Lactulose

(lak' tyoo lose)

Molecule Info

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Indication(s) & Dosage

Oral route
Constipation
Adult: Initially, 10-20 g (15-30 ml) daily as a single dose or in 2 divided doses; gradually adjust according to patient's response. Max dose: 45 ml (or up to 40 g of the reconstituted oral powder formulation)/day.
Child: As 3.35 mg/5 ml solution: 1 mth to 1 yr: 2.5 ml; 1-5 yr: 5 ml; 5-10 yr: 10 ml; 10-18 yr: 15 ml. All doses to be given bid.

Hepatic encephalopathy
Adult: 60-100 g (90-150 ml) daily in 3 divided doses; adjust to produce 2 or 3 soft stools each day.

Rectal route
Hepatic encephalopathy
Adult: Mix 200 g (300 ml) with 700 ml water or 0.9% sodium chloride as a retention enema. Retain enema for 30-60 minutes; repeat every 4-6 hr until oral medication can be administered.

Administration May be taken with or without food. Take with a full glass of water & remain upright for at least ½ hr. Take with food or milk if GI irritation occurs.
Contraindications Galactosaemia, intestinal obstruction. Patients on low galactose diet.
Special Precautions Monitor electrolyte imbalance. Lactose intolerance; diabetics.
Adverse Drug Reaction(s) Diarrhoea (dose-related), nausea, vomiting, hypokalaemia, bloating and abdominal cramps.
Potentially Fatal: Dehydration and hypernatraemia on aggressive treatment.
Drug Interactions May prevent release of mesalazine in the colon. Decreased effect with oral neomycin, antacids.
Pregnancy Category (FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Storage Oral: Store at 15-30°C (59-86°F). Rectal: Store at 2-30°C (36-86°F).
Pharmacology Lactulose promotes peristalsis by producing an osmotic effect in the colon with resultant distention. In hepatic encephalopathy, it reduces absorption of ammonium ions and toxic nitrogenous compounds, resulting in reduced blood ammonia concentrations.
Onset: 48 hr.
Absorption: Not appreciable (oral).
Metabolism: Via colonic flora to lactic acid and acetic acid.
Excretion: Faeces, urine (as unchanged drug).
ATC Classification A06AD11 - lactulose; Belongs to the class of osmotically acting laxatives.

 

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Brand/Product Info


Total Products : 41                                         
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ACTILAC 100ml Healthcare Pharmacuticals Ltd. Lactulose USP 3.35gm/5ml Solution 100ml, MRP 125 Tk
ACTILAC 200ml Healthcare Pharmacuticals Ltd. Lactulose USP 3.35gm/5ml Solution 200ml, MRP 230 Tk
ACTULOSE Silva Pharmaceuticals Limited Lactulose USP 3.35gm/5ml Syrup 100ml, 200ml: 60.22 & 120.46 MRP
ASILAC Asiatic Laboratories Ltd. Lactulose USP 3.35gm/5ml Syrup 100ml: 100.00 MRP
AVOLAC Aristopharma Ltd. Lactulose USP 3.35gm/5ml Solution 100ml, 200ml: 120.00 & 230.00 MRP
COMFORT APC Pharmaceuticals Ltd. Lactulose USP 3.35gm/5ml Syrup 100ml: 80.00 MRP
CONLAX Unimed & Unihealth Manufacturers Ltd. Lactulose USP 3.35gm/5ml Solution 100ml, 200ml: 100.00 & 200.00 MRP
D-LAC Drug International Ltd Lactulose USP 3.35gm/5ml Solution 100ml, 200ml: 100.00 & 150.00 MRP
DEVOLAC Desh Pharmaceuticals (Pvt) Ltd Lactulose USP 3.35gm/5ml Solution 100ml, 200ml: 100.00 & 195.00 MRP
DULAC Chemist Laboratories Ltd. Lactulose USP 3.35gm/5ml Solution 100ml: 100.00 MRP
ELAX Edruc Limited Lactulose USP 3.35gm/5ml Syrup 100ml: 100.00 IP
EZYLAX Orion Pharma Ltd. Lactulose USP 3.35gm/5ml Solution 50ml, 100ml: 50.19 & 100.38 MRP
Inolac Oral Incepta Pharmaceuticals Limited Lactulose USP 3.35gm/5ml Solution 100ml :MRP 95 Tk
LACLOSE Opsonin Pharma Limited Lactulose USP 3.4gm/5ml Solution 100ml, 200ml: 100.00 & 200.00 MRP
LACTOLAX Pharmasia Limited Lactulose USP 3.35gm/5ml Solution 100ml: 100.38 IP
LACTOMOSE Monico Pharma Limited Lactulose USP 3.35gm/5ml Solution 100ml: 100.00 MRP
LACTU Biopharma Laboratories Ltd Lactulose USP 3.4gm/5ml Solution 100ml, 200ml: 120.00 & 200.00 MRP
LACTULOSE-H Hudson Pharmaceuticals Ltd Lactulose USP 3.4gm/5ml Solution 100ml: 60.00 MRP
LAX Medicon Laboratories Ltd Lactulose USP 3.4gm/5ml Solution 100ml: 120.00 MRP
LAXATIV Rangs Pharmaceuticals Ltd. Lactulose USP 3.4gm/5ml Solution 100ml, 200ml: 75.00 & 140.00 MRP
LAXOL Navana Pharmaceuticals Limited Lactulose USP 3.35gm/5ml Solution 50ml, 100ml, 200ml: 50.19, 100.38 & 200.75 IP
LAXOLAC Globe Pharmaceuticals Ltd Lactulose USP 3.35gm/5ml Solution 100ml: 95.00 MRP
LEAXE Alco Pharma Ltd Lactulose USP 3.35gm/5ml Solution 100ml: 90.00 MRP
LIVOTON Kemiko Pharmaceuticals Ltd Lactulose USP 3.35gm/5ml Syrup 50ml, 100ml, 200ml: 50.00, 100.00 & 200.00 MRP
LOCTOZ Amico Laboratories Ltd. Lactulose USP 3.35gm/5ml Syrup 100ml: 100.00 MRP
LUBLAC NIPRO JMI Pharma Ltd. Lactulose USP 3.35gm/5ml Solution 100ml: 100.00 MRP
MYLAC Mystic Pharmaceuticals Limited Lactulose USP 3.35gm/5ml Syrup 100ml, 200ml: 75.00 & 140.00 MRP
ORALAX Somatec Pharmaceuticals Ltd. Lactulose USP 3.35gm/5ml Syrup 100ml: 100.38 MRP
OSMOLAX SOLN Square Pharmaceuticals Ltd. Lactulose 3.4 gm/5 ml Solution 100 ml: 140.00 MRP
OSMOLAX SOLN 200 Square Pharmaceuticals Ltd. Lactulose 3.4 gm/5 ml Solution 200 ml: 250.00 MRP
P-LAC Pharmadesh Laboratories Limited Lactulose USP 3.35gm/5ml Solution 100ml: 93.12 MRP
REGULOSE General Pharmaceuticals Ltd Lactulose USP 3.35gm/5ml Syrup 100ml, 200ml: 100.38 & 200.75 MRP
REWAT Kumudini Pharma Ltd Lactulose USP 3.35gm/5ml Solution 100ml: 95.00 MRP
SERELOSE SOLN Beximco Pharmaceuticals Ltd Lactulose BP 3.35G/5ml Solution 100ml: 120.00 MRP
SINALAC IBN SINA Pharmaceutical Industry Ltd. Lactulose USP 3.35gm/5ml Solution 60ml, 100ml, 200ml, 450ml: 60.00, 100.00, 200.00 & 425.00 IP
SIVOLAC Sharif Pharmaceuticals Ltd. Lactulose USP 3.35gm/5ml Syrup 100ml: 100.00 MRP
TULAC Eskayef Bangladesh Ltd Lactulose USP 3.35gm/5ml Solution 100ml MRP: 100.00
TULOS The Acme Laboratories Ltd. Lactulose USP 3.35gm/5ml Solution 100ml, 200ml: 100.38 & 200.75 MRP
UVAX Pacific Pharmaceuticals Ltd. Lactulose USP 3.35gm/5ml Solution 100ml, 200ml: 120.00 & 230.00 MRP
XYLOSE Delta Pharma Limited Lactulose USP 3.35gm/5ml Solution 100ml: 100.00 MRP
ZENILAC Zenith Pharmaceuticals Ltd. Lactulose USP 3.35gm/5ml Solution 100ml, 200ml: 70.00 & 130.00 MRP

Gen. MedInfo

Why is Lactulose prescribed?

Lactulose is a synthetic sugar used to treat constipation. It is broken down in the colon into products that pull water out from the body and into the colon. This water softens stools. Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease. It works by drawing ammonia from the blood into the colon where it is removed from the body.

Lactulose is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should Lactulose be used?

Lactulose comes as liquid to take by mouth. It usually is taken once a day for treatment of constipation and three or four times a day for liver disease. Your prescription label tells you how much medicine to take at each dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lactulose exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What special precautions to follow?

Before taking lactulose,
  • tell your doctor if you are allergic to lactulose or any other drugs.
  • tell your doctor what prescription and nonprescription medications you are taking, especially antacids, antibiotics including neomycin, and other laxatives.
  • tell your doctor if you have diabetes or require a low-lactose diet.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lactulose, call your doctor.
  • if you are having surgery or tests on your colon or rectum, tell the doctor that you are taking lactulose.

What to do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can Lactulose cause?

Lactulose may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • diarrhea

  • gas

  • nausea

If you have any of the following symptoms, stop taking lactulose and call your doctor immediately:
  • stomach pain or cramps

  • vomiting

What storage conditions are needed for Lactulose?

Keep Lactulose in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.  

Ref: MedlinePlus, U.S. Natl. Library of Medicine