P - Caution when used during pregnancy
|Indication(s) & Dosage||
|Administration||May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
|Overdosage||Overdosage may result in diarrhoea with excessive loss of water and electrolytes.|
|Contraindications||Acute surgical abdomen or intestinal obstruction, severe dehydration, faecal impaction, chronic use.|
|Special Precautions||Swallow the tab whole. Pregnancy; inflammatory bowel disease.|
|Adverse Drug Reaction(s)||Abdominal discomfort (colic, cramps). Suppositories may cause irritation and proctitis.|
|Drug Interactions||Do not give antacids or milk within 1 hr of taking the drug (enteric coated).
|Lab Interference||False urinary glucose levels.|
|Pregnancy Category (FDA)||Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.|
|Storage||Oral: Store below 25Â°C. Rectal: Store below 25Â°C.|
|Pharmacology||Bisacodyl acts mainly in the large intestine by increasng its motility to effect bowel evacuation.
Onset: 6-12 hr (oral). 15-60 min (rectal).
Absorption: Minimal from the GI tract (oral, as enteric-coated tablets/suppositories).
Metabolism: Converted to bis(p-hydroxyphenyl)pyridyl-2-methane by intestinal or bacterial enzymes.
Excretion: Faeces; urine (as glucuronide).
|ATC Classification||A06AB02 - bisacodyl; Belongs to the class of contact laxatives.
A06AG02 - bisacodyl; Belongs to the class of enemas. Used in the treatment of constipation.
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