P :Contraindicated in pregnancy
L :Contraindicated in lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||
|Administration||Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after
|Contraindications||Hypersensitivity to tetracyclines, children <8 yr, renal damage. Pregnancy, lactation.|
|Special Precautions||Elderly, renal or hepatic impairment; myasthenia gravis; lupus erythematosus, children <12 yr.|
|Adverse Drug Reaction(s)||Anorexia, nausea, vomiting,diarrhoea, glossitis, dysphagia, photosensitivity, oesphageal irritation and ulceration, nephrotoxicity,
enterocolitis, rash (rare), blood dyscrasias. Headache, visual disturbances; intracranial hypertension; bulging fontanelles (infants).
Potentially Fatal: Rare. Fulminant diarrhoea in post operative patients.
|Drug Interactions||Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption. Concurrent use may cause increased levels of lithium,
digoxin, halofantrine and theophylline; decreased concentrations of atovaquone. Increased risk of ergotism with ergot alkaloids. May cause failure of oral
Potentially Fatal: Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption. Concurrent use may cause increased levels of lithium, digoxin, halofantrine and theophylline; decreased concentrations of atovaquone. Increased risk of ergotism with ergot alkaloids. May cause failure of oral contraception. Please consult manufacturer's PIL (Prescribing Information Leaflet) for detailed drug interactions.
|Food Interaction||Absorption reduced by food, milk and milk products. Give 1 hr before or 2 hr after meals.|
|Lab Interference||Interferes with urinary glucose and catecholamine estimations.|
||Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).|
||Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, thus inhibiting bacterial protein
synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.
Distribution: Protein-binding: 20-40%
Metabolism: Hepatic (small amounts).
Excretion: Urine, faeces; 9 hr (elimination half-life).
|ATC Classification||S01AA04 - oxytetracycline; Belongs to
the class of antibiotics. Used in the treatment of eye infections.
D06AA03 - oxytetracycline; Belongs to the class of topical tetracycline and derivatives agents used in the treatment of dermatological diseases.
G01AA07 - oxytetracycline; Belongs to the class of antibiotics. Used in the treatment of gynecological infections.
J01AA06 - oxytetracycline; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|CHEMOMYCIN||Salton Pharmaceuticals Ltd.||Oxytetracycline 250mg||Capsule||100's: 120.00 MRP|
|ORAMYCIN||Desh Pharmaceuticals (Pvt) Ltd||Oxytetracycline 250mg & 500mg||Capsule||250mg x60's, 500mg x100's: 72.00 & 215.00 MRP|
|OXECYLIN||The Acme Laboratories Ltd.||Oxytetracycline 250mg||Capsule||100's: 110.00 MRP|
|OXYTETRACYCLINE||Reliance Pharmaceuticals Ltd.||Oxytetracycline 250mg||Capsule||60's: 90.00 MRP|
|RENAMYCIN Capsule||Renata Limited||Oxytetracycline 250mg||Capsule||60's: 73.80 MRP|
|RENAMYCIN E/E Ointment||Renata Limited||Oxytetracycline 5mg (0.5%) + Polymixin B Sulphate 1000 IU/gm eye/ear Ointment||Ointment||3.5gm: 17.49 MRP|
|RENAMYCIN Injection||Renata Limited||Oxytetracycline 50mg/ml||Injection||10ml vial: 16.19 MRP|
|RENAMYCIN Otic Solution||Renata Limited||Oxytetracycline 0.025%+ Benzocaine 0.25%+ Polymixin B Sulphate 500 IU/ml Ear Drop||Solution||5ml vial: 24.27 MRP|