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Bromocriptine

(broe moe krip' teen)

PCI  : Contraindicated in pregnancy

LCI  : Contraindicated in lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage Parkinson's disease
Adult: As adjunct to levodopa: 1st wk: Initially, 1-1.25 mg at night; 2nd wk: 2-2.5 mg at night; 3rd wk: 2.5 mg bid; 4th wk: 2.5 mg tid, then increased by 2.5 mg every 3-14 days as required. Maintenance: 10-40 mg daily.

Hypogonadism
Adult: 1-1.25 mg at bedtime increased to 2-2.5 mg at bedtime after 2-3 days and subsequently increased by 1 mg at 2-3 days intervals, up to 2.5 mg bid or more if necessary. Max: 30 mg daily.

Galactorrhoea
Adult: 1-1.25 mg at bedtime increased to 2-2.5 mg at bedtime after 2-3 days and subsequently increased by 1 mg at 2-3 days intervals, up to 2.5 mg bid or more if necessary. Max: 30 mg daily.

Infertility
Adult: 1-1.25 mg at bedtime increased to 2-2.5 mg at bedtime after 2-3 days and subsequently increased by 1 mg at 2-3 days intervals, up to 2.5 mg bid or more if necessary. Max: 30 mg daily.

Adjunct to surgery and radiotherapy in patients with acromegaly
Adult: Initially, 2.5 mg bid, may increase further by 2.5 mg every 2-3 days, if necessary up to 5 mg every 6 hr depending on response.

Suppression of lactation
Adult: 2.5 mg daily for 2-3 days, increased gradually to 2.5 mg bid for 14 days.

Prophylaxis of puerperal lactation
Adult: 2.5 mg on the day of delivery followed by 2.5 mg bid for 14 days.

Cyclical benign breast and menstrual disorders
Adult: 2.5 mg bid.
Administration Should be taken with food.
Contraindications Breast carcinoma, hypersensitivity to ergot alkaloids, uncontrolled hypertension, severe ischaemic heart disease. Pregnancy and lactation.
Special Precautions Increased risk of conception, patients with peptic ulcer, diabetes, diabetic retinopathy, impaired hepatic or renal function, pleuropulmonary signs and symptoms, history of psychosis, CV disease, dementia or concurrent antihypertensive therapy, ability to drive vehicles or operating machinery may be impaired.
Adverse Drug Reaction(s) Nausea, vomiting, gastric haemorrhage (acromegaly), dizziness, headache, drowsiness, depression, postural hypotension, nasal congestion, pleural effusion, mania, ataxia. High doses produce confusion, hallucinations, delirium, psychosis.
Drug Interactions Bioavailability increased if given along with erythromycin. Alcohol reduces tolerance to bromocriptine and vice-versa. Effects of antihypertensives may be potentiated. Avoid concurrent psychotropics. Please consult detailed drug interactions before prescribing. 
Food Interaction Food reduces nausea caused by bromocriptine.
Pregnancy Category (FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Pharmacology Bromocriptine is a dopamine D2 and D3-agonist which works by activating postsynaptic dopamine receptors in the tuberoinfundibular and nigrostriatal pathways. It also inhibits the secretion of prolactin from the anterior pituitary and is used in the treatment of prolactinoma and in endocrinological disorders.
Absorption: 30% absorbed from the GIT (oral).
Distribution: Protein-binding: 90-96%
Metabolism: Extensive hepatic first-pass metabolism by hydrolysis to lysergic acid and peptides.
Excretion: Mainly via faeces, via urine (minimal amounts).
ATC Classification G02CB01 - bromocriptine; Belongs to the class of prolactine inhibitors. Used to suppress lactation. 
N04BC01 - bromocriptine; Belongs to the class of dopamine agonist. Used in the management of parkinson's disease.

Brand/Product Info


Total Products : 6      
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
BROMERGON Sandoz/Novartis Bromocriptine mesylate 2.5mg Tablet 30's & 60's: 400.20 & 840.00 MRP
BROMOCRIPTINE RICHTER Gedeon Richter/City Overseas Bromocriptine mesylate 2.5mg Tablet 30's: 550.00 TP
BROMODEL Opsonin Pharma Limited Bromocriptine mesylate 2.5mg Tablet 30's: 300.00 MRP
BROMOLAC 2.5 Square Pharmaceuticals Ltd. Bromocriptine 2.5mg Tablet 2x15's: 360.90 MRP
BROMOTINE Nuvista Pharma Limited Bromocriptine mesylate 2.5mg Tablet 30's: 300.00 MRP
CRIPTINE Renata Limited Bromocriptine mesylate 2.5mg Tablet 30's: 301.20 MRP

Gen. MedInfo

Why is Bromocriptine prescribed?

Bromocriptine is used to treat symptoms of hyperprolactinemia (high levels of a natural substance called prolactin in the body) including lack of menstrual periods, discharge from the nipples, infertility (difficulty becoming pregnant) and hypogonadism (low levels of certain natural substances needed for normal development and sexual function). Bromocriptine may be used to treat hyperprolactinemia caused by certain types of tumors that produce prolactin, and may shrink these tumors. Bromocriptine is also used alone or with other treatments to treat acromegaly (condition in which there is too much growth hormone in the body) and Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance). Bromocriptine is used with a diet and exercise program and sometimes with other medications to control blood sugar levels in people with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Bromocriptine is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated). Bromocriptine is in a class of medications called dopamine receptor agonists. It treats hyperprolactinemia by decreasing the amount of prolactin in the body. It treats acromegaly by decreasing the amount of growth hormone in the body. It treats Parkinson's disease by stimulating the nerves that control movement. The way bromocriptine works to treat diabetes is not known.

How should Bromocriptine be used?

Bromocriptine comes as a capsule and a tablet to take by mouth. Bromocriptine comes as a tablet to take by mouth. When bromocriptine is used to treat hyperprolactinemia, it is usually taken once a day with food. When bromocriptine is used to treat acromegaly, it is usually taken once a day at bedtime with food. When bromocriptine is used to treat Parkinson's disease, it is usually taken twice a day with food. Bromocriptine is usually taken once a day with food within 2 hours of waking in the morning. Take bromocriptine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Take bromocriptine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of bromocriptine and gradually increase your dose, not more than once every 2 to 28 days. The timing of the dose increases depends on the condition being treated and on your response to the medication.

Bromocriptine may help to control your condition but will not cure it. It may take some time for you to feel the full benefit of bromocriptine. Do not stop taking bromocriptine without talking to your doctor. If you stop taking bromocriptine, your condition may worsen.

If you are taking bromocriptine for diabetes, please carefully read manufacturer's information for the patient.

Other uses for Bromocriptine

Bromocriptine should not be used to stop breast milk production in women who have had an abortion or stillbirth or who have chosen not to breast-feed; bromocriptine may cause serious or fatal adverse effects in these women.Talk with your doctor about the possible risks of using Bromocriptine for your condition.

Bromocriptine may be prescribed for other uses; ask your doctor for more information.

What special precautions to follow?

Before taking bromocriptine, 

  • inform your doctor if you are allergic to bromocriptine; ergot alkaloids such as cabergoline, dihydroergotamine, ergoloid mesylates, ergonovine, ergotamine, methylergonovine, methysergide, and pergolide; any other medications; or any of the ingredients in bromocriptine tablets or capsules. 
  • inform your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amitriptyline; antifungals such as itraconazole  and ketoconazole; antihistamines; chloramphenicol; dexamethasone; other dopamine agonists such as cabergoline, levodopa, pergolide, and ropinirole; ergot-type medications such as dihydroergotamine, ergoloid mesylates, ergonovine, ergotamine, methylergonovine, and methysergide; haloperidol; imipramine; insulin; macrolide antibiotics such as clarithromycin  and erythromycin; certain medications for human immunodeficiency virus  or acquired immunodeficiency syndrome  such as indinavir, nelfinavir, and ritonavir; oral medications for diabetes; medications for asthma, colds, high blood pressure, migraines, and nausea; medications for mental illness such as clozapine, olanzapine, thiothixene, and ziprasidone; methyldopa; metoclopramide; nefazodone; octreotide; pimozide; probenecid; reserpine; rifampin; and sumatriptan . Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with bromocriptine, so be sure to inform your doctor about all the medications you are taking, even those that do not appear on this list.
  • inform your doctor if you have high blood pressure or migraine headaches that cause fainting. Your doctor may inform you not to take bromocriptine.
  • inform your doctor if you have recently given birth, if you have ever fainted, and if you have or have ever had a heart attack; a slow, fast, or irregular heartbeat; mental illness; low blood pressure;ulcers; bleeding in the stomach or intestines; Raynaud's syndrome (condition in which the hands and feet become numb and cool when exposed to cold temperatures); heart, kidney, or liver disease; or any condition that prevents you from digesting foods containing sugar, starch, or dairy products normally.
  • inform your doctor if you are pregnant or plan to become pregnant. If you are taking bromocriptine to treat lack of menstrual periods and infertility caused by hyperprolactinemia, use a method of birth control other than hormonal contraceptives (birth control pills, patches, rings, or injections) until you have regular menstrual periods; then stop using birth control. You should be tested for pregnancy once every 4 weeks as long as you do not menstruate. Once your menstrual period returns, you should be tested for pregnancy any time your menstrual period is 3 days late. If you do not wish to become pregnant, use a method of birth control other than hormonal contraceptives while you are taking bromocriptine. If you become pregnant during your treatment with bromocriptine, stop taking the medication and call your doctor.
  • do not breast-feed while you are taking bromocriptine.
  • if you are having surgery, including dental surgery, inform the doctor or dentist that you are taking bromocriptine.
  • you should know that bromocriptine may make you drowsy and cause you to suddenly fall asleep. Do not drive a car or operate machinery until you know how Bromocriptine affects you.
  • ask your doctor about the safe use of alcoholic beverages while you are taking bromocriptine. Alcohol can make the side effects from bromocriptine worse.
  • you should know that bromocriptine may cause dizziness, nausea, sweating, and fainting when you get up too quickly from a lying position. This is more common when you first start taking bromocriptine or when your dose is increased. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
  • ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar and the amount of bromocriptine you may need.

What special dietary instructions to follow 

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking Bromocriptine.

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian.

What to do if I forget a dose 

If you take bromocriptine, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you take bromocriptine once a day and miss your morning dose, wait until the next morning to take your medication. Do not take a double dose to make up for a missed one.

What side effects can Bromocriptine cause?

Bromocriptine may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

Bromocriptine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away 

  • nausea

  • vomiting

  • diarrhea

  • constipation

  • stomach cramps

  • heartburn

  • loss of appetite

  • headache

  • weakness

  • tiredness

  • dizziness or lightheadedness

  • drowsiness

  • difficulty falling asleep or staying asleep

  • depression

 Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • fainting

  • watery discharge from the nose

  • numbness, tingling, or pain in your fingers especially in cold weather

  • black and tarry stools

  • bloody vomit

  • vomiting material that looks like coffee grounds

  • swelling of the feet, ankles, or lower legs

  • seizures

  • severe headache

  • blurred or impaired vision

  • slow or difficult speech

  • weakness or numbness of an arm or leg

  • chest pain

  • pain in the arms, back, neck or jaw

  • shortness of breath

  • confusion

  • hallucinations (seeing things or hearing voices that do not exist)

Bromocriptine may cause other side effects. Call your doctor if you have any unusual problems while taking Bromocriptine.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

Symptoms of overdose may include:

  • nausea

  • vomiting

  • constipation

  • sweating

  • pale skin

  • general feeling of discomfort or uneasiness

  • lack of energy

  • fainting

  • dizziness

  • drowsiness

  • confusion

  • hallucinations (seeing things or hearing voices that do not exist)

  • believing things that are not true

  • yawning repeatedly

What other information to know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Bromocriptine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

 Ref: MedlinePlus, U.S. Natl. Library of Medicine 


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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