Levofloxacin

(lee voe flox' a sin)

P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

 
Indication & Dosage Oral
Acute bacterial sinusitis
Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr.

Oral
Acute bacterial exacerbation of chronic bronchitis
Adult: 500 mg once daily for 7 days.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr.

Oral
Community-acquired pneumonia
Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr.

Oral
Nosocomial pneumonia
Adult: 750 mg once daily for 7-14 days.
Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 750 mg daily, then 750 mg every 48 hr.
10-19 Initially, 750 mg daily, then 500 mg every 48 hr.

Oral
Complicated skin and skin structure infections
Adult: 750 mg once daily for 7-14 days.
Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 750 mg daily, then 750 mg every 48 hr.
10-19 Initially, 750 mg daily, then 500 mg every 48 hr.

Oral
Uncomplicated urinary tract infections
Adult: 250 mg once daily for 3 days.
Oral
Complicated urinary tract infections
Adult: 250 mg once daily for 10 days.
CrCl (ml/min) Dosage Recommendation
10-19 Initially 250 mg daily, then 250 mg every 48 hr.

Oral
Acute pyelonephritis
Adult: 250 mg once daily for 10 days.
CrCl (ml/min) Dosage Recommendation
10-19 Initially 250 mg daily, then 250 mg every 48 hr.

Oral
Uncomplicated skin and skin structure infections
Adult: 500 mg once daily for 7-10 days.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr.

Oral
Chronic bacterial prostatitis
Adult: 500 mg once daily for 28 days.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr
10-19 Initially, 500 mg daily, then 250 mg every 48 hr.

Oral
Treatment and postexposure prophylaxis of inhalation anthrax
Adult: 500 mg once daily for 60 days.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr.

Intravenous
Acute bacterial sinusitis
Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr.

Intravenous
Acute bacterial exacerbation of chronic bronchitis
Adult: 500 mg once daily for 7 days. Infuse slowly over 60 min.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr.

Intravenous
Community-acquired pneumonia
Adult: 500 mg once for 7-14 days. Alternatively, 750 mg once daily for 5 days. Infuse slowly over 60-90 min.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr.

Intravenous
Nosocomial pneumonia
Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min.
Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 750 mg daily, then 750 mg every 48 hr.
10-19 Initially, 750 mg daily, then 500 mg every 48 hr.

Intravenous
Complicated skin and skin structure infections
Adult: 750 mg once daily for 7-14 days. Infuse slowly over 60-90 min.
Renal impairment: Haemodialysis/CAPD: Initially, 750 mg daily, then 500 mg every 48 hr. Infuse slowly over 60-90 min.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 750 mg daily, then 750 mg every 48 hr.
10-19 Initially, 750 mg daily, then 500 mg every 48 hr.

Intravenous
Uncomplicated urinary tract infections
Adult: 250 mg once daily for 3 days. Infuse slowly over 60-90 min.
Intravenous
Complicated urinary tract infections
Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min.
CrCl (ml/min) Dosage Recommendation
10-19 Initially 250 mg daily, then 250 mg every 48 hr.

Intravenous
Acute pyelonephritis
Adult: 250 mg once daily for 10 days. Infuse slowly over 60-90 min.
CrCl (ml/min) Dosage Recommendation
10-19 Initially 250 mg daily, then 250 mg every 48 hr.

Intravenous
Uncomplicated skin and skin structure infections
Adult: 500 mg once daily for 7-10 days. Infuse slowly over 60-90 min.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr.

Intravenous
Chronic bacterial prostatitis
Adult: 500 mg once daily for 28 days. Infuse slowly over 60-90 min.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr.

Intravenous
Treatment and postexposure prophylaxis of inhalation anthrax
Adult: 500 mg once daily for 60 days. Infuse slowly over 60-90 min.
Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Infuse slowly over 60-90 min.
CrCl (ml/min) Dosage Recommendation
20-49 Initially, 500 mg daily, then 250 mg every 24 hr.
10-19 Initially, 500 mg daily, then 250 mg every 48 hr.

Ophthalmic
Ocular infections
Adult: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.
Child: >1 yr: 1-2 drops of 0.5% solution every 2 hr while awake (up to 8 times daily) for 2 days, then 1-2 drops every 4 hr while awake (up to 4 times daily) for the next 5 days.

Special Populations: For patients with CrCl of 20-49 mL/min, the initial dose of 500 mg is administered followed by 250 mg once daily. If CrCl is 10-19 mL/min, the initial dose of 500 mg is administered followed by 250 mg every 48 hours. Reduce dose in patients with renal impairment.
Administration May be taken with or without food.
Contraindications Hypersensitivity to levofloxacin or other quinolones. Child <18 yr.
Special Precautions Known or suspected CNS disorders (e.g. severe cerebral arteriosclerosis, epilepsy) or other risk factors that predispose to seizures. Avoid unnecessary exposure to sunlight or artificial UV light. History of prolonged QT interval, uncorrected electrolyte disturbances. DM (carefully monitor blood glucose levels). Periodically monitor renal, hepatic and haematopoietic functions during treatment. Pregnancy and lactation. Elderly. May impair ability to drive or operate machinery.
Adverse Drug Reactions Oral/IV: Nausea, diarrhoea, constipation, headache, insomnia, inj site reactions (IV). Ophthalmic: Transient decrease in vision, ocular burning, ocular pain or discomfort, foreign body sensation, headache, fever, pharyngitis, photophobia.
Potentially Fatal: Anaphylaxis.
Drug Interactions Increased concentration of ciclosporin or tacrolimus. Reduced absorption with didanosine, ferrous sulfate or dietary supplements containing zinc, calcium, magnesium or iron. May increase plasma levels of theophylline. Increased risk of tendon rupture with corticosteroids. Reduced absorption with sucralfate and antacids containing magnesium and aluminium; administer at least 2 hr before or 2 hr after antacids. Increased half-life and decreased clearance of procainamide. Altered glucose levels with antidiabetic agents (e.g. insulin, glyburide).
Potentially Fatal: Increased risks of ventricular arrhythmias with QT prolonging drugs e.g. class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmics, fluoxetine, imipramine. Increased risk of CNS stimulation and seizures with NSAIDs. Increased prothrombin time with warfarin. Please consult detailed drug interactions before prescribing.
Lab Interference False-positive tests for opiates.
Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Intravenous: Store below 25°C (77°F). Ophthalmic: Store at 15-25°C (59-77°F). Oral: Tablet: Store at 15-30°C (59-86°F). Oral solution: Store at 25°C (77°F).
 Pharmacology Levofloxacin exerts antibacterial action by inhibiting bacterial topoisomerase IV and DNA gyrase, the enzymes required for DNA replication, transcription repair and recombination. It has in vitro activity against a wide range of gram-negative and gram-positive microorganisms.
Absorption: Rapid and complete absorption from the GIT (oral); peak plasma concentrations within 1-2 hr.
Distribution: Widely distributed in bronchial mucosa, lungs; CSF (relatively poor). Protein-binding: 30-40%.
Metabolism: Limited.
Excretion: Mainly via urine (largely as unchanged drug); 6-8 hr (elimination half-life).
ATC Classification S01AX19 - levofloxacin ; Belongs to the class of other antiinfectives. Used in the treatment of eye infections. 
J01MA12 - levofloxacin ; Belongs to the class of quinolones, fluoroquinolone. Used in the treatment of systemic infections.

Brand/Product Info


Total Products : 112                                                                                                                
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
3-F 500 Edruc Limited Levofloxacin hemihydrate INN 500mg Tablet 20's: 280.00 IP
ANLEV UniDerma Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg Tablet 10's: 150.00 MRP
AVELOX-500 Shamsul Alamin Pharmaceuticals Ltd Levofloxacin hemihydrate INN 500mg Tablet 20's: 240.00 MRP
BACNIL Rephco Laboratories Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP
BELOXIN Belsen Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP
BENFLOXIN 500 Benham Pharmaceuticals Ltd Levofloxacin hemihydrate INN 500mg Tablet 20's: 238.60 MRP
CORBIC Novo Healthcare and Pharma Ltd. Levofloxacin hemihydrate INN 500mg Tablet 10's: 150.00 MRP
COSLEV Cosmo Pharma Laboratories Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 280.00 MRP
EVO 250 Beximco Pharmaceuticals Ltd Levofloxacin Hemihydrate INN eq. to Levofloxacin 250mg Tablet 30's: 270.00 MRP
EVO 500 Beximco Pharmaceuticals Ltd Levofloxacin Hemihydrate INN eq. to Levofloxacin 500mg Tablet 20's: 320.00 MRP
EVO 500 IV Beximco Pharmaceuticals Ltd Levofloxacin INN 500mg (5mg/ml) IV Infusion 100ml: 100.00 MRP
EVO 750 Beximco Pharmaceuticals Ltd Levofloxacin Hemihydrate INN eq. to Levofloxacin 750mg Tablet 10's: 200.00 MRP
EVO DROP Beximco Pharmaceuticals Ltd Levofloxacin INN 0.5% Drop 5ml: 80.00 MRP
EVO SOLUTION Beximco Pharmaceuticals Ltd Levofloxacin INN 125mg/5ml Solution 100ml: 75.00 MRP
EVO TS Beximco Pharmaceuticals Ltd Levofloxacin INN 1.5% ophthalimic solution Solution 5ml: 130.00 MRP
EVOCIN Hudson Pharmaceuticals Ltd Levofloxacin hemihydrate INN 500mg Tablet 20's: 240.00 MRP
EVOLOXIN 500 Hallmark Pharmaceuticals Ltd Levofloxacin hemihydrate INN 500mg Tablet 20's: 261.00 MRP
EVONEX Jayson Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 250mg & 500mg Tablet 250mg x30's, 500mg x20's: 210.90 & 261.00 MRP
EXOLEV Sandoz/Novartis Levofloxacin hemihydrate INN 500mg & 750mg Tablet 250mgx30's: MRP 210.00; 500mgx20's: 320.00; 750mgx10's: 200.00
FLOVO Decent Pharma Laboratories Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP
LAXOD-500 Millat Pharmaceuticals Ltd Levofloxacin hemihydrate INN 500mg Tablet 30's: 450.00 MRP
LEEVOTIN Syntho Laboratories Ltd. Levofloxacin hemihydrate INN 500mg Tablet 30's: 450.00 MRP
LEFEX 500 Doctors Chemical Works Ltd Levofloxacin hemihydrate INN 500mg Tablet 30's: 420.00 MRP
LEFLOX ACI Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 5mg/ml (0.5%) Eye Drop 5ml: 120.00 MRP
LEFLOX TS ACI Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 15mg/ml (1.5%) Eye Drop 5ml: 120.00 MRP
LEO The Acme Laboratories Ltd. Levofloxacin hemihydrate INN 250mg & 500mg,750mg Tablet 250mg x32's: 257.28, 500mg x20's: 301.00 & 750mg x12's: 240.84 MRP
LEO Drop The Acme Laboratories Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 5mg/ml (0.5%) Eye Drop 5ml: 80.30 MRP
LEO I/V The Acme Laboratories Ltd. Levofloxacin hemihydrate INN 500mg/100ml (I/V) Infusion 100ml: 100.00 MRP
LEOFLOX Alco Pharma Ltd Levofloxacin hemihydrate INN 250mg & 500mg Tablet 250mg x10's, 500mg x20's: 70.00 & 240.00 MRP
LEQUIN Apex Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 200.00 MRP
LEQUIN Drop Apex Pharmaceuticals Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 5mg/ml (0.5%) Eye Drop 5ml: 80.00 MRP
LETAB Chemist Laboratories Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 200.00 MRP
LETHIQUIN 500 Rangs Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP
LEVIN Amico Laboratories Ltd. Levofloxacin hemihydrate INN 500mg Tablet 10's: 140.00 MRP
LEVOBAC Popular Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg & 750mg Tablet 24's each: 358.53 & 481.92 MRP
LEVOBAC Drop Popular Pharmaceuticals Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 5mg/ml (0.5%) Eye Drop 5ml: 90.00 MRP
LEVOBAC I/V Popular Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg/100ml (I/V) Infusion 100ml: 100.38 MRP
LEVOBAC TS Popular Pharmaceuticals Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 15mg/ml (1.5%) Eye Drop 5ml: 90.00 MRP
LEVOCIN-500 Desh Pharmaceuticals (Pvt) Ltd Levofloxacin hemihydrate INN 500mg Tablet 30's: 420.00 MRP
LEVOCOS Cosmic Chemical Industries Limited Levofloxacin hemihydrate INN 500mg Tablet 30's: 420.00 MRP
LEVODON Apollo Pharmaceutical Laboratories Ltd. Levofloxacin hemihydrate INN 500mg Tablet 16's: 240.00 MRP
LEVOFLOX Drug International Ltd Levofloxacin hemihydrate INN 500mg & 750mg Tablet 500mg x20's, 750mg x10's: 300.00 & 200.00 MRP
LEVOFLOX Drop Drug International Ltd Levofloxacin hemihydrate INN equivalent to levofloxacin 5mg/ml (0.5%) Eye Drop 5ml: 60.00 MRP
LEVOFLOX I/V Drug International Ltd Levofloxacin hemihydrate INN 500mg/100ml (I/V) Infusion 100ml: 100.00 MRP
LEVOGEN General Pharmaceuticals Ltd Levofloxacin hemihydrate INN 250mg & 500mg Tablet 250mg x30's, 500mg x20's: 240.90 & 301.20 MRP
LEVOKING Renata Limited Levofloxacin hemihydrate INN 250mg & 500mg,750mg Tablet 250 & 500mg x30's:240.90 & 451.80; 750mg x18's: 361.26 MRP
LEVOKING Syrup Renata Limited Levofloxacin hemihydrate INN 125mg/5ml Syrup 100ml: 75.28 MRP
LEVOLEX Pharmadesh Laboratories Limited Levofloxacin hemihydrate INN 500mg Tablet 20's: 280.00 MRP
LEVOLON Peoples Pharma Ltd. Levofloxacin hemihydrate INN 250mg & 500mg Tablet 20's each: 150.00 & 280.00 MRP
LEVOMAX Eskayef Bangladesh Ltd Levofloxacin hemihydrate INN 500mg & 750mg Tablet 500mg x20's & 750mg x10's MRP: 300.00 & 200.00
LEVOMET 250 Medimet Pharmaceuticals Ltd Levofloxacin hemihydrate INN 250mg Tablet 20's: 160.00 MRP
LEVONCE Bristol Pharma Limited Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP
LEVONIX 500 Ziska Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg Tablet 10's: 294.00 MRP
LEVOQUIN Navana Pharmaceuticals Limited Levofloxacin hemihydrate INN 250mg & 500mg Tablet 250mg x20's, 500mg x24's: 160.60, 361.46 IP
LEVORA Somatec Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 250mg & 500mg,750mg Tablet 250 & 500mg x20's: 160.60, 281.00; 750mg x10's: 180.70 MRP
LEVORA Solution Somatec Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 125mg/5ml Oral Solution 100ml: 75.28 MRP
LEVOSEEM-500 Seema Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 320.00 MRP
LEVOSINA IBN SINA Pharmaceutical Industry Ltd. Levofloxacin hemihydrate INN 250mg & 500mg,750mg Tablet 250 & 500mg x20's: 160.00 & 310.00; 750mg x20's: 420.00 IP
LEVOSINA Drop IBN SINA Pharmaceutical Industry Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 5mg/ml (0.5%) Eye Drop 5ml: 90.00 MRP
LEVOSTIN Aexim Pharmaceutical Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 260.00 MRP
LEVOX Opsonin Pharma Limited Levofloxacin hemihydrate INN 250mg & 500mg,750mg Tablet 250mg x30's: 240.00, 500mg x20's: 300.00, 750mg x10's,12's: 200.00 & 240.00 MRP
LEVOX I/V Opsonin Pharma Limited Levofloxacin hemihydrate INN 500mg/100ml (I/V) Infusion 100ml: 100.00 MRP
LEVOX Solution Opsonin Pharma Limited Levofloxacin hemihydrate INN 125mg/5ml Oral Solution 100ml: 75.00 MRP
Levoxin 250 Incepta Pharmaceuticals Limited Levofloxacin Hemihydrate INN equivalent to Levofloxacin 250 mg Film Coated Tablet 10x3's:MRP 240 Tk
Levoxin 500 Incepta Pharmaceuticals Limited Levofloxacin Hemihydrate INN equivalent to Levofloxacin 500 mg Film Coated Tablet 4x5's:MRP 300 Tk
Levoxin 750 Incepta Pharmaceuticals Limited Levofloxacin Hemihydrate INN equivalent to Levofloxacin 750 mg Film Coated Tablet 10x1's:MRP 200 Tk
Levoxin Drop Incepta Pharmaceuticals Limited Levofloxacin Hemihydrate INN equivalent to Levofloxacin 5mg/ml Drop 5ml:MRP 90 Tk
Levoxin IV Incepta Pharmaceuticals Limited Levofloxacin Hemihydrate INN equivalent to Levofloxacin 500mg/100ml Infusion 100ml:MRP 100 Tk
Levoxin Oral Incepta Pharmaceuticals Limited Levofloxacin Hemihydrate INN equivalent to Levofloxacin 125mg/5ml Solution 100ml:MRP 80 Tk
Levoxin TS Incepta Pharmaceuticals Limited Levofloxacin Hemihydrate USP 15.37 mg equivalent to Levofloxacin 15mg/ml Eye Drop 5ml:MRP 130 Tk
LEXAZEN Zenith Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 250mg & 500mg Tablet 250mg x20's, 500mg x18's: 240.00 & 252.00 MRP
LEXLO Ambee Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 250mg & 500mg Tablet 20's each: 160.60 & 261.00 MRP
LEXVO-500 Modern Pharmaceuticals Ltd Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP
LEZON Euro Pharma Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP
LIFCIN Biopharma Laboratories Ltd Levofloxacin hemihydrate INN 500mg & 750mg Tablet 500mg x20's, 750mg x12's: 301.20 & 240.96 MRP
LIFCIN I/V Biopharma Laboratories Ltd Levofloxacin hemihydrate INN 500mg/100ml (I/V) Infusion 100ml: 100.00 MRP
LIFCIN Syrup Biopharma Laboratories Ltd Levofloxacin hemihydrate INN 125mg/5ml Syrup 100ml: 75.28 MRP
LIN Kemiko Pharmaceuticals Ltd Levofloxacin hemihydrate INN 250mg & 500mg Tablet 250mg x30's, 500mg x20's: 300.00 & 300.00 MRP
LIVACIN Gaco Pharmaceutical Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 5mg/ml (0.5%) Eye Drop 5ml: 80.00 MRP
LIVACIN-500 Gaco Pharmaceutical Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP
LOCE 500 Everest Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 288.00 MRP
LOCIN Globe Pharmaceuticals Ltd Levofloxacin hemihydrate INN 250mg & 500mg Tablet 20's each: 140.00 & 240.00 MRP
LOVICIN Nipa Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg Tablet 30's: 450.00 MRP
LOVICIN Drop Nipa Pharmaceuticals Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 5mg/ml (0.5%) Eye Drop 5ml: 80.00 MRP
LOXIN Medicon Laboratories Ltd Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP
MAXLEV- 500 Novus Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 240.00 MRP
NEOLEV 500 Marksman Pharmaceuticals Ltd Levofloxacin hemihydrate INN 500mg Tablet 20's: 240.00 MRP
NEOVOX 500 R A K Pharmaceuticals Pvt. Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP
NIVOLOC 500 Kumudini Pharma Ltd Levofloxacin hemihydrate INN 500mg Tablet 20's: 280.00 MRP
OLCIN Delta Pharma Limited Levofloxacin hemihydrate INN 500mg Tablet 15's, 20's, 30's: 60.00 & 80.00 & 120.00 MRP
ORLEV Orion Pharma Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 301.20 MRP
OVEL Aristopharma Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 5mg/ml (in Benzalkonium Chloride 0.005% preservative) Eye Drop 5ml: 90.00 MRP
OVEL TS Aristopharma Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 15mg/ml (1.5%) Eye Drop 5ml: 120.00 MRP
OVEL-500 Aristopharma Ltd. Levofloxacin hemihydrate INN 500mg Tablet 30's: 450.00 MRP
QUILEV Monico Pharma Limited Levofloxacin hemihydrate INN 500mg Tablet 24's: 360.00 MRP
QUIXIN Beacon Pharmaceuticals Limited Levofloxacin hemihydrate INN 500mg Tablet 30's: 450.00 MRP
RADIBAC-500 Concord Pharmaceuticals Ltd. Levofloxacin hemihydrate INN 500mg Tablet 20's: 260.00 MRP
RESQUIN 250 Healthcare Pharmacuticals Ltd. Levofloxacin Hemihydrate INN equivalent to Levofloxacin 250mg Tablet 30's MRP 240 Tk
RESQUIN 500 Healthcare Pharmacuticals Ltd. Levofloxacin Hemihydrate INN equivalent to Levofloxacin 500mg Tablet 24's MRP 360 Tk
RESQUIN 750 Healthcare Pharmacuticals Ltd. Levofloxacin Hemihydrate INN equivalent to Levofloxacin 750mg Tablet 18's MRP 360 Tk
RESQUIN EYE DROP DROP Healthcare Pharmacuticals Ltd. Levofloxacin INN 0.5% Drop 5ml, MRP 90 Tk
REVACIN TS Reman Drug Laboratories Ltd. Levofloxacin hemihydrate INN equivalent to levofloxacin 15mg/ml (1.5%) Eye Drop 5ml: 150.00 MRP
TIVANIK Silva Pharmaceuticals Limited Levofloxacin hemihydrate INN 250mg & 500mg Tablet 250mg x30's, 500mg x20's: 240.90 & 301.14 MRP
TOPLEVO 500 NIPRO JMI Pharma Ltd. Levofloxacin hemihydrate INN 500mg Tablet 30's: 450.00 MRP
TREVOX 500 Square Pharmaceuticals Ltd. Levofloxacin 500mg Tablet 3x10's: 453.00 MRP
TREVOX 500 IV Square Pharmaceuticals Ltd. Levofloxacin 5mg/ml IV Infusion 100 ml: 100.30 MRP
TREVOX 750 Square Pharmaceuticals Ltd. Levofloxacin 750mg Tablet 2x10's: 402.60 MRP
TREVOX O-SOLN Square Pharmaceuticals Ltd. Levofloxacin 125mg/5 ml Oral Solution 100 ml: 80.24 MRP
TRILON-500 The White Horse Pharma Levofloxacin hemihydrate INN 500mg Tablet 24's: 360.00 MRP
URILEV 750 Techno Drugs Levofloxacin hemihydrate INN 250mg & 500mg,750mg Tablet 250 & 500mg x20's:170.00 & 300.00; 750mg x18's: 360.00 MRP
URILEV I/V Techno Drugs Levofloxacin hemihydrate INN 500mg/100ml (I/V) Infusion 100ml: 100.00 MRP
XELEVO-500 Pharmasia Limited Levofloxacin hemihydrate INN 500mg Tablet 20's: 300.00 MRP

Gen. MedInfo

Notice: Raised in the U.S. Market

[Posted 08/15/2013] ISSUE: ISSUE: FDA has required the drug labels and Medication Guides for all fluoroquinolone antibacterial drugs be updated to better describe the serious side effect of peripheral neuropathy. This serious nerve damage potentially caused by fluoroquinolones may occur soon after these drugs are taken and may be permanent.

BACKGROUND: The risk of peripheral neuropathy occurs only with fluoroquinolones that are taken by mouth or by injection. Approved fluoroquinolone drugs include levofloxacin, ciprofloxacin, moxifloxacin, norfloxacin, ofloxacin and gemifloxacin. The topical formulations of fluoroquinolones, applied to the ears or eyes, are not known to be associated with this risk.

RECOMMENDATION: Make sure your patients know to contact you if they develop symptoms of peripheral neuropathy. Make sure your patients receive the Medication Guide with every prescription. If a patient develops symptoms of peripheral neuropathy, the fluoroquinolone should be stopped, and the patient should be switched to another, non-fluoroquinolone antibacterial drug, unless the benefit of continued treatment with a fluoroquinolone outweighs the risk. Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program.

For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety.

 

IMPORTANT WARNING:

Taking Oral levofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor if you are taking oral or injectable steroids such as dexamethasone (Decadron, Dexpak), methylprednisolone (Medrol), or prednisone (Sterapred). If you experience any of the following symptoms of tendinitis, stop taking levofloxacin, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop taking levofloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or bear weight on an affected area.

Taking levofloxacin may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to take levofloxacin. If you have myasthenia gravis and your doctor tells you that you should take levofloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment.

Using levofloxacin injection increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor if you are taking oral or injectable steroids such as dexamethasone (Decadron, Dexpak), methylprednisolone (Medrol), or prednisone (Sterapred). If you experience any of the following symptoms of tendinitis, stop using levofloxacin injection, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop using levofloxacin injection and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or to bear weight on an affected area.

Using levofloxacin injection may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to use levofloxacin injection. If you have myasthenia gravis and your doctor tells you that you should use levofloxacin injection, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment.

Talk to your doctor about the risks of taking levofloxacin.

Your doctor will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with levofloxacin. Read the information carefully and ask your doctor if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

 

Why is this medication prescribed? 

Levofloxacin is used to treat certain infections such as pneumonia, chronic bronchitis and sinus, urinary tract, kidney, prostate (a male reproductive gland), and skin infections. Levofloxacin is also used to prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax germs in the air. Levofloxacin is in a class of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections. Antibiotics will not work for colds, flu, or other viral infections.

How should this medicine be used?

Levofloxacin may come as a tablet/capsule and a solution (liquid) to take by mouth. It is usually taken once a day. The length of your treatment depends on the type of infection you have. Your doctor will tell you how long to take levofloxacin. The tablet may be taken with or without food. The solution should be taken 1 hour before or 2 hours after eating. Take levofloxacin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Take levofloxacin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You should begin to feel better during the first few days of treatment with levofloxacin. If your symptoms do not improve or if they get worse, call your doctor.

Levofloxacin injection is used to treat infections such as pneumonia; chronic bronchitis; and sinus, urinary tract, kidney, prostate (a male reproductive gland), and skin infections. Levofloxacin injection is also used to prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax germs in the air. Levofloxacin injection is in a class of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections. Antibiotics will not work for colds, flu, or other viral infections.

Take levofloxacin until you finish the prescription, even if you feel better. Do not stop taking levofloxacin unless you experience the symptoms of tendinitis or tendon rupture described in the IMPORTANT WARNING section or the symptoms of allergic reaction described in the SIDE EFFECTS section. If you stop taking levofloxacin too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Other uses for this medicine

Levofloxacin is also sometimes used to treat endocarditis (infection of the heart lining and valves), certain sexually transmitted diseases, and tuberculosis (TB). Levofloxacin is also sometimes used to prevent or treat traveler's diarrhea and plague (a serious infection that may be spread on purpose as part of a bioterror attack). Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor for more information.

What special precautions should I follow?

Before taking levofloxacin,

  • tell your doctor if you are allergic or have had a severe reaction to levofloxacin; any other quinolone or fluoroquinolone antibiotic such as ciprofloxacin, gatifloxacin, gemifloxacin, lomefloxacin, moxifloxacin, nalidixic acid, norfloxacin, ofloxacin, and sparfloxacin: or any other medications, or if you are allergic to any of the ingredients in levofloxacin tablets or solution. 
  • tell your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: anticoagulants ('blood thinners') such as warfarin; certain antidepressants; antipsychotics (medications to treat mental illness); cyclosporine (Gengraf, Neoral, Sandimmune); diuretics ('water pills'); insulin; oral medications for diabetes such as glyburide; certain medications for irregular heartbeat such as amiodarone, procainamide, quinidine, and sotalol; nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen; tacrolimus (Prograf); or theophylline. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • if you are taking antacids containing aluminum hydroxide or magnesium hydroxide, didanosine, sucralfate or vitamin or mineral supplements that contain iron or zinc, take these medications 2 hours before or after you take levofloxacin.
  • tell your doctor if you or anyone in your family has or has ever had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death) or an irregular heartbeat, and if you have or have ever had nerve problems; a low level of potassium in your blood; a slow heartbeat; cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or mini-stroke); seizures; chest pain; or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking levofloxacin, call your doctor.
  • you should know that levofloxacin may cause confusion, dizziness, lightheadedness, and tiredness. Do not drive a car, operate machinery, or participate in activities requiring alertness or coordination until you know how this medication affects you.
  • plan to avoid unnecessary or prolonged exposure to sunlight or ultraviolet light (tanning beds and sunlamps) and to wear protective clothing, sunglasses, and sunscreen. Levofloxacin may make your skin sensitive to sunlight or ultraviolet light. If your skin becomes reddened, swollen, or blistered, like a bad sunburn, call your doctor.

What special dietary instructions should I follow?

Make sure you drink plenty of water or other fluids every day while you are taking levofloxacin.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Levofloxacin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • vomiting

  • diarrhea

  • stomach pain

  • constipation

  • heartburn

  • headache

  • vaginal itching and/or discharge

Some side effects can be serious. If you experience any of these symptoms, or those mentioned in the IMPORTANT WARNING section, stop taking levofloxacin, and call your doctor immediately:

  • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)

  • skin rash or blisters

  • itching

  • hives

  • tingling or swelling of the face, neck, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

  • difficulty breathing or swallowing

  • hoarseness or throat tightness

  • fainting

  • rapid, irregular, or pounding heartbeat

  • chest pain

  • joint or muscle pain

  • fever

  • unusual bruising or bleeding

  • extreme tiredness

  • lack of energy

  • loss of appetite

  • pain in the upper right part of the stomach

  • yellowing of the skin or eyes

  • dark urine

  • pale stools

  • flu-like symptoms

  • seizures

  • dizziness

  • confusion

  • nervousness

  • restlessness

  • anxiety

  • not trusting others or feeling that others want to hurt you

  • difficulty falling asleep or staying asleep

  • nightmares or abnormal dreams

  • hallucinations (seeing things or hearing voices that do not exist)

  • depression

  • thoughts about dying or killing yourself

  • uncontrollable shaking of a part of the body

  • pain, burning, tingling, numbness, and/or weakness in a part of the body

Levofloxacin may cause problems with bones, joints, and tissues around joints in children. Levofloxacin should not normally be given to children younger than 18 years of age unless they have been exposed to anthrax in the air. If your doctor prescribes levofloxacin for your child, be sure to tell the doctor if your child has or has ever had joint-related problems. Call your doctor if your child develops joint problems, such as pain or swelling, while taking levofloxacin or after treatment with levofloxacin. Talk to your child's doctor about the risks of giving levofloxacin to your child.

Levofloxacin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.