(pre gab' a lin)
P : Contraindicated in pregnancy
L : Contraindicated in lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||Postherpetic neuralgia
Adult: 75-150 mg bid. May increase up to 600 mg/day in patients with ongoing pain and can tolerate 300 mg/day.
Adjunct in partial seizures
Renal impairment: Dosage adjustment is required. Patients undergoing haemodialysis should receive a supplementary dose of 25-100 mg immediately after each 4-hr haemodialysis session.
|Administration||May be taken with or without food.
|Contraindications||Hypersensitivity. Pregnancy, lactation. Driving or working with machines, or do other dangerous activities.|
|Special Precautions||Discontinue treatment if patients develop severe angioedema. Withdraw treatment gradually over at least 1 wk. May cause peripheral oedema. Regular vision check is recommended. May decrease platelet count and prolong PR interval.|
|Adverse Drug Reaction(s)||Dizziness, drowsiness, visual disturbance (including blurred vision, diplopia), ataxia, dysarthria, tremor, lethargy, memory impairment, euphoria, wt gain, constipation, dry mouth, peripheral edema, depression, confusion, agitation, hallucinations, myoclonus, hypoaesthesia, hyperaesthesia, tachycardia, excessive salivation, sweating, flushing, rash, muscle cramp, myalgia, arthralgia, urinary incontinence, dysuria, thrombocytopenia, neutropenia, 1st Â° heart block, hypotension, hypertension, pancreatitis, dysphagia, oliguria, rhabdomyolysis.|
|Drug Interactions||Concurrent use with oxycodone, lorazepam and ethanol may increase the CNS effects
|Pregnancy Category (FDA)||Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.|
|Storage||Oral: Store at 25Â°C.|
|Pharmacology||Pregabalin is an analog of the neurotransmitter GABA. It binds potently to the alpha2-delta subunit resulting in modulation of Ca channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P.
Absorption: Rapidly absorbed after oral doses. Peak plasma concentrations are achieved within 1.5 hr.
Distribution: Not bound to plasma proteins.
Metabolism: Negligible metabolism.
Excretion: About 98% excreted unchanged in urine. Elimination half life: about 6.3 hr.
|ATC Classification||N03AX16 - pregabalin.|
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|GABAROL||ACI Ltd.||Pregabalin 50mg & 75mg & 100mg & 150mg||Capsule||50mg x20's, 75mg x30's, 100mg x20's, 150mg x20's: 240.00 &481.80 & 441.80 & 602.20 MRP|
|LYRIC 150||Healthcare Pharmacuticals Ltd.||Pregabalin INN 150mg||Capsule||24's MRP 720 Tk|
|LYRIC 75||Healthcare Pharmacuticals Ltd.||Pregabalin INN 75 mg||Capsule||30's MRP 540 Tk|
|MYRICA||Unimed & Unihealth Manufacturers Ltd.||Pregabalin INN 50mg, 75mg & 100mg||Capsule||28's each: 280.00, 420.00, 560.00 MRP|
|NERFID||The White Horse Pharma||Pregabalin BP 75mg & 150mg||Capsule||75mg x50's, 150mg x30's: 360.00 &603.00 MRP|
|NERVALIN||Beximco Pharmaceuticals Ltd||Pregabalin 50 & 75mg||Capsule||30's each: 330 & 480.00 MRP|
|NEUREGA||IBN SINA Pharmaceutical Industry Ltd.||Pregabalin BP 50mg & 75mg & 100mg||Capsule||50 & 75mg x20's: 260.00 & 340.00; 100mg x12's: 264.00 IP|
|NEUROLIN 25||Square Pharmaceuticals Ltd.||Pregabalin 25mg||Capsule||3x10's: 240.90 MRP|
|NEUROLIN 50||Square Pharmaceuticals Ltd.||Pregabalin 50mg||Capsule||3x10's: 360.90 MRP|
|NEUROLIN 75||Square Pharmaceuticals Ltd.||Pregabalin 75mg||Capsule||3x10's: 481.50 MRP|
|NEUROVAN||Aristopharma Ltd.||Pregabalin INN 50mg & 75mg,100mg||Capsule||50 & 75mg x30's: 330.00 & 480.00; 150mgx 20's: 600.00 MRP|
|PEGALIN||Popular Pharmaceuticals Ltd.||Pregabalin INN 75mg & 100mg & 150mg||Capsule||75 & 100mg x30's: 481.79 & 662.42; 150mgx 20's: 602.20 MRP|
|PG||Eskayef Bangladesh Ltd||Pregabalin INN 75mg & 150mg||Capsule||75mg x30's & 150mg x12's MRP: 480.00 & 360.00|
|PREBALIN||General Pharmaceuticals Ltd||Pregabalin INN 50mg & 75mg & 100mg||Capsule||50 & 75mg x30's: 330.00 & 481.80; 150mgx 20's: 602.20 MRP|
|PREGABA||Opsonin Pharma Limited||Pregabalin INN 50mg & 75mg & 100mg & 150mg||Capsule||30 each: 360.00 & 480.00 & 660.00 & 900.00 MRP|
|Pregaben 150||Incepta Pharmaceuticals Limited||Pregabalin INN 150 mg||Capsule||10x2's :MRP 600 Tk|
|Pregaben 50||Incepta Pharmaceuticals Limited||Pregabalin INN 50 mg||Capsule||10x3's:MRP 360 Tk|
|Pregaben 75||Incepta Pharmaceuticals Limited||Pregabalin INN 75 mg||Capsule||10x3's :MRP 480 Tk|
|PREGADEL 75||Delta Pharma Limited||Pregabalin INN 75mg||Capsule||16's: 240.00 MRP|
|PREGALEX||Sharif Pharmaceuticals Ltd.||Pregabalin INN 75mg & 150mg||Capsule||75mg x30's, 150mg x20's: 480.00 & 600.00 MRP|
|PRELIN||Drug International Ltd||Pregabalin INN 75mg & 150mg||Capsule||75mg x20's, 150mg x10's: 320.00 & 300.00 MRP|
|PRIGA 75||Monico Pharma Limited||Pregabalin INN 75mg||Capsule||30's: 480.00 MRP|
|XABLIN||Sandoz/Novartis||Pregabalin INN 75mg||Capsule||30's, MRP 448.42|
|XIL||Orion Pharma Ltd.||Pregabalin INN 75mg||Capsule||30's: 301.20 MRP|
Why is Pregabalin prescribed?
Pregabalin is used to relieve neuropathic pain (pain from damaged nerves) that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes or in the area of your rash if you have had shingles (a painful rash that occurs after infection with herpes zoster). It is also used to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). Pregabalin is used with other medications to treat certain types of seizures in people with epilepsy. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body.
How should Pregabalin be used?
Pregabalin comes as a capsule to take by mouth. It is usually taken with or without food two or three times a day. Take pregabalin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand.
Your doctor will probably start you on a low dose of pregabalin and may gradually increase your dose during the first week of treatment.
Take pregabalin exactly as directed. Pregabalin may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.
Pregabalin may help control your symptoms but will not cure your condition. It may take several weeks or longer before you feel the full benefit of pregabalin. Continue to take pregabalin even if you feel well. Do not stop taking pregabalin without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking pregabalin, you may experience withdrawal symptoms, including trouble falling asleep or staying asleep, nausea, diarrhea, headaches, or seizures. Your doctor will probably decrease your dose gradually over at least one week.
Your doctor will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with pregabalin and each time you refill your prescription. Read the information carefully and ask your doctor if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.
Other uses for Pregabalin
Pregabalin may be prescribed for other uses; ask your doctor for more information.
What special precautions to follow?
Before taking pregabalin,
- inform your doctor if you are allergic to pregabalin, any other medications, or any of the ingredients in pregabalin capsules. Ask your pharmacist for a list of the ingredients.
- inform your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiotensin converting enzyme (ACE) inhibitors such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, and trandolapril; antidepressants; antihistamines; medications for anxiety, including lorazepam; medications for mental illness or seizures; certain medications for diabetes such as pioglitazone and rosiglitazone; narcotic pain medications, including oxycodone; sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- inform your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications. Also inform your doctor if you have or have ever had swelling of the eyes, face, lips, tongue, or throat; problems with your vision, bleeding problems or a low number of platelets (type of blood cell needed for blood clotting) in your blood, or heart or kidney disease.
- inform your doctor if you are pregnant, or if you or your partner plans to become pregnant. Also inform your doctor if you are breast-feeding. If you or your partner becomes pregnant while you are taking pregabalin, call your doctor. Pregabalin has caused decreased fertility in male animals and birth defects in the offspring of male and female animals who were treated with the medication. There is not enough information to inform if pregabalin causes these problems in humans.
- if you are having surgery, including dental surgery, inform the doctor or dentist that you are taking pregabalin.
- you should know that pregabalin may make you dizzy or drowsy. Do not drive a car operate machinery, or do other dangerous activities until you know how Pregabalin affects you. Ask your doctor when you may do these activities.
- do not drink alcohol while taking pregabalin. Alcohol can add to the drowsiness caused by Pregabalin.
- you should know that your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking pregabalin for the treatment of epilepsy, mental illness, or other conditions. A small number of adults and children 5 years of age and older (about 1 in 500 people) who took anticonvulsants such as pregabalin to treat various conditions during clinical studies became suicidal during their treatment. Some of these people developed suicidal thoughts and behavior as early as one week after they started taking the medication. There is a risk that you may experience changes in your mental health if you take an anticonvulsant medication such as pregabalin, but there may also be a risk that you will experience changes in your mental health if your condition is not treated. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood); talking or thinking about wanting to hurt yourself or end your life; withdrawing from friends and family; preoccupation with death and dying; giving away prized possessions; or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.
What special dietary instructions to follow?
Unless your doctor informs you otherwise, continue your normal diet.
What to do if I forget a dose?
If you forget to take a dose and remember a few hours later, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can Pregabalin cause?
Pregabalin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
''high'' or elevated mood
difficulty concentrating or paying attention
difficulty remembering or forgetfulness
lack of coordination
loss of balance or unsteadiness
uncontrollable shaking or jerking of a part of the body
swelling of the arms, hands, feet, ankles, or lower legs
- back pain
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
blurred vision, double vision, or other changes in eyesight
swelling of the eyes face, throat, mouth, lips, gums, tongue, head or neck
shortness of breath
muscle pain, tenderness, soreness, or weakness, especially if it comes along with fever
If you have diabetes, you should know that pregabalin has caused skin sores in animals. Pay extra attention to your skin while taking pregabalin, and inform your doctor if you have any sores, redness, or skin problems.
Pregabalin may cause other side effects. Consult your doctor if you have any unusual problems while taking Pregabalin.
What other information to know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Pregabalin.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: MedlinePlus, U.S. Natl. Library of Medicine
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.