(er ith roe mye' sin)
P :Contraindicated in pregnancy
L:Caution when used during lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||
Severe campylobacter enteritis
Prophylaxis of streptococcal infections in patients with evidence ofrheumatic
fever or heart disease
Renal impairment: Adult: Severe impairment: Max: 1.5 g daily.
|Administration||Erythromycin base: Should be taken on an empty stomach. Best taken on an empty stomach at least Â½ hr & preferably 2 hr before
|Overdosage||Treatment is supportive. Erythromycin is not removed by peritoneal dialysis or haemodialysis.|
|Contraindications||Hypersensitivity; porphyria; hepatic impairment; pregnancy.|
|Special Precautions||Increased risk of cholestatic hepatitis when treatment is >10 days or in patients with previous history of erythromycin usage. History of hepatic disorders; arrhythmias; prolonged QT interval; lactation. Monitor liver function. Avoid estolate in liver impairment. Caution when using lactobionate in patients with severe renal impairment. May aggravate muscle weakness in patients with myasthenia gravis.|
|Adverse Drug Reaction(s)||Rash, urticaria; nausea, vomiting, GI discomfort; ototoxicity; central neurotoxicity; agranulocytosis; arrhythmias; pancreatitis.
Potentially Fatal: Hepatotoxicity, cholestatic jaundice; raised serum transaminases; eosinophilia.
|Drug Interactions||May antagonise therapeutic effects lincomycin and clindamycin. Concurrent usage may lead to increased
absorption of alcohol.
Potentially Fatal: May potentiate actions of neuromuscular blockers, oral anticoagulants, ciclosporin, theophylline. Terfenadine, astemizole, cisapride toxicity increased. Please consult detailed drug interactions before prescribing.
|Food Interaction||Increased absorption when taken with meals.|
|Lab Interference||False-positive urinary catecholamines. Falsely elevated serum-aspartate aminotransferase values.|
|Pregnancy Category (FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Storage||Intravenous: Store at 15-25Â°C. Oral susp: Refrigerate at 2-8Â°C. Topical/Cutaneous: Store at 15-25Â°C. Oral susp: Refrigerate at 2-8Â°C.|
inhibits protein synthesis by irreversibly binding to the 50S ribosomal subunit thus blocking the transpeptidation or translocation reactions of susceptible
organisms resulting in stunted cell growth.
Absorption: Variable and unreliable due to instability in GI environment; may be reduced in the presence of food (as the stearate or base). Peak plasma concentrations after 1-4 hr.
Distribution: Widely distributed into body tissues and fluids, liver and spleen (high concentrations), polymorphonuclear lymphocytes and macrophages; crosses the placenta (5-20% foetal plasma concentrations) and enters the breast milk. Protein-binding: 70-75% (as the base), 95% (as the propionate ester).
Metabolism: Hepatic (demethylation).
Excretion: Via the urine (2-5% of the oral dose, 12-15% of the IV dose); 1.5-2.5 hr (elimination half-life).
|ATC Classification||S01AA17 - erythromycin; Belongs to the
class of antibiotics. Used in the treatment of eye infections.
J01FA01 - erythromycin; Belongs to the class of macrolides. Used in the treatment of systemic infections.
D10AF02 - erythromycin; Belongs to the class of topical antiinfective preparations used in the treatment of acne.
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|A-MYCIN||Aristopharma Ltd.||Erythromycin 250mg & 500mg||Tablet||250mg x100's & 500mg x50's: 480.00 & 450.00 MRP|
|A-MYCIN DS||Aristopharma Ltd.||Erythromycin 250mg/5ml||Suspension||100ml: 104.20 MRP|
|A-MYCIN Lotion||Aristopharma Ltd.||Erythromycin BP 2% lotion||Lotion||25ml: 120.00 MRP|
|A-MYCIN Paediatric Drop||Aristopharma Ltd.||Erythromycin 200mg/5ml||Paediatric Drop||60ml: 60.00 MRP|
|A-MYCIN Suspension||Aristopharma Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 61.29 MRP|
|ACRYTH||Monico Pharma Limited||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|ARIGRAM||Central Pharmaceuticals Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|CPMYCIN||Cosmo Pharma Laboratories Ltd.||Erythromycin 250mg||Tablet||100's: 400.00 MRP|
|E-LID||Syntho Laboratories Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 54.00 MRP|
|E-ROX||Desh Pharmaceuticals (Pvt) Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|E-ROX 500||Desh Pharmaceuticals (Pvt) Ltd||Erythromycin 500mg||Tablet||50's: 350.00 MRP|
|ECIN||Gaco Pharmaceutical Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|EDRY||Edruc Limited||Erythromycin 125mg/5ml||Suspension||100ml: 55.00 MRP|
|EM||Modern Pharmaceuticals Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|EMYCIN||Medimet Pharmaceuticals Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 61.00 MRP|
|ERES||Everest Pharmaceuticals Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 56.00 MRP|
|ERES 500||Everest Pharmaceuticals Ltd.||Erythromycin 500mg||Tablet||30's: 240.00 MRP|
|ERIXIN||Amico Laboratories Ltd.||Erythromycin 200mg/5ml||Paediatric Drop||60ml: 60.00 MRP|
|ERIXIN Suspension||Amico Laboratories Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|ERMAC||Opsonin Pharma Limited||Erythromycin 125mg/5ml||Suspension||100ml: 56.64 MRP|
|ERO||Hudson Pharmaceuticals Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|EROCIN||The Acme Laboratories Ltd.||Erythromycin 250mg & 500mg||Tablet||250mg x50's, 500mg x30's: 243.50 & 258.90 MRP|
|EROCIN Suspension||The Acme Laboratories Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.22 MRP|
|EROM||Kemiko Pharmaceuticals Ltd||Erythromycin 250mg & 500mg||Tablet||250mg x100's & 500mg x50's: 485.00 & 430.00 MRP|
|EROM Suspension||Kemiko Pharmaceuticals Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|EROMAC||General Pharmaceuticals Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 61.33 MRP|
|EROMED||Aexim Pharmaceutical Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 55.00 MRP|
|EROMYCIN 250||Square Pharmaceuticals Ltd.||Erythromycin 250mg||Tablet||5x10's: 259.00 MRP|
|EROMYCIN DS||Square Pharmaceuticals Ltd.||Erythromycin 500mg||Tablet||5x6's: 310.50 MRP|
|EROMYCIN LOTION||Square Pharmaceuticals Ltd.||Erythromycin 3% w/v||Lotion||25 ml: 120.37 MRP|
|EROMYCIN P-DROP||Square Pharmaceuticals Ltd.||Erythromycin Ethylsuccinate 200mg/5 ml||Paediatric Drops||60 ml: 60.40 MRP|
|EROMYCIN PFS||Square Pharmaceuticals Ltd.||Erythromycin 125mg/5 ml||Powder for Syrup||100 ml: 69.53 MRP|
|ERONA||Delta Pharma Limited||Erythromycin 125mg/5ml||Suspension||100ml: 61.29 MRP|
|ERONA 500||Delta Pharma Limited||Erythromycin 500mg||Tablet||50's: 454.50 MRP|
|ERONIX||Ziska Pharmaceuticals Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|EROSA||Biopharma Laboratories Ltd||Erythromycin 250mg & 500mg||Tablet||250mg x100's & 500mg x50's: 452.00 & 401.50 MRP|
|EROSA Suspension||Biopharma Laboratories Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 55.21 MRP|
|ERRIN||Radiant Pharmaceuticals Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|ERY||Alco Pharma Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 50.00 MRP|
|ERY-250||Alco Pharma Ltd||Erythromycin 250mg||Tablet||50's: 200.00 MRP|
|ERY-500||Alco Pharma Ltd||Erythromycin 500mg||Tablet||50's: 350.00 MRP|
|ERYBAC||Drug International Ltd||Erythromycin 250mg & 500mg||Tablet||250mg x50's, 500mg x30's: 200.00 & 210.00 MRP|
|ERYBAC Suspension||Drug International Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 55.00 MRP|
|ERYCIN||Somatec Pharmaceuticals Ltd.||Erythromycin 250mg & 500mg||Tablet||250mg x50's, 500mg x30's: 216.00 & 240.90 MRP|
|ERYCIN Suspension||Somatec Pharmaceuticals Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 56.21 MRP|
|ERYLIN||Cosmic Chemical Industries Limited||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|ERYMEX||IBN SINA Pharmaceutical Industry Ltd.||Erythromycin 500mg||Tablet||30's: 243.00 MRP|
|ERYMEX Suspension||IBN SINA Pharmaceutical Industry Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.50 MRP|
|ERYNET||Bristol Pharma Limited||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|ERYROX||Navana Pharmaceuticals Limited||Erythromycin 500mg||Tablet||30's: 240.90 MRP|
|ERYROX Suspension||Navana Pharmaceuticals Limited||Erythromycin 125mg/5ml||Suspension||100ml: 60.22 MRP|
|ERYTHIN||ACI Ltd.||Erythromycin 500mg||Tablet||30's: 240.00 MRP|
|ERYTHIN Suspension||ACI Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 61.29 MRP|
|ERYTHRO||Medicon Laboratories Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 57.00 MRP|
|ERYTHROMYCIN-A||Ad-din pharmaceuticals Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|ERYTHROX||Renata Limited||Erythromycin 250mg & 500mg||Tablet||50's each: 242.50 & 429.50 MRP|
|ERYTHROX Suspension||Renata Limited||Erythromycin 125mg/5ml||Suspension||100ml: 61.07 MRP|
|ERYZEN||Zenith Pharmaceuticals Ltd.||Erythromycin 250mg & 500mg||Tablet||250mg x60's, 500mg x20's: 261.00 & 172.00 MRP|
|ERYZEN Suspension||Zenith Pharmaceuticals Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 56.64 MRP|
|ETHRO||Pharmadesh Laboratories Limited||Erythromycin 125mg/5ml||Suspension||100ml: 75.00 MRP|
|ETHROLEX||Mystic Pharmaceuticals Limited||Erythromycin 125mg/5ml||Suspension||100ml: 54.50 MRP|
|ETHROLEX 500||Mystic Pharmaceuticals Limited||Erythromycin 500mg||Tablet||30's: 217.50 MRP|
|ETROCIN 250||Beximco Pharmaceuticals Ltd||Erythromycin Ethylsuccinate BP eq. to Erythromycin 250mg||Tablet||100's: 480.00 MRP|
|ETROCIN 500||Beximco Pharmaceuticals Ltd||Erythromycin Ethylsuccinate BP eq. to Erythromycin 500mg||Tablet||50's: 450.00 MRP|
|ETROCIN Suspension||Beximco Pharmaceuticals Ltd||Erythromycin Ethylsuccinate BP eq. to Erythromycin 125mg/5ml||Suspension||100ml: 69.32 MRP|
|EURO||Nipa Pharmaceuticals Ltd.||Erythromycin 250mg & 500mg||Tablet||250mg x50's, 500mg x30's: 212.50 & 240.00 MRP|
|EURO Suspension||Nipa Pharmaceuticals Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|Firmac||Incepta Pharmaceuticals Limited||Erythromycin Ethylsuccinate BP equivalent to Erythromycin 125mg/5ml||Suspension||100ml:MRP 60 Tk|
|ILOCIN||Doctors Chemical Works Ltd||Erythromycin 500mg||Tablet||20's: 160.00 MRP|
|ILOCIN Suspension||Doctors Chemical Works Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|KUMUCIN||Kumudini Pharma Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 55.00 MRP|
|MAC||Orion Pharma Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.27 MRP|
|MAC DS||Orion Pharma Ltd.||Erythromycin 250mg/5ml||Suspension||70ml, 100ml: 74.27 & 103.39 MRP|
|MACAS||Asiatic Laboratories Ltd.||Erythromycin 500mg||Tablet||24's: 194.88 MRP|
|MACAS Suspension||Asiatic Laboratories Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 56.85 MRP|
|MACERY||Pacific Pharmaceuticals Ltd.||Erythromycin 250mg & 500mg||Tablet||250mg x50's, 500mg x30's: 225.00 & 246.00 MRP|
|MACERY Suspension||Pacific Pharmaceuticals Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 46.00 MRP|
|MACIN||Hallmark Pharmaceuticals Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|MACROCIN||Sanofi||Erythromycin 250mg & 500mg||Tablet||250mg x100's & 500mg x50's: 488.11 & 432.92 MRP|
|MACROCIN Suspension||Sanofi||Erythromycin 125mg/5ml||Suspension||100ml: 61.23 MRP|
|MACROCIN-T||Sanofi||Erythromycin BP 2% solution||Solution||30ml: 177.67 MRP|
|MAKCIN||Techno Drugs||Erythromycin 125mg/5ml||Suspension||100ml: 50.00 MRP|
|MITROCIN||Millat Pharmaceuticals Ltd||Erythromycin 250mg & 500mg||Tablet||250mg x30's, 500mg x20's: 136.50 & 170.20 MRP|
|MITROCIN DS||Millat Pharmaceuticals Ltd||Erythromycin 250mg/5ml||Suspension||100ml: 103.00 MRP|
|MITROCIN Suspension||Millat Pharmaceuticals Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|MYCIN||Ambee Pharmaceuticals Ltd.||Erythromycin 500mg||Tablet||50's: 401.00 MRP|
|MYCIN Suspension||Ambee Pharmaceuticals Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.22 MRP|
|PEDICIN||Rangs Pharmaceuticals Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 60.00 MRP|
|PRIOCIN||Eskayef Bangladesh Ltd||Erythromycin Ethylsuccinate BP equivalent to Erythromycin 500mg||Tablet||40's MRP: 280.00|
|PRIOCIN Suspension||Eskayef Bangladesh Ltd||Erythromycin Ethylsuccinate BP equivalent to Erythromycin 125mg/5ml||Suspension||100ml MRP: 60.00|
|SERVITROCIN 250 MG||Sandoz/Novartis||Erythromycin Ethylsuccinate BP equivalent to Erythromycin 250mg||Tablet||10x10's, MRP 485|
|SERVITROCIN 500 MG||Sandoz/Novartis||Erythromycin Ethylsuccinate BP equivalent to Erythromycin 500mg||Tablet||5x10's, MRP 430|
|SERVITROCIN SUSPENSION||Sandoz/Novartis||Erythromycin Ethylsuccinate BP equivalent to Erythromycin 125mg/5ml||Suspension||100ml, MRP 60.68|
|THROCIN||Globe Pharmaceuticals Ltd||Erythromycin 125mg/5ml||Suspension||100ml: 56.00 MRP|
|ZEROBAC||Chemist Laboratories Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 55.00 MRP|
|ZURACIN||Rephco Laboratories Ltd.||Erythromycin 125mg/5ml||Suspension||100ml: 61.07 MRP|
Why is Erythromycin prescribed?
Erythromycin is an antibiotic used to treat certain infections caused by bacteria, such as bronchitis; diphtheria; Legionnaires' disease; pertussis (whooping cough); pneumonia; rheumatic fever; venereal disease (VD); and ear, intestine, lung, urinary tract, and skin infections. It is also used before some surgery or dental work to prevent infection. Antibiotics will not work for colds, flu, or other viral infections.
Erythromycin is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should Erythromycin be used?
Erythromycin comes as a capsule, tablet, long-acting capsule, long-acting tablet, chewable tablet, liquid, and pediatric drops to take by mouth. It usually is taken every 6 hours (four times a day) or every 8 hours (three times a day) for 7 to 21 days. Some infections may require a longer time. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take erythromycin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Shake the liquid and pediatric drops well before each use to mix the medication evenly. Use the bottle dropper to measure the dose of pediatric drops.
The chewable tablets should be crushed or chewed thoroughly before they are swallowed. The other capsules and tablets should be swallowed whole and taken with a full glass of water.
Continue to take erythromycin even if you feel well. Do not stop taking erythromycin without talking to your doctor.
What special precautions to follow?
Before taking erythromycin,
- inform your doctor if you are allergic to erythromycin, azithromycin, clarithromycin, dirithromycin or any other drugs.
- inform your doctor what prescription and nonprescription medications you are taking, especially other antibiotics, anticoagulants ('blood thinners'), astemizole, carbamazepine (Tegretol), cisapride, clozapine, cyclosporine (Neoral, Sandimmune), digoxin, disopyramide, ergotamine, felodipine, lovastatin, phenytoin, pimozide, terfenadine, theophylline, triazolam and vitamins.
- inform your doctor if you have or have ever had liver disease, yellowing of the skin or eyes, colitis, or stomach problems.
- inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking erythromycin, call your doctor.
- if you are having surgery, including dental surgery, inform the doctor or dentist that you are taking erythromycin.
What special dietary instructions to follow?
Take erythromycin at least 1 hour before or 2 hours after meals. Do not take Erythromycin with, or just after, fruit juices or carbonated drinks. Certain brands of erythromycin may be taken with meals; check with your doctor or pharmacist.
What to do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can Erythromycin cause?
Erythromycin may cause side effects. inform your doctor if any of these symptoms are severe or do not go away:
mild skin rash
- stomach pain
If you experience any of the following symptoms, call your doctor immediately:
severe skin rash
difficulty breathing or swallowing
yellowing of the skin or eyes
What to know about storage and disposal of Erythromycin?
Keep Erythromycin in the container it came in, tightly closed, and out of reach of children. Store the capsules and tablets at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Keep liquid medicine in the refrigerator, closed tightly, and throw away any unused medication after 14 days. Do not freeze. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.
What other information to know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Erythromycin.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: U.S. National Library of Medicine.
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.