mph Bangladesh


Ketorolac

(kee toe role' ak)

PCI / LCIContraindication for pregnancy & lactation (breast feeding)

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication & Dosage Oral
Moderate to severe pain
Adult: 10 mg every 4-6 hr. Max: 40 mg/day. Max duration: 7 days.
Elderly: 10 mg every 6-8 hr. Max duration: 7 days.
Renal impairment: Contraindicated in moderate to severe impairment. 
Parenteral
Moderate to severe pain
Adult: 60 mg as a single dose via IM inj or 30 mg as a single IV dose. Alternatively, 30 mg every 6 hr via IM or IV admin up to a max of 120 mg daily. Halve the doses in patients weighing <50 kg. Max duration: 2 days; patient should be transferred to oral therapy as soon as possible. 
Elderly: 30 mg as a single dose via IM inj or 15 mg as a single IV dose. Alternatively, 15 mg every 6 hr via IM or IV admin up to a max of 60 mg daily.
Renal impairment: 30 mg as a single dose via IM inj or 15 mg as a single IV dose. Alternatively, 15 mg every 6 hr via IM or IV admin up to a max of 60 mg daily. Contraindicated in moderate to severe impairment. 
Ophthalmic
Ocular itching associated with seasonal allergic conjunctivitis
Adult: As trometamol: Instil 1 drop of a 0.5% solution into the affected eye(s) 4 times daily.
Renal impairment: Contraindicated in moderate to severe impairment. 
Ophthalmic
Prophylaxis and reduction of postoperative ocular inflammation
Adult: As trometamol: Instil 1 drop of a 0.5% solution into the appropriate eye(s) 4 times daily starting 24 hr after surgery. Continue for 2 wk.
Renal impairment: Contraindicated in moderate to severe impairment. 
Ophthalmic
Cystoid macular oedema
Adult: As trometamol: Instil 1-2 drops of a 0.5% solution into the appropriate eye(s) every 6-8 hr starting 24 hr before surgery and continue for 3-4 wk after surgery.
Renal impairment: Contraindicated in moderate to severe impairment. 
Ophthalmic
Pain and photophobia after incisional refractive surgery
Adult: As trometamol: Instil 1 drop of a 0.5% solution 4 times daily into the operated eye for up to 3 days after surgery.
Renal impairment: Contraindicated in moderate to severe impairment.

Special Populations: Renal impairment: Max dose for parenteral admin is 60 mg/day.

Incompatibility: Y-site incompatibility: Fenoldopam, azithromycin. Syringe incompatibility: Promethazine, hydroxyzine, nalbuphine, haloperidol, prochorperazine edisylate, triethylperazine. Admixture incompatibility: Promethazine, morphine, hydroxyzine, meperidine.
Overdosage Symptoms: Abdominal pain, nausea, vomiting, hyperventilation, peptic ulceration, erosive gastritis and renal dysfunction. Management: Supportive and symptomatic.
Contraindications Hypersensitivity to aspirin or other NSAIDs, asthma. Hypovolaemia or dehydration. Do not give postoperatively to patients with high risk of haemorrhage. History of peptic ulcer or coagulation disorders. Nasal polyps, angioedema, bronchospasm. Labour. Moderate to severe renal impairment. GI bleeding, cerebrovascular bleeding. As prophylactic analgesic before surgery. Pregnancy, lactation.
Special Precautions Elderly, patients weighing <50 kg, hepatic dysfunction, heart failure, predisposition to reduced blood volume or renal blood flow. Mild renal impairment; monitor renal function closely.
Adverse Drug Reactions GI ulcer, bleeding and perforation, drowsiness, rash, bronchospasm, hypotension, psychosis, dry mouth, fever, bradycardia, chest pain, dizziness, headache, sweating, oedema, pallor, liver function changes. Transient stinging and local irritation (ophthalmic).
Potentially Fatal: Anaphylaxis. Severe skin reactions. MI, stroke, GI bleeding.
Drug Interactions May reduce effects of antihypertensives eg ACE inhibitors or angiotensin II receptor antagonists (AIIA). Increased risk of renal toxicity with ACE inhibitors, diuretics. Increased adverse effects with aspirin or other NSAIDs. Hallucinations may occur when used with fluoxetine, thiothixene, alprazolam.
Potentially Fatal: Increased risk of GI bleeding with warfarin. May increase toxicity of methotrexate (MTX) and lithium. Increased plasma concentrations with probenecid. Please consult detailed drug interactions before prescribing.
Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
 
Category DIn 3rd trimester or near delivery.There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Storage Ophthalmic: Store at 15-25°C or 59-77°F. Oral/Parenteral: Store at 15-30°C or 59-86°F.
Pharmacology Ketorolac inhibits prostaglandin synthesis by decreasing the activity of the cyclooxygenase enzyme.
Onset: 30-60 min (oral); 10 min (IM).
Duration: 6-8 hr (oral/IM).
Absorption: Well absorbed (oral/IM); peak plasma concentrations after 30-60 min.
Distribution: Protein-binding: 99%. Crosses the placenta; enters breast milk; poorly penetrates into CSF.
Metabolism: Hepatic via glucuronic acid conjugation.
Excretion: Via urine (90%, as unchanged drug and metabolites); via faeces (remaining dose). Terminal elimination half-life: 4-6 hr; 6-7 hr (elderly); 9-10 hr (renal impairment).
ATC Classification M01AB15 - ketorolac; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products. Used in the treatment of inflammation and rheumatism. 
S01BC05 - ketorolac; Belongs to the class of non-steroidal antiinflammatory agents. Used in the treatment of inflammation of the eye.

Brand/Product Info


Total Products : 111                                                                                                               
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ACUPAIN Beacon Pharmaceuticals Limited Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.90 MRP
ACUPAIN Injection Beacon Pharmaceuticals Limited Ketorolac tromethamine 30mg/1ml ampoule (IM/IV) Injection 5 amps: 276.00 MRP
ANALAC Ziska Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
ANALAC Injection Ziska Pharmaceuticals Ltd. Ketorolac tromethamine 30mg/ml & 60mg/2ml (IM/IV) Injection 30mg x5's, 60mg x1's: 275.00 & 95.00 MRP
ANGESIC 10 The White Horse Pharma Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
AROLAK Ambee Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
AROLAK Injection Ambee Pharmaceuticals Ltd. Ketorolac tromethamine 10mg/1ml, 30mg/1ml (IM/IV) Injection 5 amp. each: 150.60 & 276.05 MRP
DOLOKET Kumudini Pharma Ltd Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
E-KET Edruc Limited Ketorolac tromethamine 30mg/ml (IM/IV) Injection 30mg amp. x5's: 250.00 IP
E-KET-10 Edruc Limited Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
EMODOL Jayson Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 203.00 MRP
EMODOL Drop Jayson Pharmaceuticals Ltd. Ketorolac tromethamine 5mg/ml (0.5% isotonic soln.) Eye Drop 5ml: 60.92 IP
EMODOL Injection Jayson Pharmaceuticals Ltd. Ketorolac tromethamine 10mg/ml & 30mg/1ml (IM/IV) Injection 10mg x10's, 30mg x5's: 332.50, 250.95 IP
ETOLAC IBN SINA Pharmaceutical Industry Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 210.00 MRP
ETOLAC Drop IBN SINA Pharmaceutical Industry Ltd. Ketorolac tromethamine 5mg/ml (0.5% isotonic soln.) Eye Drop 5ml: 85.00 IP
ETOLAC Injection IBN SINA Pharmaceutical Industry Ltd. Ketorolac tromethamine 30mg/ml, 60mg/2ml (IM/IV) Injection 30mg x5's, 60mg x1's: 300.00, 100.00 IP
Etorac Incepta Pharmaceuticals Limited Ketorolac Tromethamine USP 10 mg Film Coated Tablet 10x3's:MRP 300 Tk
Etorac 30 Incepta Pharmaceuticals Limited Ketorolac Tromethamine USP 30 mg IM/IV Injection 1x1's:MRP 55 Tk
Etorac 60 Incepta Pharmaceuticals Limited Ketorolac Tromethamine USP 60 mg IM Injection 1x1's:MRP 95 Tk
Etorac Drop Incepta Pharmaceuticals Limited Ketorolac Tromethamine 0.5% USP Eye Drop 5ml:MRP 80 Tk
EUROLAC Euro Pharma Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
INKET Indo-Bangla Pharmaceuticals Works Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 40's: 400.00 MRP
K-NIL Rephco Laboratories Ltd. Ketorolac tromethamine 30mg/ml ampoule (IM/IV) Injection 30mg amp. x1's: 60.00 MRP
KELAC Chemist Laboratories Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 160.00 MRP
KELAC Injection Chemist Laboratories Ltd. Ketorolac tromethamine 30mg/ml ampoule (IM/IV) Injection 5 amps: 175.00 MRP
KENODOL Rangs Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 240.00 MRP
KENODOL Injection Rangs Pharmaceuticals Ltd. Ketorolac tromethamine 30mg/ml ampoule (IM/IV) Injection 6 amps: 300.00 MRP
KEPROS Monico Pharma Limited Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
KEPROS Injection Monico Pharma Limited Ketorolac tromethamine 30mg/ml ampoule (IM/IV) Injection 5 amps: 275.00 MRP
KEROLAC Gaco Pharmaceutical Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
KEROLAC Drop Gaco Pharmaceutical Ltd. Ketorolac tromethamine 5mg/ml (0.5% isotonic soln.) Eye Drop 5ml: 60.00 MRP
KET Delta Pharma Limited Ketorolac tromethamine 10mg Film Coated Tablet 20's: 160.00 MRP
KETEKS R A K Pharmaceuticals Pvt. Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
KETEKS Injection R A K Pharmaceuticals Pvt. Ltd. Ketorolac tromethamine 30mg/ml, 60mg/2ml (IM/IV) Injection 30mg x5's, 60mg x1's: 275.00 & 95.00 MRP
KETOBE 10 Benham Pharmaceuticals Ltd Ketorolac tromethamine 10mg Film Coated Tablet 30's: 298.20 MRP
KETOFLEX Somatec Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.60 MRP
KETONIC Eskayef Bangladesh Ltd Ketorolac Tromethamine USP 10mg Film Coated Tablet 30's MRP: 300.00
KETONIC Injection Eskayef Bangladesh Ltd Ketorolac Tromethamine USP 30mg/ml Injection 30mg/ml x1's, 4's, 5's & 60mg/2ml,MRP: 55.00, 220.00, 275.00 & 95.00
KETOPRIX Sharif Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
KETORA Medicon Laboratories Ltd Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
KETORIN Orion Pharma Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
KETORIN Injection Orion Pharma Ltd. Ketorolac tromethamine 30mg/ml ampoule (IM/IV) Injection 5 amps: 250.95 MRP
KETOROLAC APC Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 30's: 200.00 MRP
KETOROLAC, Bristol Bristol Pharma Limited Ketorolac tromethamine 10mg Film Coated Tablet 40's: 400.00 MRP
KETOSEEM Seema Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
KETROMIN Pacific Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
KFLAM Apex Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
KFLAM Injection Apex Pharmaceuticals Ltd. Ketorolac tromethamine 30mg/1ml ampoule (IM/IV) Injection 5 amps: 275.00 MRP
KILPAN Decent Pharma Laboratories Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
KITOLAC Nipa Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
KITOREX S.N. Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 30's: 301.50 MRP
KPR Central Pharmaceuticals Ltd Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
KTMET NIPRO JMI Pharma Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 30's: 301.20 MRP
LACOR Ad-din pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 160.00 MRP
LIXIDOL Cosmic Chemical Industries Limited Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
LOPADOL Popular Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 50's: 502.00 MRP
LOPADOL Drop Popular Pharmaceuticals Ltd. Ketorolac tromethamine 5mg/ml (0.5% isotonic soln.) Eye Drop 5ml: 80.30 MRP
LOPADOL Injection Popular Pharmaceuticals Ltd. Ketorolac tromethamine 30mg/ml, 60mg/2ml (IM/IV) Injection 30mg x5's, 60mg x1's: 276.05 & 95.36 MRP
MAXDOL Concord Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
MINOLAC ACI Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 40's: 401.60 MRP
MINOLAC Injection ACI Ltd. Ketorolac tromethamine 10mg/ml, 30mg/ml & 60mg/2ml (IM/IV) Injection 10mg/ml, 30mg/ml & 60mg/2ml amp: 33.00, 55.21 & 95.36 MRP
OFPAIN Kemiko Pharmaceuticals Ltd Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
OFPAIN Drop Kemiko Pharmaceuticals Ltd Ketorolac tromethamine 5mg/ml (0.5% isotonic soln.) Eye Drop 5ml: 80.00 MRP
OFPAIN Injection Kemiko Pharmaceuticals Ltd Ketorolac tromethamine 30mg/1ml ampoule (IM/IV) Injection 1's: 50.00 MRP
ORADOL Aristopharma Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's, 30's: 200.00 & 300.00 MRP
ORADOL Drop Aristopharma Ltd. Ketorolac tromethamine 5mg/ml (0.5% isotonic soln.) Eye Drop 5ml: 80.00 MRP
ORADOL Injection Aristopharma Ltd. Ketorolac tromethamine 30mg/ml, 60mg/2ml (IM/IV) Injection 30mg/ml x1's & 5's: 55.00, 275.00; 60mg/2ml: 95.00 MRP
ORC Navana Pharmaceuticals Limited Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.80 MRP
PAINLOK Novus Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
PAIR Drug International Ltd Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
PAIR Injection Drug International Ltd Ketorolac tromethamine 30mg/ml (IM/IV) Injection 1 ml amp: 55.00 MRP
PERILAC Biopharma Laboratories Ltd Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
PERILAC Injection Biopharma Laboratories Ltd Ketorolac tromethamine 10mg/ml, 30mg/ml (IM/IV) Injection 5 amp. each: 150.55 & 276.05 MRP
RECULAR Reman Drug Laboratories Ltd. Ketorolac tromethamine 5mg/ml (0.5% isotonic soln.) Eye Drop 5ml: 80.30 MRP
ROKET Globe Pharmaceuticals Ltd Ketorolac tromethamine 30mg/ml, 60mg/2ml (IM/IV) Injection 30mg/ml x5's, 60mg/2ml x1's: 250.00 & 95.00 MRP
ROKET 10 Globe Pharmaceuticals Ltd Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
ROLAC Renata Limited Ketorolac tromethamine 10mg Film Coated Tablet 40's: 400.00 MRP
ROLAC Injection Renata Limited Ketorolac tromethamine 10mg/ml, 30mg/ml & 60mg/2ml (IM/IV) Injection 10mg/ml, 30mg/ml & 60mg/2ml amp: 32.13, 55.21 & 190.00 MRP
ROMILAC Techno Drugs Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
ROMILAC Injection Techno Drugs Ketorolac tromethamine 30mg/ml ampoule (IM/IV) Injection 1ml amp. x10's: 560.00 MRP
ROTALAC Pharmasia Limited Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.80 MRP
ROTALAC Injection Pharmasia Limited Ketorolac tromethamine 30mg/ml, 60mg/2ml (IM/IV) Injection 30mg/ml & 60mg/2ml amp: 55.00 & 95.00 MRP
ROTEK Novo Healthcare and Pharma Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
ROTEK Injection Novo Healthcare and Pharma Ltd. Ketorolac tromethamine 30mg/ml ampoule (IM/IV) Injection 1ml amp. x5's: 250.00 MRP
SANOKET Sanofi Ketorolac tromethamine 10mg Film Coated Tablet 30's: 270.90 MRP
SANOKET Injection Sanofi Ketorolac tromethamine 10mg/ml, 30mg/ml (IM/IV) Injection 5 amp. each: 150.55 & 276.05 MRP
TODOL Opsonin Pharma Limited Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
TODOL Injection Opsonin Pharma Limited Ketorolac tromethamine 30mg/ml, 60mg/2ml (IM/IV) Injection 30mg/ml & 60mg/2ml amp: 280.00 & 95.00 MRP
TOLEC Alco Pharma Ltd Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.80 MRP
TORADOL Radiant Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 460.20 MRP
TORADOL Injection Radiant Pharmaceuticals Ltd. Ketorolac tromethamine 30mg/1ml ampoule (IM/IV) Injection 5 amps: 550.00 MRP
TORAX 10 Square Pharmaceuticals Ltd. Ketorolac Tromethamine 10mg Tablet 5x10's: 503.50 MRP
TORAX 30 Square Pharmaceuticals Ltd. Ketorolac Tromethamine 30mg / ml IM/IV Injection 5x1's: 276.85 MRP
TORAX 60 Square Pharmaceuticals Ltd. Ketorolac Tromethamine 60mg/2 ml IM Injection 1x1's: 95.65 MRP
TOROAID General Pharmaceuticals Ltd Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.00 MRP
TOROLAC 10 Silva Pharmaceuticals Limited Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.75 MRP
TROY Amico Laboratories Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 30's: 300.00 MRP
VESLAC Reliance Pharmaceuticals Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 30's: 309.15 MRP
WINOP The Acme Laboratories Ltd. Ketorolac tromethamine 10mg Film Coated Tablet 20's: 200.80 MRP
WINOP Drop The Acme Laboratories Ltd. Ketorolac tromethamine 5mg/ml (0.5% isotonic soln.) Eye Drop 5ml: 80.00 MRP
WINOP Injection The Acme Laboratories Ltd. Ketorolac tromethamine 10mg/ml, 30mg/ml & 60mg/2ml (IM/IV) Injection 10mg x30's, 20mg x10's: 300.00 & 180.00 MRP
XENOLAC-10 Shamsul Alamin Pharmaceuticals Ltd Ketorolac tromethamine 10mg Film Coated Tablet 10mg/1ml: 150.55; 30mg/ml x1's &5's: 55.21 & 250.00; 60mg/2ml x1's:95.36 MRP
XIDOLAC Beximco Pharmaceuticals Ltd Ketorolac Tromethamine USP 10mg Tablet 20's: 200.00 MRP
XIDOLAC 10 Beximco Pharmaceuticals Ltd Ketorolac Tromethamine USP 10mg/ml Injection 5's: 150.00 MRP
XIDOLAC 30 Injection Beximco Pharmaceuticals Ltd Ketorolac Tromethamine USP 30mg/ml Injection 1's: 55.00 MRP
XIDOLAC DROP Beximco Pharmaceuticals Ltd Ketorolac Tromethamine USP 0.5% Drop 5ml: 80.00 MRP
ZEPAC 10MG TAB Sandoz/Novartis Ketorolac Tromethamine USP 10mg Tablet 3x10's, MRP 300
ZEPAC 30 MG AMP. Sandoz/Novartis Ketorolac Tromethamine USP 30mg Injection 1x5's, MRP 300
ZEROPAIN Healthcare Pharmacuticals Ltd. Ketorolac Tromethamine USP 10 mg Tablet 20's MRP 240 Tk
ZEROPAIN 30mg Healthcare Pharmacuticals Ltd. Ketorolac Tromethamine USP 30mg Injection 5's MRP 300 Tk
ZEROPAIN 60mg Healthcare Pharmacuticals Ltd. Ketorolac Tromethamine USP 60 mg Injection 2's MRP 200 Tk

Gen. MedInfo

IMPORTANT WARNING:

Ketorolac is used for the short-term relief of moderately severe pain and should not be used for longer than 5 days, for mild pain, or for pain from chronic (long-term) conditions. You will receive your first doses of ketorolac by intravenous (into a vein) or intramuscular (into a muscle) injection in a hospital or medical office. After that, your doctor may choose to continue your treatment with oral ketorolac. You must stop taking oral ketorolac on the fifth day after you received your first ketorolac injection. Talk to your doctor if you still have pain after 5 days or if your pain is not controlled with this medication. Ketorolac may cause serious side effects, especially when taken improperly. Take ketorolac exactly as directed. Do not take more of it or take it more often than prescribed by your doctor.

People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as ketorolac may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke or 'ministroke;' if you smoke; and if you have or have ever had high cholesterol, high blood pressure, bleeding or clotting problems, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking ketorolac. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take ketorolac right before or right after the surgery.

NSAIDs such as ketorolac may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while taking ketorolac. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin; or oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone). Do not take aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn) while you are taking ketorolac. Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines. If you experience any of the following symptoms, stop taking ketorolac and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Ketorolac may cause kidney failure. Tell your doctor if you have kidney or liver disease, if you have had severe vomiting or diarrhea or think you may be dehydrated, and if you are taking angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); or diuretics ('water pills'). If you experience any of the following symptoms, stop taking ketorolac and call your doctor: swelling of the hands, arms, feet, ankles, or lower legs; unexplained weight gain; confusion; or seizures.

Some people have severe allergic reactions to ketorolac. Tell your doctor if you are allergic to ketorolac, aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn), or any other medications. Also tell your doctor if you have or have ever had asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose). If you experience any of the following symptoms, stop taking ketorolac and call your doctor right away: rash; hives; itching; swelling of the eyes, face, throat, tongue, arms, hands, ankles, or lower legs; difficulty breathing or swallowing; or hoarseness.

Do not breastfeed while you are taking ketorolac.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to ketorolac. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ketorolac and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

 

Why is this medication prescribed?

Ketorolac is used to relieve moderately severe pain, usually after surgery. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

How should this medicine be used?

Ketorolac comes as a tablet to take by mouth. It is usually taken every 4 to 6 hours on a schedule or as needed for pain. If you are taking ketorolac on a schedule, take it at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Other uses for this medicine

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking ketorolac,

  • do not take ketorolac if you are taking probenecid.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: antidepressants; medications for anxiety or mental illness; medications for seizures such as carbamazepine (Tegretol) or phenytoin; methotrexate; sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
  • tell your doctor if you have or have ever had the conditions mentioned in the IMPORTANT WARNING section or swelling of the hands, feet, ankles, or lower legs.
  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or you plan to become pregnant. If you become pregnant while taking ketorolac, call your doctor.

talk to your doctor about the risks and benefits of taking ketorolac if you are 65 years of age or older. Older adults should not usually take ketorolac because it is not as safe as other medications that can be used to treat the same condition.

  • you should know that this medication may make you drowsy or dizzy. Do not drive a car or operate machinery until you know how this medication affects you.
  • talk to your doctor about the safe use of alcohol while taking this medication. Alcohol can make the side effects of ketorolac worse.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

If your doctor has told you to take ketorolac regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Ketorolac may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache

  • dizziness

  • drowsiness

  • diarrhe a

  • constipation

  • gas

  • sores in the mouth

  • sweating

Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more ketorolac until you speak to your doctor.

  • fever

  • blisters

  • yellowing of the skin or eyes

  • excessive tiredness

  • unusual bleeding or bruising

  • lack of energy

  • nausea

  • loss of appetite

  • pain in the upper right part of the stomach

  • flu-like symptoms

  • pale skin

  • fast heartbeat

  • cloudy, discolored, or bloody urine

  • back pain

  • difficult or painful urination

Ketorolac may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

Symptoms of overdose may include the following:

  • nausea

  • vomiting

  • stomach pain

  • bloody, black, or tarry stools

  • vomit that is bloody or looks like coffee grounds

  • drowsiness

  • slowed breathing or fast, shallow breathing

  • coma (loss of consciousness for a period of time)

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

 

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