(moe met' a sone)
P Â - Caution when used during pregnancy
L Â - Caution when used during lactation
|Indication & Dosage||Nasal
Treatment and prophylaxis ofÂ allergic rhinitis
Adult:Â 100 mcg in each nostril once daily, increased to 200 mcg into each nostril once daily if needed. Maintenance: 50 mcg in each nostril daily.
Child:Â 2-11 yr: 50 mcg in each nostril daily; â‰¥12 yr: 100 mcg in each nostril daily.
Adult:Â 100 mcg in each nostril once daily; may increase to bid after 5-6 wk if needed.Â
Adult:Â Mild to moderate: Initially, 400 mcg once daily in the evening. Maintenance: 200 mcg once to bid. Severe: Initially, 400 mcg bid, then titrated to lowest effective dose once controlled.
Child:Â Mild to moderate: Initially, 400 mcg once daily. Maintenance: 200 mcg once to bid. Severe: Initially, 400 mcg bid, then titrated to lowest effective dose once controlled.
Adult:Â As 0.1% cream/ointment/lotion: Apply onto the affected areas as directed.
Child:Â Cream/Ointment: â‰¥2 yr: Apply thin film to affected area once daily. Do not use for > 3 wk. Lotion: â‰¥12 yr: Apply a few drops to affected area once daily.
|Overdosage||Systemic corticosteroid effects.|
|Special Precautions||Discontinue if irritation or sensitisation occurs. Systemic absorption increases when area of application is extensive or an occlusive dressing is used. Pregnancy and lactation. DM, hepatic and renal diseases, myasthenia gravis, CV disease, ocular diseases, osteoporosis, GI diseases, history of seizure disorders. Not for status asthmaticus or relief of acute bronchospasm. Requires dosage adjustments with thyroid status. May reduce growth velocity in children; monitor growth. Taper withdrawal.|
|Adverse Drug Reactions||Nasal/Oral inhalation: Headache, fatigue, depression;
musculoskeletal pain, arthalgia; sinusitis, rhinitis, upper respiratory infection, pharyngitis, cough, epistaxis; viral infection, nasal and oral
candidiasis; chest pain; abdominal pain, dry throat, vomiting, diarrhoea, dyspepsia, flatulence, gastroenteritis, nausea, vomiting; dysmenorrhoea; back pain,
myalgia; conjunctivitis; earache, otitis media; asthma, bronchitis, dysphonia; nasal irritation, burning and septal perforation; wheezing; nasal ulcers;
growth suppression. Topical: Bacterial skin infection, burning, furunculosis, pruritus, skin atrophy, tingling/stinging, folliculitis, moniliasis,
paraesthesia, skin depigmentation, rosacea, cataract, growth suppression.
Potentially Fatal:Â Adrenal suppression, immunosuppression, Kaposi's sarcoma in prolonged periods, anaphylaxis.
|Drug Interactions||Increased risk of hypokalaemia with amphotericin B, potassium-wasting diuretics. Decreases hypoglycaemic effects of antidiabetic drugs. Increased serum levels with antifungals (imidazole). Increased risk of tendinopathies with fluoroquinolones.Â Please consult detailed drug interactions before prescribing.|
|Pregnancy Category (US FDA)
||Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.|
|Storage||Inhalation:Â Store at 15-30Â°C. Discard when counter reads "0" or 45 days after opening.Â Nasal:Â Store at 15-30Â°C. Protect from light.Â Topical/Cutaneous:Cream: Store at 2-25Â°C. Lotion: Store at 2-30Â°C. Ointment: Store at 15-30Â°C.|
||Mometasone depresses the formation, release
and activity of endogenous inflammatory chemical mediators (e.g. kinins, histamine, liposomal enzymes and prostaglandin). It inhibits the margination and
subsequent cell migration to the injury site, reverses vascular dilatation and permeability, resulting in decreased access of cells to the area of injury.
Absorption:Â Ointment: 0.7%; increased with occlusive dressings. Nasal spray: Undetectable in plasma. Oral inhalation: <1%.
Distribution:Â Protein-binding: 98-99%.
Excretion:Â Via faeces, bile, urine.
|ATC Classification||D07AC13 - mometasone; Belongs to the class of potent (group
III) corticosteroids. Used in the treatment of dermatological diseases.Â
R03BA07 - mometasone; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, glucocorticooids.Â
D07XC03 - mometasone; Belongs to the class of potent (group III) corticosteroids in other combinations. Used in the treatment of dermatological diseases.Â
R01AD09 - mometasone; Belongs to the class of topical corticosteroids used as nasal decongestants.
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ELOCAN||General Pharmaceuticals Ltd||Mometasone furoate 0.1% cream||Ointment||5gm: 100.38 MRP|
|METASPRAY N-SPRAY||Square Pharmaceuticals Ltd.||Mometasone Furoate 50 mcg/spray||Nasal Spray||120 sprays: 251.70 MRP|
|Momeson Cream||Incepta Pharmaceuticals Limited||Mometasone Furoate BP 1 mg/gm||Cream||5gm x 1:MRP 100 Tk|
|Momeson Spray||Incepta Pharmaceuticals Limited||Mometasone Furoate 50 mcg/Metered Inhalation Nasal Spray||Nasal Spray||120 Metered Dose :MRP 250 Tk|
|MOMETA||Popular Pharmaceuticals Ltd.||Mometasone furoate 0.1% cream||Cream||10gm: 180.68 MRP|
|NASOMET SPRAY||Beximco Pharmaceuticals Ltd||Mometasone Furoate 50mcg/Actuation||Nasal Spray||1's: 250.00 MRP|
|NASONEX||Opsonin Pharma Limited||Mometasone furoate 50mcg/actuation||Nasal Spray||120 doses spray unit: 250.00 MRP|
|SONETA||Aristopharma Ltd.||Mometasone furoate 0.1% cream||Cream/Ointment||5gm Cream & Oint.: 100.00 & 100.00 MRP|
Why is this medication prescribed?
Mometasone inhalation is used to prevent difficulty breathing, chest tightness, wheezing, and coughing caused by asthma. Mometasone inhalation is not used to treat an asthma attack (sudden episode of shortness of breath, wheezing, and coughing) that has already started. Mometasone is in a class of medications called corticosteroids. It works by decreasing swelling and irritation in the airways to allow for easier breathing.
Mometasone nasal inhalation is used for the treatment and prevention of nasal symptoms of seasonal and year-round allergies, including runny nose, sneezing, and itchy nose. Mometasone nasal inhalation is in a class of medications called topical steroids. It works by reducing inflammation (swelling) in the nasal passages.
Mometasone topical is used to relieve the itching and inflammation of numerous skin conditions.
How should this medicine be used?
Mometasone Oral Inhaler
Mometasone inhalation comes as a powder to inhale by mouth. It is usually inhaled twice daily or once a day in the evening. Use mometasone inhalation at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Use mometasone inhalation exactly as directed. Do not inhale more or less of it or inhale it more often than prescribed by your doctor.
Talk to your doctor about how you should use your other oral and inhaled medications for asthma during your treatment with mometasone inhalation. If you were taking an oral steroid such as dexamethasone, methylprednisolone (Medrol), or prednisone, your doctor may want to gradually decrease your steroid dose starting at least 1 week after you begin to use mometasone inhalation. Special care will be needed in certain situations for several months as your body adjusts to the change in medication. Ask your doctor for more information.
Mometasone inhalation helps to prevent asthma attacks but will not stop an asthma attack that has already started. Do not use mometasone inhalation during an asthma attack. Your doctor will prescribe a short-acting inhaler to use during asthma attacks.
Your doctor will probably start you on an average dose of mometasone inhalation. Your doctor may decrease your dose if your symptoms are controlled or gradually increase your dose if your symptoms have not improved after 2 weeks.
Mometasone inhalation controls asthma but does not cure it. It may take 1 to 2 weeks or longer before you feel the full benefit of the medication. Continue to use mometasone inhalation even if you feel well. Do not stop using mometasone inhalation without talking to your doctor.
Tell your doctor if your asthma worsens during your treatment. Call your doctor immediately if you have an asthma attack that does not stop when you use your fast-acting asthma medication, or if you need to use more of your fast-acting medication than usual.
Before you use your mometasone oral inhaler the first time, read the written instructions that come with it. Look at the diagrams carefully and be sure that you recognize all the parts of the inhaler. Ask your doctor, pharmacist, or respiratory therapist to show you how to use it. Practice using the inhaler while he or she watches.
The dose counter on the base of your mometasone inhaler tells you how many doses of medication are left in your inhaler. Read the numbers on the dose counter from top to bottom. The number on the dose counter decreases every time you lift the cap to load a dose of medication and will read ''01'' just before you use your last dose of medication. Do not use the inhaler if the numbers on the dose counter do not change after you load a dose. Call your pharmacist if your inhaler is not working properly.
Throw away the inhaler after you use the last dose or 45 days after you removed it from the package, whichever is sooner.
To use the inhaler, follow these steps:
If you are using a new inhaler for the first time, remove it from the foil pouch. Write the date that you opened the inhaler in the space provided on the cap label.
Hold the inhaler straight up with the colored base on the bottom. Twist the white cap counterclockwise and remove it. This loads the correct amount of medication in the base of the inhaler, so it is important to twist the cap and not twist the base with your hand. As you lift the cap off, the dose counter on the base will count down by one to show the number of doses left after this use.
Breathe out fully.
Hold the inhaler on its side with the mouthpiece facing you. Be sure that you are not covering the ventilation holes on the sides of the inhaler. Place the mouthpiece of the inhaler in your mouth and close your lips firmly around it.
Breathe in a fast, deep breath. You will receive your medication as a very fine powder, so you may not be able to smell, feel, or taste it as you inhale.
Remove the inhaler from your mouth and hold your breath for 10 seconds or as long as you comfortably can. Do not breathe out into the inhaler.
Wipe the mouthpiece dry. Put the cap back onto the inhaler so that the indented arrow is in line with the dose counter. Gently press down and turn clockwise until you hear a click.
Rinse your mouth with water.
If your inhaler needs to be cleaned, gently wipe it with a dry cloth. Do not wash the inhaler. Keep the inhaler away from water or other liquids.
Mometasone Nasal Inhaler
Mometasone comes as a spray to inhale through the nose. It is usually sprayed once a day in each nostril. To help you remember to use mometasone nasal inhalation, use it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use mometasone nasal inhalation exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Shake the pump well before each use.
Do not spray mometasone nasal inhalation into the eyes.
For the prevention of nasal symptoms of seasonal allergies, begin using mometasone nasal inhalation 2 to 4 weeks before the beginning of the pollen season.
Mometasone nasal inhalation controls the nasal symptoms of allergies but does not cure them. You should begin to feel an improvement in your nasal allergies within 1 to 2 days of the first dose of mometasone nasal inhalation. It may take 1 to 2 weeks until you feel the full benefit of mometasone nasal inhalation. Continue to use mometasone nasal inhalation even if you feel well.
Before you use mometasone nasal inhalation the first time, read the written instructions that come with it. Ask your doctor or pharmacist to show you how to use it. Practice using the inhaler while he or she watches.
To use the nasal inhalation, follow these steps:
Gently blow your nose to clear the nostrils.
Close one nostril. Tilt your head forward slightly and keep the bottle upright while inserting the nasal applicator into the other nostril.
For each spray, press down firmly once on the shoulders of the white applicator using your forefinger and middle finger. Support the base of the bottle with your thumb. Breathe gently inward through the nostril.
Breathe out through the mouth.
Repeat in the other nostril.
Replace the plastic cap.
Before using a new pump of mometasone nasal inhalation for the first time, prime the pump by spraying ten times or until a fine spray appears. If you do not use the pump for more than 1 week, prime it again by spraying two times or until a fine spray appears.
Mometasone comes as a topical cream, ointment, and lotion. It usually is applied externally once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use mometasone exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
To use mometasone cream or ointment, apply a thin film to the affected skin areas once daily.
To apply the lotion, place a few drops on the affected areas once daily and massage lightly until it disappears. To be most effective and economical, hold the nozzle of the bottle very close to the affected areas and gently squeeze.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor for more information.
What special precautions should I follow?
Before using mometasone oral inhalation,
- tell your doctor if you are allergic to mometasone or any other medications.
- tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention ketoconazole (Nizoral). Also tell your doctor if you are taking corticosteroids or medications for seizures, or if you have taken these medications in the past. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you or anyone in your family has or has ever had osteoporosis (a condition in which the bones become thin and weak and break easily) and if you have or have ever had tuberculosis (a type of infection) in your lungs, cataracts (clouding of the lens of the eye), glaucoma (an eye disease) or high pressure in the eye, or liver disease. Also tell your doctor if you have any type of untreated infection anywhere in your body or a herpes infection (a type of infection that causes a sore on the eyelid or eye surface) in your eye, or if you are on bedrest or unable to move around.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using mometasone inhalation, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are using mometasone inhalation.
- you should know that your body may be less able to cope with stress such as surgery, illness, severe asthma attack, or injury. Call your doctor right away if you get sick and be sure that all healthcare providers who treat you know that you are using mometasone inhalation.
- tell your doctor if you have never had chickenpox or measles and you have not been vaccinated against these infections. Stay away from people who are sick, especially people who have chickenpox or measles. If you are exposed to one of these infections or if you develop symptoms of one of these infections, call your doctor right away. You may need treatment to protect you from these infections.
- you should know that mometasone inhalation sometimes causes wheezing and difficulty breathing immediately after it is inhaled. If this happens, use your fast-acting (rescue) asthma medication right away and call your doctor. Do not use mometasone inhalation again unless your doctor tells you that you should.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not inhale a double dose to make up for a missed one.
What side effects can this medication cause?
Mometasone inhalation may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
bone, muscle, joint, or back pain
loss of appetite
nose irritation or nosebleed
difficult, frequent, or painful urination
- painful menstrual periods
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
swelling of the eyes, face, tongue, throat, arms, hands, feet, ankles, or lower legs
difficulty breathing or swallowing
weight gain in the upper body, neck, and face
thinning arms and legs
fragile skin that bruises easily
excess hair growth
irregular or missed menstrual periods
decreased sexual desire
painful white patches in the mouth or throat
Mometasone inhalation may cause slowed growth in children. Your child's doctor will monitor your child's growth carefully while he or she is using mometasone inhalation. Talk to your doctor about the risks of giving this medication to your child.
Mometasone inhalation may cause a decrease in your bone mineral density (bone strength and thickness). Talk to your doctor about the risks of using mometasone inhalation.
Mometasone inhalation may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away your inhaler 45 days after you open the package and throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose,Â consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.
Symptoms of overdose may include:
weight gain in the upper body, neck, and face
thinning arms and legs
fragile skin that bruises easily
excess hair growth
irregular or missed menstrual periods
decreased sexual desire
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref:Â Â U.S. National Library of Medicine.
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.