mph Bangladesh


Tamsulosin

(tam soo' loe sin)

Molecule Info

 
Indication & Dosage Oral
Benign prostatic hyperplasia
Adult: As HCl: As modified-release preparation: 400 mcg once daily. May increase to 800 mcg once daily after 2-4 wk if necessary. If therapy is interrupted for several days, restart with 400 mcg once daily. Dose to be taken 30 minutes after the same meal each day.
CrCl (ml/min) Dosage Recommendation
≥10 No dose adjustment needed.
<10 Not studied.
Hepatic impairment: Moderate hepatic impairment (Child-Pugh classification A and B): No dose adjustment needed. Severe hepatic impairment: Avoid.
Administration Orodispersible extended release tab: Should be taken with food. Take after meals. Place on the tongue & allow to dissolve. Then, swallow w/ saliva or water. 
Prolonged release tab: May be taken with or without food. Swallow whole, do not chew/crush.
Cap: Should be taken with food. Take ½ hr following the same meal daily. Swallow whole, do not open/chew/crush.
Overdose Hypotension, headache. Keep in supine position to restore BP and heart rate. If needed, admin of IV fluid and vasopressors. Dialysis unlikely to be of benefit.
Contraindications Hypersensitivity to sulfonamide, severe hepatic impairment, lactation.
Special Precautions Prostate carcinoma should be ruled out before starting the therapy. Risk of intraoperative floppy iris syndrome in patients who undergo cataract surgery. May cause orthostatic hypotension or syncope especially with first dose, if dosage is increased or an antihypertensive drug or a phosphodiesterase-5 inhibitor is added to the treatment regimen. Caution when used in patients with sulfa allergy. May cause priapism (rare); immediate medical attention is recommended. Pregnancy.
Adverse Drug Reactions Postural hypotension, dizziness and vertigo, malaise, headache, rhinitis, pharyngitis, cough, sinusitis, diarrhoea, nausea, infection, asthenia, back pain, tooth disorder, chest pain, somnolence, insomnia, decreased libido, abnormal ejaculation, priapism, blurred vision. Risk of intraoperative floppy iris syndrome during phacoemulsification surgery.
Drug Interactions Concomitant admin with moderate or strong inhibitors of CYP2D6 (eg. fluoxetine) or CYP34A (eg. ketoconazole, cimetidine) increases serum concentration.
Potentially Fatal: Concomitant admin with moderate or strong inhibitors of CYP2D6 (eg. fluoxetine) or CYP34A (eg. ketoconazole, cimetidine) increases serum concentration. Please consult manufacturer's PIL (Prescribing Information Leaflet) for detailed drug interactions.
Food Interaction Food reduced extent and rate of absorption.
Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Storage Oral: Store at 25°C.
Pharmacology Tamsulosin is a selective α1 adrenoreceptor-blocking agent. Smooth muscle tone is mediated by the sympathetic nervous stimulation of α1adrenoreceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck. Blockade of these adrenoceptors can cause smooth muscles in the bladder neck and prostate to relax, resulting in an improvement in urine flow rate and reduction in symptoms in BPH.
Absorption: Completely absorbed from the GI tract. Peak plasma concentrations after 1 hr; 6 hr (modified-release preparation).
Distribution: Protein-binding: 99%.
Metabolism: Metabolised slowly in the liver primarily by CYP2D6 and CYP3A4.
Excretion: Excreted in urine (76%) and faeces (21%). Plasma elimination half life: 4-5.5 hr; as modified-release preparation : 10-13 hr.
ATC Classification G04CA02 - tamsulosin; Belongs to the class of alpha-adrenoreceptor antagonists. Used in the treatment of benign prostatic hypertrophy.

Brand/Product Info


Total Products : 20                    
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
FLONOR Novo Healthcare and Pharma Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x16's: 160.00 MRP
MAXFLO-U Rangs Pharmaceuticals Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x28's: 280.00 MRP
MAXRIN 0.4 Square Pharmaceuticals Ltd. Tamsulosin 0.4mg Capsule 3x10's: 302.10 MRP
MICTROL Radiant Pharmaceuticals Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x30's: 300.00 MRP
Prostacin MR Incepta Pharmaceuticals Limited Tamsulosin Hydrochloride INN 0.4 mg Capsule (Modified Release) 28's:MRP 280 Tk
PROSTAM Drug International Ltd Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x30's: 300.00 MRP
PROSTANIL MR Aristopharma Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x30's: 300.00 MRP
SASOLIN MR ACI Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x16'sp ack: 160.64 MRP
TAMISOL MR Healthcare Pharmacuticals Ltd. Tamsulosin Hydrochloride INN 0.4mg Capsule (Modified Release) 30's MRP 300 Tk
TAMLOSIN Orion Pharma Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x20's: 200.80 MRP
TAMOSIN Supreme Pharmaceuticals Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x20's: 200.00 MRP
TAMSIN Delta Pharma Limited Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x12's, 0.4mg x30's: 120.00 & 300.00 MRP
TAMSOL Apex Pharmaceuticals Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x20's: 200.00 MRP
URINOM Opsonin Pharma Limited Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x20's: 200.00 MRP
UROCAP IBN SINA Pharmaceutical Industry Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x30's: 300.00 MRP
UROFLO Beximco Pharmaceuticals Ltd Tamsulosin Hydrochloride INN 0.4mg Capsule (Modified Release) 20's: 200.00 MRP
UROLOSIN General Pharmaceuticals Ltd Tamsulosin hydrochloride INN 0.4mg Tablet 0.4mg x28's: 281.12 MRP
UROMAX Unimed & Unihealth Manufacturers Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x28's: 280.00 MRP
UROPASS The Acme Laboratories Ltd. Tamsulosin hydrochloride INN 0.4mg Capsule 0.4mg x20's: 200.80 MRP
UROSIN SR Eskayef Bangladesh Ltd Tamsulosin Hydrochloride INN 0.4mg Capsule (Sustained Release) 18's MRP: 180.00

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