mph Bangladesh


(ra be' pray zole)

PCaution when used during lactation : Caution - pregnancy 

Molecule Info

Indication(s) & dosage

Gastro-oesophageal reflux disease
Adult: For erosive oesophagitis: 20 mg once daily in the morning for 4-8 wk. Maintenance: 10-20 mg once daily according to response. For non-erosive oesophagitis: 10 mg once daily for 4 wk, upon symptom resolution, may continue with 10 mg once daily when necessary. 
Hypersecretory conditions
Adult: Initially, 60 mg orally daily adjusted according to response. Max dose: 120 mg daily. 
Active peptic ulcer disease
Adult: 20 mg orally daily given for 4-8 wk for duodenal ulcer and 6-12 wk for gastric ulcer.
H.pylori infection
Adult: As a combination with two antibacterials: 20 mg orally bid combined with clarithromycin 500 mg bid and either amoxicillin 1 g bid or metronidazole 400 mg bid. To be taken for a wk.


Should be taken on an empty stomach. Take 15-30 min before meals.


May result in drowsiness, headache and tachycardia.



Special Precautions

Severe hepatic impairment, gastric malignancy. May increase the risk of GI infections due to acid suppressive effects. Pregnancy.

Adverse Drug Reaction(s)

Headache, diarrhoea, rash, infection and flu-like syndrome. Dizziness, fatigue, constipation, nausea and vomiting.
Potentially Fatal: Anaphylaxis, agranulocytosis.

Drug Interactions

May reduce absorption of ketoconazole and itraconazole. May prolong the elimination of diazepam, phenytoin andwarfarin.

Food Interaction

Delayed absorption with high-fat meals.

Pregnancy Category (FDA) 

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).


Oral: Store at 15-30°C.


Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell.
Onset: 1 hr.
Duration: 24 hr.
Absorption: Oral bioavailability: about 52% and peak plasma concentrations are reached about 3.5 hr after oral admin.
Distribution: Protein-binding: 97%.
Metabolism: Extensively metabolised in the liver by cytochrome P450 isoenzymes.
Excretion: Metabolites are mainly excreted in the urine (90%). Half-life: about 1 hr.

ATC Classification

A02BC04 - rabeprazole; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Brand Info

Total Products : 10          
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ACIFIX Beximco Pharmaceuticals Ltd Rabeprazole Sodium INN 20mg Enteric Coated Tablet 50's: 250.00 MRP
FINIX Opsonin Pharma Limited Rabeprazole sodium INN 20mg Tablet 50's: 250.00 MRP
PARICEL ACI Ltd. Rabeprazole sodium INN 20mg Tablet 60's 301.20 MRP
RABE-20 Aristopharma Ltd. Rabeprazole sodium INN 20mg Tablet 50's 250.00 MRP
RABECA 20 Square Pharmaceuticals Ltd. Rabeprazole 20mg Tablet 5x10's: 251.00 MRP
RABESEC Drug International Ltd Rabeprazole sodium INN 20mg Tablet 50's 250.00 MRP
RABETAC Navana Pharmaceuticals Limited Rabeprazole sodium INN 20mg Tablet 30's 150.00 MRP
RABIZOL The Acme Laboratories Ltd. Rabeprazole sodium INN 20mg Tablet 50's 250.00 MRP
Rasonix 20 Incepta Pharmaceuticals Limited Rabeprazole Sodium INN 20 mg Tablet (Enteric Coated) 10x5's:MRP 250 Tk
RAZOLE-20 Kemiko Pharmaceuticals Ltd Rabeprazole sodium INN 20mg Tablet 50's 250.00 MRP

Gen. MedInfo

Why this medicine is required?

Rabeprazole is a gastric medicine.

It is used to treat conditions caused by excessive acidity in your stomach, such as stomach ulcers and reflux disease (reflux is also known as "heartburn", in which food or acid from your stomach backs up into your mouth, leaving a sour or bitter taste).

Rabeprazole treats these conditions by reducing the amount of acid your stomach makes.

Rabeprazole may also be used together with other medicines to treat a specific type of gastric problem called Helicobacter pylori or H. pylori gastritis.

How to take this medicine?

Take Rabeprazole exactly as directed by your doctor. Do not take more or less than instructed by your doctor.

You may need to take Rabeprazole for some time before the full benefits can be felt. Continue to take it even when you feel better and do not stop taking it unless advised by your doctor to do so.

You may take Rabeprazole with or without food. Swallow the tablet whole, do not chew, crush or split the tablet. Try to take it at the same time each day.

What to do incase of forgotten dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

Remember to take your medicine regularly. Rabeprazole must be taken exactly as directed for it to be effective. If you often forget to take your medicine, let your doctor and pharmacist know.

When should not to use this medicine?

Inform your doctor if you have ever had an allergic reaction to other gastric medicines such as omeprazole, pantoprazole or lansoprazole.

What should be noted while taking this medicine?

Inform your doctor if you are pregnant or breastfeeding.

Do not breastfeed while you are being treated with Rabeprazole.

Alert your doctor if you have liver disease.

Let your doctor know if your gastric problem seems to be getting worse. Do not take Rabeprazole for a long period of time unless instructed by your doctor.

What side effects could appear?

Rabeprazole may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be alert.

Other side effects with Rabeprazole may include headache, diarrhoea, nausea and wind in the stomach. These should get better or go away as your body adjusts to the medicine.

Let your doctor know if these side effects bother you or if they do not go away.

Can this be taken with other medicines?

Inform your doctor if you are taking any other medicines, especially those listed here:

- warfarin (a blood-thinning medicine)
- ketoconazole, itraconazole, voriconazole or similar antifungal medicines
- other medicines such as atazanavir and iron pills.

Do not take antacids together with Rabeprazole. If you must take antacids, take them at least 1 hour before or 2 hours after you have taken Rabeprazole. Antacids can reduce the effectiveness of Rabeprazole when taken together.

Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

What special dietary instructions to follow?

It may be helpful to discuss your diet with your doctor or dietitian. A change in diet may help improve your symptoms. For example, spicy food tends to worsen reflux and should be avoided. Likewise, carbonated ("fizzy") drinks such as soft drinks should also be avoided.

You should also try to avoid lying down soon after eating as this will worsen the reflux symptoms.

Avoid alcohol.

How to store this medicine?

Store in a cool, dry place away from the reach of children. Medicines must not be used past the expiry date.


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