(lak' tyoo lose)
|Indication(s) & Dosage||
|Administration||May be taken with or without food. Take with a full glass of water & remain upright for at least Â½ hr. Take with food or milk if GI irritation occurs.
|Contraindications||Galactosaemia, intestinal obstruction. Patients on low galactose diet.|
|Special Precautions||Monitor electrolyte imbalance. Lactose intolerance; diabetics.|
|Adverse Drug Reaction(s)||Diarrhoea (dose-related), nausea, vomiting, hypokalaemia, bloating and abdominal cramps.
Potentially Fatal: Dehydration and hypernatraemia on aggressive treatment.
|Drug Interactions||May prevent release of mesalazine in the colon. Decreased effect with oral neomycin, antacids.
|Pregnancy Category (FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Storage||Oral: Store at 15-30Â°C (59-86Â°F). Rectal: Store at 2-30Â°C (36-86Â°F).|
|Pharmacology||Lactulose promotes peristalsis by producing an osmotic effect in the colon with resultant distention. In hepatic encephalopathy, it reduces absorption of ammonium ions and toxic nitrogenous compounds, resulting in reduced blood ammonia concentrations.
Onset: 48 hr.
Absorption: Not appreciable (oral).
Metabolism: Via colonic flora to lactic acid and acetic acid.
Excretion: Faeces, urine (as unchanged drug).
|ATC Classification||A06AD11 - lactulose; Belongs to the class of osmotically acting laxatives.|
Search Google: Lactulose
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ACTILAC 100ml||Healthcare Pharmacuticals Ltd.||Lactulose USP 3.35gm/5ml||Solution||100ml, MRP 125 Tk|
|ACTILAC 200ml||Healthcare Pharmacuticals Ltd.||Lactulose USP 3.35gm/5ml||Solution||200ml, MRP 230 Tk|
|ACTULOSE||Silva Pharmaceuticals Limited||Lactulose USP 3.35gm/5ml||Syrup||100ml, 200ml: 60.22 & 120.46 MRP|
|ASILAC||Asiatic Laboratories Ltd.||Lactulose USP 3.35gm/5ml||Syrup||100ml: 100.00 MRP|
|AVOLAC||Aristopharma Ltd.||Lactulose USP 3.35gm/5ml||Solution||100ml, 200ml: 120.00 & 230.00 MRP|
|COMFORT||APC Pharmaceuticals Ltd.||Lactulose USP 3.35gm/5ml||Syrup||100ml: 80.00 MRP|
|CONLAX||Unimed & Unihealth Manufacturers Ltd.||Lactulose USP 3.35gm/5ml||Solution||100ml, 200ml: 100.00 & 200.00 MRP|
|D-LAC||Drug International Ltd||Lactulose USP 3.35gm/5ml||Solution||100ml, 200ml: 100.00 & 150.00 MRP|
|DEVOLAC||Desh Pharmaceuticals (Pvt) Ltd||Lactulose USP 3.35gm/5ml||Solution||100ml, 200ml: 100.00 & 195.00 MRP|
|DULAC||Chemist Laboratories Ltd.||Lactulose USP 3.35gm/5ml||Solution||100ml: 100.00 MRP|
|ELAX||Edruc Limited||Lactulose USP 3.35gm/5ml||Syrup||100ml: 100.00 IP|
|EZYLAX||Orion Pharma Ltd.||Lactulose USP 3.35gm/5ml||Solution||50ml, 100ml: 50.19 & 100.38 MRP|
|Inolac Oral||Incepta Pharmaceuticals Limited||Lactulose USP 3.35gm/5ml||Solution||100ml :MRP 95 Tk|
|LACLOSE||Opsonin Pharma Limited||Lactulose USP 3.4gm/5ml||Solution||100ml, 200ml: 100.00 & 200.00 MRP|
|LACTOLAX||Pharmasia Limited||Lactulose USP 3.35gm/5ml||Solution||100ml: 100.38 IP|
|LACTOMOSE||Monico Pharma Limited||Lactulose USP 3.35gm/5ml||Solution||100ml: 100.00 MRP|
|LACTU||Biopharma Laboratories Ltd||Lactulose USP 3.4gm/5ml||Solution||100ml, 200ml: 120.00 & 200.00 MRP|
|LACTULOSE-H||Hudson Pharmaceuticals Ltd||Lactulose USP 3.4gm/5ml||Solution||100ml: 60.00 MRP|
|LAX||Medicon Laboratories Ltd||Lactulose USP 3.4gm/5ml||Solution||100ml: 120.00 MRP|
|LAXATIV||Rangs Pharmaceuticals Ltd.||Lactulose USP 3.4gm/5ml||Solution||100ml, 200ml: 75.00 & 140.00 MRP|
|LAXOL||Navana Pharmaceuticals Limited||Lactulose USP 3.35gm/5ml||Solution||50ml, 100ml, 200ml: 50.19, 100.38 & 200.75 IP|
|LAXOLAC||Globe Pharmaceuticals Ltd||Lactulose USP 3.35gm/5ml||Solution||100ml: 95.00 MRP|
|LEAXE||Alco Pharma Ltd||Lactulose USP 3.35gm/5ml||Solution||100ml: 90.00 MRP|
|LIVOTON||Kemiko Pharmaceuticals Ltd||Lactulose USP 3.35gm/5ml||Syrup||50ml, 100ml, 200ml: 50.00, 100.00 & 200.00 MRP|
|LOCTOZ||Amico Laboratories Ltd.||Lactulose USP 3.35gm/5ml||Syrup||100ml: 100.00 MRP|
|LUBLAC||NIPRO JMI Pharma Ltd.||Lactulose USP 3.35gm/5ml||Solution||100ml: 100.00 MRP|
|MYLAC||Mystic Pharmaceuticals Limited||Lactulose USP 3.35gm/5ml||Syrup||100ml, 200ml: 75.00 & 140.00 MRP|
|ORALAX||Somatec Pharmaceuticals Ltd.||Lactulose USP 3.35gm/5ml||Syrup||100ml: 100.38 MRP|
|OSMOLAX SOLN||Square Pharmaceuticals Ltd.||Lactulose 3.4 gm/5 ml||Solution||100 ml: 140.00 MRP|
|OSMOLAX SOLN 200||Square Pharmaceuticals Ltd.||Lactulose 3.4 gm/5 ml||Solution||200 ml: 250.00 MRP|
|P-LAC||Pharmadesh Laboratories Limited||Lactulose USP 3.35gm/5ml||Solution||100ml: 93.12 MRP|
|REGULOSE||General Pharmaceuticals Ltd||Lactulose USP 3.35gm/5ml||Syrup||100ml, 200ml: 100.38 & 200.75 MRP|
|REWAT||Kumudini Pharma Ltd||Lactulose USP 3.35gm/5ml||Solution||100ml: 95.00 MRP|
|SERELOSE SOLN||Beximco Pharmaceuticals Ltd||Lactulose BP 3.35G/5ml||Solution||100ml: 120.00 MRP|
|SINALAC||IBN SINA Pharmaceutical Industry Ltd.||Lactulose USP 3.35gm/5ml||Solution||60ml, 100ml, 200ml, 450ml: 60.00, 100.00, 200.00 & 425.00 IP|
|SIVOLAC||Sharif Pharmaceuticals Ltd.||Lactulose USP 3.35gm/5ml||Syrup||100ml: 100.00 MRP|
|TULAC||Eskayef Bangladesh Ltd||Lactulose USP 3.35gm/5ml||Solution||100ml MRP: 100.00|
|TULOS||The Acme Laboratories Ltd.||Lactulose USP 3.35gm/5ml||Solution||100ml, 200ml: 100.38 & 200.75 MRP|
|UVAX||Pacific Pharmaceuticals Ltd.||Lactulose USP 3.35gm/5ml||Solution||100ml, 200ml: 120.00 & 230.00 MRP|
|XYLOSE||Delta Pharma Limited||Lactulose USP 3.35gm/5ml||Solution||100ml: 100.00 MRP|
|ZENILAC||Zenith Pharmaceuticals Ltd.||Lactulose USP 3.35gm/5ml||Solution||100ml, 200ml: 70.00 & 130.00 MRP|
Why is Lactulose prescribed?
Lactulose is a synthetic sugar used to treat constipation. It is broken down in the colon into products that pull water out from the body and into the colon. This water softens stools. Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease. It works by drawing ammonia from the blood into the colon where it is removed from the body.
Lactulose is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should Lactulose be used?
Lactulose comes as liquid to take by mouth. It usually is taken once a day for treatment of constipation and three or four times a day for liver disease. Your prescription label tells you how much medicine to take at each dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lactulose exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
What special precautions to follow?
Before taking lactulose,
- tell your doctor if you are allergic to lactulose or any other drugs.
- tell your doctor what prescription and nonprescription medications you are taking, especially antacids, antibiotics including neomycin, and other laxatives.
- tell your doctor if you have diabetes or require a low-lactose diet.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lactulose, call your doctor.
- if you are having surgery or tests on your colon or rectum, tell the doctor that you are taking lactulose.
What to do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can Lactulose cause?
Lactulose may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
If you have any of the following symptoms, stop taking lactulose and call your doctor immediately:
stomach pain or cramps
What storage conditions are needed for Lactulose?
Keep Lactulose in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.
Ref: MedlinePlus, U.S. Natl. Library of Medicine