Betaxolol

(be tax' oh lol)

P  - Contraindicated in pregnancy

L  - Caution when used during lactation

Molecule Info

Indication & Dosage

Oral
Angina pectoris
Adult: Initially, 10-20 mg once daily. May increase dose to 40 mg/day if necessary after 7-14 days depending on the patient's response.
Elderly: Initial dose of 5-10 mg/day.
Renal impairment: Patients with severe impairment or on dialysis: initially, 5 mg daily. May increase by 5 mg every 2 wk. Max: 20 mg daily. 
Oral
Hypertension
Adult: Initially, 10-20 mg once daily. May increase dose to 40 mg/day if necessary after 7-14 days depending on the patient's response.
Elderly: Initial dose of 5-10 mg/day.
Renal impairment: Patients with severe impairment or on dialysis: initially, 5 mg daily. May increase by 5 mg every 2 wk. Max: 20 mg daily. 
Ophthalmic
Open-angle glaucoma
Adult: Instil 1 drop of 0.25% or 0.5% solution bid.
Ophthalmic
Ocular hypertension
Adult: Instil 1 drop of 0.25% or 0.5% solution bid.

Special Populations: Reduce dose in patients with severe renal impairment.

Administration

May be taken with or without food.

Overdosage

May lead to bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia. Stop treatment and observe patient.

Contraindications

Sinus bradycardia, cardiogenic shock, overt cardiac failure. Pregnancy .

Special Precautions

Poor cardiac reserve, bronchospastic diseases, DM, renal or hepatic impairment. May mask signs of hyperthyroidism. Gradual withdrawal is recommended. Children. Lactation.

Adverse Drug Reactions

Topical use in eye: Mild ocular stinging and discomfort, usually transient and well-tolerated. Rarely, decreased corneal sensitivity, erythema, itching, keratitis and photophobia reported; tiredness, fatigue, headache, impotence, sleep disturbances, cold hands and feet, GI upsets, bradycardia especially in elderly.

Drug Interactions

May cause mydriasis when used concurrently with epinephrine. Close observation needed when on β-blocker and catecholamine-depleting drugs such as reserpine, due to possible additive effects resulting in hypotension and/or bradycardia. Caution when used concomitantly with adrenergic, psychotropic drugs.
Potentially Fatal: Enhances calcium channel blockers, anaesthetics and clonidine.
 betaxolol

Pregnancy Category

ROUTE : OPHTH

Category C: Either studies in animals have revealed adverse effects on the foetus and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

 

ROUTE : PO

D in 2nd & 3rd trimesters.

Category C: Either studies in animals have revealed adverse effects on the foetus and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Storage

Store at 15-25°C.

Pharmacology

Betaxolol is a cardioselective β-blocker which has greater affinity for β1-receptors and has little or no effect on β2-receptors. It also causes the reduction of intraocular pressure by decreasing the production of aqueous humor.
Absorption: Completely absorbed from the GI tract and undergoes minimal first pass effect.
Distribution: Protein binding: 50%. Crosses the placenta and distributes into the breast milk.
Excretion: Elimination half-life: about 16-20 hr. Mainly excreted via hepatic metabolism and urinary excretion.

mph Class

Beta-Blockers / Antiglaucoma Preparations

ATC Classification

S01ED02 - betaxolol; Belongs to the class of beta blocking agents used in the treatment of glaucoma and miosis. 
C07AB05 - betaxolol; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.

 

Search Google: Betaxolol

Brand/Product Info


Total Products : 4    
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
BETAXOL Aristopharma Ltd. Betaxolol hydrochloride BP equivalent to Betaxolol 2.5mg/ml (0.25% w/v) Eye Drop 5ml: 150.00 MRP
GLUCOVIS Beximco Pharmaceuticals Ltd Betaxolol Hydrochloride BP eq. to Betaxolol 2.5mg/ml Drop 5ml: 200.00 MRP
OPTALOC Popular Pharmaceuticals Ltd. Betaxolol hydrochloride BP equivalent to Betaxolol 5mg/ml (0.5% w/v) Eye Drop 5ml: 200.75 MRP
OPTIBET Jayson Pharmaceuticals Ltd. Betaxolol hydrochloride BP equivalent to Betaxolol 2.5mg/ml (0.25% w/v) Eye Drop 5ml: 150.56 IP

Gen. MedInfo

Why is this medication prescribed 

Betaxolol is used alone or with other medications to control high blood pressure. Betaxolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure.

How should this medicine be used?

Betaxolol may come as a tablet to take by mouth. It is usually taken once a day. Take betaxolol at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take betaxolol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on an average dose of betaxolol and may increase your dose after 7-14 days if your blood pressure is not controlled.

Betaxolol controls high blood pressure but does not cure it. It may take 1-2 weeks or longer before the full benefit of betaxolol is noted. Continue to take betaxolol even if you feel well. Do not stop taking betaxolol without talking to your doctor. If you suddenly stop taking betaxolol, your blood pressure may increases and you may develop new or worsening chest pain. Your doctor will probably decrease your dose gradually over about 2 weeks and will monitor you carefully during this time. Your doctor may also tell you to limit physical activity while your dose is being decreased.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking betaxolol,

  • tell your doctor if you are allergic to betaxolol, any other medications, or any of the ingredients in betaxolol tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone; beta blocker eye drops such as betaxolol, Carteolol, levobunolol, metipranolol, and timolol; calcium channel blockers such as diltiazem, nifedipine, and verapamil; clonidine; digoxin; disopyramide; epinephrine; and reserpine . Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have heart failure or any other heart problems. Your doctor may tell you not to take betaxolol if you have serious heart failure or certain other heart problems.
  • tell your doctor if you have or have ever had angina; asthma or other lung disease; diabetes; psoriasis; pheochromocytoma; or kidney, liver, or thyroid disease. Also tell your doctor if you have ever had a serious allergic reaction to any food, medication, or other substance.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking betaxolol, consult your doctor.
  • tell any doctor/ dentist who will be treating you that you are taking betaxolol. This is especially important if you are having surgery, including dental surgery.
  • you should know that betaxolol may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Symptoms of overdose may include:

  • difficulty breathing, especially during activity or when lying down
  • swelling of the arms, hands, feet, ankles, or lower legs
  • unexplained weight gain
  • chest pain
  • fast, pounding, slow, or irregular heartbeat

What side effects can this medication cause?

Betaxolol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • extreme tiredness
  • difficulty falling asleep or staying asleep
  • unusual dreams
  • heartburn
  • nausea
  • diarrhea
  • joint pain
  • decreased sexual ability in men
  • cold hands and feet
  • numbness, burning, or tingling in the arms, legs, hands, or feet
  • rash

Some side effects can be serious. If you experience any of these symptoms, consult your doctor immediately:

  • difficulty breathing, especially during activity or when lying down
  • swelling of the arms, hands, feet, ankles, or lower legs
  • unexplained weight gain
  • fast, slow, pounding, or irregular heartbeat
  • chest pain

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture . Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Betaxolol may cause other side effects. Consult your doctor if you have any unusual problems while taking this medication.

This medication may cause other side effects.  Consult your doctor if you have any unusual problems while taking this.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

 


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.