mph Bangladesh


P  - Caution when used during pregnancy

Molecule Info

 
Indication & Dosage Oral
Vitamin K deficiency due to drugs or malabsorption
Adult: 10-40 mg daily. 
Oral
Over-anticoagulation
Adult: Up to 5 mg may be used. Dose depends on INR and degree ofhaemorrhage. 
Intramuscular
Prophylaxis of vitamin K deficiency bleeding in neonates
Child: Neonate: 0.5-1 mg, given as a single dose via IM inj. Alternatively, 2 mg may be given orally, followed by a 2nd dose of 2 mg after 4-7 days. 
Intravenous
Over-anticoagulation
Adult: 0.5-5 mg via slow IV inj. Dose depends on INR and degree of haemorrhage. 
Parenteral
Vitamin K deficiency bleeding in neonates
Child: Infant: 1 mg by IV/IM/SC inj, further doses may be given if necessary
Administration May be taken with or without food.
Contraindications Hypersensitivity.
Special Precautions Increased risk of severe haemolytic anaemia in neonates after large doses; severe hepatic impairment; pregnancy. Premature neonates weighing <2.5 kg.
Adverse Drug Reactions Anaphylaxis, dyspnoea, cyanosis, pain, swelling, phloebitis at the Inj site, diaphoresis, dizziness, hypotension (rare), allergic reactions after SC and IM inj.
Drug Interactions Decreased effect of oral anticoagulants. Please consult detailed drug interactions before prescribing.
Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Intramuscular: Store at 15-30°C. Intravenous: Store at 15-30°C. Oral: Store at 15-30°C. Parenteral: Store at 15-30°C.
Pharmacology Phytomenadione promotes hepatic synthesis of clotting factors. It is a naturally occurring compound that is used to prevent and treat haemorrhages related to vitamin K deficiency.
Absorption: Requires bile for absorption in GI tract.
Distribution: Mainly in the liver.
Metabolism: Rapidly metabolised to glucuronide and sulfate conjugates.
Excretion: In bile and urine as metabolites.
ATC Classification B02BA01 - phytomenadione; Belongs to the class of vitamin K. Used in the treatment of hemorrhage.

Brand/Product Info


Total Products : 7       
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
BABYKION Oral/IM/IV Chemist Laboratories Ltd. Phytomenadione 2mg/0.2ml Injection 2mg amp x5's: 100.00 MRP
DINAKION-10 Oral/IM/IV Drug International Ltd Phytomenadione 10mg/1ml Injection 10mg amp x5's: 225.00 MRP
DINAKION-MM Drug International Ltd Phytomenadione 2mg/0.2ml Injection 2mg amp x5's: 99.45 MRP
Injection K MM Incepta Pharmaceuticals Limited Phytomenadione 10mg/1ml bile acid/lecithin mixed-micelle solution Injection Adult 1x5's:MRP 229.3 Tk
Injection K MM Paed. Incepta Pharmaceuticals Limited Phytomenadione 2mg/0.2ml bile acid/lecithin mixed-micelle solution Injection Paediatric 1x5's:MRP 99.45 Tk
K-ONE MM Square Pharmaceuticals Ltd. Phytomenadione 2mg/0.2 ml IM/IV/Oral Injection 1x3's: 59.82 MRP
KONAKION MM Roche Bangladesh Limited Phytomenadione 2mg/0.2ml, 10mg/1ml Injection 5's each: 551.00 & 575.00 MRP

Gen. MedInfo

Why is this medication prescribed?

Phytomenadione (Vitamin K) is a vitamin found in leafy green vegetables, broccoli, and Brussels sprouts. The name Vitamin K comes from the German word “Koagulationsvitamin.”

Several forms of Phytomenadione (Vitamin K) are used around the world as medicine. But in the U.S., the only form available is Vitamin K1 (phytonadione). Vitamin K1 is generally the preferred form of Vitamin K because it is less toxic, works faster, is stronger, and works better for certain conditions.

In the body, Phytomenadione (Vitamin K) plays a major role in blood clotting. So it is used to reverse the effects of “blood thinning” medications when too much is given; to prevent clotting problems in newborns who don’t have enough Phytomenadione (Vitamin K); and to treat bleeding caused by medications including salicylates, sulfonamides, quinine, quinidine, or antibiotics. Phytomenadione (Vitamin K) is also given to treat and prevent Phytomenadione (Vitamin K) deficiency, a condition in which the body doesn’t have enough Phytomenadione (Vitamin K). It is also used to prevent and treat weak bones (osteoporosis) and relieve itching that often accompanies a liver disease called biliary cirrhosis.

People apply Phytomenadione (Vitamin K) to the skin to remove spider veins, bruises, scars, stretch marks, and burns. It is also used topically to treat rosacea, a skin condition that causes redness and pimples on the face. After surgery, Phytomenadione (Vitamin K) is used to speed up skin healing and reduce bruising and swelling.

Healthcare providers also give Phytomenadione (Vitamin K) by injection to treat clotting problems.

An increased understanding of the role of Phytomenadione (Vitamin K) in the body beyond blood clotting led some researchers to suggest that the recommended amounts for dietary intake of Phytomenadione (Vitamin K) be increased. In 2001, the National Institute of Medicine Food and Nutrition Board increased their recommended amounts of Phytomenadione (Vitamin K) slightly, but refused to make larger increases. They explained there wasn’t enough scientific evidence to make larger increases in the recommended amount of Phytomenadione (Vitamin K).
 
How effective is it? 
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for Phytomenadione (Vitamin K) are as follows:

Effective for,

  • Treating and preventing Vitamin K deficiency.
  • Preventing certain bleeding or blood clotting problems.
  • Reversing the effects of too much warfarin used to prevent blood clotting.

Insufficient evidence to rate effectiveness for...

  • Weak bones (osteoporosis). So far, research results on the effects of Phytomenadione (Vitamin K) on bone strength and fracture risk in people with osteoporosis don’t agree.
  • Cystic fibrosis.
  • Heart disease.
  • High cholesterol.
  • Spider veins.
  • Bruises.
  • Scars.
  • Stretch marks.
  • Burns.
  • Swelling.
  • Other conditions.
More evidence is needed to rate Phytomenadione (Vitamin K) for these uses.
How does it work?

Phytomenadione (Vitamin K) is an essential vitamin that is needed by the body for blood clotting and other important processes.

Are there safety concerns?

Phytomenadione (Vitamin K) is safe for most people. Most people do not experience any side effects when taking in the recommended amount each day.

Special precautions & warnings:

Pregnancy and breast-feeding: When taken in the recommended amount each day, Phytomenadione (Vitamin K) is considered safe for pregnant and breast-feeding women, but don't use higher amounts without the advice of your healthcare professional.

Kidney disease: Too much Phytomenadione (Vitamin K) can be harmful if you are receiving dialysis treatments due to kidney disease.

Liver disease: Phytomenadione (Vitamin K) is not effective for treating clotting problems caused by severe liver disease. In fact, high doses of Phytomenadione (Vitamin K) can make clotting problems worse in these people.
Are there interactions with medications?

Major

Do not take this combination.

Warfarin
Phytomenadione (Vitamin K) is used by the body to help blood clot. Warfarin (Coumadin) is used to slow blood clotting. By helping the blood clot, Phytomenadione (Vitamin K) might decrease the effectiveness of warfarin (Coumadin). Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Are there interactions with herbs and supplements?

Coenzyme Q-10

Coenzyme Q-10 is chemically similar to Phytomenadione (Vitamin K) and, like Phytomenadione (Vitamin K), can promote blood clotting. Using these two products together can promote blood clotting more than using just one. This combination can be a problem for people who are taking warfarin to slow blood clotting. Coenzyme Q-10 plus Phytomenadione (Vitamin K) might overwhelm the effects of warfarin and could allow the blood to clot.

Tiratricol

There is a concern that tiratricol might interfere with Vitamin K's role in blood clotting.

Vitamin A

In animals, high doses of vitamin A interfere with Vitamin K's ability to clot blood. But it's not known if this also happens in people.

Vitamin E

High doses of vitamin E (e.g. greater than 800 units/day) can make Phytomenadione (Vitamin K) less effective in clotting blood. In people who are taking warfarin to keep their blood from clotting, or in people who have low Phytomenadione (Vitamin K) intakes, high doses of vitamin E can increase the risk of bleeding.

Are there interactions with foods?

There are no known interactions with foods.

What dose is used?

The following doses have been studied in scientific research: 

BY MOUTH:
  • For bleeding disorders such as hypoprothrombinemia: 2.5-25 mg of Vitamin K1 (phytonadione).
  • For counteracting bleeding that can occur when too much of the anticoagulant warfarin is given: 1-5 mg of Phytomenadione (Vitamin K) is typically used; however, the exact dose needed is determined by a lab test called the INR.
There isn't enough scientific information to determine recommended dietary allowances (RDAs) for Phytomenadione (Vitamin K), so daily adequate intake (AI) recommendations have been formed instead: The AIs are: infants 0-6 months, 2 mcg; infants 6-12 months, 2.5 mcg; children 1-3 years, 30 mcg; children 4-8 years, 55 mcg; children 9-13 years, 60 mcg; adolescents 14-18 years (including those who are pregnant or breast-feeding), 75 mcg; men over 19 years, 120 mcg; women over 19 years (including those who are pregnant and breast-feeding), 90 mcg.
 
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This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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