRP|
|SAGA 200||Square Pharmaceuticals Ltd.||Sparfloxacin 200mg||Tablet||3x5's: 225.75 MRP|
|SALOCIN||Kemiko Pharmaceuticals Ltd||Sparfloxacin INN 200mg||Tablet||10's: 170.00 MRP|
|SPACIN||Sandoz/Novartis||Sparfloxacin INN 200mg||Tablet||1x10's, MRP 260|
|SPALOCIN||Pacific Pharmaceuticals Ltd.||Sparfloxacin INN 200mg||Tablet||10's: 200.00 MRP|
|SPALOX||Edruc Limited||Sparfloxacin INN 200mg||Tablet||10's: 160.00 IP|
|SPAR||Globe Pharmaceuticals Ltd||Sparfloxacin INN 200mg||Tablet||10's: 150.00 MRP|
|SPARCIN-200||Chemist Laboratories Ltd.||Sparfloxacin INN 200mg||Tablet||20's: 300.00 MRP|
|SPARDON||Apollo Pharmaceutical Laboratories Ltd.||Sparfloxacin INN 200mg||Tablet||12's: 192.00 IP|
|SPARFLOX||Alco Pharma Ltd||Sparfloxacin INN 200mg||Tablet||10's: 160.00 MRP|
|SPARFLOXIN-200||Desh Pharmaceuticals (Pvt) Ltd||Sparfloxacin INN 200mg||Tablet||10's: 160.00 MRP|
|SPARK||Navana Pharmaceuticals Limited||Sparfloxacin INN 200mg||Tablet||10's: 140.50 IP|
|SPARLIN||Beximco Pharmaceuticals Ltd||Sparfloxacin INN 200mg||Tablet||10's: 150.60 MRP|
|SPARONEX||Drug International Ltd||Sparfloxacin INN 200mg||Tablet||20's: 360.00 MRP|