Dicycloverine (US, Dicyclomine)
P : Caution when used during pregnancy
L : Contraindicated in lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||Oral route
Gastrointestinal tract spasm
Adult: 10-20 mg tid.
Child: 2-12 yr: 10 mg tid; 6 mth-2 yr: 5-10 mg 3-4 times daily.
Gastrointestinal tract spasm
Adult: 20 mg 4 times a day given only for 1-2 days. Replace with oral therapy as soon as possible.
|Administration||Dicycloverine: May be taken with or without food. May be taken before or after meals.
|Overdosage||Symptoms: headache, dizziness, nausea, dry mouth, difficulty in swallowing, dilated pupils and hot dry skin. Management: treatment is symptomatic. Reduce drug absorption by emetics or gastric lavage.|
|Contraindications||Intestinal obstruction; intestinal atony; myasthenia gravis; glaucoma; reflux oesophagitis; infants <6 mth; lactation.|
|Special Precautions||Hepatic or renal disease, urinary retention, paralytic ileus, hyperthyroidism, hypertension, congestive heart failure, cardiac tachyarrhythmia, children, elderly, pregnancy.|
|Adverse Drug Reaction(s)||Difficulty in accommodation, exacerbation of glaucoma; tachycardia, palpitations, arrhythmias; urinary retention; restlessness; confusion, excitement, hallucination and delirium.
Potentially Fatal: Respiratory arrest in infants <10 wk.
|Drug Interactions||Antagonise the effect of drugs that affect GI motility e.g. metoclopramide. Absorption affected by concurrent admin with antacids.
|Pregnancy Category (FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Storage||Store below 30°C.
|Pharmacology||Dicycloverine HCl relieves smooth muscle spasm in the GI and urinary tract. This effect is partly due to antimuscarinic action and partly direct action on the smooth|
|ATC Classification||A03AA07 - dicycloverine (dicyclomine); Belongs to the class of synthetic anticholinergics, esters with tertiary amino group. Used in the treatment of functional bowel disorders.|
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ABDORIN||Opsonin Pharma Limited||Dicycloverine Hydrochloride 10mg||Tablet||50's: 100.00 MRP|
|ABDORIN Syrup||Opsonin Pharma Limited||Dicycloverine Hydrochloride 10mg/5ml||Syrup||50ml: 30.00 MRP|
|COLICON 10||Square Pharmaceuticals Ltd.||Dicycloverine 10mg||Tablet||10x10's: 201.00 MRP|
|COLICON SYP||Square Pharmaceuticals Ltd.||Dicycloverine 10mg/5 ml||Syrup||50 ml: 30.20 MRP|
|Cyclopan||Incepta Pharmaceuticals Limited||Dicycloverine Hydrochloride 10 mg Tablet||Tablet||10x10's :MRP 200 Tk|
|Cyclopan Injection||Incepta Pharmaceuticals Limited||Dicycloverine Hydrochloride 20mg/2ml Injection||Injection||1x5's:MRP 40 Tk|
|Cyclopan Syrup||Incepta Pharmaceuticals Limited||Dicycloverine Hydrochloride 10mg/5ml Syrup||Syrup||50ml :MRP 30 Tk|
|CYCLOVIN||Somatec Pharmaceuticals Ltd.||Dicycloverine Hydrochloride 10mg||Tablet||100's: 201.00 MRP|
|CYCLOVIN Syrup||Somatec Pharmaceuticals Ltd.||Dicycloverine Hydrochloride 10mg/5ml||Syrup||50ml: 30.11 MRP|
|DIRIN||Alco Pharma Ltd||Dicycloverine Hydrochloride 10mg||Tablet||100's: 200.00 MRP|
|DIRIN Syrup||Alco Pharma Ltd||Dicycloverine Hydrochloride 10mg/5ml||Syrup||50ml: 30.00 MRP|
|DIVERIN||ACI Ltd.||Dicycloverine Hydrochloride 10mg||Tablet||50's: 100.50 & 175.50 MRP|
|DIVERIN Syrup||ACI Ltd.||Dicycloverine Hydrochloride 10mg/5ml||Syrup||50ml: 30.11 MRP|
|IBSPA||Pacific Pharmaceuticals Ltd.||Dicycloverine Hydrochloride 10mg||Tablet||100's: 200.00 MRP|
|IBSPA Syrup||Pacific Pharmaceuticals Ltd.||Dicycloverine Hydrochloride 10mg/5ml||Syrup||50ml: 25.00 MRP|
|LOVERIN||Beximco Pharmaceuticals Ltd||Dicycloverine Hydrochloride 10mg||Tablet||50's: 100.50 MRP|
|LOVERIN SYRUP||Beximco Pharmaceuticals Ltd||Dicycloverin Hydrochloride||Syrup||50ml: 30.00 MRP|
|ROBENTYL||Healthcare Pharmacuticals Ltd.||Dicycloverine Hydrochloride 10mg||Tablet||100's MRP 200 Tk|
|ROBENTYL SYRUP||Healthcare Pharmacuticals Ltd.||Dicycloverine Hydrochloride 10mg/5ml Syrup||Syrup||50ml, MRP 40 Tk|
|SPALAX||Navana Pharmaceuticals Limited||Dicycloverine Hydrochloride 10mg||Tablet||60's: 120.60 MRP|
|SPALAX Syrup||Navana Pharmaceuticals Limited||Dicycloverine Hydrochloride 10mg/5ml||Syrup||50ml: 30.11 MRP|
|WINSPA||Apex Pharmaceuticals Ltd.||Dicycloverine Hydrochloride 10mg||Tablet||50's: 100.00 MRP|
|WINSPA Syrup||Apex Pharmaceuticals Ltd.||Dicycloverine Hydrochloride 10mg/5ml||Syrup||50ml: 30.00 MRP|
|| See Brand Manufacturer's Prescribing Information |||| Back to top ||