mph Bangladesh


P  - Contraindicated in pregnancy

L  - Caution when used during lactation

Molecule Info

Indication & Dosage

Oral

Menopausal hormone replacement therapy, Adult: 0. 5-3mg daily for 1 mth followed by 0. 5-1mg daily; or 0. 25-2mg daily in combination with other natural oestrogens. A progestogen is required if administered to women with a uterus.

Oral

Infertility due to cervical hostility, Adult: 0. 25-1mg/day on days 6-15 of the menstrual cycle. Increase dose each mth until an optimal effect is obtained.

Vaginal

Menopausal atrophic vaginitis, Adult: As 0. 01% or 0. 1% cream or 500 mcg pessary: Apply 500 mcg once daily, reduce to twice wkly subsequently.

 

Administration

May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take w/ antacids, Fe or dairy products.

 

Contraindications

Pregnancy, thrombosis, known or suspected oestrogen-dependent tumors, vag bleeding, history of undiagnosed manifesation of deterioration of otosclerosis during pregnancy or previous use of steroids.

Special Precautions

Thrombosis, severe liver disorders, porphyria, history during pregnancy or previous use of steroids of severe pruritus, cholestatic jaundice, herpes gestationis or otosclerosis. Lactation.

Adverse Drug Reactions

Breast tension or pain, nausea, spotting. Fluid retention, cervical hypersecretion.

Drug Interactions

Reduced efficacy may occur when used with activated charcoal, barbiturates, carbamazepine, griseofulvin, hydantoin and rifampicin. May possibly change efficacy of oral anticoagulants and increase pharmacologic effects of succinylcholine, theophyllines and troleandromycin.

Lab Interference

Reduce responses to metyrapone test. May interfere with thyroid function and glucose tolerance tests.

Pharmacology

Estriol is a naturally occurring oestrogen. It induces normalization of vag epithelium. It is claimed to have only a mild proliferative effect on the endometrium. It only has a short retention time in the nuclei of endometrial cells.

mph Class

Oestrogens & Progesterones & Related Synthetic Drugs/Preparations for Vaginal Conditions

ATC Classification

G03CC06 - estriol; Belongs to the class of estrogens in combination with other drugs used in estrogenic hormone preparations. G03CA04 - estriol; Belongs to the class of natural and semisynthetic estrogens used in estrogenic hormone preparations.

   

 

 

Brand/Product Info


Total Products : 5     
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
Defogen Incepta Pharmaceuticals Limited Estriol BP 1mg Tablet 10x3's:MRP 240 Tk
FEMASTIN Square Pharmaceuticals Ltd. Estriol 1mg Tablet 3x10's: 240.90 MRP
FEMASTIN CRM Square Pharmaceuticals Ltd. Estriol 0.1% Cream 15 gm: 1000.00 MRP
OVESTIN Nuvista Pharma Limited Estriol 1mg Tablet 30's: 256.20 MRP
OVESTIN cream Nuvista Pharma Limited Estriol 1mg/gram Cream 15gm with applicator: 1114.00 MRP

 

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