P : Contraindicated in pregnancy
L : Caution when used during lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||Oral Contraception
Adult: 0.5 mg daily when used alone or 0.75-2.5 mg daily when used in combination with an oestrogen.
Adult: 5-10 mg orally daily as cyclic regimen.
|Administration||Normal release prep: May be taken with
or without food. Admin instructions for modified release prep may vary according to brands, refer to lit.
|Contraindications||Undiagnosed vaginal bleeding, active venous thromboembolic disorders or severe arterial disease, hepatic impairment, progestogen-dependent tumours, porphyria. Pregnancy.|
CV or renal dysfunction, hypertension, epilepsy, migraine, asthma, DM, conditions which may be exacerbated by fluid retention, malabsorption syndrome, post ectopic pregnancy, functional ovarian cysts, thromboembolism. Lactation.
|Adverse Drug Reaction(s)||
GI disturbances, changes in
appetite or weight, fluid retention, oedema, rashes, urticaria, mental depression, breast tenderness and pain, gynaecomastia, changes in libido, headache,
migraine, altered menstrual cycle, irregular menstrual bleeding, changes in LFTs and serum lipid profile.
|Drug Interactions||Increased metabolism and subsequent reduction in efficacy with enzyme-inducing agents e.g. carbamazepine, griseofulvin,
phenobarbital, phenytoin and rifampicin. Adjustment in antidiabetic dose may be required.
Potentially Fatal: May increase plasma levels and toxicity of ciclosporin.
|Pregnancy Category (FDA)||
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
|Pharmacology||Lynestrenol is a progestogen structurally related to norethisterone. It may be used alone or as the progestogenic component of some oral contraceptives.|
|ATC Classification||G03AC02 - lynestrenol; Belongs to the class of progestogens. Used as
G03DC03 - lynestrenol; Belongs to the class of estren derivative progestogens used in progestogenic hormone preparations.
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