P : Contraindicated in pregnancy
L : Contraindicated in lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||Disturbed biorhythms, Sleep disorders
Adult: Usual dose 3-6 mg orally at bedtime.
Child: 2-3 mg at bedtime, increased after 1-2 wk to 4-6 mg if needed. Max dose 10 mg.
|Contraindications||Pregnancy and lactation.|
|Special Precautions||May impair ability to drive or operate machinery. Epilepsy|
|Adverse Drug Reaction(s)||Increased seizure activity; drowsiness, headache. Disruption of normal circadian rhythm. May worsen symptoms for individuals with depression.|
|Pharmacology||Melatonin is the hormone secreted by the pineal gland. In humans, the plasma levels of melatonin are high at night and low during the day and it appears to have a role in circardian rhythm regulation. This action of melotonin finds a possible place in the management of jet lag and other sleep disorders. Melatonin is also being used in the treatment of cluster headaches.|
|ATC Classification||N05CH01 - melatonin.|