|| See TERMINOLOGY & ABBREVIATIONS ||
Citicoline also known as cytidine diphosphate-choline (CDP-Choline) & cytidine 5'-diphosphocholine is a psychostimulant/nootropic. It is an intermediate in the generation of phosphatidylcholine from choline and is indicated in the treatment of unconsciousness following cerebral trauma, traffic accident & brain operation. Chronic stage: Neural & psychiatric disorders (hemiplegia, dyskinesia, motorpalsy, amnesia aphasia, disorientation & headache) following apoplexy, head injury & cerebral operation.
|ATC Classification||N06BX06 - citicoline; Belongs to the class of other agents used as CNS stimulant.|
|Indication(s) & Dosage||
Citicoline is indicated in the treatment of unconsciousness following cerebral trauma, traffic accident & brain operation. Chronic stage: Neural & psychiatric disorders (hemiplegia, dyskinesia, motorpalsy, amnesia aphasia, disorientation & headache) following apoplexy, head injury & cerebral operation.
Head injury Adult: 200-600 mg daily in divided doses. Cerebrovascular disorders Adult: 200-600 mg daily in divided doses. Parkinsonism Adult: 200-600 mg daily in divided doses.
Head injury Adult: Up to 1 g IM/IV daily. Cerebrovascular disorders Adult: Up to 1 g IM/IV daily. Parkinsonism Adult: Up to 1 g IM/IV daily.
For patients with acute, severe and progressive disturbances of consciousness due to head injury and brain surgery, Citicoline injection should be administered in conjunction with hemostatics and intracranial pressure relieving drugs, or treatment such as hypothermyPatients are advised not to operate heavy machinery or automobiles until the full effect of Citicoline is known. Do not consume alcohol while taking Citicoline. Make sure your doctor is aware of upcoming surgeries you may have scheduled; or will be scheduling while taking this medication. Contact your doctor for professional advice if you experience a cold, coughs or allergies. You should not try to treat yourself for such symptoms. Some ingredients found in other medications may have conflicting affects while taking Citicoline and may affect desired results.
|Adverse Drug Reaction(s)||
Most common adverse reactions associated with Citicoline are:
|Pregnancy Category (FDA)
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Nursing mothers: There is not enough evidence on citicolineâ€™s safety in breastfeeding women. Citicoline should be used in lactation only when benefits justify the potential risks.
Citicoline is reported to increase blood flow and O2 consumption in the brain. It is also involved in the biosynthesis of lecithin.
When infused intravenously in humans, it is rapidly hydrolyzed to choline and cytidine
for delivery to tissues throughout the body. In normal volunteers, at the end of a 30 minute infusion, plasma levels of citicoline are already
virtually undetectable, while choline and cytidine levels are at a peak, with continued elevated circulating concentrations for 6 hours. Though not as
rapid as intravenous administration, oral administration also provides an efficient means of delivery, with choline and cytidine plasma levels peaking 2
hours after a single oral dose.
|| See Brand Manufacturer's Prescribing Information |||| Back to top ||