mph Bangladesh

PCaution when used during lactation : Caution when used during pregnancy

LCI  : Contraindicated in lactation

Molecule Info

Indication(s) & Dosage Psychoses
Adult: 2-5 mg orally bid gradually increased to 15-20 mg daily, or 40 mg daily in severe or resistant psychoses.
Child: Max: 5 mg  orally daily in divided doses adjusted according to age, body weight and response.
Elderly: Initiate at lower dose and increase gradually.
Nausea and vomiting
Adult: 1-2 mg bid. Max 6 mg daily.
Child: 3-5 yrs: max 1 mg daily in divided doses; 6-12 yrs: max 4 mg daily.
Elderly: Initiate at lower dose and increase gradually.
Short-term management of anxiety
Adult: 1-2 mg bid. Max: 6 mg daily. Max duration: 12 wk.
Child: 3-5 yr: max 1 mg daily in divided doses; 6-12 yr: max 4 mg daily in divided doses.
Elderly: Initiate at lower dose and increase gradually.
Acute psychosis
Adult: 1-2 mg by deep IM, repeated if necessary every 4-6 hr. Max: 6 mg daily.
Child: 1 mg by deep IM once or twice daily.
Elderly: Initiate at lower dose and increase gradually.
Administration May be taken with or without food.
Overdosage Symptoms: extrapyramidal side effects, CNS depression, somnolence, agitation, restlessness, convulsions, ECG changes, cardiac arrhythmias, fever, autonomic reactions such as hypotension, dry mouth and ileus. Management: Treatment is symptomatic and supportive. Maintain an open airway as dysphagia and respiratory difficulty may occur in severe overdosage. Gastric lavage may be performed. Do not induce emesis as dystonic reaction of the head or neck may develop and this may lead to aspiration of vomitus. Extrapyramidal symptoms may be treated with anti-parkinsonism drugs, barbiturates, or diphenhydramine hydrochloride. If pressor agents are required, norepinephrine bitartrate and phenylephrine HCl may be used but not epinephrine. This is because trifluoperazine may reverse the usual elevating action of these agents and cause a further drop in blood pressure. Haemodialysis is not likely to be useful.
Contraindications Preexisting CNS depression and coma; bone marrow depression, blood dyscrasias, liver disease, hypersensitivity to phenothiazines, prolactin dependent tumours. Pregnancy (1st trimester), lactation.
Special Precautions Cardiovascular disease, epilepsy, angle-closure glaucoma, exposure to extreme temperatures, elderly, parkinson's disease, myasthenia gravis, benign prostatic hyperplasia, DM, renal amd hepatic impairment. Discontinue trifluoperazine at least 48 hr before myelography and do not resume for at least 24 hr after procedure. Do not use trifluoperazine in control of nausea and vomiting occurring either prior to myelography or postprocedure with metrizamide. Pregnancy.
Adverse Drug Reaction(s) Drowsiness, dry mouth, blurred vision, dizziness, sedation, antimuscarinic affects, postural hypotension, akathisia, muscle weakness, anorexia, insomnia, rash, amenorrhoea, fatigue, increased prolactin levels, extrapyramidal side effects.
Potentially Fatal: Neuroleptic malignant syndrome, blood dyscrasias.
Drug Interactions Increased CNS depression with CNS depressants such as opiates or other analgesics, barbiturates or other sedatives, general anaesthetics, or alcohol. Increased risk of side effects with drugs with antimuscarinic properties e.g. TCA, antiparkinsonian drugs. Antagonised effects of dopaminergic drugs such as levodopa. Increased risk of hypotension with antihypertensives,trazodone. Reverses antihypertensive effect of guanethidine. Increased risk of severe extrapyramidal side-effects or severe neurotoxicity with lithium. Possible decrease in absorption with antacids.
Pregnancy Category (FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Oral: Store at 15-30°C
Pharmacology Trifluoperazine inhibits dopamine D2 receptors in the brain. It has weak anticholinergic and sedative effects but strong extrapyramidal and antiemetic effects. It controls severely disturbed, agitated or violent behaviour but may also be used for nonpsychotic anxiety.
Absorption: Readily absorbed from GI tract. Peak plasma concentrations: 1.5-6 hr. Bioavailability: subject to interindividual variation.
Distribution: Protein binding: highly bound. Distributed into breast milk.
Excretion: Terminal half life: 22 hr.
ATC Classification N05AB06 - trifluoperazine; Belongs to the class of phenothiazine antipsychotics with piperazine structure.

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Brand/Product Info

Total Products : 6      
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
Flurazine 1 Incepta Pharmaceuticals Limited Trifluoperazine hydrochloride BP equivalent to trifluoperazine 1mg Film Coated Tablet 10x10's:MRP 150 Tk
Flurazine 5 Incepta Pharmaceuticals Limited Trifluoperazine hydrochloride BP equivalent to trifluoperazine 5mg Film Coated Tablet 10x10's:MRP 250 Tk
SIZONIL 1 Healthcare Pharmacuticals Ltd. Trifluoperazine hydrochloride BP equivalent to trifluoperazine 1mg Tablet 100's MRP 200 Tk
SIZONIL 5 Healthcare Pharmacuticals Ltd. Trifluoperazine hydrochloride BP equivalent to trifluoperazine 5mg Tablet 100's MRP 350 Tk
STELA Delta Pharma Limited Trifluoperazine dihydrochlor 1mg & 5mg Tablet 50's each: 75.0 & 125.00 MRP
TELAZINE Eskayef Bangladesh Ltd Trifluoperazine hydrochloride BP equivalent to Trifluoperazine 1mg & 5mg Tablet 100's each, MRP: 150.00 & 250.00

Gen. MedInfo

Why do I need Trifluoperazine?

Trifluoperazine is used to treat schizophrenia and paranoia. It helps to relieve symptoms common in schizophrenia and paranoia, such as distorted thinking and emotional instability.

It is also used in the short-term treatment of anxiety, agitation and dangerously impulsive behaviour.

Trifluoperazine may also be used for other medical conditions, such as nausea and vomiting.

How do I take Trifluoperazine?

Take Trifluoperazine exactly as directed by your doctor. Do not take more or less than instructed by your doctor.

You may need to take Trifluoperazine for some time before the full benefits can be felt. Do not be discouraged if you do not feel better soon after taking the medicine. Trifluoperazine must be taken regularly for it to work well.

Do not stop taking Trifluoperazine unless your doctor has decided that you can stop. If Trifluoperazine is stopped suddenly, you may feel unwell or your condition may worsen. When your doctor decides that you do not need Trifluoperazine anymore, he will usually reduce your dose slowly. Follow the doctor's instructions carefully.

Take Trifluoperazine with food. This will help to minimise any stomach discomfort that Trifluoperazine may cause. Try to take it at the same time everyday.

Trifluoperazine is available as a tablet and oral solution.

If you have been given the oral solution, use the dropper, measuring spoon or cup provided to measure out your dose accurately.

What to do if I have forgotten to take Trifluoperazine?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

Remember to take your medicine regularly. Trifluoperazine must be taken exactly as directed for it to be effective. If you often forget to take your medicine, let your doctor know.

When to not use Trifluoperazine?

Alert your doctor if you have liver disease, any blood disorders or bone marrow suppression.

What to take note of while using Trifluoperazine?

Alert your doctor if you are pregnant or if you become pregnant while being treated with Trifluoperazine. Use effective birth control methods while being treated with Trifluoperazine.

Do not breastfeed while you are being treated with Trifluoperazine. Alert your doctor if you are breastfeeding.

Alert your doctor if you have any of these conditions:

- an enlarged prostate or difficulty urinating
- epilepsy (fits) or a history of fits
- Parkinson's disease
- glaucoma (high pressure in the eye)
- heart, liver, kidney or lung disease
- angina (chest pain)
- myasthenia gravis (a condition that causes muscle weakness)
- breast cancer or tumours dependent on a hormone known as prolactin 

Trifluoperazine may affect the way your body adjusts to temperature changes in the environment. Avoid exposure to very cold or very hot environments.

If you are going for an operation, including minor operations and dental work, inform your doctor or dentist that you are being treated with Trifluoperazine.

For as long as you are being treated with Trifluoperazine, you will need to have regular blood tests to make sure that your blood counts are normal. Your doctor will advise you about how often you need to have blood tests.

What side effects could I experience?

Trifluoperazine may cause you to temporarily develop some symptoms similar to Parkinson's disease such as slow movements, shaky or stiff hands or legs, poor sense of balance, drooling, lethargy and fixed stare. These symptoms may be more frequent during the first few days of starting treatment or may occur if your dose is being adjusted. Alert your doctor if these symptoms appear.

Trifluoperazine may also make you drowsy or dizzy. If you feel drowsy or dizzy, do not drive or take part in any activity in which you need to be alert.

You may feel dizzy when getting up from a sitting or lying down position, especially if you are taking Trifluoperazine for the first time or if your dose is still being adjusted. This is normal and should disappear gradually as you get used to the medicine. It will help if you get up slowly from a sitting or lying down position.

Other common side effects of Trifluoperazine include dry mouth, blurred vision, restlessness, difficulty sleeping, muscle weakness, loss of appetite, weight gain, confusion and water retention. Inform your doctor if these side effects get worse or do not go away.

It may also cause your skin to be more sensitive to sunlight. Avoid exposure to the sun and UV lamps. Wear sunblock or a hat if you go outdoors.

Other side effects are less common but may need immediate medical help. Alert your doctor immediately if you develop any of these symptoms:
- fast or irregular heartbeat
- any signs of an impending heart attack
- difficulty breathing or wheezing
- uncontrolled muscle movements of your body, face or tongue, such as lip smacking or worm-like movements of the tongue
- muscle stiffness or spasm with excessive sweating
- uncontrollable urge to move constantly or an inability to sit still
- shaky or trembling hands or legs
- excessive drowsiness, dizziness or if you faint
- unexplained fever
- confusion or disorientation
- rapid rise in your body temperature or an inability to cool down on a hot day
- yellowing of the eyes or skin
- swelling, redness or pain of the lower leg
- severe tiredness or weakness
- fever with persistent sore throat or mouth ulcers, or other signs of infection

Can I take this with other medicines?

Alert your doctor if you are taking any of these medicines:

- sleeping pills or anxiety medication such as diazepam, alprazolam or similar
- medicines that can cause drowsiness such as opioid painkillers (e.g. morphine, codeine), hay fever medicines
- antidepressants or mood medicines such as fluvoxamine, lithium, venlafaxine
- epilepsy (fits) medicines such as phenytoin, carbamazepine, valproate or phenobarbitone
- Parkinson's disease medicines such as levodopa and apomorphine
- heart medicines used to treat irregular heart rate, such as quinidine
- high blood pressure medicines such as guanethidine, propranolol and diuretics (water pills)
- medicines used to treat low blood pressure such as midodrine
- anti-fungal medicines such as ketoconazole or itraconazole
- metoclopramide (medicine to treat vomiting)
- antibiotics such as moxifloxacin, ciprofloxacin and ofloxacin
- blood-thinning medicines such as warfarin
- desferrioxamine (an iron-binder)

Trifluoperazine must not be taken together with antacids as antacids can reduce the effectiveness of Trifluoperazine. If you must take antacids, take between meals at least 2 hours after you have taken Trifluoperazine.

What special dietary instructions to follow?

Avoid alcohol. Alcohol will worsen the dizziness and drowsiness caused by Trifluoperazine.

How to store Trifluoperazine?

Store in a cool, dry place away from the reach of children.

Medicines must be used within the expiry date.

If you have been given the oral solution, throw it away 1 month after you open the container.

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