P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

 
Indication & Dosage Ophthalmic
Ocular inflammation with suspected or confirmed bacterial infection
Adult: As suspension containing tobramycin 0.3% and dexamethasone 0.1%: 1-2 drops instilled into the conjunctival sac(s) 4-6 hrly. Dosage may be increased to every 2 hrly during the initial 24-48 hr, decrease frequency gradually as improvement seen. As ointment containing tobramycin 0.3% and dexamethasone 0.1%: Apply about ½ inch of ointment into the conjunctival sac(s) up to 3-4 times daily.
Administration May be taken with or without food.
Contraindications Viral infections of corneal and conjunctiva (e.g. epithelial herpes simplex keratitis, vaccinia, varicella). Mycobacterial or fungal infection of the eye.
Special Precautions Pregnancy and lactation. Avoid prolonged use, monitor intraocular pressure routinely. Safety and effectiveness in children <2 yr not established.
Adverse Drug Reactions Hypersensitivity reactions, lid itching and swelling, conjunctival erythema, increase in intraocular pressure, glaucoma, optic nerve damage, posterior subcapsular cataract formation and delayed wound healing. Secondary infections especially after prolonged use.
Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Ophthalmic: Suspension: Store between 8-27°C (46-80°F); shake well before using. Ointment: Store between 8-27°C (46-80°F).
Pharmacology Tobramycin, an aminoglycoside antibiotic, has actions similar to that of gentamicin and is active against Staphylococci, Streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgarisstrains, Haemophilus influenzae and H. aegyptius, Moraxella lacunata,Acinetobacter calcoaceticus and some Neisseria species. Dexamethasone, a synthetic fluorinated corticosteroid, has mainly glucocorticoid activity and suppresses inflammatory response.
ATC Classification S01CB01 - dexamethasone; Belongs to the class of corticosteroids/antiinfectives/mydriatics combinations. Used in the treatment of eye diseases. 
S01AA12 - tobramycin; Belongs to the class of antibiotics. Used in the treatment of eye infections. 
H02AB02 - dexamethasone; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations. 
C05AA09 - dexamethasone; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids. 
D07AB19 - dexamethasone; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases. 
D10AA03 - dexamethasone; Belongs to the class of topical corticosteroids used in the treatment of acne. 
S03BA01 - dexamethasone; Belongs to the class of corticosteroids used in ophthalmologic and otologic preparations. 
J01GB01 - tobramycin; Belongs to the class of other aminoglycosides. Used in the treatment of systemic infections. 
S02BA06 - dexamethasone; Belongs to the class of corticosteroids used in the treatment of inflammation of the ear. 
A01AC02 - dexamethasone; Belongs to the class of local corticosteroid preparations. Used in the treatment of diseases of the mouth. 
D07XB05 - dexamethasone; Belongs to the class of moderately potent (group II) corticosteroids in other combinations. Used in the treatment of dermatological diseases. 
R01AD03 - dexamethasone; Belongs to the class of topical corticosteroids used as nasal decongestants. 
S01BA01 - dexamethasone; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.

Brand/Product Info


Total Products : 10          
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
CINAREX D Beximco Pharmaceuticals Ltd Dexamethasone 0.1% + Tobramycin 0.3% Ophthalmic Drop 5ml: 150.00 MRP
Dextrobac Incepta Pharmaceuticals Limited Dexamethasone 0.1% + Tobramycin 0.3% Eye Drop 5ml:MRP 150 Tk
EYTEX Nipa Pharmaceuticals Ltd. Dexamethasone 0.1%+ Tobramycin 0.3% Eye Drop/Ointment 5ml & 3gm Ointment: 125.00 & 90.00 MRP
ORBIDEX T Popular Pharmaceuticals Ltd. Dexamethasone 0.1%+ Tobramycin 0.3% Eye Drop 5ml: 150.00 MRP
T-DEX Reman Drug Laboratories Ltd. Dexamethasone 0.1%+ Tobramycin 0.3% Eye Drop/Ointment 5ml & 4gm Ointment: 150.00 & 90.00 MRP
T-MYCIN Plus Aristopharma Ltd. Dexamethasone 0.1%+ Tobramycin 0.3% Eye Drop/Ointment 5ml & 3.5gm Ointment: 150.00 & 90.00 MRP
TEXA Drug International Ltd Dexamethasone 0.1%+ Tobramycin 0.3% Ophthalmic Suspension 5ml: 125.00 MRP
TOBICORT Asiatic Laboratories Ltd. Dexamethasone 0.1%+ Tobramycin 0.3% Eye Drop 5ml: 125.00 MRP
TOBIDEX Gaco Pharmaceutical Ltd. Dexamethasone 0.1%+ Tobramycin 0.3% Eye Drop/Ointment 5ml & 3.5gm Ointment: 130.00 & 90.00 MRP
TOMYCIN-D IBN SINA Pharmaceutical Industry Ltd. Dexamethasone 0.1%+ Tobramycin 0.3% Eye Drop 5ml: 130.00 MRP