mph Bangladesh


P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

 
Indication & Dosage Ophthalmic
Ocular inflammation with suspected or confirmed bacterial infection
Adult: As ophthalmic ointment containing betamethasone Na phosphate 0.1% w/w and neomycin sulfate 0.5% w/w: Apply ¼ inch long to the lower eye lid 2-3 times daily and/or at night. Usual treatment duration: Up to 7 days per course. 
Topical/Cutaneous
Corticosteriod-responsive dermatoses with secondary infection
Adult: As betamethasone (valerate) crm/oint containing 0.122% w/w and neomycin sulfate 0.5% w/w: Apply onto the affected area(s) 2-3 times daily. 
Child: ≥2 yr: As cream/ointment containing betamethasone (as valerate) 0.122% w/w and neomycin sulfate 0.5% w/w: Apply onto the affected area(s) 2-3 times daily. Usual treatment duration: Up to 5 days/course. 
Renal impairment: Dose reduction may be necessary.
Overdosage Acute overdosage is unlikely to occur. Prolonged excessive use may lead to sufficient systemic absorption resulting in symptoms of Cushing's syndrome, in which case, gradual withdrawal of the drug is recommended. Significant systemic absorption of neomycin sulfate may cause ototoxicity and nephrotoxicity. Treatment involves withdrawal of drug and monitoring general status, hearing acuity, renal and neuromuscular functions of the patient.
Contraindications Hypersensitivity. Rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritus and primary cutaneous viral infections. Not to be used in otitis externa complicated by ear-drum perforation. Treatment of primary infected skin lesions caused by fungi or bacteria; primary or secondary infections due to yeast; or secondary infections due to Pseudomonas or Proteus species. Children <2 yr. Ophthalmic preparation: Not to be used in patients with glaucoma or herpetic keratitis.
Special Precautions Avoid prolonged treatment as it may lead to systemic corticosteroid effects even withour occlusion. Avoid prolonged excessive application to the facial areas. Withdraw treatment if there is spread of the infection. Risk of glaucoma development if preparation enters eye(s). Regular monitoring is recommended when used in psoriasis due to treatment tolerance, rebound relapses, generalised pustular psoriasis or systemic toxicity. Increased risk of contact sensitisation when used for extended period or recurrently. Pregnancy and lactation. Ophthalmic preparation: Monitor intraocular pressure, cataract formation of unsuspected infections; evaluate treatment if there is no clinical improvement after 7 days. Not to be used for undiagnosed red eye.
Adverse Drug Reactions Prolonged use may cause local atrophic changes in the skin e.g. thining, striae and dilatation of superficial blood vessels. Local skin burning sensation, pruritus, pigmentation changes, allergic contact dermatitis and hypertrichosis. Ophthalmic preparation: Corneal ulceration, increased intraocular pressure, mydriasis, ptosis, epithelial punctate keratitis.
Drug Interactions

If there is significant systemic absorption, neomycin sulfate may increase the respiratory depressant effects of neuromuscular blockers.

Storage Ophthalmic: Store <25°C. Topical/Cutaneous: Store <25°C.
Pharmacology Betamethasone valerate is a corticosteroid which is effective in inflammatory dermatoses. It is also effective in less responsive conditions such as psoriasis. Neomycin sulfate is a broad spectrum antibiotic. It is bactericidal against many bacteria which are commonly associated with skin infections.
Absorption: Betamethasone: Absorption through the skin depends on several factors e.g. presence of occlusive dressing, integrity of the epidermal barrier.
Distribution: Betamethasone: Bound to plasma proteins to varying extent.
Metabolism: Betamethasone: Largely metabolised hepatically.
Excretion: Betamethasone: Mainly excreted via the kidneys.
ATC Classification S01CB04 - betamethasone ; Belongs to the class of corticosteroids/antiinfectives/mydriatics combinations. Used in the treatment of eye diseases. 
D07AC01 - betamethasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases. 
D06AX04 - neomycin ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases. 
H02AB01 - betamethasone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations. 
B05CA09 - neomycin ; Belongs to the class of antiinfectives used as irrigating solutions. 
J01GB05 - neomycin ; Belongs to the class of other aminoglycosides. Used in the treatment of systemic infections. 
S02AA07 - neomycin ; Belongs to the class of antiinfectives used in the treatment of ear infections. 
S02BA07 - betamethasone ; Belongs to the class of corticosteroids used in the treatment of inflammation of the ear. 
A07AA01 - neomycin ; Belongs to the class of antibiotics. Used for the treatment of intestinal infections. 
A07EA04 - betamethasone ; Belongs to the class of corticosteroids acting locally. Used in the treatment of intestinal inflammation. 
R03BA04 - betamethasone ; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, glucocorticooids. 
R02AB01 - neomycin ; Belongs to the class of antibiotics used in throat preparations. 
S03AA01 - neomycin ; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations. 
S03BA03 - betamethasone ; Belongs to the class of corticosteroids used in ophthalmologic and otologic preparations. 
C05AA05 - betamethasone ; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids. 
A01AB08 - neomycin ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. 
D07XC01 - betamethasone ; Belongs to the class of potent (group III) corticosteroids in other combinations. Used in the treatment of dermatological diseases. 
R01AD06 - betamethasone ; Belongs to the class of topical corticosteroids used as nasal decongestants. 
S01AA03 - neomycin ; Belongs to the class of antibiotics. Used in the treatment of eye infections. 
S01BA06 - betamethasone ; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.
 

Brand/Product Info



Total Products : 37                                     
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ARISTOBET-N Aristopharma Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye/Ear Drop 5ml vial: 32.30 MRP
ARISTOBET-N Drop Aristopharma Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Drop 5ml: 32.30 MRP
ARISTOBET-N Ointment Aristopharma Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Ointment 5gm: 10.80 MRP
BACTOVATE R A K Pharmaceuticals Pvt. Ltd. Betamethasone dipropionate 0.1%+ Neomycin sulphate 0.5% Cream 10gm: 22.00 MRP
BESONE-N Pharmadesh Laboratories Limited Betamethasone dipropionate 0.1%+ Neomycin sulphate 0.5% Ointment 5gm: 18.00 MRP
BETACIN-N IBN SINA Pharmaceutical Industry Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Ear Drop 5ml vial: 35.00 MRP
BETACIN-N Drop IBN SINA Pharmaceutical Industry Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Drop 5ml vial: 35.00 MRP
Betaderm N Incepta Pharmaceuticals Limited Betamethasone Valerate BP equivalent to 1mg Betamethasone & Neomycin sulphate BP 5mg per gm Ointment 10gm x 1:MRP 22 Tk
BETAMESON-N CRM Square Pharmaceuticals Ltd. Betamethasone + Neomycin (1mg + 5mg)/gm Cream 10 gm: 22.14 MRP
BETAMYCIN Supreme Pharmaceuticals Ltd. Betamethasone dipropionate 0.1%+ Neomycin sulphate 0.5% Ointment 5gm: 15.30 MRP
BETANOSOL-N Edruc Limited Betamethasone dipropionate 0.1%+ Neomycin sulphate 0.5% Cream 5gm: 15.00 MRP
BETANOSOL-N Ointment Edruc Limited Betamethasone dipropionate 0.1%+ Neomycin sulphate 0.5% Ointment 5gm: 18.00 MRP
BETASONE-N Reman Drug Laboratories Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye/Ear Drop 5ml vial: 32.44 MRP
BETASONE-N 5gm Reman Drug Laboratories Ltd. Betamethasone dipropionate 0.1%+ Neomycin sulphate 0.5% Ointment 5gm: 18.00 MRP
BETASONE-N Drop Reman Drug Laboratories Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Drop 5ml: 32.44 MRP
BETASONE-N Ointment Reman Drug Laboratories Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Ointment 3gm: 10.81 MRP
BETAVAL -N CREAM Healthcare Pharmacuticals Ltd. Betamethasone Valerate BP equivalent to Betamethasone 1mg + Neomycin sulphate BP 5mg per gm Cream 5gm, MRP 18.51 Tk
BETAVAL -N OINMENT Healthcare Pharmacuticals Ltd. Betamethasone Valerate BP equivalent to Betamethasone 1mg + Neomycin sulphate BP 5mg per gm Ointment 5gm, MRP 18.54 Tk
BETAVATE-N Drug International Ltd Betamethasone dipropionate 0.1%+ Neomycin sulphate 0.5% Cream 10gm: 21.55 MRP
BETNOVATE-N GlaxoSmithKline Bangladesh Limited Betamethasone dipropionate 0.1%+ Neomycin sulphate 0.5% Cream/Ointment 5gm Cream & Oint.: 18.51 & 18.54 MRP
BETRICIN-N Nipa Pharmaceuticals Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Ear Drop 5ml vial: 32.00 MRP
BETRICIN-N Drop Nipa Pharmaceuticals Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Drop 5ml: 32.00 MRP
BETRICIN-N Ointment Nipa Pharmaceuticals Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Ointment 3gm: 10.77 MRP
BETSON-N Opsonin Pharma Limited Betamethasone 0.1%+ Neomycin Sulphate 0.5% Cream 5gm: 15.22 MRP
BN Asiatic Laboratories Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Ear Drop 5ml vial: 28.45 MRP
BN Drop Asiatic Laboratories Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Drop 5ml: 28.45 MRP
METHASOL-N Gaco Pharmaceutical Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Ear Drop 5ml vial: 32.20 MRP
METHASOL-N Drop Gaco Pharmaceutical Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Drop 5ml: 32.20 MRP
METHASOL-N Ointment Gaco Pharmaceutical Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Ointment 5gm: 12.67 MRP
METHOVATE-N Gaco Pharmaceutical Ltd. Betamethasone 0.1%+ Neomycin Sulphate 0.5% Cream/Ointment Cream 5 & 10gm; Oint. 5gm: 15.34 & 22.00; 18.53 MRP
MEXIDERM-N Biopharma Laboratories Ltd Betamethasone 0.1%+ Neomycin Sulphate 0.5% Cream/Ointment 5gm Cream & Oint.: 15.06 & 18.00 MRP
NEOBET The Acme Laboratories Ltd. Betamethasone 0.1%+ Neomycin Sulphate 0.5% Cream 5gm, 10mg & 15gm: 15.28 & 18.28 & 27.00 MRP
NEOBET-E The Acme Laboratories Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Ointment 2.5gm, 3gm: 12.39 & 18.23 MRP
NEOCORT IBN SINA Pharmaceutical Industry Ltd. Betamethasone 0.1%+ Neomycin Sulphate 0.5% Cream/Ointment 5gm: 18.53 MRP
OPTISON-N Opso Saline Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Ear Drop 5ml vial: 30.41 MRP
OPTISON-N Drop Opso Saline Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye/Ear Drop 5ml vial: 30.41 MRP
OPTISON-N Ointment Opso Saline Ltd. Betamethasone sodium phosphate 0.1%+ Neomycin sulphate 0.5% Eye Ointment 3gm: 10.54 MRP
 

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