(kan des ar' tan)
P / L : Contraindicated in pregnancy and lactation
Indication(s) & Dosage
Candesartan is indicated for the treatment of hypertension in adults and children 1 to <17 years of age. It may be used alone or in combination with other antihypertensive agents.
Candesartan is indicated for the treatment of heart failure (NYHA Class II-IV) in patients with left-ventricular systolic dysfunction (ejection fraction â‰¤40%) to reduce cardiovascular death and to reduce heart failure hospitalizations. Candesartan also has an added effect on these outcomes when used with an ACE inhibitor.
Hypertension Adult: Initially, 8 mg once daily adjusted according to response. Maintenance: 8 mg once daily. Max: 32 mg daily. Renal impairment: For patients with renal impairment or on haemodialysis: Initially, 4 mg once daily. Hepatic impairment: Initially, 2 mg once daily. Avoid in severe impairment. Oral Heart failure Adult: Initially, 4 mg once daily, may double dose at intervals of not <2 wk. Max: 32 mg daily. Renal impairment: Reduce dose or discontinue treatment if renal function deteriorates. Hepatic impairment: Initially, 2 mg once daily. Avoid in severe impairment. Special Populations: Patients with renal and hepatic impairment: Initially, 2 mg once daily.
May be taken with or without food.
Hypersensitivity. Pregnancy and lactation.
Volume or sodium depletion, preexisting renal insufficiency; aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy, renal artery stenosis, primary hyperaldosteronism. Patients with a history of angioedema, urticaria. Monitor serum potassium levels especially in elderly and renally impaired patients. Hypotension may occur during major surgery and anaesthesia due to suppression of the renin-angiotensin system.
Dizziness, headache, vertigo, depression, somnolence, fever, back pain, upper respiratory tract infections, 1st dose orthostatic hypotension, rash, diarrhoea, decreased haemoglobin, renal impairment, hepatitis.
Prior treatment with diuretics increases risk of excessive hypotension; use a lower initial dose. Potassium, potassium-sparing diuretics, trimethoprim or potassium supplements may increase risk of hyperkalaemia. NSAIDs may reduce antihypertensive response and increase risk of hyperkalaemia or acute renal failure. Excretion of lithium may be reduced; monitor lithium concentration.
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk.
Oral: Store at 15-30°C.
Candesartan inhibits the binding of angiotensin II to AT1 receptors in many tissues such as vascular smooth muscles and adrenal gland which leads to vasoconstriction blockade and aldosterone release. Absorption: Absorbed from the GI tract; peak plasma concentrations after 3-4 hr. Distribution: Protein-binding: 99%. Metabolism: Hydrolysed to the active form, candesartan. Excretion: Via urine and bile; 9 hr.
C09CA06 - candesartan; Belongs to the class of angiotensin II antagonists. Used in the treatment of cardiovascular disease.
Search Google: Candesartan
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ARB 8||Square Pharmaceuticals Ltd.||Candesartan cilexetil INN 8mg/tablet||Tablet||8mg x 30s pack: 180.00 MRP|
|CANDESA||General Pharmaceuticals Ltd||Candesartan cilexetil INN 4,8 & 16mg /tablet||Tablet||30's pack each: 105.00, 180.00 & 330.00 MRP|
|GIRAN||Aristopharma Ltd.||Candesartan cilexetil INN 8 & 16mg||Tablet||30's each: 180.00 & 330.00 MRP|
|VESOTAN||Rangs Pharmaceuticals Ltd.||Candesartan cilexetil INN 8 & 16mg||Tablet||30's each: 180.00 & 330.00 MRP|
|Tell your doctor if you are pregnant or plan to become pregnant. Do not take candesartan if you are pregnant. If you become pregnant while you are taking candesartan, stop taking candesartan and consult your doctor immediately. Candesartan may cause death or serious injury to the fetus when taken in the last 6 months of pregnancy.|
Why Candesartan is prescribed?
Candesartan is used alone or in combination with other medications to treat high blood pressure. Candesartan is also used alone or in combination with other medications to treat congestive heart failure. Candesartan is in a class of medications called angiotensin II receptor antagonists. It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently.
Candesartan comes as a tablet to take by mouth. It is usually taken once or twice a day with or without food. To help you remember to take candesartan, take it at around the same time every day. Follow the directions on your prescription label carefully, and ask your Doctor to explain any part you do not understand. Take candesartan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of candesartan and gradually increase your dose not more than once every 2 weeks.
Candesartan controls high blood pressure but does not cure it. Your blood pressure may decrease during the first 2 weeks of your treatment, but it may take 4 to 6 weeks for you to notice the full benefit of candesartan. Continue to take candesartan even if you feel well. Do not stop taking candesartan without talking to your doctor.
Candesartan is also sometimes used to treat diabetic nephropathy. Talk to your doctor about the risks of using this medication for your condition.
This medication may be prescribed for other uses; ask your Doctor for more information.
What Special Precautions should I follow?
Before taking candesartan,
- tell your Doctor if you are allergic to candesartan, any other medications, or any of the ingredients in candesartan tablets. Ask your Doctor for a list of the ingredients.
- tell your doctor if you have diabetes and you are taking aliskiren. Your doctor will probably tell you not to take candesartan if you have diabetes and you are also taking aliskiren.
- tell your Doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiotensin-converting enzyme inhibitors such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril,, quinapril, ramipril, and trandolapril; aspirin and other nonsteroidal anti-inflammatory medications such as ibuprofen and naproxen, diuretics including spironolactone; lithium; medications for diabetes; other medications for high blood pressure;and potassium supplements. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had heart, kidney, or liver disease.
- tell your doctor if you are breast-feeding.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking candesartan.
- you should know that candesartan may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking candesartan. To help void this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
- you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting. Tell your doctor if you have any of these problems or develop them during your treatment.
What special dietary instructions should I follow?
Do not use salt substitutes containing potassium without talking to your doctor. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Candesartan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- back pain
- sore throat
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- difficulty breathing or swallowing
- decreased urination
Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, consult your doctor immediately:
Candesartan may cause other side effects. Consult your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Office of Directorate General, Drugs Administration.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed. Talk to your Doctor about the proper disposal of your medication.
In case of overdose, consult your Doctor. If the victim has collapsed or is not breathing, consult local medical emergency services..
Symptoms of overdose may include the following:
- fast or slow heart beat
- What other information should I know?
Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to candesartan.
Do not let anyone else take your medication.
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Before Calling Emergency
Determine the following information:
- Patient's age, weight and condition
- Name of the product/medicine (ingredients and strengths, if possible)
- Time it was swallowed/taken
- Amount swallowed/taken
What to Expect at the Emergency Room
The Health Care Provider/ Emergency Doctor will measure and monitor the patient's vital signs, including temperature, pulse, breathing rate and blood pressure. Symptoms will be treated as appropriate. The patient may receive:
- Antidote, gastric lavage, activated charcoal or other drugs/procedures as required
- Blood tests to determine body chemical levels and blood acid/base balance
- EKG/ECG test
- Medicines to correct fluid and electrolyte imbalances
Do not let anyone else take your medicine.
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted into a hospital. It is also important information to carry with you in case of emergencies.
Ref: U.S. Natl. Library of Medicine
|| See Brand Manufacturer's Prescribing Information |||| CANDESARTAN ||