mph Bangladesh

Flupenthixol (Flupentixol)

PCaution when used during lactation : Caution when used during pregnancy

LCI  : Contraindicated in lactation

Molecule Info

Indication(s) & Dosage Oral
Adult: Initially, 3-9 mg bid, adjusted according to response. Max: 18 mg daily. 
Elderly: Initial dose: ¼ or ½ of the usual initial dose.
Depression with or without anxiety
Adult: Initially, 1 mg daily increased after 1 wk to 2 mg daily and then to a max of 3 mg daily, last dose should be given not later than 4 p.m. Doses >2 mg should be given in 2 divided doses. Discontinue treatment if there is no improvement within 1 wk of using the max dose. 
Elderly: Initially, 0.5 mg daily increased after 1 wk to 1 mg daily with the last dose given not later than 4 p.m. Max: 2 mg daily in 2 divided doses.
Max Dosage: 
Adult: As decanoate: Initially, 20 mg (1 ml of a 2% oily solution) is given as test dose. After at least 7 days and depending on the response, subsequent doses of 20-40 mg may be given at intervals of 2-4 wk. Usual maintenance dose: 50 mg every 4 wk to 300 mg every 2 wk. Up to 400 mg wkly may be used in severe or resistant cases. 
Elderly: Initial dose: ¼ or ½ of the usual initial dose.
Administration May be taken with or without food. May be taken w/ food or milk to reduce GI discomfort.
Contraindications Hypersensitivity. Extremely excitable and overactive patients; mania; porphyria; coma; preexisting CNS depression; bone-marrow supression; phaeochromocytoma. Lactation.
Special Precautions Patients with convulsive disorders; advanced hepatic, renal, CV or resp disease; tasks requiring mental alertness; elderly (especially with dementia), and debilitated patients; neuroleptics with sedative effect must be withdrawn gradually; history of angle-closure glaucoma; urinary retention; prostatic hyperplasia; breast cancer, prolactin dependent tumours; parkinsonism; myasthenia gravis; pregnancy; Avoid direct sunlight.
Adverse Drug Reaction(s) Rigidity, tremors, restlessness, tardive dyskinesia, insomnia, dryness of mouth, wt gain, sexual dysfunction, galactorrhoea and menstrual disturbances.
Potentially Fatal: Neuroleptic malignant syndrome (hyperthermia, hypertonicity of skeletal muscles, unconsciousness and autonomic nervous system instability).
Drug Interactions May potentiate the adverse effects of drugs with antimuscarinic effects e.g. TCAs. Reduced efficacy of levodopa. Increases adverse extrapyramidal symptoms with dopamine antagonists (metoclopramide and prochlorperazine).
Potentially Fatal: Potentiates CNS effects of alcohol, general anaesthetics, hypnotics, anxiolytics and opioids. Blocks antihypertensive effect of guanethidine. Please consult detailed drug interactions before prescribing.
Pregnancy Category (FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Intramuscular: Store below 25°C. Oral: Store below 25°C.
Pharmacology Flupentixol/Flupenthixol is a thioxanthene antipsychotic that inhibits dopamine-mediated effects by blocking postsynaptic dopamine receptors in the CNS.
Onset: 24-72 hr (IM).
Duration: 2-4 wk (IM).
Absorption: Readily absorbed from the GI tract, peak plasma concentrations after 3-8 hr (oral); slowly absorbed from the inj site, peak plasma concentrations after 4-7 days (IM).
Distribution: Crosses the blood-brain barrier and placenta; enters breast milk. >95% bound to plasma proteins.
Metabolism: Extensively hepatic via sulfoxidation, side-chain N-dealkylation and glucuronic acid conjugation.
Excretion: Urine and faeces (as metabolites).
ATC Classification N05AF01 - flupentixol/Flupenthixol; Belongs to the class of thioxanthene derivatives antipsychotics. Used in the management of psychosis.

Brand/Product Info

Total Products : 4    
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ADELAX ACI Ltd. Flupenthixol Dihydrochloride INN 0.5mg + Melitracen Hydrochloride INN 10mg Tablet 50's, 80's: 175.00 & 280.80 MRP
FLUANXOL Lundbeck/Lilac Flupenthixol dihydrochloride 0.5mg & 1mg Tablet 0.5mg x100's, 1mg x50's: 981.00 & 792.00 MRP
FLUANXOL Depot Lundbeck/Lilac Flupenthixol dihydrochloride 20mg/ml & 40mg/2ml Injection 10's each: 3045.50 & 5769.20 MRP
SENTIX Eskayef Bangladesh Ltd Flupenthixol Dihydrochloride BP 0.5mg & 1mg Tablet 0.5mg x50's & 1mg x30's MRP: 150.00 each
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