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Dimenhydrinate

(dye men hye' dri nate)

PCaution when used during lactation : Caution when used during pregnancy

LCI  : Contraindicated in lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication & Dosage

Oral route
Treatment and prophylaxis of motion sickness
Adult: 50-100 mg 3-4 times daily. For prevention of motion sickness, 1st dose to be given at least 30 minutes before traveling. 
Child: 2-6 yr: 12.5-25 mg; 6-12 yr: 25-50 mg; Doses can be repeated every 6-8 hr. Max: 75 mg daily (2-6 yr) and 150 mg daily (6-12 yr).

Nausea and vertigo caused by Meniere's disease
Adult: 50-100 mg 3-4 times daily. For prevention of motion sickness, 1st dose to be given at least 30 minutes before traveling. 
Child: 2-6 yr: 12.5-25 mg; 6-12 yr: 25-50 mg; Doses can be repeated every 6-8 hr. Max: 75 mg daily (2-6 yr) and 150 mg daily (6-12 yr).

Parenteral route
Treatment and prophylaxis of motion sickness
Adult: 50 mg in a 5% solution given IM or 0.5% slow IV inj given over 2 min.
Child: 1.25 mg/kg IM or slow IV inj 4 times daily. Max: 300 mg/day.

Nausea and vertigo caused by Meniere's disease
Adult: 50 mg in a 5% solution given IM or 0.5% slow IV inj given over 2 min.
Child: 1.25 mg/kg IM or slow IV inj 4 times daily. Max: 300 mg/day.

Administration May be taken with or without food.
Overdosage Symptoms in children: dilated pupils, flushed face, excitation, hallucinations, confusion, ataxia, intermittent clonic convulsions, coma, cardiorespiratory collapse, and death. Symptoms may manifest up to 2 hr after ingestion and death may occur within 18 hr. Symptoms in adult: Difficulty in speech and swallowing, psychosis, sedation then CNS excitation, leading to a cycle of CNS excitation, seizures and postictal depression. Mangagement: Treatment is symptomatic and supportive. Gastric lavage may be performed with an endotracheal tube with cuff inflated in place to prevent aspiration of gastric contents. Keep patient quiet to reduce CNS stimulation. Convulsions may be treated with diazepam in adults and phenobarbital in children.
Contraindications Hypersensitivity to dimenhydrinate, porphyria. Neonates. Lactation.
Special Precautions Angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction, epilepsy. Elderly. Tasks requiring mental alertness. Pregnancy.
Adverse Drug Reactions Sedation, dry mouth, thickened respiratory tract secretions, tightness of chest, bradycardia followed by tachycardia and arrhythmias, blurred vision, urinary retention, constipation, GI disturbance, blood dyscrasias. Paradoxical CNS stimulation may occur in children and occasionally in adults.
Drug Interactions Physically incompatible with aminophylline, hydrocortisone, phenothiazines and some barbiturates in solution.
Potentially Fatal: Potentiates the sedative effects of CNS depressants including alcohol, barbiturates, opioid analgesics, sedatives and neuroleptics. MAOIs, atropine, TCAs enhance antimuscarinic effect. Masks ototoxicity produced by aminoglycoside antibiotics. Please consult detailed drug interactions before prescribing.
Lab Interference May interfere with plasma theophylline estimation by radioimmunoassay.
Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Storage Oral: Store below 25°C. Parenteral: Store below 25°C.
Pharmacology Dimenhydrinate is an antihistamine which also has antimuscarinic and central sedative action. It also exerts a depressant action on hyperstimulated labyrinthine function.

Brand/Product Info


Total Products : 0
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price

Gen. MedInfo

Why is Dimenhydrinate prescribed?

Dimenhydrinate is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. Dimenhydrinate is in a class of medications called antihistamines. It works by preventing problems with body balance.

How should Dimenhydrinate be used 

Dimenhydrinate comes as a tablet and chewable tablet to take by mouth with or without food. To prevent motion sickness, the first dose should be taken 30 minutes to 1 hour before you travel or begin motion activity. Adults and children older than age 12 may usually take dimenhydrinate every 4 to 6 hours as needed to prevent or treat motion sickness. Children under age 12 may usually be given dimenhydrinate every 6 to 8 hours as needed to prevent or treat motion sickness. Follow the directions on the package carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dimenhydrinate exactly as directed. Do not take more or less of it or take it more often than directed by the package label.

Do not give dimenhydrinate to children younger than 2 years of age unless your doctor has told you to do so.

Other uses for Dimenhydrinate 

Dimenhydrinate is also sometimes used to treat Meniere's disease (condition of the inner ear which causes extreme dizziness, loss of balance, ringing in the ears, and hearing loss) and other inner ear problems. Talk to your doctor about the risks of using Dimenhydrinate for your condition.

Dimenhydrinate may be prescribed for other uses; ask your doctor for more information.

What special precautions to follow? 

Before taking dimenhydrinate, 

  • talk with your doctor if you are allergic to dimenhydrinate or any other medications. If you are taking dimenhydrinate chewable tablets, talk to your doctor if you are allergic to tartrazine (FD&C Yellow No. 5, a color additive) or aspirin.
  • talk with your doctor about what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as such as amikacin, gentamicin, kanamycin, neomycin, netilmicin, paromomycin, streptomycin, and tobramycin; antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine, doxepin, imipramine (Tofranil), nortriptyline, protriptyline, and trimipramine; antihistamines, such as diphenhydramine; cough and cold medications; ipratropium (Atrovent); medications for anxiety, irritable bowel disease, mental illness, Parkinson's disease, seizures, ulcers, or urinary problems; narcotic or strong pain relievers or muscle relaxants; sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • talk with your doctor if you have or have ever had asthma; shortness of breath or difficulty breathing, including chronic bronchitis (swelling of the air passages that lead to the lungs) or emphysema (damage to air sacs in the lungs); difficulty urinating due to enlargement of the prostate (male reproductive organ); glaucoma (an eye disease that can cause vision loss); or seizures.
  • talk with your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking dimenhydrinate, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking dimenhydrinate.
  • you should know that dimenhydrinate may make you drowsy. Do not drive a car, operate machinery, or participate in potentially dangerous activities until you know how Dimenhydrinate affects you.
  • avoid alcoholic beverages or products containing alcohol while taking dimenhydrinate. Alcohol can make the side effects from dimenhydrinate worse.
  • if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent mental retardation), read the package label carefully before taking dimenhydrinate. Dimenhydrinate chewable tablets contain aspartame that forms phenylalanine.

What special dietary instructions to follow? 

Unless your doctor tells you otherwise, continue your normal diet.

What to do if I forget a dose? 

Dimenhydrinate is usually taken as needed. If your doctor has told you to take dimenhydrinate regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can Dimenhydrinate cause? 

Dimenhydrinate may cause side effects. Talk to your doctor if any of these symptoms are severe or do not go away: 

  • drowsiness

  • excitement or hyperactivity (especially in children)

  • headache

  • new or worsening dizziness

  • blurred vision

  • ringing in the ears

  • dry mouth, nose, or throat

  • problems with coordination

  • fainting

  • dizziness

  • nausea

Some side effects can be serious. If you experience the following symptom, call your doctor immediately:

  • fast, pounding, or irregular heartbeat

Dimenhydrinate may cause other side effects. Call your doctor if you have any unusual problems while taking Dimenhydrinate.

What to know about storage and disposal of Dimenhydrinate? 

Keep Dimenhydrinate in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose 

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

Symptoms of overdose may include: 

  • large pupils (black circles in the centers of the eyes)

  • flushed face

  • drowsiness or sleepiness

  • excitation or hyperactivity

  • hallucinations (seeing things or hearing voices that do not exist)

  • difficulty understanding reality

  • confusion

  • difficulty speaking or swallowing

  • unsteadiness

  • seizures

  • unresponsiveness or coma (loss of consciousness for a period of time)

What other information to know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Dimenhydrinate.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies..


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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