mph Bangladesh


Furosemide (Frusemide) + Spironolactone

PCI  : Contraindicated in pregnancy

LCI  : Contraindicated in lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage

Furosemide-Spironolactone contain a short-acting diuretic and a long-acting aldosterone antagonist. It is indicated in the treatment of resistant oedema where this is associated with secondary hyperaldosteronism; conditions include chronic congestive cardiac failure and hepatic cirrhosis.

Treatment with Furosemide-Spironolactone should be reserved for cases refractory to a diuretic alone at conventional doses.

This fixed ratio combination should only be used if titration with the component drugs separately indicates that this product is appropriate.

The use of Furosemide-Spironolactone in the management of essential hypertension should be restricted to patients with demonstrated hyperaldosteronism. It is recommended that in these patients also, this combination should only be used if titration with the component drugs separately indicates that this product is appropriate.

Hypertension, Ascites due to congestive heart failure, Oedema
Adult: Per tab contains furosemide 20 or 40mg and spironolactone 50mg. 1-4 tabs/day.

Contraindications Hypersensitivity, anuria or severe oliguria, hypovolaemia, hyponatraemia, hypotension, urinary retention due to prostatic hypertrophy, Addison's disease, renal impairment, hyperkalaemia, acute or severe liver failure. Pregnancy and lactation.
Special Precautions Concomitant use with ACE inhibitors, monitor fluids and electrolytes including changes in serum K levels. Dilutional hyponatraemia or even a true low-salt syndrome may develop. General anaesthesia.
Adverse Drug Reaction(s) Fluid and electrolyte imbalance, nausea, diarrhoea, blurred vision, headache, dizziness, hypotension, photosensitisation, hepatic dysfunction, hyperglycaemia and glycosuria, rarely bone marrow depression, gynaecomastia, hirsutism, hoarseness, menstrual irregularities, loss of libido, impotence.
Potentially Fatal: Severe hyperkalaemia in patients with preexisting renal impairment or taking ACE inhibitors, agranulocytosis, cardiac arrhythmias.
Drug Interactions Aminoglycosides and ethacrynic acid (increased ototoxicity), tubocurazine, succinylcholine (effects enhanced). Sucralfate reduces effects of furosemide. Should be given 2 hr apart. NSAIDs reduce natriuretic and antihypertensive effects of furosemide. Corticosteroids may antagonise action. Digoxin levels may be increased. Warfarin effects may be reduced.
Potentially Fatal: Potassium supplements or potassium-rich diet, ACE inhibitors, general anaesthetics (reduced vascular responsiveness to catecholamines), lithium toxicity. Please consult detailed drug interactions before prescribing.
Food Interaction Bioavailability of frusemide reduced but absorption of spironolactone improved.
Lab Interference Frusemide produces falsely low urinary sugar values by clinistix or diastrix method.
Pharmacology Furosemide inhibits reabsorption of Na+, Cl- and K+. Continuous use may also lead to secondary hyperaldosteronism. Spironolactone is a specific antagonist of aldosterone. It increases Na and water excretion but retains K+. Thus it acts both as diuretic and an antihypertensive. It reduces oedema and counteracts secondary aldosteronism caused by vol depletion Na loss. K loss is reduced.
ATC Classification C03DA01 - spironolactone; Belongs to the class of potassium-sparing agents, aldosterone antagonists. Used as diuretics. 
C03CA01 - furosemide; Belongs to the class of high-ceiling sulfonamide diuretics. Used to promote excretion of urine.

Brand/Product Info


Total Products : 38                                      
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
DILUP 20/50 ACI Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.60 MRP
DILUP 40/50 ACI Ltd. Frusemide BP 40mg+ Spironolactone BP 50mg Tablet 30's: 240.90 MRP
DIRETIC Drug International Ltd Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 50's: 300.00 MRP
DIRETIC-DS Drug International Ltd Frusemide BP 40mg+ Spironolactone BP 50mg Tablet 50's: 400.00 MRP
DIRUCOM Popular Pharmaceuticals Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.59 MRP
DIRUSID-Plus Delta Pharma Limited Frusemide BP 40mg+ Spironolactone BP 50mg Tablet 30's: 180.00 MRP
Edeloss Incepta Pharmaceuticals Limited Frusemide BP 20mg+ Spironolactone BP 50mg Film Coated Tablet 10x5's:MRP 300 Tk
Edeloss Plus Incepta Pharmaceuticals Limited Frusemide BP 40 mg + Spironolactone BP 50 mg Tablet Film Coated Tablet 10x5's:MRP 400 Tk
EDEMIDE The Acme Laboratories Ltd. Frusemide 20mg & spironolactone 50mg/tablet Tablet 30s pack: 180.00 MRP
EDEMIDE 20 The Acme Laboratories Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.60 MRP
EDEMIDE 40 The Acme Laboratories Ltd. Frusemide BP 40mg+ Spironolactone BP 50mg Tablet 30's: 241.20 MRP
EDENIL 20 Eskayef Bangladesh Ltd Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's MRP: 180.00
EDENIL 40 Eskayef Bangladesh Ltd Frusemide BP 40mg+ Spironolactone BP 50mg Tablet 30's MRP: 240.00
FRULAC Orion Pharma Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 50's: 301.00 MRP
FRULAC 40 Orion Pharma Ltd. Frusemide BP 40mg+ Spironolactone BP 50mg Tablet 30's: 240.90 MRP
FRUSEC Plus The White Horse Pharma Frusemide 20mg & spironolactone 50mg/tablet Tablet 30s pack: 180.00 MRP
FRUSELAC Aristopharma Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.00 MRP
FRUSELAC Plus Aristopharma Ltd. Frusemide BP 40mg+ Spironolactone BP 50mg Tablet 30's: 240.00 MRP
FRUSIN 20 Plus Opsonin Pharma Limited Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.00 MRP
FRUSIN 40 Plus Opsonin Pharma Limited Frusemide BP 40mg+ Spironolactone BP 50mg Tablet 30's: 240.00 MRP
FRUSON-20 IBN SINA Pharmaceutical Industry Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.00 IP
FURO Plus Beacon Pharmaceuticals Limited Frusemide BP 40mg+ Spironolactone BP 50mg Tablet 30's: 180.00 MRP
FUROPLUS Beacon Pharmaceuticals Limited Frusemide 20mg & spironolactone 50mg/tablet Tablet 30s pack: 180.00 MRP
FUROTONE Novo Healthcare and Pharma Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.00 MRP
FUSETON Alco Pharma Ltd Frusemide USP 20mg & Spironolactone USP 50mg/tablet Tablet 30s pack: 150.00 MRP
FUSID 20 PLUS Square Pharmaceuticals Ltd. Furosemide 20mg + Spironolactone 50mg Tablet 2x20's: 321.20 MRP
FUSID 40 PLUS Square Pharmaceuticals Ltd. Furosemide 40mg + Spironolactone 50mg Tablet 2x20's: 401.20 MRP
FUSID PLUS Square Pharmaceuticals Ltd. Frusemide 20mg+ Spironolactone 50mg Tablet 40's: 320.00 MRP
LACITONE General Pharmaceuticals Ltd Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.60 MRP
LASILACTONE Sanofi Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 50's: 301.00 MRP
LAXICON The White Horse Pharma Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.00 MRP
LAXUR Healthcare Pharmacuticals Ltd. Frusemide 20mg & spironolactone 50mg/tablet Tablet 30s pack: 180.00 MRP
LAXUR TAB Healthcare Pharmacuticals Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Film Coated Tablet 30's MRP 240 Tk
REDEMA 20 Rangs Pharmaceuticals Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.00 MRP
REDEMA 40 Rangs Pharmaceuticals Ltd. Frusemide BP 40mg+ Spironolactone BP 50mg Tablet 30's: 240.00 MRP
TONEMIDE Pacific Pharmaceuticals Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.00 MRP
UROSPIN Biopharma Laboratories Ltd Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 180.60 MRP
VEROSPIRON Plus Ambee Pharmaceuticals Ltd. Frusemide BP 20mg+ Spironolactone BP 50mg Tablet 30's: 150.60 MRP
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