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PCaution when used during lactation - Caution when used during pregnancy

LCaution when used during lactation - Caution when used during lactation

Molecule Info

| See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage Peptic ulcer
Adult: 5-10 mg orally bid or tid
Administration May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take w/ antacids, Fe or dairy products.
Overdosage Symptoms range from increased side effects to CNS disturbances, circulatory changes, respiratory failure, paralysis and coma. treat with immediate gastric lavage and injection of physostimine 0.5-2 mg up to a total of 5 mg. Treat symptomatically and supportively.
Contraindications Closed-angle glaucoma; obstructive uropathy; GI obstruction, paralytic ileus, intestinal atony, ulcerative colitis; toxic megacolon; myasthenia gravis.
Special Precautions Elderly; autonomic neuropathy; hepatic or renal disease; hyperthyroidism, CHF, thyrotoxicosis, MI, tachyarrhythmias, hypertension, prostatic hypertrophy; hiatal hernia. May impair ability to drive or operate machinery. Pregnancy and lactation. Down's syndrome.
Adverse Drug Reaction(s) Xerostomia, decreased sweating, urinary hesitancy and retention, blurred vision, cycloplegia, increased ocular tension, loss of taste, headache, nervousness, mental confusion, impotence, suppression of lactation, urticaria, constipation.
Drug Interactions Enhanced effect with concurrent admin of other drugs with antimuscarinic properties and MAOIs. May affect absorption of other drugs. Antagonistic effect with parasympathomimetics.
Pharmacology Oxyphencyclimine is a tertiary amine antimuscarinic. It blocks all three types of muscarinic receptors and inhibits vagally mediated reflexes by antagonising the action of acetylcholine.
ATC Classification A03AA01 - oxyphencyclimine; Belongs to the class of synthetic anticholinergics, esters with tertiary amino group. Used in the treatment of functional bowel disorders.

Brand/Product Info


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