mph Bangladesh


PCaution when used during lactation : Caution when used during pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage Prophylaxis of migraine, Prophylaxis of cluster headache
Adult: 1.5 mg/day either in 3 divided doses or as a single dose at night. Gradual increase of 0.5 mg helps to avoid drowsiness. Max dose: 4.5 mg/day and 3 mg/dose. 
Child: >2 yr: Up to 1.5 mg daily in divided doses. Max dose: 1 mg/dose. 
Renal impairment: Dose reduction may be needed.
Administration May be taken with or without food.
Overdose Overdosage may lead to antimuscarinic, extrapyramidal and CNS effects.
Contraindications Premature infants or neonates. Postural giddiness.
Special Precautions Angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction, epilepsy; hepatic impairment; elderly; young child. May affect ability to drive or operate machinery. Pregnancy, lactation.
Adverse Drug Reaction(s) CNS depression; headache, psychomotor impairment, antimuscarinic effects; GI disturbances; increased appetite; wt gain; drowsiness; palpitations, arrhythmias; hypersensitivity reactions; blood disorders; convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, sleep disturbances, confusion, tinnitus, tremor, depression, hypotension, hair loss.
Drug Interactions Enhances sedative effects of CNS depressants. Additive antimuscarinic action with other antimuscarinic drugs. May mask warning signs of damage caused by ototoxic drugs eg, aminoglycosides.
Potentially Fatal: Enhances sedative effects of CNS depressants. Additive antimuscarinic action with other antimuscarinic drugs. May mask warning signs of damage caused by ototoxic drugs eg, aminoglycosides. Please consult detailed drug interactions before prescribing.
Lab Interference Stop therapy several days before skin testing.
Pharmacology Pizotifen is a sedating antihistamine with strong serotonin antagonist and weak antimuscarinic properties. It also antagonises the action of tryptamine.
Absorption: Well absorbed.
Distribution: About 90% bound to plasma proteins. peak plasma concentrations occur about 5 hr after a single oral dose.
Metabolism: Extensively metabolised.
Excretion: About half of a dose is excreted in the urine, mainly as metabolites.
ATC Classification N02CX01 - pizotifen; Belongs to the class of other antimigraine preparations.

Brand/Product Info


Total Products : 19                   
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ANTIGRAIN IBN SINA Pharmaceutical Industry Ltd. Pizotifen malate BP 0.5mg Tablet 50's: 162.50 IP
ANTIGRAIN-TS IBN SINA Pharmaceutical Industry Ltd. Pizotifen malate BP 1.5mg (triple strength) Tablet 30's: 217.50 IP
AVIDRO Beximco Pharmaceuticals Ltd Pizotifen Malate BP eq. to Pizotifen 0.5mg & 1.5mg Tablet 0.5mg x100's: 300.00 & 1.5mg x 50: 350.00 MRP
D-FEN Drug International Ltd Pizotifen malate BP 0.5mg & 1.5mg Tablet 0.5mgx 100's, 1.5mg x50's: 200.00 & 200.00 MRP
DMIGRAIN NIPRO JMI Pharma Ltd. Pizotifen malate BP 0.5mg & 1.5mg Tablet 50's each: 150.00 & 350.00 MRP
MIGOFEN Techno Drugs Pizotifen malate 0.5mg & 1.5mg Tablet 30's each: 90.00 & 180.00 MRP
MIGRANEX Edruc Limited Pizotifen 0.5mg & 1.5mg Tablet 0.5mgx 50's, 1.5mg x30's: 150.00, 210.00 IP
MIGRANIL 0.5 Square Pharmaceuticals Ltd. Pizotifen Malate 0.5mg Tablet 5x10's: 150.50 MRP
MIGRANIL 1.5 Square Pharmaceuticals Ltd. Pizotifen Malate 1.5mg Tablet 3x10's: 211.20 MRP
PIFEN Opsonin Pharma Limited Pizotifen 0.5mg & 1.5mg Tablet 0.5mgx 50's, 1.5mg x30's: 150.00 & 210.00 MRP
PITOFEN Medicon Laboratories Ltd Pizotifen 0.5mg Tablet 100's: 300.00 MRP
PIZO-A The Acme Laboratories Ltd. Pizotifen 0.5mg & 1.5mg Tablet 0.5mgx 100's, 1.5mg x50's: 300.00 & 351.00 MRP
PIZOFEN Navana Pharmaceuticals Limited Pizotifen 0.5mg Tablet 100's: 301.00 IP
PIZOFEN-TS Navana Pharmaceuticals Limited Pizotifen malate BP 1.5mg (triple strength) Tablet 50's: 351.50 IP
PIZOTIN Nipa Pharmaceuticals Ltd. Pizotifen 0.5mg & 1.5mg Tablet 0.5mgx 100's, 1.5mg x30's: 300.00 & 210.00 MRP
ZOFEN Aristopharma Ltd. Pizotifen malate BP 1.5mg (triple strength) Tablet 50's: 155.00 MRP
ZOFEN TS Aristopharma Ltd. Pizotifen 1.5mg Tablet 50's: 360.00 MRP
ZONIL Apex Pharmaceuticals Ltd. Pizotifen 0.5mg Tablet 50's: 150.00 MRP
ZONIL-TS Apex Pharmaceuticals Ltd. Pizotifen malate BP 1.5mg (triple strength) Tablet 30's: 210.00 MRP
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