(tam soo' loe sin)
|Indication & Dosage||Oral
Benign prostatic hyperplasia
Adult:Â As HCl: As modified-release preparation: 400 mcg once daily. May increase to 800 mcg once daily after 2-4 wk if necessary. If therapy is interrupted for several days, restart with 400 mcg once daily. Dose to be taken 30 minutes after the same meal each day.
|Administration||Orodispersible extended release tab: Should be taken with food. Take after meals. Place on the tongue
& allow to dissolve. Then, swallow w/ saliva or water.Â
Prolonged release tab: May be taken with or without food. Swallow whole, do not chew/crush.
Cap: Should be taken with food. Take Â½ hr following the same meal daily. Swallow whole, do not open/chew/crush.
|Overdose||Hypotension, headache. Keep in supine position to restore BP and heart rate. If needed, admin of IV fluid and vasopressors. Dialysis unlikely to be of benefit.|
|Contraindications||Hypersensitivity to sulfonamide, severe hepatic impairment, lactation.|
|Special Precautions||Prostate carcinoma should be ruled out before starting the therapy. Risk of intraoperative floppy iris syndrome in patients who undergo cataract surgery. May cause orthostatic hypotension or syncope especially with first dose, if dosage is increased or an antihypertensive drug or a phosphodiesterase-5 inhibitor is added to the treatment regimen. Caution when used in patients with sulfa allergy. May cause priapism (rare); immediate medical attention is recommended. Pregnancy.|
|Adverse Drug Reactions||Postural hypotension, dizziness and vertigo, malaise, headache, rhinitis, pharyngitis, cough, sinusitis, diarrhoea, nausea, infection, asthenia, back pain, tooth disorder, chest pain, somnolence, insomnia, decreased libido, abnormal ejaculation, priapism, blurred vision. Risk of intraoperative floppy iris syndrome during phacoemulsification surgery.|
|Drug Interactions||Concomitant admin with moderate or strong inhibitors of CYP2D6
(eg. fluoxetine) or CYP34A (eg. ketoconazole, cimetidine) increases serum concentration.
Potentially Fatal:Â Concomitant admin with moderate or strong inhibitors of CYP2D6 (eg. fluoxetine) or CYP34A (eg. ketoconazole, cimetidine) increases serum concentration.Â Please consult manufacturer's PIL (Prescribing Information Leaflet) for detailed drug interactions.
|Food Interaction||Food reduced extent and rate of absorption.|
|Pregnancy Category (US FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Storage||Oral:Â Store at 25Â°C.|
|Pharmacology||Tamsulosin is a selective
Î±1Â adrenoreceptor-blocking agent. Smooth muscle tone is mediated by the sympathetic nervous stimulation of Î±1adrenoreceptors, which
are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck. Blockade of these adrenoceptors can cause smooth muscles in the bladder
neck and prostate to relax, resulting in an improvement in urine flow rate and reduction in symptoms in BPH.
Absorption:Â Completely absorbed from the GI tract. Peak plasma concentrations after 1 hr; 6 hr (modified-release preparation).
Distribution:Â Protein-binding: 99%.
Metabolism:Â Metabolised slowly in the liver primarily by CYP2D6 and CYP3A4.
Excretion:Â Excreted in urine (76%) and faeces (21%). Plasma elimination half life: 4-5.5 hr; as modified-release preparation : 10-13 hr.
|ATC Classification||G04CA02 - tamsulosin; Belongs to the class of alpha-adrenoreceptor antagonists. Used in the treatment of benign prostatic hypertrophy.|
Total Products : 20
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|FLONOR||Novo Healthcare and Pharma Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x16's: 160.00 MRP|
|MAXFLO-U||Rangs Pharmaceuticals Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x28's: 280.00 MRP|
|MAXRIN 0.4||Square Pharmaceuticals Ltd.||Tamsulosin 0.4mg||Capsule||3x10's: 302.10 MRP|
|MICTROL||Radiant Pharmaceuticals Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x30's: 300.00 MRP|
|Prostacin MR||Incepta Pharmaceuticals Limited||Tamsulosin Hydrochloride INN 0.4 mg||Capsule (Modified Release)||28's:MRP 280 Tk|
|PROSTAM||Drug International Ltd||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x30's: 300.00 MRP|
|PROSTANIL MR||Aristopharma Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x30's: 300.00 MRP|
|SASOLIN MR||ACI Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x16'sp ack: 160.64 MRP|
|TAMISOL MR||Healthcare Pharmacuticals Ltd.||Tamsulosin Hydrochloride INN 0.4mg||Capsule (Modified Release)||30's MRP 300 Tk|
|TAMLOSIN||Orion Pharma Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x20's: 200.80 MRP|
|TAMOSIN||Supreme Pharmaceuticals Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x20's: 200.00 MRP|
|TAMSIN||Delta Pharma Limited||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x12's, 0.4mg x30's: 120.00 & 300.00 MRP|
|TAMSOL||Apex Pharmaceuticals Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x20's: 200.00 MRP|
|URINOM||Opsonin Pharma Limited||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x20's: 200.00 MRP|
|UROCAP||IBN SINA Pharmaceutical Industry Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x30's: 300.00 MRP|
|UROFLO||Beximco Pharmaceuticals Ltd||Tamsulosin Hydrochloride INN 0.4mg||Capsule (Modified Release)||20's: 200.00 MRP|
|UROLOSIN||General Pharmaceuticals Ltd||Tamsulosin hydrochloride INN 0.4mg||Tablet||0.4mg x28's: 281.12 MRP|
|UROMAX||Unimed & Unihealth Manufacturers Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x28's: 280.00 MRP|
|UROPASS||The Acme Laboratories Ltd.||Tamsulosin hydrochloride INN 0.4mg||Capsule||0.4mg x20's: 200.80 MRP|
|UROSIN SR||Eskayef Bangladesh Ltd||Tamsulosin Hydrochloride INN 0.4mg||Capsule (Sustained Release)||18's MRP: 180.00|