P : Caution when used during pregnancy
L : Caution when used during lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication & Dosage||Subcutaneous
Adult: Usual insulin requirement: 0.3-1 IU/kg/day; may be given in 1-2 divided doses. Dose should be individualised, to be adjusted according to patient's needs. May be used alone or in combination with a fast-acting insulin.
Renal impairment: Dosage reduction may be needed.
Hepatic impairment: Dosage reduction may be needed.
|Administration||Should be taken with food.
|Overdosage||Overdose may lead to hypoglycaemic attack. Mild hypoglycaemia can be treated by oral admin of glucose or sugary products. Severe attack whereby the patient has become unconscious may require treatment using IM or SC glucagon (0.5-1 mg); IV glucose must be given concurrently if patient does not respond after 10-15 minutes. Oral carbohydrate should be administered after patient regains consciousness to prevent relapse.|
|Special Precautions||Monitor for signs of hypoglycaemia. Insulin requirements may change when there is illness, emotional disturbance or other stresses. Renal and hepatic impairment. Monitor blood glucose and haemoglobin A1c. Caution when changing insulin as changes in strength, brand, type, manufacturer and source may result in dosage changes. Inj area should be rotated to reduce the risk of lipodystrophy and inj-site reactions e.g. redness and inflammation. Î²-blockers may mask symptoms of hypoglycaemia. Pregnancy and lactation.|
|Adverse Drug Reactions||Inj
site reactions e.g. swelling, redness, itch and pain.
Potentially Fatal: Anaphylactic reactions.
use with oral antidiabetic agents, MAOIs, ACE inhibitors, salicylates, alcohol, anabolic steroids and non-selective Î²-blockers may reduce insulin
requirements. Drugs that may increase insulin requirements include: Oral contraceptives, thiazides, thyroid hormones, growth hormone, danazol and
Î²-sympathomimetics. Octreotide may affect insulin requirement.
|Storage||Subcutaneous: Unopened vial or pen: Store at 2-8Â°C. Used vial and pen should be stored below 25Â°C; discard after 4 wk.|
|Pharmacology||Insulin isophane (human) is a crystalline suspension of human insulin with protamine and zinc. It is an intermediate-acting insulin.
Insulin facilitates the uptake of glucose by binding to receptors on muscle and fat cells; it also inhibits glucose output from liver.
Onset: 1-2 hr.
Duration: 18-24 hr.
Absorption: Takes 6-12 hr to reach peak levels.
Total Products : 11
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ANSULIN N 100||Square Pharmaceuticals Ltd.||Insulin Human (rDNA) 100 IU/ml||SC Injection||10 ml: 415.00 MRP|
|ANSULIN N 40||Square Pharmaceuticals Ltd.||Insulin Human (rDNA) 40 IU/ml||SC Injection||10 ml: 195.00 MRP|
|ANSULIN N PEN||Square Pharmaceuticals Ltd.||Insulin Human (rDNA) 100 IU/ml||SC Injection||3 ml: 220.00 MRP|
|HUMULIN N||Eli Lilly/International Agencies (Bd.) Ltd.||Neutral isophane (NPH) human insulin (rDNA) 100 IU/ml||Injection||4ml & 10ml vial x1's; 3ml cartridge x5's: 316.00 & 666.00; 1957.30 MRP|
|INSUL N||Popular Pharmaceuticals Ltd.||Neutral isophane human insulin (rDNA) BP 40 IU & 100 IU/ml||Injection||40 IU x10ml: 195.00; 100 IU 10ml vial x1's & 3ml cartridge x5's: 415.00 & 1110.00 MRP|
|INSULATARD HM||Novo Nordisk Pharma (Private) Ltd.||Neutral isophane human insulin (rDNA) BP 100 IU/ml, Penfill||Injection||3ml x5's: 1830. 00 MRP|
|INSULATARD HM 100IU||Novo Nordisk Pharma (Private) Ltd.||Neutral isophane human insulin (rDNA) BP 100 IU/ml||Injection||10ml vial: 580.00 MRP|
|INSULATARD HM 40IU||Novo Nordisk Pharma (Private) Ltd.||Neutral isophane human insulin (rDNA) BP 40 IU/ml||Injection||10ml vial: 260.00 MRP|
|INSULET N||Aristopharma Ltd.||Neutral isophane human insulin (rDNA) BP 100 IU/ml||Injection||4ml & 10ml vial: 169.70 & 415.00 MRP|
|INSUMAN Basal||Sanofi||Neutral isophane (NPH) human insulin (rDNA) 100 IU/ml||Injection||5ml vial: 281.70 MRP|
|MAXSULIN N||Incepta Pharmaceuticals Limited||Human Insulin (rDNA) BP 40 & 100 IU/ml as Isophane Human Insulin (NPH)||Injection||10ml vial each: 195.00 & 415.00 MRP|