(mek' li zeen)
P - Caution when used during pregnancy
L - Caution when used during lactation
|Indication(s) & Dosage||Oral route
Adult: 25-50 mg 1 hr before travelling and repeat every 24 hr if needed.
Child: As hydrochloride: 2-6 yr: 6.25 mg once daily; 6-12 yr: 12.5 mg once daily; >12 yr: 25-50 mg 1 hr before travelling and repeat every 24 hr if needed.
Vertigo and vestibular disorders
Adult: Up to 100 mg daily in divided doses.
|Special Precautions||Angle-closure glaucoma, prostatic hyperplasia; pyloric or duodenal obstruction; asthma. Elderly. May affect the ability to drive or operate machinery. Pregnancy and lactation.|
|Adverse Drug Reaction(s)||Drowsiness, thickening of bronchial secretions, dry mouth, fatigue, blurred vision.|
|Drug Interactions||Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol. Please consult detailed drug interactions before prescribing.|
|Pregnancy Category (FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Storage||Oral: Conventional tablet: Store at 15-30°C (59-86°F). Chewable tablet: Store below 30°C (86°F).|
|Pharmacology||Meclozine blocks vasopressor response to histamine and has a slight blocking action against acetylcholine. It decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways.
Onset: About 1 hr (oral).
Duration: 8-24 hr (oral).
Excretion: Via urine (as metabolites); via faeces (as unchanged drug).
|ATC Classification||R06AE05 - meclizine/meclozine; Belongs to the class of piperazine derivatives used as systemic antihistamines.|
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ACLIZ||Aristopharma Ltd.||Meclizine hydrochloride 50mg||Tablet||100's: 250.00 MRP|
|ANOSEA||IBN SINA Pharmaceutical Industry Ltd.||Meclizine hydrochloride 50mg||Tablet||50's: 130.00 IP|
|ANTIVERT||Chemist Laboratories Ltd.||Meclizine hydrochloride 50mg||Tablet||100's: 250.00 MRP|
|AVERT||Biopharma Laboratories Ltd||Meclizine hydrochloride 50mg||Tablet||50's: 125.50 MRP|
|CLIZIN||Peoples Pharma Ltd.||Meclizine hydrochloride 50mg||Tablet||100's: 219.82 MRP|
|EMEGO||Opsonin Pharma Limited||Meclizine hydrochloride 50mg||Tablet||50's: 125.00 MRP|
|Emenil||Incepta Pharmaceuticals Limited||Meclizine Hydrochloride USP 50 mg||Film Coated Tablet||10x10's:MRP 250 Tk|
|EMEZIN||Eskayef Bangladesh Ltd||Meclizine Hydrochloride USP 50mg||Tablet||50's MRP: 125.00|
|MECZIN 10||Ad-din pharmaceuticals Ltd.||Meclizine hydrochloride 10mg||Tablet||50's: 125.00 MRP|
|MECZIN 50||Ad-din pharmaceuticals Ltd.||Meclizine hydrochloride 50mg||Tablet||50's: 125.00 MRP|
|NOMOSIC||Drug International Ltd||Meclizine hydrochloride 50mg||Tablet||50's: 125.00 MRP|
|VOMEC||Beximco Pharmaceuticals Ltd||Meclizine Hydrochloride USP 50mg||Tablet||50's: 125.00 MRP|
Why is this medication prescribed?
Meclizine is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. It is most effective if taken before symptoms appear.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?
Meclizine comes as a regular and chewable tablet and a capsule. For motion sickness, meclizine should be taken 1 hour before you start to travel. Doses may be taken every 24 hours if needed. For dizziness caused by an ear condition, follow your doctor's directions. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take meclizine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
The chewable tablets may be chewed or swallowed whole.
What special precautions should I follow?
Before taking meclizine,
- tell your doctor if you are allergic to meclizine or any other drugs.
- tell your doctor what prescription and nonprescription medications you are taking, especially amobarbital (Amytal), medications for colds or allergies, pain medications, phenobarbital, sedatives, seizure medications, sleeping pills, tranquilizers, and vitamins. These drugs may increase the drowsiness caused by meclizine.
- tell your doctor if you have or have ever had glaucoma, an enlarged prostate, urinary tract blockage, or asthma.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking meclizine, call your doctor.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Meclizine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
drowsiness or fatigue
- dry mouth
If you experience the following symptom, call your doctor immediately:
- blurred vision
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: U.S. National Library of Medicine.
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.