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PCI  : Contraindicated in pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage Oral Contraception
Adult: 0.5 mg daily when used alone or 0.75-2.5 mg daily when used in combination with an oestrogen.

Menstrual disorders
Adult: 5-10 mg orally daily as cyclic regimen.
Administration Normal release prep: May be taken with or without food. Admin instructions for modified release prep may vary according to brands, refer to lit.
Contraindications Undiagnosed vaginal bleeding, active venous thromboembolic disorders or severe arterial disease, hepatic impairment, progestogen-dependent tumours, porphyria. Pregnancy.
Special Precautions

CV or renal dysfunction, hypertension, epilepsy, migraine, asthma, DM, conditions which may be exacerbated by fluid retention, malabsorption syndrome, post ectopic pregnancy, functional ovarian cysts, thromboembolism. Lactation.

Adverse Drug Reaction(s)

GI disturbances, changes in appetite or weight, fluid retention, oedema, rashes, urticaria, mental depression, breast tenderness and pain, gynaecomastia, changes in libido, headache, migraine, altered menstrual cycle, irregular menstrual bleeding, changes in LFTs and serum lipid profile.
Potentially Fatal: Anaphylaxis or anaphylactoid reactions.

Drug Interactions Increased metabolism and subsequent reduction in efficacy with enzyme-inducing agents e.g. carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Adjustment in antidiabetic dose may be required.
Potentially Fatal: May increase plasma levels and toxicity of ciclosporin.

Pregnancy Category (FDA)

Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Pharmacology Lynestrenol is a progestogen structurally related to norethisterone. It may be used alone or as the progestogenic component of some oral contraceptives.
ATC Classification G03AC02 - lynestrenol; Belongs to the class of progestogens. Used as systemic contraceptives. 
G03DC03 - lynestrenol; Belongs to the class of estren derivative progestogens used in progestogenic hormone preparations.
 

Brand/Product Info


Total Products : 1 
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ORGATRIL Nuvista Pharma Limited Lynestrenol 5mg Tablet 30's: 298.50 MRP

 

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