mph Bangladesh


PCI  :Contraindicated in pregnancy

LCI  :Contraindicated in lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage

Oral route
Susceptible infections
Adult: 250-500 mg 4 times daily. Max 4 g daily.
Child: >8 yr: 25-50 mg/kg daily in 4 divided doses.
Renal impairment: Dosage may need to be reduced.

Acne
Adult: 250-500 mg bid.
Renal impairment: Dosage may need to be reduced.

Uncomplicated gonorrhoea
Adult: 1.5 g initially, followed by 0.5 g four times daily up to a total of 9 g per treatment course.
Renal impairment: Dosage may need to be reduced.
Intramuscular route
Susceptible infections
Adult: 250 mg once daily or 300 mg daily in 2-3 divided doses.
Child: >8 yr: 15-25 mg/kg (max 250 mg) daily in 2-3 divided doses.
Renal impairment: Dosage may need to be reduced.
Ophthalmic route
Superficial ophthalmic infections
Adult: Used in combination with other agents: As ointment: Apply a small amount in the lower conjunctival sac of the infected eye 2-4 times daily. As suspension: Instill 1-2 drops into the affected eye tid.
Topical/Cutaneous application
Infected dermatitis
Adult: In combination with a topical steroid: Apply up to 4 times daily.

Administration Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Contraindications Hypersensitivity to tetracyclines, children <8 yr, renal damage. Pregnancy, lactation.
Special Precautions Elderly, renal or hepatic impairment; myasthenia gravis; lupus erythematosus, children <12 yr.
Adverse Drug Reaction(s) Anorexia, nausea, vomiting,diarrhoea, glossitis, dysphagia, photosensitivity, oesphageal irritation and ulceration, nephrotoxicity, enterocolitis, rash (rare), blood dyscrasias. Headache, visual disturbances; intracranial hypertension; bulging fontanelles (infants).
Potentially Fatal: Rare. Fulminant diarrhoea in post operative patients.
Drug Interactions Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption. Concurrent use may cause increased levels of lithium, digoxin, halofantrine and theophylline; decreased concentrations of atovaquone. Increased risk of ergotism with ergot alkaloids. May cause failure of oral contraception.
Potentially Fatal: Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption. Concurrent use may cause increased levels of lithium, digoxin, halofantrine and theophylline; decreased concentrations of atovaquone. Increased risk of ergotism with ergot alkaloids. May cause failure of oral contraception. Please consult manufacturer's PIL (Prescribing Information Leaflet) for detailed drug interactions.
Food Interaction Absorption reduced by food, milk and milk products. Give 1 hr before or 2 hr after meals.
Lab Interference Interferes with urinary glucose and catecholamine estimations.
Pregnancy Category (FDA)
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Pharmacology
Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, thus inhibiting bacterial protein synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.
Distribution: Protein-binding: 20-40%
Metabolism: Hepatic (small amounts).
Excretion: Urine, faeces; 9 hr (elimination half-life).
ATC Classification S01AA04 - oxytetracycline; Belongs to the class of antibiotics. Used in the treatment of eye infections. 
D06AA03 - oxytetracycline; Belongs to the class of topical tetracycline and derivatives agents used in the treatment of dermatological diseases. 
G01AA07 - oxytetracycline; Belongs to the class of antibiotics. Used in the treatment of gynecological infections. 
J01AA06 - oxytetracycline; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.

Brand/Product Info


Total Products : 8        
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
CHEMOMYCIN Salton Pharmaceuticals Ltd. Oxytetracycline 250mg Capsule 100's: 120.00 MRP
ORAMYCIN Desh Pharmaceuticals (Pvt) Ltd Oxytetracycline 250mg & 500mg Capsule 250mg x60's, 500mg x100's: 72.00 & 215.00 MRP
OXECYLIN The Acme Laboratories Ltd. Oxytetracycline 250mg Capsule 100's: 110.00 MRP
OXYTETRACYCLINE Reliance Pharmaceuticals Ltd. Oxytetracycline 250mg Capsule 60's: 90.00 MRP
RENAMYCIN Capsule Renata Limited Oxytetracycline 250mg Capsule 60's: 73.80 MRP
RENAMYCIN E/E Ointment Renata Limited Oxytetracycline 5mg (0.5%) + Polymixin B Sulphate 1000 IU/gm eye/ear Ointment Ointment 3.5gm: 17.49 MRP
RENAMYCIN Injection Renata Limited Oxytetracycline 50mg/ml Injection 10ml vial: 16.19 MRP
RENAMYCIN Otic Solution Renata Limited Oxytetracycline 0.025%+ Benzocaine 0.25%+ Polymixin B Sulphate 500 IU/ml Ear Drop Solution 5ml vial: 24.27 MRP
Simple Breath Test Might Diagnose Heart Failure An experimental breath test, designed to quickly identify patients suffering from heart failure simply by analyzing the contents of a...
Osteoporosis drug stops Breast cancer growth   News & Events News & Events     HIGHLIGHTS Osteoporosis drug stops growth of breast cancer...
Generic drug safety info loophole FDA plans to close generic drug safety info loophole The US Food and Drug Administration has announced plans to speed up the dissemination of...
Large trials unpublished   News & Events News & Events   HIGHLIGHTS Almost 1 in 3 of large clinical trials unpublished after...
TB activists boo Indian minister News & Events News & Events   HIGHLIGHTS TB activists at world conference boo Indian minister off...
Key bone marrow protein identified News & Events News & Events   HIGHLIGHTS Key bone marrow protein identified as potential new leukemia...