Paracetamol (US, Acetaminophen)
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||
Paracetamol (Acetaminophen) is used to treat mild to moderate pain, including headache, migraine, neuralgia, pain in teething, toothache, sore throat, aches and pains. Symptomatic relief of rheumatic aches and pains. Symptomatic relief of influenza, feverishness and feverish colds.
Mild to moderate pain and fever
Reconstitution: Can be diluted in 0.9% sodium chloride or 5% glucose solution up to one 1/10.
Renal impairment: Following dosage recommendation applies-
|Administration||May be taken with or without food.
|Overdosage||Overdosage: Consult local protocols. Early symptoms: nausea and vomiting (normally settle within 24 hr of ingestion). After 24 hr symptoms may include right subcostal pain and tenderness, usually indicates development of hepatic necrosis. Liver damage is greatest 3-4 days after ingestion and may lead to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Treatment: based on plasma concentration. Acetylcysteine protects the liver if administered within 24 hr after ingestion (most effective if given within 8 hr). Dose: 140 mg/kg orally (loading) followed by 70 mg/kg every 4 hr for 17 doses. Parenteral acetylcysteine is given to those unable to take oral dosing. Activated charcoal may be given if paracetamol is 150 mg/kg or 12 g (whichever is smaller) if it is thought that the paracetamol has been ingested within the previous hr.|
|Special Precautions||Renal or hepatic impairment; alcohol-dependent patients; G6PD deficiency.|
|Adverse Drug Reaction(s)||Nausea, allergic reactions, skin rashes, acute renal tubular necrosis.
Potentially Fatal: Very rare, blood dyscrasias (e.g. thrombocytopenia, leucopenia, neutropenia, agranulocytosis); liver damage.
|Drug Interactions||Reduced absorption of cholestyramine within 1 hr of admin. Accelerated absorption with metoclopramide. Decreased effect with barbiturates,carbamazepine, hydantoins, rifampicin and sulfinpyrazone. Paracetamol may increase effect of warfarin.
Potentially Fatal: Paracetamol increases the risk of liver damage in chronic alcoholics. Increased risk of toxicity with other hepatotoxic drugs or drugs which induce microsomal enzymes e.g. barbiturates, carbamazepine, hydantoins, rifampicin and sulfinpyrazone. Please consult detailed drug interactions before prescribing.
|Food Interaction||St John's Wort may decrease effect.|
|Lab Interference||May produce false-positive test results for 5-hydroxyindoleacetic acid.|
|Pregnancy Category (FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Storage||Do not store above 30°C; do not freeze or refrigerate; if parenteral solution is diluted: use within an hr (infusion time included).
|Pharmacology||Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.
Onset: <1 hr.
Duration: 4-6 hr.
Absorption: Incomplete; depends upon dosage form. Time to peak, serum: oral: 10-60 min; may be delayed in acute overdoses. Decreased rate of absorption with food.
Distribution: Present in most body tissues; crosses the placenta and enters the breast milk. Protein binding: 8-43% (at toxic doses).
Metabolism: Hepatic via glucuronic and sulphuric acid conjugation. At normal therapeutic levels, glucuronide metabolites are metabolised to reactive intermediate (acetylimidoquinone) which is conjugated with glutathione and inactivated; at toxic doses, glutathione conjugation is insufficient leading to increased acetylimidoquinone which may cause hepatic cell necrosis.
Excretion: Plasma half-life: 2.7 hr (adults); 1.5-2 hr (infants and children); 3.5 hr (neonates). Neonates, infants and children up â‰¤10 yr excrete less glucuronide than adults. Half-life may be longer after toxic doses. Excreted mainly via urine (2- 5% unchanged; 55% as glucuronide metabolites). Total body clearance: 18 L/hr.
|ATC Classification||N02BE01 - paracetamol; Belongs to the class of anilide preparations. Used to relieve pain and fever.|
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|2A||Mystic Pharmaceuticals Limited||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|2A 500||Mystic Pharmaceuticals Limited||Paracetamol 500mg||Tablet||500's: 325.00 MRP|
|ACE||Square Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||50x10's: 400.00 MRP|
|ACE 125 SUPP||Square Pharmaceuticals Ltd.||Paracetamol 125mg||Suppository||4x5's: 80.60 MRP|
|ACE 250 SUPP||Square Pharmaceuticals Ltd.||Paracetamol 250mg||Suppository||4x5's: 100.60 MRP|
|ACE 500 SUPP||Square Pharmaceuticals Ltd.||Paracetamol 500mg||Suppository||4x5's: 161.20 MRP|
|ACE 60 SUPP||Square Pharmaceuticals Ltd.||Paracetamol 60mg||Suppository||2x5's: 35.20 MRP|
|ACE P-DROP 15||Square Pharmaceuticals Ltd.||Paracetamol 80mg/ml||Paediatric Drops||15 ml: 14.81 MRP|
|ACE P-DROP 30||Square Pharmaceuticals Ltd.||Paracetamol 80mg/ml||Paediatric Drops||30 ml: 20.70 MRP|
|ACE SUSP||Square Pharmaceuticals Ltd.||Paracetamol 120mg/5 ml||Suspension||60 ml: 20.70 MRP|
|ACE SYP 100||Square Pharmaceuticals Ltd.||Paracetamol 120mg/5 ml||Syrup||100 ml: 31.88 MRP|
|ACE SYP 60||Square Pharmaceuticals Ltd.||Paracetamol 120mg/5 ml||Syrup||60 ml: 20.70 MRP|
|ACE XR||Square Pharmaceuticals Ltd.||Paracetamol 665mg||Tablet||10x10's: 151.00 MRP|
|ACEP||Zenith Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||200's: 120.00 MRP|
|ACEP Drop||Zenith Pharmaceuticals Ltd.||Paracetamol 80mg/ml||Drop||15ml: 10.87 MRP|
|ACEP Suspension||Zenith Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.00 MRP|
|ACETA||Biopharma Laboratories Ltd||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|ACETA Drop||Biopharma Laboratories Ltd||Paracetamol 80mg/ml||Drop||15ml: 12.30 MRP|
|ACETA Suspension||Biopharma Laboratories Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 16.34 MRP|
|ACETO||Elixir Pharmaceuticals Ltd||Paracetamol 500mg/tablet||Suspension||60ml bot: 16.25 MRP|
|ACETO 500||Reliance Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||500's: 395.00 MRP|
|ACETOPEN||Reliance Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 13.25 MRP|
|ACETOPHEN||Elixir Pharmaceuticals Ltd||Paracetamol 500mg/tablet||Paediatric Drop||15ml bot: 12.25 MRP|
|ACT||Ambee Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||250's: 200.00 MRP|
|ACT Drop||Ambee Pharmaceuticals Ltd.||Paracetamol 80mg/ml||Drop||15ml: 12.31 MRP|
|ACT Suspension||Ambee Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.34 MRP|
|ACTOL||Somatec Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|ACTOL Suspension||Somatec Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.26 MRP|
|ANALPAIN||Pharmadesh Laboratories Limited||Paracetamol 500mg||Tablet||500's: 350.00 MRP|
|ANALPAIN Drop||Pharmadesh Laboratories Limited||Paracetamol 80mg/ml||Drop||15ml: 12.25 MRP|
|ANALPAIN Suspension||Pharmadesh Laboratories Limited||Paracetamol 120mg/5ml||Suspension||60ml: 16.26 MRP|
|ARCHI||Aexim Pharmaceutical Ltd.||Paracetamol 500mg||Tablet||200's: 100.00 MRP|
|ARCHI Suspension||Aexim Pharmaceutical Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 18.00 MRP|
|ASMOL||Sharif Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||100's: 80.00 MRP|
|ASMOL Suspension||Sharif Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 20.64 MRP|
|ASTA||Rephco Laboratories Ltd.||Paracetamol 500mg||Tablet||250's: 200.00 MRP|
|ASTA Suspension||Rephco Laboratories Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|ATOPEN||Kemiko Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||200's, 400's: 160.00 & 320.00 MRP|
|ATOPEN Suspension||Kemiko Pharmaceuticals Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|ATP||General Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||250's: 200.00 MRP|
|ATP Suspension||General Pharmaceuticals Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 16.34 MRP|
|CENTAMOL||Central Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|CENTAMOL Suspension||Central Pharmaceuticals Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 16.00 MRP|
|CETADOL||Doctors Chemical Works Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|CETAL||Supreme Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||24's, 240's: 14.40 & 144.00 MRP|
|CETAL Suspension||Supreme Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.00 MRP|
|CETAM||Pacific Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||500's: 400.00 MRP|
|CETAM Suspension||Pacific Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|CPMOL||Cosmo Pharma Laboratories Ltd.||Paracetamol 500mg||Tablet||250's: 150.00 MRP|
|D-CETAMOL||Decent Pharma Laboratories Ltd.||Paracetamol 500mg||Tablet||250's: 200.00 MRP|
|D-CETAMOL Suspension||Decent Pharma Laboratories Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.00 MRP|
|DECETAMOL||Decent Pharma Laboratories Ltd.||Paracetamol 500mg/tablet||Suspension||50ml bot: 11.00 MRP|
|DEPOL||Desh Pharmaceuticals (Pvt) Ltd||Paracetamol 500mg||Tablet||400's: 240.00 MRP|
|DEPOL Suspension||Desh Pharmaceuticals (Pvt) Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 12.73 MRP|
|DEPYRIN||Delta Pharma Limited||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|DEPYRIN Suspension||Delta Pharma Limited||Paracetamol 120mg/5ml||Suspension||60ml: 16.35 MRP|
|DOLA||Millat Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|DOLA Suspension||Millat Pharmaceuticals Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|ENYL||Euro Pharma Ltd.||Paracetamol 500mg||Tablet||500's: 400.00 MRP|
|ENYL Suspension||Euro Pharma Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.00 MRP|
|FAP||Beacon Pharmaceuticals Limited||Paracetamol 500mg||Tablet||200's: 130.00 MRP|
|FAST||The Acme Laboratories Ltd.||Paracetamol 500mg||Tablet||500's: 400.00 MRP|
|FAST Suppository||The Acme Laboratories Ltd.||Paracetamol 125mg, 250mg & 500mg||Suppository||10's each: 40.10, 50.10 & 80.40 MRP|
|FAST Suspension||The Acme Laboratories Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.34 MRP|
|FEA||Navana Pharmaceuticals Limited||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|FEA Suspension||Navana Pharmaceuticals Limited||Paracetamol 120mg/5ml||Suspension||60ml: 16.06 MRP|
|FEVA||Ad-din pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||200's: 150.00 MRP|
|FEVA Drop||Ad-din pharmaceuticals Ltd.||Paracetamol 80mg/ml||Drop||15ml: 12.27 MRP|
|FEVA Suspension||Ad-din pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.26 MRP|
|FEVAC||Orion Pharma Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.34 MRP|
|FIBI||Syntho Laboratories Ltd.||Paracetamol 500mg||Tablet||200's: 120.00 MRP|
|FIBI Suspension||Syntho Laboratories Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 12.10 MRP|
|G-PARACETAMOL||Gonoshasthaya Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||100's & 1000's pot: 61.00 & 380.00 MRP|
|G-PARACETAMOL Suspension||Gonoshasthaya Pharmaceuticals Ltd||Paracetamol 250mg/5ml||Suspension||60ml: 15.05 MRP|
|G-PARACETAMOL Syrup||Gonoshasthaya Pharmaceuticals Ltd||Paracetamol 250mg/5ml||Syrup||50ml, 100ml: 15.05 & 27.10 MRP|
|HEPA||Hudson Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||500's: 275.00 MRP|
|HEPA Suspension||Hudson Pharmaceuticals Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|HIPA||Rasa Pharmaceuticals Ltd.||Paracetamol 500mg/tablet||Suspension||60ml bot: 16.28 MRP|
|ISPHA||Globex Pharmaceuticals Ltd.||Paracetamol 500mg/tablet||Tablet||250spack: 130.00 MRP|
|KNOCK||Proteety Pharmaceuticals Ltd.||Paracetamol 500mg/tablet||Tablet||250s pack: 125.00 MRP|
|LONGPARA||IBN SINA Pharmaceutical Industry Ltd.||Paracetamol 665m||Tablet (extended release)||120's: 181.20 MRP|
|M-POL||Modern Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|NAPA||Beximco Pharmaceuticals Ltd||Paracetamol BP 500mg||Tablet||500's: 400.00 MRP|
|NAPA 125||Beximco Pharmaceuticals Ltd||Paracetamol BP 125mg||Suppository||20's: 80.00 MRP|
|NAPA 250||Beximco Pharmaceuticals Ltd||Paracetamol BP 250mg||Suppository||20's: 100.00 MRP|
|NAPA 500||Beximco Pharmaceuticals Ltd||Paracetamol BP 500mg||Suppository||20's: 160.00 MRP|
|NAPA 60||Beximco Pharmaceuticals Ltd||Paracetamol BP 60mg||Suppository||20's: 70.00 MRP|
|NAPA DROP||Beximco Pharmaceuticals Ltd||Paracetamol 80mg/ml||Drop||15ml: 12.30 MRP|
|NAPA DT||Beximco Pharmaceuticals Ltd||Paracetamol 120mg||Tablet (DT)||200's: 256.00 MRP|
|NAPA EXTEND||Beximco Pharmaceuticals Ltd||Paracetamol BP 665mg Extended Release Tablet||Tablet (ER)||120's: 180.00 MRP|
|NAPA IV||Beximco Pharmaceuticals Ltd||Paracetamol BP 10mg/ml Infusion||IV Infusion||100ml: 120.00 MRP|
|NAPA SUSPENSION||Beximco Pharmaceuticals Ltd||Paracetamol BP 120mg/5ml||Suspension||50 & 60ml: 18.23 & 20.63 MRP|
|NAPA SYRUP||Beximco Pharmaceuticals Ltd||Paracetamol BP 120mg/5ml||Syrup||50, 60 & 100ml:18.24, 20.64 & 31.77 MRP|
|NEOPARA||Bristol Pharma Limited||Paracetamol 500mg||Tablet||100's: 50.00 MRP|
|NIPA||Nipa Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||100's: 65.00 MRP|
|NIPA Drop||Nipa Pharmaceuticals Ltd.||Paracetamol 80mg/ml||Drop||15ml: 10.87 MRP|
|NIPA Suspension||Nipa Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 12.66 MRP|
|NOVA||Cosmic Chemical Industries Limited||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|NOVA Suspension||Cosmic Chemical Industries Limited||Paracetamol 120mg/5ml||Suspension||60ml: 16.00 MRP|
|ORPA||Belsen Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||100's: 50.00 MRP|
|PAINIL||Kumudini Pharma Ltd||Paracetamol 500mg||Tablet||500's: 325.00 MRP|
|PAINIL Suspension||Kumudini Pharma Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 16.34 MRP|
|PAM||Everest Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.00 MRP|
|PANA||Skylab Pharmaceuticals Ltd.||Paracetamol 500mg/tablet||Tablet||500s pack: 300.00 MRP|
|PARA||Amico Laboratories Ltd.||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|PARA Drop||Amico Laboratories Ltd.||Paracetamol 80mg/ml||Drop||15ml: 12.00 MRP|
|PARA Suspension||Amico Laboratories Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.00 MRP|
|PARACETAMOL||Indo-Bangla Pharmaceuticals Works Ltd.||Paracetamol 500mg||Tablet||200's: 150.00 MRP|
|PARACETAMOL SAPL||Shamsul Alamin Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||200's: 130.00 MRP|
|PARACETAMOL Susp||Indo-Bangla Pharmaceuticals Works Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.00 MRF|
|PARAFEN||Ziska Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|PARAMOL||Seema Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 20.63 MRP|
|PARAPYROL||GlaxoSmithKline Bangladesh Limited||Paracetamol 500mg||Tablet||500's: 360.56 MRP|
|PARAPYROL Suspension||GlaxoSmithKline Bangladesh Limited||Paracetamol 120mg/5ml||Suspension||100ml: 30.00 MRP|
|PARAXIA||Pharmasia Limited||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|PARAXIA Suspension||Pharmasia Limited||Paracetamol 120mg/5ml||Suspension||60ml: 16.34 MRP|
|POL||Globe Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||200's: 130.00 MRP|
|POL Suspension||Globe Pharmaceuticals Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 20.56 MRP|
|PREDUET||Silva Pharmaceuticals Limited||Paracetamol 500mg||Tablet||250's: 200.75 MRP|
|PREDUET Suspension||Silva Pharmaceuticals Limited||Paracetamol 120mg/5ml||Suspension||60ml: 16.35 MRP|
|PREFER||Marksman Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||300's: 165.00 MRP|
|PREFER Suspension||Marksman Pharmaceuticals Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 12.00 MRP|
|PROMEL||Apollo Pharmaceutical Laboratories Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.00 MRP|
|PYRAC||Medimet Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||500's: 325.00 MRP|
|PYRAC Suspension||Medimet Pharmaceuticals Ltd||Paracetamol 120mg/5ml||Suspension||50ml, 60ml: 18.25 & 16.25 MRP|
|PYRALGIN||Renata Limited||Paracetamol 500mg||Tablet||500's: 400.00 MRP|
|PYRALGIN Suspension||Renata Limited||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|PYRAMOL||Peoples Pharma Ltd.||Paracetamol 500mg||Tablet||250's: 100.00 MRP|
|REMALGIN||Reman Drug Laboratories Ltd.||Paracetamol 500mg||Tablet||250's: 162.50 MRP|
|REMALGIN Suspension||Reman Drug Laboratories Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 15.00 MRP|
|RENOVA||Opsonin Pharma Limited||Paracetamol 500mg||Tablet||250's: 155.00 MRP|
|RENOVA Drop||Opsonin Pharma Limited||Paracetamol 80mg/ml||Drop||15ml: 10.87 MRP|
|RENOVA Suppository||Opsonin Pharma Limited||Paracetamol 125mg, 250mg & 500mg||Suppository||10's each: 40.00 & 50.00 & 80.00 MRP|
|RENOVA Suspension||Opsonin Pharma Limited||Paracetamol 120mg/5ml||Suspension||60ml, 100ml: 16.35 & 24.53 MRP|
|RENOVA Syrup||Opsonin Pharma Limited||Paracetamol 120mg/5ml||Syrup||60ml, 100ml: 20.64 & 31.60 MRP|
|RENOVA XR||Opsonin Pharma Limited||Paracetamol 665m||Tablet (extended release)||100's: 150.00 MRP|
|Reset||Incepta Pharmaceuticals Limited||Paracetamol BP 500 mg||Tablet||20x10's:MRP 160 Tk|
|Reset Drop||Incepta Pharmaceuticals Limited||Paracetamol BP 80mg/ml||Paed. Drop||15ml:MRP 12.3 Tk|
|Reset Injection||Incepta Pharmaceuticals Limited||Paracetamol BP 500mg/100ml||IV Infusion||1x1's:MRP 120 Tk|
|Reset Syrup||Incepta Pharmaceuticals Limited||Paracetamol BP 120mg/5ml||Syrup||60ml:MRP 20.64 Tk|
|SERIDOL||Sonear Laboratories Ltd.||Paracetamol 500mg||Tablet||100's: 67.00 MRP|
|SERVIGESIC||Sandoz/Novartis||Paracetamol BP 500mg||Tablet||500's: MRP 400.00|
|SILPA||Silva Pharmaceuticals Limited||Paracetamol 500mg||Tablet||250's: 150.56 MRP|
|SILPA Suspension||Silva Pharmaceuticals Limited||Paracetamol 120mg/5ml||Suspension||60ml: 16.35 MRP|
|SINAPOL||IBN SINA Pharmaceutical Industry Ltd.||Paracetamol 500mg||Tablet||250's: 200.00 MRP|
|SINAPOL Suspension||IBN SINA Pharmaceutical Industry Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.34 MRP|
|SKYMOL||Skylab Pharmaceuticals Ltd.||Paracetamol 500mg/tablet||Tablet||250s pack: 200.00 MRP|
|TAMEN||Eskayef Bangladesh Ltd||Paracetamol BP 500mg||Tablet||200's & 500's MRP: 160.00 & 400.00|
|TAMEN Drop||Eskayef Bangladesh Ltd||Paracetamol BP 80mg/ml||Drop||15ml MRP: 12.26|
|TAMEN Suspension||Eskayef Bangladesh Ltd||Paracetamol BP 120mg/5ml Suspension||Suspension||60ml MRP: 16.28|
|TAMEN Syrup||Eskayef Bangladesh Ltd||Paracetamol BP120mg/5ml||Syrup||60ml & 100ml MRP: 20.56, 31.66|
|TAMINO||NIPRO JMI Pharma Ltd.||Paracetamol 500mg||Tablet||200's: 130.00 MRP|
|TAMINO Suspension||NIPRO JMI Pharma Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|TAMOL||Apex Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|TAMOL Suspension||Apex Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.34 MRP|
|TANDAMOL||Medicon Laboratories Ltd||Paracetamol 500mg||Tablet||300's: 225.00 MRP|
|TANDAMOL Suspension||Medicon Laboratories Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 16.20 MRP|
|TEMPAC||Hallmark Pharmaceuticals Ltd||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|TEMPAC Suspension||Hallmark Pharmaceuticals Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 20.00 MRP|
|TEMPIL||Alco Pharma Ltd||Paracetamol 500mg||Tablet||200's, 500's: 160.00 & 400.00 MRP|
|TEMPIL Suspension||Alco Pharma Ltd||Paracetamol 120mg/5ml||Suspension||60ml: 24.53 MRP|
|TEMPOL||Asiatic Laboratories Ltd.||Paracetamol 80mg/ml||Drop||15ml, 30ml: 12.31 & 15.73 MRP|
|TEMPOL Suspension||Asiatic Laboratories Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.38 MRP|
|TIMIDAL||Gaco Pharmaceutical Ltd.||Paracetamol 500mg||Tablet||250's: 200.00 MRP|
|TIMIDAL Suspension||Gaco Pharmaceutical Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|TYDENOL||Edruc Limited||Paracetamol 500mg||Tablet||200's: 102.00 MRP|
|TYDENOL Suspension||Edruc Limited||Paracetamol 120mg/5ml||Suspension||60ml: 18.00 MRP|
|TYLEN||R A K Pharmaceuticals Pvt. Ltd.||Paracetamol 500mg||Tablet||200's: 160.00 MRP|
|TYLEN Suspension||R A K Pharmaceuticals Pvt. Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.28 MRP|
|TYNOL||Salton Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.35 MRP|
|XCEL||ACI Ltd.||Paracetamol 500mg||Tablet||500's: 400.00 MRP|
|XCEL Drop||ACI Ltd.||Paracetamol 80mg/ml||Drop||15ml: 12.31 MRP|
|XCEL DT||ACI Ltd.||Paracetamol 120mg||Dispersible Tablet||100's: 128.00 MRP|
|XCEL Suspension||ACI Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 20.63 MRP|
|XCEL Syrup||ACI Ltd.||Paracetamol 120mg/5ml||Syrup||60ml: 20.64 MRP|
|XPA||Aristopharma Ltd.||Paracetamol 500mg||Tablet||250's: 200.00 MRP|
|XPA Drop||Aristopharma Ltd.||Paracetamol 80mg/ml||Drop||15ml: 12.30 MRP|
|XPA Suspension||Aristopharma Ltd.||Paracetamol 120mg/5ml||Suspension||60ml, 100ml: 16.30 & 24.60 MRP|
|XPA XR||Aristopharma Ltd.||Paracetamol 665mg||Tablet (extended release)||100's: 150.00 MRP|
|ZERIN||Jayson Pharmaceuticals Ltd.||Paracetamol 500mg||Tablet||500's: 400.00 MRP|
|ZERIN Drop||Jayson Pharmaceuticals Ltd.||Paracetamol 80mg/ml||Drop||15ml: 12.30 MRP|
|ZERIN Suspension||Jayson Pharmaceuticals Ltd.||Paracetamol 120mg/5ml||Suspension||60ml: 16.34 MRP|
Notice: Raised in the US market.
[Posted 08/01/2013] ISSUE: FDA notified healthcare professionals and patients that acetaminophen has been associated with a risk of rare but serious skin reactions. Acetaminophen is a common active ingredient to treat pain and reduce fever; it is included in many prescription and over-the-counter (OTC) products. These skin reactions, known as Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP), can be fatal. These reactions can occur with first-time use of acetaminophen or at any time while it is being taken. Other drugs used to treat fever and pain/body aches (e.g., non-steroidal anti-inflammatory drugs, or NSAIDS, such as ibuprofen and naproxen) also carry the risk of causing serious skin reactions, which is already described in the warnings section of their drug labels.
BACKGROUND: This new information resulted from the Agency's review of the FDA Adverse Event Reporting System (FAERS) database and the medical literature to evaluate cases of serious skin reactions associated with acetaminophen (see Data Summary at link below). It is difficult to determine how frequently serious skin reactions occur with paracetamol/acetaminophen, due to the widespread use of the drug, differences in usage among individuals (e.g., occasional vs. long-term use), and the long period of time that the drug has been on the market; however it is likely that these events (i.e., SJS, TEN, and AGEP) occur rarely.
RECOMMENDATION: Health care professionals should be aware of this rare risk and consider acetaminophen, along with other drugs already known to have such an association, when assessing patients with potentially drug-induced skin reactions. Any patient who develops a skin rash or reaction while using acetaminophen or any other pain reliever/fever reducer should stop the drug and seek medical attention right away. Anyone who has experienced a serious skin reaction with acetaminophen should not take the drug again and should contact their health care professional to discuss alternative pain relievers/fever reducers.
FDA will require that a warning be added to the labels of prescription drug products containing acetaminophen to address the risk of serious skin reactions. FDA will also request that manufacturers add a warning about serious skin reactions to the product labels of OTC acetaminophen drug products marketed under a new drug application and will encourage manufacturers of drug products marketed under the OTC monograph do the same.
For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety.
Infants' Paracetamol/Acetaminophen Product Changes
Children's paracetamol/acetaminophen has been available as concentrated infant drops (containing 80 mg of acetaminophen per 0.8 mL of drops or 80 mg of acetaminophen per 1 mL of drops) and as a less concentrated liquid (containing 160 mg acetaminophen per 5 mL of liquid) for older children. The Food and Drug Administration (FDA) received reports of children who were given too much acetaminophen when their caregivers mistakenly used a more concentrated product in place of a less concentrated product. To prevent this type of mistake, the concentrated infant drops will no longer be manufactured for sale in the U.S. Instead, all liquid acetaminophen products for children under 12 years of age will contain 160 mg of acetaminophen in 5 mL of medication.
Although the more concentrated products are no longer being manufactured, they may still be available in stores for some time, and you may already have these products in your home. You may continue to buy and to give your child the concentrated products, but you will need to be especially careful to follow directions so that you give your child the right amount of medication.
Before you give your child paracetamol/acetaminophen, check the active ingredient section in the Drug Facts label on the package to see whether the medication is an older concentrated product containing 80 mg per 0.8 mL or a newer product containing 160 mg per 5 mL. Do not assume that a product with the word ''new'' on the package contains the new concentration because the word ''new'' may also appear on older products. Read the directions on each product label carefully and give only the amount of medication listed in the instructions on that package to your child. Do not just give your child the same amount of medication that you have given in the past, follow instructions that you have read on a different package in the past, or rely on dosing instructions from the Internet, old dosing charts, or family members. If your child's doctor prescribes acetaminophen for your child, be sure that he or she knows which product you will be using so that he or she can prescribe the correct dose.
If you have an older concentrated product, it will probably come with a dropper, and if you have a newer product, it may come with an oral syringe. Only measure your child's medication with the device included in that package . Do not switch measuring devices between the old and new acetaminophen liquid products.
Talk to your doctor if you have questions about these paracetamol/acetaminophen product changes.
Taking too much Paracetamol (Acetaminophen) can cause liver damage, sometimes serious enough to require liver transplantation or cause death. You might accidentally take too much Paracetamol if you do not follow the directions on the prescription or package label carefully, or if you take more than one product that contains Paracetamol.
To be sure that you take Paracetamol (Acetaminophen) safely, you should:
Talk to your doctor if you have questions about the safe use of Paracetamol (Acetaminophen)-containing products.
Why Paracetamol is prescribed?
Paracetamol (Acetaminophen) is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. Paracetamol (Acetaminophen) may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints). Paracetamol (Acetaminophen) is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
How should Paracetamol be used?
Paracetamol often comes as a tablet, solution (liquid syrup) and drops to take by mouth, with or without food. Paracetamol also comes as a suppository to use rectally. Paracetamol is available without a prescription, but your doctor may prescribe Paracetamol to treat certain conditions. Follow the directions on the package or prescription label carefully, and ask your doctor to explain any part you do not understand.
If you are giving Paracetamol to your child, read the package label carefully to make sure that it is the right product for the age of the child. Do not give children Paracetamol products that are made for adults. Some products for adults and older children may contain too much Paracetamol for a younger child. Check the package label to find out how much medication the child needs. If you know how much your child weighs, give the dose that matches that weight on the chart. If you don't know your child's weight, give the dose that matches your child's age. Ask your child's doctor if you don't know how much medication to give your child.
Paracetamol comes in combination with other medications to treat cough and cold symptoms. Ask your doctor for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using two or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.
Swallow the extended-release tablets (if available) whole; do not split, chew, crush, or dissolve them.
Shake the suspension well before each use to mix the medication evenly. Always use the measuring cup or syringe provided by the manufacturer to measure each dose of the solution or suspension. Do not switch dosing devices between different products; always use the device that comes in the product packaging.
To insert a Paracetamol suppository into the rectum, follow these steps:
- Remove the wrapper.
- Dip the tip of the suppository in water.
- Lie down on your left side and raise your right knee to your chest. (A left-handed person should lie on the right side and raise the left knee.)
- Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in infants and children and 1 inch (2.5 centimeters) in adults. Hold it in place for a few moments.
- Stand up after about 15 minutes. Wash your hands thoroughly and resume your normal activities.
Stop taking Paracetamol and call your doctor if your symptoms get worse, you develop new or unexpected symptoms, including redness or swelling, your pain lasts for more than 10 days, or your fever gets worse or lasts more than 3 days. Also stop giving Paracetamol to your child and call your child's doctor if your child develops new symptoms, including redness or swelling, or your child's pain lasts for longer than 5 days, or fever get worse or lasts longer than 3 days.
Do not give Paracetamol to a child who has a sore throat that is severe or does not go away, or that occurs along with fever, headache, rash, nausea, or vomiting. Call the child's doctor right away, because these symptoms may be signs of a more serious condition.
Other uses for Paracetamol
Paracetamol (Acetaminophen) may also be used in combination with aspirin and caffeine to relieve the pain associated with migraine headache.
Paracetamol is sometimes prescribed for other uses; ask your doctor for more information.
What special precautions to follow?
Before taking Paracetamol (Acetaminophen),
- inform your doctor if you are allergic to Paracetamol, any other medications, or any of the ingredients in the product. Please also carefully check the label on the package for a list of ingredients.
- inform your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, or herbal products you are taking or plan to take. Be sure to mention anticoagulants ('blood thinners') such as warfarin; isoniazid (INH); certain medications for seizures including carbamazepine (Tegretol), phenobarbital, and phenytoin; medications for pain, fever, coughs, and colds; and phenothiazines (medications for mental illness and nausea). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- inform your doctor if you have any serious medical condition.
- inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Paracetamol, call your doctor.
- if you drink three or more alcoholic beverages every day, ask your doctor if you should take Paracetamol. Ask your doctor about the safe use of alcoholic beverages while taking Paracetamol.
- you should know that combination Paracetamol products for cough and colds that contain nasal decongestants, antihistamines, cough suppressants, and expectorants should not be used in children younger than 2 years of age. Use of these medications in young children can cause serious and life-threatening effects or death. In children 2 through 11 years of age, combination cough and cold products should be used carefully and only according to the directions on the label.
- if you have phenylketonuria (PKU, a inherited condition in which a special diet must be followed to prevent mental retardation), you should know that some brands of Paracetamol chewable tablets may be sweetened with aspartame. a source of phenylalanine.
What special dietary instructions to follow?
Unless your doctor informs you otherwise, continue your normal diet.
What to do if I forget a dose?
Paracetamol is usually taken as needed. If your doctor has told you to take Paracetamol regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can Paracetamol cause?
Paracetamol may cause side effects.
Some side effects can be serious. If you experience any of the following symptoms, stop taking Paracetamol (Acetaminophen) and call your doctor immediately:
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- difficulty breathing or swallowing
Paracetamol (Acetaminophen) may cause other side effects. Call your doctor if you have any unusual problems while you are taking Paracetamol.
What storage conditions are needed for Paracetamol?
Keep Paracetamol in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, contact Hospital Emergency.
If someone takes more than the recommended dose of Paracetamol (Acetaminophen), get medical help immediately, even if the person does not have any symptoms. Symptoms of overdose may include:
- loss of appetite
- extreme tiredness
- unusual bleeding or bruising
- pain in the upper right part of the stomach
- yellowing of the skin or eyes
- flu-like symptoms
What other information to know?
Before having any laboratory test, inform your doctor and the laboratory personnel that you are taking acetaminophen.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: U.S. National Library of Medicine.
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.
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