Chloramphenicol

(klor am fen' i kol)

P  - Contraindicated in pregnancy

L  - Contraindicated in lactation

Molecule Info

 
Indication & Dosage Oral
Bacterial meningitis
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Brain abscess
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Granuloma inguinale
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Anthrax
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Listeriosis
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Gas gangrene
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Whipple's disease
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Severe systemic infections with Camphylobacter fetus
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Infections caused by H. influenzae
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Ehrlichiosis
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Severe gastroenteritis
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Severe melioidosis
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Plague
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Psittacosis
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Q fever
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Anaerobic bacterial infections
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Oral
Tularaemia
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever. 
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. 
Elderly: 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Ophthalmic
Ocular infections
Adult: Instill 1 drop of a 0.5% solution every 2 hr. Increase dosage interval upon improvement. To continue treatment for at least 48 hr after complete healing. Reduce dose once symptoms are controlled or apply a 1% ointment 3-4 times daily. 
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required. 
Otic/Aural
Otitis externa
Adult: Instill 2-3 drops of a 5% solution into the ear bid-tid.
Renal impairment: Dose reduction may be required. 
Hepatic impairment: Dose reduction may be required.
Administration Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Contraindications History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; preexisting bone marrow depression or blood dyscrasias.
Special Precautions Impaired renal or hepatic function; premature and full-term neonates. Monitor plasma concentrations to avoid toxicity.
Adverse Drug Reactions GI symptoms; bleeding; peripheral and optic neuritis, visual impairment, blindness; encephalopathy, confusion, delirium, mental depression, headache. Haemolysis in patients with G6PD deficiency. ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema. Ear drops: Ototoxicity.
Potentially Fatal: Bone marrow suppression and irreversible aplastic anaemia. Neutropenia, thrombocytopenia. Grey baby syndrome. Rarely, anaphylaxis.
Drug Interactions Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives.
Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function. Please consult detailed drug interactions before prescribing.
Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Ophthalmic: Refrigerate at 2-8°C. Do not freeze. Oral: Store at 15-25°C.Otic/Aural: Refrigerate at 2-8°C. Do not freeze.
Pharmacology Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.
Duration: Typhoid: 8-10 days; meningitis: 7-10 days; brain abscess: Up to 4 wk.
Absorption: Readily absorbed with peak plasma concentrations after 1 or 2 hr (oral).
Distribution: Distributed widely into tissues and fluids, CSF (up to 50% even in the absence of meningitis), eye (aqueous and vitreous humours); crosses the placenta and enters the breast milk. Protein-binding: 60%.
Metabolism: Hydrolysed to the free drug in the GI tract (palmitate); liver by conjugation with glucuronic acid, lungs and kidneys after parenteral admin (sodium succinate).
Excretion: Via the urine (30% as unchanged before hydrolysis, 5-10% of an oral dose), via the bile (3%), via the faeces (1% as inactive form); 1.5-4 hr (elimination half-life).
ATC Classification D06AX02 - chloramphenicol ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases. 
J01BA01 - chloramphenicol ; Belongs to the class of amphenicols. Used in the treatment of systemic infections. 
D10AF03 - chloramphenicol ; Belongs to the class of topical antiinfective preparations used in the treatment of acne. 
S03AA08 - chloramphenicol ; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations. 
S02AA01 - chloramphenicol ; Belongs to the class of antiinfectives used in the treatment of ear infections. 
G01AA05 - chloramphenicol ; Belongs to the class of antibiotics. Used in the treatment of gynecological infections. 
S01AA01 - chloramphenicol ; Belongs to the class of antibiotics. Used in the treatment of eye infections
 

Brand/Product Info


Total Products : 43                                           
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
A-PHENICOL Drop The Acme Laboratories Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 30.00 MRP
A-PHENICOL Ointment The Acme Laboratories Ltd. Chloramphenicol 1% ointment Eye Ointment 5gm: 11.67 MRP
ARISTOPHEN Drop Aristopharma Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 34.40 MRP
ARISTOPHEN Ointment Aristopharma Ltd. Chloramphenicol 1% ointment Eye Ointment 3gm: 8.37 MRP
CHEMOPHENICOL Chemist Laboratories Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 25.79 MRP
CHLORAMEX Renata Limited Chloramphenicol 0.5% eye drop Eye/Ear Drop 10ml: 25.29 MRP
CHLORAMPHENICOL Hudson Pharmaceuticals Ltd Chloramphenicol 250mg Capsule 100's: 220.00 MRP
CHLORPHEN Nipa Pharmaceuticals Ltd. Chloramphenicol 250mg Capsule 100's: 200.00 MRP
CHLORPHEN Drop Nipa Pharmaceuticals Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 20.23 MRP
CHLORPHEN Ointment Nipa Pharmaceuticals Ltd. Chloramphenicol 1% ointment Eye Ointment 3gm, 5gm: 8.50 & 12.50 MRP
CLORAM Drop IBN SINA Pharmaceutical Industry Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 34.39 MRP
CLORAM Ointment IBN SINA Pharmaceutical Industry Ltd. Chloramphenicol 1% ointment Eye Ointment 5gm: 13.00 MRP
EDRUMYCETIN Edruc Limited Chloramphenicol 250mg Capsule 100's: 250.00 MRP
EDRUMYCETIN Drop Edruc Limited Chloramphenicol 0.5% eye drop Eye Drop 10ml: 34.00 MRP
G-CHLORAMPHENICOL Gonoshasthaya Pharmaceuticals Ltd Chloramphenicol 1% ointment Eye Ointment 5gm tube: 8.03 BDT
G-CHLORAMPHENICOL E/E Gonoshasthaya Pharmaceuticals Ltd Chloramphenicol 0.5% eye drop Eye/Ear Drop 10ml: 20.08 BDT
G-HLORAMPHENICOL Drop Gonoshasthaya Pharmaceuticals Ltd Chloramphenicol 0.5% eye drop Eye Drop 10ml: 20.08 MRP
G-HLORAMPHENICOL Ointment Gonoshasthaya Pharmaceuticals Ltd Chloramphenicol 1% ointment Eye Ointment 5gm: 8.03 MRP
I-guard Incepta Pharmaceuticals Limited Chloramphenicol BP 0.5% 5mg/ml Eye/Ear Drop 10ml:MRP 34.4 Tk
ICOL ACI Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 34.40 MRP
ICOL E/E Drop ACI Ltd. Chloramphenicol 0.5% eye drop Eye/Ear Drop 10ml: 34.40 MRP
OCUBAC Apex Pharmaceuticals Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 25.00 MRP
OCUTREX Beximco Pharmaceuticals Ltd Chloramphenicol BP 5mg/ml Drop 10ml: 34.39 MRP
OPSOMYCETIN Opsonin Pharma Limited Chloramphenicol 125mg/5ml Suspension 60ml: 16.00 MRP
OPSOPHENICOL Drop Opso Saline Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 34.39 MRP
OPSOPHENICOL E/E Opso Saline Ltd. Chloramphenicol 0.5% Eye/Ear drop Eye/Ear Drop 10ml: 25.09 MRP
OPSOPHENICOL Ointment Opso Saline Ltd. Chloramphenicol 1% ointment Eye Ointment 3gm: 8.53 MRP
OPTABAC Popular Pharmaceuticals Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 34.27 MRP
OPTAPHENICOL Drop Reman Drug Laboratories Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 34.00 MRP
OPTAPHENICOL Ointment Reman Drug Laboratories Ltd. Chloramphenicol 1% ointment Eye Ointment 3gm: 10.00 MRP
OPTHACOL Drug International Ltd Chloramphenicol 0.5% eye drop Eye Drop 10ml: 25.50 MRP
OPTICHLOR Drop Jayson Pharmaceuticals Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 20.23 MRP
OPTICHLOR Ointment Jayson Pharmaceuticals Ltd. Chloramphenicol 1% ointment Eye Ointment 5gm: 12.04 MRP
OPTICOL Drop Asiatic Laboratories Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 34.39 MRP
OPTICOL Ointment Asiatic Laboratories Ltd. Chloramphenicol 1% ointment Eye Ointment 3gm: 8.34 MRP
OTO-Plus Edruc Limited Chloramphenicol 0.5% + Lidocaine Hydrochloride 0.1% Ear Drop Ear Drop 10ml: 20.00 MRP
OTOPHENICOL Plus Reman Drug Laboratories Ltd. Chloramphenicol 0.5% + Lidocaine Hydrochloride 0.1% Ear Drop Ear Drop 0.5% x5 & 10ml: 20.00 & 25.00; 1% x10ml: 20.00 MRP
RAMPHEN Kemiko Pharmaceuticals Ltd Chloramphenicol 0.5% eye drop Eye Drop 10ml: 34.27 MRP
SQ-MYCETIN 0.5% Square Pharmaceuticals Ltd. Chloramphenicol 0.5% Eye/Ear Drop 10 ml: 34.50 MRP
SUPRAPHEN Gaco Pharmaceutical Ltd. Chloramphenicol 0.5% & 1.0% Eye/Ear drop Eye/Ear Drop 10ml each: 20.00 & 19.00 MRP
SUPRAPHEN Drop Gaco Pharmaceutical Ltd. Chloramphenicol 0.5% eye drop Eye Drop 10ml: 34.27 MRP
SUPRAPHEN Ointment Gaco Pharmaceutical Ltd. Chloramphenicol 1% ointment Eye Ointment 5gm: 12.50 MRP
SUPRAPHEN Plus Gaco Pharmaceutical Ltd. Chloramphenicol 0.5% + Lidocaine Hydrochloride 0.1% Ear Drop Eye/Ear Drop 10ml: 20.00 MRP

Gen. MedInfo

IMPORTANT WARNING:

Chloramphenicol injection may cause a decrease in the number of certain types of blood cells in the body. In some cases, people who experienced this decrease in blood cells later developed leukemia (cancer that begins in the white blood cells). You may experience this decrease in blood cells whether you are being treated with chloramphenicol for a long time or a short time. If you experience any of the following symptoms, call your doctor immediately: pale skin; excessive tiredness; shortness of breath; dizziness; fast heartbeat; unusual bruising or bleeding; or signs of infection such as sore throat, fever, cough, and chills.

Your doctor will order laboratory tests regularly during your treatment to check whether the number of blood cells in your body has decreased. You should know that these tests do not always detect changes in the body that may lead to a permanent decrease in the number of blood cells. It is best that you receive chloramphenicol injection in the hospital so that you can be closely monitored by your doctor.

Chloramphenicol injection should not be used when another antibiotic can treat your infection. It must not be used to treat minor infections, colds, flu, throat infections or to prevent the development of an infection.

Talk to your doctor about the risks of receiving chloramphenicol injection.

 

Why is this medication prescribed?

Chloramphenicol injection is used to treat certain types of serious infections caused by bacteria when other antibiotics cannot be used. Chloramphenicol injection is in a class of medications called antibiotics. It works by stopping the growth of bacteria. Antibiotics will not work for colds, flu, or other viral infections.

How should this medicine be used?

Chloramphenicol may come as a capsule/syrup/suspension/injection/drop or ointment. This section discusses about Chloramphenicol injection.

Chloramphenicol injection is usually given every 6 hours. The length of your treatment depends on the type of infection being treated. After your condition improves, your doctor may switch you to another antibiotic that you can take by mouth to complete your treatment.

You should begin to feel better during the first few days of treatment with chloramphenicol injection. If your symptoms do not improve or get worse, tell your doctor.

Use chloramphenicol injection for as long as your doctor tells you, even if you feel better. If you stop using chloramphenicol injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Other uses for this medicine

In the event of biological warfare, chloramphenicol injection may be used to treat and prevent dangerous illnesses that are deliberately spread such as plague, tularemia, and anthrax of the skin or mouth. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving chloramphenicol injection,

  • tell your doctor if you are allergic to chloramphenicol injection or any other medications.
  • tell your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants (''blood thinners'') such as warfarin; aztreonam; cephalosporin antibiotics such as cefoperazone, cefotaxime, ceftazidime, and ceftriaxone (Rocephin); cyanocobalamin (vitamin B12); folic acid; iron supplements; certain oral medications for diabetes such as chlorpropamide and tolbutamide; phenobarbital; phenytoin; rifampin (Rimactane); and medications that may cause a decrease in the number of blood cells in the body. Ask your doctor or pharmacist if any of the medications that you are taking may cause a decrease in the number of blood cells. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Other medications may also interact with chloramphenicol injection, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor if you have ever been treated with chloramphenicol injection before, especially if you experienced severe side effects. Your doctor may tell you not to use chloramphenicol injection.
  • tell your doctor if you have or have ever had kidney or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving chloramphenicol injection, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving chloramphenicol injection.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?

Chloramphenicol injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • vomiting

  • diarrhea

  • tongue or mouth sores

  • headache

  • depression

  • confusion

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  • hives

  • rash

  • itching

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

  • hoarseness

  • difficulty swallowing or breathing

  • watery or bloody stools (up to 2 months after your treatment)

  • stomach cramps

  • muscle aches or weakness

  • sweating

  • feelings of numbness, pain, or tingling in an arm or leg

  • sudden changes in vision

  • pain with eye movement

Chloramphenicol injection may cause a condition called gray syndrome in premature and newborn infants. There have also been reports of gray syndrome in children up to age 2 and in newborns whose mothers were treated with chloramphenicol injection during labor. Symptoms, which usually occur after 3 to 4 days of treatment, may include: stomach bloating, vomiting, blue lips and skin due to lack of oxygen in the blood, low blood pressure, difficulty breathing, and death. If treatment is stopped at the first sign of any symptoms, the symptoms may go away, and the infant may recover completely. Talk to your doctor about the risks of using this medication during labor or to treat babies and young children.

Chloramphenicol injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.